Gonadorelin hmoovyog ib qho purified khov heev - qhuav hmoov formulation. Nws cov khoom xyaw nquag yog cov khoom siv hluavtaws gonadotropin- tso tawm cov tshuaj hormones (GnRH), uas yog tib yam li cov tshuaj hormones tsim los ntawm tib neeg hypothalamus. Cov hmoov tsis muaj menyuam no feem ntau tau ntim rau hauv ib lub vial tsis muaj menyuam thiab yuav tsum tau rov ua dua tshiab nrog cov kuab tshuaj tshwj xeeb (xws li cov kua qaub ib txwm lossis cov dej tsis muaj menyuam rau kev txhaj tshuaj uas muaj benzyl cawv) ua ntej siv, yaj rau hauv cov tshuaj txhaj tshuaj ua ntej yuav siv tau.
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Gonadorelin COA
Nws cov nyhuv pharmacological tseem ceeb yog kom simulate physiological pulses ntawm tib neeg lub cev, stimulating lub anterior pituitary caj pas kom tso tawm luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH), yog li tswj kev ua haujlwm ntawm gonadal thiab txhawb kev sib txuas ntawm cov tshuaj hormones kev sib deev thiab kev loj hlob ntawm kev ua si. Qhov zoo ntawm daim ntawv hmoov yog nws cov tshuaj muaj zog heev, uas ua rau nws yooj yim rau ntev - lub sij hawm cia thiab kev thauj mus los nyob rau hauv qis - kub thiab lub teeb - pov thawj tej yam kev mob, yog li txuas ntxiv cov khoom siv lub sij hawm.
Nws yog tsuas yog siv nyob rau hauv kev tshuaj ntsuam xyuas teb thiab yog ib tug tseem ceeb lub cuab tam rau kev soj ntsuam cov kev ua ntawm lub hypothalamus -pituitary-gonadal axis, siv los txheeb xyuas lub hauv paus chiv keeb ntawm hypogonadism. Tsis tas li ntawd, nws kuj tau siv dav hauv kev tshawb fawb thiab tshuaj kho tsiaj. Nws yog ib qho tsim nyog sau cia tias nws cov txiaj ntsig lom neeg yog nyob ntawm qhov tseeb pulsatile kev tswj hwm hom. Ib qho kev hloov kho tsis raug (xws li siv cov kuab tshuaj tsis tsim nyog uas muaj cov tshuaj tua kab mob) lossis kev tswj xyuas tas mus li yuav ua rau nws tsis muaj txiaj ntsig lossis txawm tias muaj cov teebmeem inhibitory. Yog li ntawd, kev ua haujlwm aseptic nruj thiab kev tswj hwm tus kheej yuav tsum tau ua raws li kev coj ua ntawm cov neeg ua haujlwm kho mob.
Gonadorelin hmoovyog ib qho tshuaj peptide hluavtaws, tseem hu ua GnRH (Gonadotropin{0}}tso tshuaj hormone) lossis LHRH (Luteinizing hormone- tso cov tshuaj hormones). Nws muaj ntau yam kev siv tshuaj thiab kev tshawb fawb.
1. Kev kho mob ntawm cov kab mob hauv lub cev
Gonadorelin acetate yog dav siv los kho cov teeb meem cuam tshuam txog kev ua me nyuam, suav nrog txiv neej thiab poj niam muaj menyuam tsis taus, pituitary hypogonadism thiab lwm yam kev mob ntsig txog kev tsim thiab tso tawm cov tshuaj hormones gonadal. Nws nkoos lub anterior pituitary caj pas kom zais gonadotropins (LH thiab FSH), yog li txhawb kev ua haujlwm ntawm zes qe menyuam thiab cov qe ntshav.
2. Kev kho mob fertility
Hauv kev pabcuam kev ua menyuam yaus, Gonadorelin acetate feem ntau yog siv los ua cov tshuaj kho mob los txhawb lub zes qe menyuam ovulation. Los ntawm simulating lub ntuj GnRH tso tawm nyob rau hauv lub cev, nws muaj peev xwm kho qhov sib npaug ntawm androgen thiab estrogen, txhawb lub sij hawm ib txwm ovulation ntawm zes qe menyuam, thiab ua rau kom muaj feem ntawm cev xeeb tub.
3. Txhim kho lub zog thiab txhim kho cov leeg nqaij
Gonadorelin acetate yog siv rau hauv qee qhov chaw qoj ib ce thiab kev cob qhia lub zog ua ib qho ntxiv los ua kom cov leeg nqaij thiab txhim kho lub zog. Los ntawm tshwj xeeb stimulating gonadotropin secretion nyob rau hauv lub anterior pituitary caj pas, nws zoo nce zus tau tej cov testosterone thiab estrogen nyob rau hauv lub cev. Cov tshuaj hormones no ua lub luag haujlwm tseem ceeb hauv kev txhawb kev loj hlob ntawm cov leeg thiab ua kom cov leeg kho mob sai tom qab kev cob qhia hnyav, pab txo cov leeg mob thiab ua kom lub sijhawm rov qab los. Nws kuj tseem pab txhim kho kev ua kom muaj zog, tso cai rau cov neeg ncaws pob thiab cov neeg nyiam kev noj qab haus huv los tswj kev siv zog ntau dua rau lub sijhawm ntev, yog li ua tiav cov txiaj ntsig kev cob qhia zoo dua.
4. Kev tshawb fawb txog kev kho mob qog noj ntshav
Gonadorelin acetate kuj muaj cov ntawv thov hauv kev tshawb fawb kho mob qog noj ntshav. Vim nws muaj peev xwm tswj tau qhov tso tawm ntawm gonadal cov tshuaj hormones hauv lub cev, nws tau siv dav hauv kev tshawb fawb txog kev kho mob thiab kev tshawb fawb los tshawb txog nws cov txiaj ntsig ntawm cov tshuaj hormones -cov qog nqaij hlav uas loj hlob nrog kev txhawb nqa ntawm gonadal cov tshuaj hormones. Tsis tas li ntawd, nws raug siv los kho qee yam mob cancer ntawm lub mis thiab prostate-los ntawm kev txo qis cov tshuaj estrogen lossis testosterone uas txhawb cov qog nqaij hlav, nws tuaj yeem cuam tshuam cov qog nqaij hlav thiab txhim kho cov kev mob tshwm sim ntawm cov neeg mob, feem ntau siv nrog rau lwm yam tshuaj tiv thaiv - qog nqaij hlav los txhim kho kev ua tau zoo.
5. Kev Tshawb Fawb Txog Tsiaj thiab Kev Tiv Thaiv Kev Loj Hlob
Gonadorelin acetate kuj muaj cov ntawv thov hauv kev tshawb fawb tsiaj thiab tsiaj txhu. Nws yog siv los tswj lub voj voog kev loj hlob ntawm cov tsiaj txhu thiab tswj kev yug me nyuam. Gonadorelin acetate tuaj yeem siv los txhawb lossis inhibit gonadal hormone secretion thiab zes qe menyuam ua haujlwm hauv cov tsiaj, raws li xav tau.
Cov no yog qee qhov kev siv tseem ceeb ntawm Gonadorelin acetate. Nws cov ntawv thov sib txawv hauv cov tshuaj thiab kev tshawb fawb ua rau nws yog ib qho tseem ceeb ntawm kev siv tshuaj thiab kev tshawb fawb. Txawm li cas los xij, thaum siv Gonadorelin acetate, koj yuav tsum ua raws li kev taw qhia ntawm tus kws kho mob lossis kws tshaj lij, thiab qhov ntau npaum li cas thiab kev kho mob yuav tsum tau txiav txim siab raws li qhov xwm txheej tshwj xeeb.
Txoj kev Synthesis
Thawj kauj ruam hauv kev sib txuas ntawm Gonadorelin acetate yog los ua ke cov saw hlau polypeptide. Polypeptide chains yog tsim los ntawm cov amino acids txuas ua ke hauv ib qho kev txiav txim tshwj xeeb. Qhov kev sib txuas no feem ntau yog siv cov khoom sib txuas-theem synthesis method lossis kua-theem synthesis method. Hauv cov khoom sib xyaw ua ke -theem synthesis, qhov pib amino acid txuas nrog cov khoom siv-theem cov khoom siv los ntawm cov pab pawg tiv thaiv, thiab cov amino acids tau ntxiv los ntawm cov voj voog ntawm cov tshuaj tiv thaiv thiab tiv thaiv pab pawg tshem tawm kom txog rau thaum cov saw hlau ua tiav polypeptide tau tsim.
Tom qab kev sib txuas ntawm cov saw hlau polypeptide tiav lawm, pawg acyl (acetate) yuav tsum tau txuas nrog hydroxyl pawg ntawm polypeptide los tsim Gonadorelin acetate. Cov kauj ruam no feem ntau yog siv cov activator (xws li dimethyl sulfoxide, dimethyl carboimide, thiab lwm yam) thiab carbonic anhydride rau acylation. Cov pab pawg acyl reacts nrog pawg hydroxyl ntawm cov saw hlau polypeptide los tsim ib daim ntawv cog lus ester, uas kho cov acyl pawg hauv polypeptide.
Cov kauj ruam kawg hauv kev sib txuas ntawm Gonadorelin acetate yog kom tau txais cov khoom kawg los ntawm cov tshuaj tiv thaiv cleavage. Cov kauj ruam no feem ntau yog siv cov kua qaub lossis cov kab mob yooj yim txhawm rau txhawm rau cov nyiaj tshwj xeeb thiab tso Gonadorelin acetate. Cov xwm txheej thiab cov txheej txheem rau daim ntawv cog lus cleavage nyob ntawm seb qhov yuav tsum tau muaj ntawm cov txheej txheem hluavtaws tshwj xeeb.
Ntxiv rau cov theem pib saum toj no, muaj qee txoj hauv kev siv los ua ke Gonadorelin acetate, suav nrog:
1. Boc zoo:
Boc (t-Butyloxycarbonyl) tiv thaiv pab pawg tswv yim yog ib qho kev siv tiv thaiv pab pawg tswv yim rau peptide synthesis. Hauv kev sib xyaw ntawm Gonadorelin acetate, Boc lub tswv yim tuaj yeem siv los tiv thaiv cov amino pawg ntawm cov amino acids. Los ntawm cov voj voog ntawm kev xaiv deprotection thiab kev tiv thaiv, ua tiav polypeptide chains tuaj yeem ua ke ua ke.
2. Fmoc lub tswv yim:
Fmoc (Fluorenylmethoxycarbonyl) tiv thaiv pab pawg lub tswv yim yog lwm qhov kev tiv thaiv pab pawg zoo rau peptide synthesis. Tsis zoo li Boc lub tswv yim, Fmoc lub tswv yim siv Fmoc pawg los tiv thaiv cov amino pawg ntawm cov amino acids. Los ntawm cov voj voog ntawm cov tshuaj tiv thaiv thiab kev tiv thaiv, ua tiav cov saw hlau polypeptide tuaj yeem ua ke cov kauj ruam -los ntawm - kauj ruam.
Cov no yog cov lus piav qhia luv luv ntawm cov kauj ruam yooj yim thiab ntau txoj hauv kev rau kev sib txuas ntawm cov khoom. Cov txheej txheem hluavtaws tiag tiag tuaj yeem sib txawv raws li kev tshawb fawb lub hom phiaj, cov tshuaj tiv thaiv kab mob, thiab tus kheej nyiam ntawm tus kws tshuaj. Nco ntsoov tias cov synthesis ntawm nws yog ib tug complex txheej txheem uas yuav tsum tau nqa tawm nyob rau hauv tsim nyog kuaj tej yam kev mob thiab ua los ntawm ib tug tej yam chemist los yog cov kws tshawb fawb.
Gonadorelin hmoovyog ib qho tshuaj hormones uas yog nyob rau hauv gonadotropin-tso tshuaj hormone (GnRH) tsev neeg. Cov qauv molecular yam ntxwv ntawm Gonadorelin acetate feem ntau suav nrog cov hauv qab no:
Polypeptide chain structure:
Gonadorelin acetate yog cov saw hlau polypeptide tsim los ntawm 10 amino acids, tseem hu ua decapeptide hauv biology. Cov amino acids no txuas ua ke hauv ib qho kev txiav txim los tsim cov qauv molecular ntawm Gonadorelin acetate.
Amino acid ua ntu zus:
Cov amino acid sequence ntawm Gonadorelin acetate yog pyroGlu-Nws-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2. Ntawm lawv, pyroGlu sawv cev rau "pyroglutamic acid" residue ntawm N-terminus, thiab NH2 sawv cev rau pawg davhlau ya nyob twg ntawm C-terminus. Cov kev npaj tshwj xeeb ntawm cov amino acid ib ntus txiav txim siab txog kev ua haujlwm lom neeg thiab cov tshuaj pharmacological ntawm Gonadorelin acetate.
Peptidic Bonds:
Txhua amino acid nyob rau hauv Gonadorelin Acetate yog txuas ua ke los ntawm peptide bonds los tsim ib tug polypeptide saw. Peptide bonds yog covalent bonds ntawm carbon thiab nitrogen tebchaw ntawm cov amino acids thiab muaj cov qauv thiab tshuaj lom neeg. Cov peptide bonds txuas cov carboxyl thiab amino pawg ntawm cov amino acids, tsim cov pob txha ntawm Gonadorelin acetate molecule.
Acetate pawg:
Gonadorelin acetate muaj ib pawg acetate (CH3COO-) hauv nws cov qauv tshuaj. Cov pab pawg acetic acid feem ntau dhau los ua cov tshuaj tiv thaiv esterification nrog cov pab pawg hydroxyl ntawm cov saw hlau polypeptide los tsim ib daim ntawv cog lus ester. Cov pab pawg acetate txuas nrog ester daim ntawv cog lus ntawm Gonadorelin los tsim cov qauv ntawm Gonadorelin acetate.
Peb -dimensional configuration:
Stereoisomers muaj nyob rau hauv polypeptide saw ntawm Gonadorelin acetate. Cov kab sib txuas ntawm cov amino acids sib txawv thiab cov kev sib txuas ntawm lawv tuaj yeem txiav txim siab qhov sib txawv ntawm peb - qhov sib txawv. Stereoconfiguration tuaj yeem cuam tshuam rau kev ua haujlwm thiab kev cuam tshuam ntawm Gonadorelin acetate.
Hydrogen bonding thiab tsis yog -covalent kev sib cuam tshuam:
Cov amino acid residues ntawm Gonadorelin acetate polypeptide saw tuaj yeem cuam tshuam los ntawm hydrogen bonds thiab lwm yam tsis yog -covalent kev sib cuam tshuam. Cov kev sib cuam tshuam no tuaj yeem cuam tshuam rau kev ruaj ntseg, folding thiab kev ua haujlwm lom neeg ntawm Gonadorelin acetate.
Cov saum toj no yog qee cov lus piav qhia txog cov qauv molecular yam ntxwv ntawm nws. Nws yog tsim los ntawm polypeptide chains nrog ib ntu ntawm cov amino acids txuas los ntawm pawg acetate. Nta xws li stereoconfiguration, hydrogen bonding, thiab noncovalent kev sib cuam tshuam kuj ua lub luag haujlwm tseem ceeb hauv lawv cov khoom. Nco ntsoov tias cov yam ntxwv ntawm cov qauv no yog qhov tseem ceeb rau kev nkag siab txog cov tshuaj pharmacological ntawmGonadorelin hmoovthiab kev sib cuam tshuam nrog lwm cov molecules.
Gonarelin tuaj yeem txhawb nqa kev sib txuas thiab tso tawm ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH) nyob rau hauv lub caj pas anterior pituitary, uas tuaj yeem siv los txheeb xyuas pituitary gonadotropin cia muaj nuj nqi. Tom qab txhaj tshuaj ntawm cov khoom no, qhov nce ntawm LH hauv cov tib neeg ib txwm muaj ntau dua li ntawm FSH, thiab FSH cov lus teb hauv cov poj niam prepubertal yog siab dua LH. Cov tib neeg uas muaj gonadotropin tsis txaus- tso tawm cov tshuaj hormones tuaj yeem ua rau muaj kev cuam tshuam qeeb tom qab txhaj tshuaj ntawm cov khoom, thiab qee zaum yuav tsum tau txhaj cov tshuaj txhaj tshuaj rau ob peb hnub ua ntej kev sim pib.
Simulating qhov kev tso tawm ib txwm muaj ntawm gonadotropin- tso tawm cov tshuaj hormones hauv hypothalamus, qis- noj cov tshuaj pulsed tuaj yeem siv los kho ncua kev laus, amenorrhea, thiab kev muaj menyuam tsis taus los ntawm hypothalamic etiology. Yog tias siab - koob tshuaj tas mus li yog siv, qhov txawv txav yuav tshwm sim tom qab luv luv - lub sij hawm stimulation ntawm pituitary gonadotropins, es tsis txhob inhibiting pituitary gonadal muaj nuj nqi. Qhov tshwm sim no tau tshaj tawm thaum siv cov tshuaj analogues nrog cov txiaj ntsig zoo dua thiab ntev dua li cov khoom nws tus kheej.
Gonarelin yog ib qho khoom tsim tawm gonadotropin- tso cov tshuaj hormones, peptide compound, thiab decapeptide. Cov khoom no tuaj yeem txhawb kev sib txuas thiab tso tawm ntawm gonadotropins (FSH thiab LH) hauv lub caj pas pituitary, thaum gonadotropins txhawb kev tso tawm cov tshuaj hormones kev sib deev los ntawm gonads. Kev tso tawm ntawm gonadotropin- tso tawm cov tshuaj hormones los ntawm hypothalamus yog tswj los ntawm ntau yam, suav nrog cov tshuaj hormones sib deev. Kev siv tshuaj ib zaug tuaj yeem ua rau cov tshuaj hormones sib deev; Kev siv tsis tu ncua tuaj yeem ua rau txo qis ntawm gonadotropin- tso cov tshuaj hormones receptors hauv lub caj pas pituitary, yog li txo qis cov tshuaj hormones kev sib deev.
Gonadorelin, Kuj hu ua gonadotropin - tso tawm cov tshuaj hormones (GnRH), nws yog ib qho tshuaj decapeptide secreted los ntawm hypothalamus, uas nws lub luag haujlwm tseem ceeb yog tswj kev tso tawm ntawm gonadotropins (LH thiab FSH) los ntawm cov qog pituitary anterior. Qhov kev tshawb pom ntawm nws tuaj yeem taug qab mus rau nruab nrab xyoo pua 20th, thaum cov kws tshawb fawb tau pib muaj kev txaus siab rau cov txheej txheem tswj hwm ntawm hypothalamic pituitary gonadal axis (HPG axis). Nyob rau xyoo 1960, pab pawg tshawb fawb coj los ntawm American endocrinologists Roger Guillemin thiab Andrew Schally feem cais tawm thawj zaug ib yam khoom los ntawm hypothalamus ntawm npua thiab yaj uas tuaj yeem txhawb kev tso LH thiab FSH los ntawm cov qog pituitary thaum tshawb nrhiav cov tshuaj hormones hypothalamic.
Tom qab ntau xyoo ntawm kev siv zog, Guillemin thiab Schally tau ua tiav cais thiab txheeb xyuas cov qauv ntawm nws xyoo 1971, txiav txim siab tias nws yog ib qho tshuaj hormone decapeptide. Qhov kev tshawb pom no tsis yog tsuas yog nthuav tawm cov txheej txheem tswj hwm ntawm HPG axis, tab sis kuj tseem muab cov pov thawj tseem ceeb rau kev tshawb fawb txog kev ua me nyuam tom qab. Hauv xyoo 1970 thiab 1980s, nrog kev nce qib hauv peptide chemistry thiab molecular biology cov txheej txheem, cov kws tshawb fawb tau nkag siab tob txog cov qauv thiab kev ua haujlwm ntawm nws. Xyoo 1977, Guillemin thiab Schally tau sib koom ua ke tau txais txiaj ntsig Nobel nqi zog hauv Physiology lossis Tshuaj rau lawv cov txiaj ntsig zoo hauv kev tshawb fawb peptide hormone. Tom qab ntawd, kev tshawb fawb ntawm Gonadorilin tau nkag mus rau theem tshiab, thiab cov kws tshawb fawb tau pib tshawb nrhiav nws cov txheej txheem ntawm kev ua raws li kev sib txawv ntawm lub cev thiab kab mob.
FAQ
Cov khoom puas raug cai?
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Nws yogmuaj nyob thoob plaws lub ntiaj teb no rau veterinary siv, suav nrog hauv Tebchaws Meskas, Canada, United Kingdom, Ireland, lwm qhov thoob plaws Tebchaws Europe, South Africa, Australia, New Zealand, Nyiv, Taiwan. Txawm li cas los xij, nws tsis muaj rau kev kho mob rau tib neeg hauv Tebchaws Meskas.
Cov khoom puas kho cov qe menyuam loj?
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Cov neeg mob ntawm testosterone uas xav kom qia los yog thim rov qab cov qog ntshav tuaj yeem siv gonadorelin lossis qis dua - koob hCG. Gonadorelin tuaj yeem muaj cov teebmeem estrogenic tsawg dua piv rau hCG thiab feem ntau suav hais tias yog cov tshuaj xaiv hauv cov neeg mob hluas uas muaj kev xav tsis zoo.
Cim npe nrov: gonadorelin hmoov cas 34973-08-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom