Leucine enkephalinyog ib qho endogenous pentapeptide uas muaj leucine, enkephalin, glycine, tyrosine, thiab serine. Cov mis mos molecular C28H37N5O7, CAS 58822-25{17}}6. Structurely, raws li ib tug pentapeptide, nws muaj ib tug kuj yooj yim tab sis compact qauv molecular. Txhua cov amino acid residue txuas nrog peptide bonds los tsim cov kab peptide saw qauv. Cov qauv no muab cov khoom lag luam zoo sib xws, tso cai rau nws ua nws cov haujlwm lom neeg tshwj xeeb hauv cov kab mob nyob. Lub caij no, vim muaj ntau yam amino acid residues nyob rau hauv nws cov molecule, nws nthuav tawm ib qho kev sib txawv ntawm cov txheej txheem thiab complexity. Secondly, nyob rau hauv cov nqe lus ntawm solubility, nws feem ntau muaj zoo solubility dej. Qhov no yog vim nws cov molecule muaj hydrophilic amino acid residues xws li glycine, tyrosine, thiab serine, uas pab kom cov khoom tsim ib tug ruaj khov molecular qauv nyob rau hauv aqueous kua. Tej zaum yuav muaj lwm yam kev ua haujlwm lom neeg. Piv txwv li, nws tuaj yeem koom nrog hauv kev tswj hwm kev nco thiab kev txawj ntse, thiab muaj txiaj ntsig zoo rau kev txhim kho cov teeb meem xws li kev nco poob thiab tsis muaj kev xav. Tsis tas li ntawd, nws kuj tseem tuaj yeem muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob, uas yog qhov tseem ceeb hauv kev tiv thaiv cov hlwb los ntawm kev puas tsuaj thiab tiv thaiv qhov tshwm sim ntawm cov kab mob. Nws muaj ntau yam kev ua haujlwm lom neeg thiab ua lub luag haujlwm tseem ceeb hauv cov kab mob neurological, cov kab mob metabolic, kev kho mob, kev tiv thaiv kab mob, thiab kev tiv thaiv neuroprotection. Nrog rau kev tshawb fawb tob thiab nkag siab txog kev ua haujlwm ntawm cov khoom, peb xav tias yuav tsim cov kev kho mob zoo dua rau cov kab mob ntsig txog thiab ua kom muaj txiaj ntsig zoo rau tib neeg kev noj qab haus huv.
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Customized Bottle Caps Thiab Corks:
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Tshuaj Formula |
C28H37N5O7 |
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Exact Mass |
555 |
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Molecular Luj |
556 |
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m/z |
555 (100.0%), 556 (30.3%), 557 (2.7%), 556 (1.8%), 557 (1.7%), 557 (1.4%) |
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Elemental Analysis |
C, 60.53; H, 6.71; N, 12.60; O, 20.16 |
Leucine Enkephalinyog ib qho tseem ceeb neuropeptide uas muaj dav nyob rau hauv lub hauv paus paj hlwb thiab muaj ntau yam kev ua haujlwm lom neeg. Nws cuam tshuam nrog lub paj hlwb μ, δ thiab κ Kev sib txuas ntawm peb opioid receptors plays lub luag haujlwm tseem ceeb hauv kev mob nyem, sedation, thiab anticonvulsant cuam tshuam, txhim kho lub paj hlwb kev ua haujlwm, tswj cov metabolism, cuam tshuam kev qab los noj mov, tswj lub cev kub, thiab kev tiv thaiv kab mob.
1. Tswj kev ua haujlwm ntawm lub paj hlwb
Ua lub luag haujlwm tseem ceeb hauv kev tswj hwm lub paj hlwb. Nws tuaj yeem txhawb kev loj hlob, sib txawv, thiab rov tsim dua tshiab ntawm cov neurons los ntawm kev tswj hwm kev tso tawm ntawm cov neurotransmitters, yog li txhim kho kev ua haujlwm ntawm lub paj hlwb. Qhov kev ua haujlwm no ua rau leucine enkephali ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob neurological xws li Parkinson's disease thiab Alzheimer's disease. Los ntawm kev tswj hwm kev ua haujlwm ntawm lub paj hlwb, leucine enkephali tuaj yeem txhim kho cov tsos mob xws li lub cev muaj zog thiab kev nco tsis zoo hauv cov neeg mob, thiab txhim kho lawv lub neej zoo.
2. Tswj cov metabolism
Nws muaj lub luag haujlwm ntawm kev tswj cov metabolism. Nws tuaj yeem txhawb kev noj qab haus huv, tswj cov metabolism hauv cov rog thiab qab zib, kom ua tiav cov txiaj ntsig ntawm kev tswj qhov hnyav, txhim kho kev rog, ntshav qab zib thiab lwm yam kab mob metabolic. Qhov kev ua haujlwm no ua rau leucine enkephali muaj peev xwm siv tus nqi hauv kev kho cov kab mob metabolic.
3. Cov teebmeem analgesic thiab sedative
Los ntawm kev khi rau opioid receptors nyob rau hauv lub hlwb, nws muaj peev xwm exert analgesic thiab sedative teebmeem. Nyob rau hauv cov xwm txheej ntawm qhov mob, kev nyuaj siab, thiab lwm yam., qhov tso tawm ntawm cov khoom no yuav nce, yog li txo qhov mob thiab txo qhov nro. Qhov kev ua haujlwm no ua rau leucine enkephali muaj peev xwm thov kev cia siab rau hauv kev kho mob thiab kev loj hlob ntawm sedatives.
4. cuam tshuam kev qab los noj mov thiab kev tswj kub
tuaj yeem cuam tshuam kev qab los noj mov thiab kev tswj kub. Nws tuaj yeem pab tswj qhov hnyav los ntawm kev tswj lub qab los noj mov chaw, cuam tshuam rau kev tsim khoom thiab inhibition ntawm qab los noj mov. Nyob rau tib lub sijhawm, nws tseem tuaj yeem koom nrog hauv cov txheej txheem ntawm kev tswj xyuas qhov kub thiab txias thiab tswj kev ruaj ntseg ntawm lub cev kub.
5. Kev tswj hwm kev tiv thaiv kab mob
Tsis tas li ntawd, nws muaj lub zog tiv thaiv kab mob. Nws tuaj yeem cuam tshuam rau kev ua haujlwm thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, tswj kev tiv thaiv kab mob, thiab yog li koom nrog kev sib npaug thiab kev tswj hwm ntawm lub cev tiv thaiv kab mob. Qhov kev ua haujlwm no ua rau nws muaj peev xwm siv tus nqi hauv kev kho cov kab mob tiv thaiv kab mob.
6. Cov nyhuv neuroprotective
Nws muaj cov teebmeem neuroprotective. Nws tuaj yeem txhim kho cerebral ntshav ncig thiab cov metabolism, txhawb kev kho thiab rov tsim dua tshiab ntawm lub hlwb. Qhov no muaj nuj nqi ualeucine enkephalinua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob neurological xws li kev raug mob ntawm lub hlwb thiab cerebral ischemia.
Leucineenkephalin yog ib qho tseem ceeb endogenous pentapeptide nrog ntau yam kev ua haujlwm lom neeg, tshwj xeeb tshaj yog ua lub luag haujlwm tseem ceeb hauv lub paj hlwb. Vim nws cov teebmeem physiological tseem ceeb thiab muaj peev xwm siv tau, cov txheej txheem synthesis ntawm leucine enkephali yeej ib txwm yog ib qho kev tshawb fawb hotspot nyob rau hauv cov teb ntawm chemistry thiab biology.
Cov theem synthesis ntawmleucine enkephalin:
1. Kev xaiv thiab pretreatment ntawm cov khoom khov-theem nqa khoom
Cov neeg nqa khoom uas nquag siv hauv cov khoom siv -theem peptide synthesis muaj xws li polystyrene resin, polyamide resin, thiab lwm yam. Cov cab kuj muaj cov tshuaj lom neeg ruaj khov thiab lub zog txhua yam, uas tuaj yeem txhim kho peptide chains zoo thiab tiv thaiv kom tsis txhob poob ntawm kev txhawb nqa. Thaum xaiv cov cab kuj, nws yog ib qho tsim nyog yuav tau xav txog nws cov yam ntxwv xws li qhov pore loj, thaj chaw tshwj xeeb, thiab pab pawg ua haujlwm kom ntseeg tau tias kev ua tiav ntawm cov txheej txheem synthesis.
2. Ua kom thiab condensation ntawm cov amino acids
Kev ua kom cov amino acids yog ib qho ntawm cov kauj ruam tseem ceeb hauv cov khoom -theem peptide synthesis. Feem ntau, cov amino acids reacts nrog activation reagents xws li N-hydroxysuccinimide, pentafluorophenol, thiab lwm yam. los tsim cov amino acid derivatives activated rau condensation cov tshuaj tiv thaiv nrog peptide chains ntawm khoom -theem nqa khoom. Cov tshuaj tiv thaiv condensation feem ntau yog ua raws li alkaline tej yam kev mob los ntawm kev ntxiv ib qho tsim nyog tus neeg sawv cev condensation (xws li triethylamine, N, N-dimethylformamide, thiab lwm yam) los txhawb cov tshuaj tiv thaiv.
3. Extension thiab tiv thaiv peptide chains
Nyob rau hauv lub hauv paus ntawm amino acid activation thiab condensation, maj mam txuas cov peptide saw tuaj yeem ua tiav los ntawm kev rov ntxiv cov amino acid monomers tshiab thiab ua kom reagents. Tom qab ntxiv txhua cov amino acid monomer, cov txheej txheem ntxuav thiab ziab kom tsim nyog yuav tsum tau tshem tawm cov tshuaj reacted unreacted thiab los ntawm - khoom.
4. Txiav thiab purification ntawm peptide chains
Thaum cov saw peptide txuas mus rau lub hom phiaj ntev, nws yuav tsum raug txiav tawm ntawm cov khoom thauj khoom -theem. Qhov no feem ntau yog ua tiav los ntawm acid hydrolysis lossis alkaline hydrolysis, nyob ntawm seb cov khoom siv thiab cov saw peptide siv. Cov saw peptide txiav yuav tsum tau ua kom huv huv los ntawm cov kauj ruam tsim nyog kom tshem tawm cov impurities thiab cov tshuaj tsis ua haujlwm. Cov txheej txheem purification feem ntau suav nrog gel pom, ion pauv chromatography thiab ua haujlwm siab ua kua chromatography.
Scope ntawm kev muag khoom channel
Leucine Enkephalin, raws li ib qho tseem ceeb bioactive peptide, muaj cov nqi siv dav hauv cov teb xws li neuroscience, pharmacology, thiab kev tshawb fawb biomedical. Cov hauv qab no yog kev tshuaj xyuas ntawm nws qhov kev muag khoom channel:
Cov kws tshaj lij bio reagent tsum
Renowned thoob ntiaj teb thiab domestic lwm tus neeg
Cov khoom lag luam muaj npe nrov thoob ntiaj teb xws li WAKO muaj lub koob npe nrov thiab kev lag luam dav dav hauv kev lag luam roj ntsha. Cov neeg muag khoom no feem ntau muaj cov txheej txheem tswj xyuas zoo thiab cov thev naus laus zis ntau lawm, muaj peev xwm muab siab - purity, siab - cov khoom zoo leucine enkephalin. Nws lub network muag khoom npog thoob ntiaj teb, ua tau raws li cov kev xav tau ntawm cov neeg siv khoom hauv cheeb tsam sib txawv los ntawm kev koom tes nrog cov neeg xa khoom hauv ntau qhov chaw lossis ncaj qha muag cov khoom lag luam rau cov koom haum tshawb fawb thiab kev lag luam. Tseem muaj ntau tus kws tshaj lij cov khoom siv roj ntsha hauv Suav teb, uas muaj lub hauv paus tob hauv kev lag luam hauv zos thiab kev nkag siab tob txog kev tshawb fawb hauv tsev thiab kev lag luam ib puag ncig. Lawv tuaj yeem muab cov kev pabcuam tus kheej thiab cov nqi sib tw ntau dua raws li cov yam ntxwv ntawm cov neeg siv khoom hauv tsev.
Peptide synthesis thiab ntau lawm tuam txhab
Qee lub tuam txhab loj peptide ntau lawm, xws li Jiangsu Jitai Peptide Industry Technology Co., Ltd., muaj peev xwm tsim muaj zog thiab kev tshawb fawb thiab kev tsim kho. Lawv tuaj yeem tsis tsuas yog tsim cov khoom lag luam xws li leucine enkephalin ntawm cov nplai loj, tab sis kuj tuaj yeem hloov kho synthesis raws li cov neeg siv khoom xav tau tshwj xeeb. Cov tuam txhab me me thiab nruab nrab- cov tuam txhab peptide synthesis feem ntau yog hloov tau yooj yim thiab tuaj yeem teb sai sai rau cov neeg siv khoom xav tau. Lawv tsom mus rau peptide synthesis thev naus laus zis thiab muaj qee yam kev ua tau zoo hauv qee cov khoom lag luam peptide tshwj xeeb. Cov tuam txhab no tuaj yeem ua haujlwm feem ntau hauv zos lossis ib puag ncig cov chaw tshawb fawb thiab cov lag luam, tuav ib qho chaw hauv kev lag luam los ntawm kev muab cov kev pabcuam sib txuas tus kheej thiab siab - cov khoom zoo.
Chaw muag khoom
Cov teb chaws tsim nyob hauv Europe thiab Amelikas
Cov teb chaws tsim kho nyob hauv Europe thiab Amelikas yog thawj zaug ntawm kev tshawb fawb biomedical thiab kws tshuaj, nrog rau kev thov siab rau siab -kawg roj ntsha reagents xws li leucine enkephalin. Cov teb chaws cov chaw tshawb fawb thiab cov tuam txhab lag luam tau nqis peev ntau ntawm cov peev nyiaj thiab cov neeg ua haujlwm hauv kev tshawb fawb neuroscience, kev tsim tshuaj, thiab muaj cov kev xav tau siab rau cov khoom zoo thiab kev ua tau zoo. Cov khoom lag luam muaj npe nrov thoob ntiaj teb cov khoom siv tshuaj lom neeg feem ntau yog qhov tseem ceeb ntawm European thiab Asmeskas kev lag luam los ntawm kev tsim cov kev muag khoom, koom nrog kev nthuav qhia thoob ntiaj teb, thiab txhawb nqa thiab muag cov khoom lag luam leucine enkephalin. Piv txwv li, cov chaw tshawb fawb thiab cov tuam txhab hauv lub tebchaws xws li Tebchaws Meskas, Tebchaws Askiv, thiab Lub Tebchaws Yelemees yog cov neeg siv khoom tseem ceeb thoob ntiaj teb rau leucine enkephalin.
IB TUG ASIA
Kev lag luam tshiab hauv Asia, xws li Is Nrias teb, Kaus Lim Qab Teb, Singapore, thiab lwm yam, tau maj mam nce lawv cov peev txheej hauv kev tshawb fawb biomedical nrog kev txhim kho sai ntawm lawv cov kev lag luam thiab kev txhim kho txuas ntxiv ntawm lawv cov thev naus laus zis. Qhov kev thov rau cov khoom siv roj ntsha xws li leucine enkephalin tab tom qhia txog kev loj hlob sai ntawm cov chaw tshawb fawb thiab cov lag luam hauv cov tebchaws no. Qee cov neeg muag khoom tau pib ua tib zoo saib rau cov kev lag luam tawm tshiab no, nthuav lawv txoj kev lag luam hauv cov teb chaws Esxias kev lag luam tshiab los ntawm kev koom tes nrog cov neeg muag khoom hauv zos lossis teeb tsa cov chaw ua haujlwm.
- Nyob rau hauv nruab nrab-1970s, nrog kev nce qib ntawm kev sib cais thiab kev soj ntsuam, cov kws tshawb fawb tau pib muaj peev xwm cais tawm thiab txheeb xyuas cov kab mob bioactive los ntawm cov ntaub so ntswg nyuaj. J. Hughes thiab lwm tus kws tshawb fawb tau txiav txim siab los kawm npua hlwb vim nws muaj ntau cov neuropeptides thiab yooj yim kom tau txais. Lawv tau tsim cov txheej txheem kev sim nruj uas tsom rau kev cais cov tshuaj nrog opioid zoo li kev ua haujlwm los ntawm npua hlwb.
- Pab neeg tshawb fawb ua ntej homogenized npua hlwb, thiab tom qab ntawd siv cov txheej txheem ntawm chromatographic sib cais thev naus laus zis, xws li ion txauv chromatography, gel filtration chromatography, maj mam cais cov npua hlwb homogenate. Hauv cov txheej txheem no, lawv yuav tsum tau ua qhov kev sim ua haujlwm nruj rau txhua kauj ruam sib cais kom ntseeg tau tias cov khoom sib cais muaj opioid zoo li kev ua haujlwm. Tom qab suav tsis txheeb rov sim dua thiab ua kom zoo rau kev sib cais, lawv thaum kawg tau cais cov khoom me me peptide nrog opioid zoo li kev ua si los ntawm npua hlwb.
- Tom qab ua tiav kev cais cov tshuaj nrog opioid zoo li kev ua haujlwm, pab pawg tshawb fawb tau siv cov thev naus laus zis xws li huab hwm coj spectrometry thiab amino acid sib lawv li kev txheeb xyuas los txheeb xyuas cov qauv ntawm cov khoom. Tom qab kev soj ntsuam ntxaws, lawv txiav txim siab cov amino acid ib ntus ntawm cov khoom no li Tyr Gly Gly Phe Leu thiab muab nws lub npe hu ua Leucine Enkephalin. Qhov kev tshawb pom no tau tshaj tawm hauv xyoo 1975, ua rau lub hnub yug ntawm leucine enkephalin.
Leucine enkephalin piv txwv qhov sib cuam tshuam sib cuam tshuam ntawm endogenous peptides thiab cov txheej txheem physiological. Nws ob lub luag haujlwm hauv kev kho mob thiab kev tswj hwm lub siab lub ntsws qhia txog nws txoj kev kho mob, thaum cov teeb meem hauv pharmacokinetics thiab receptor dynamics qhia txog qhov xav tau rau kev tsim tshuaj tshiab. Raws li kev tshawb fawb txuas ntxiv mus, Leu-ENK thiab nws cov derivatives tuaj yeem hloov kho kev tswj qhov mob thiab muab cov kev kho tshiab rau cov kab mob plawv thiab cov hlab plawv. Lub neej yav tom ntej ntawm kev kho opioid yog nyob rau hauv kev siv lub cev cov txheej txheem, thiab Leu-ENK sawv ntawm qhov ua ntej ntawm qhov kev hloov pauv no.
Cim npe nrov: leucine enkephalin cas 58822-25-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom