Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm leucine enkephalin hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo leucine enkephalin rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Leucine enkephalinyog ib qho endogenous opioid peptide tsim los ntawm tsib amino acids, nrog rau cov amino acid sequence Tyr Gly Gly Phe Leu, thiab yog ib qho tseem ceeb ntawm tsev neeg enkephalin. Cov molecule no yog tsim los ntawm enzymatic cleavage ntawm precursor protein proenkephalin thiab yog dav nyob rau hauv lub nruab nrab khaus system thiab ntau yam peripheral ntaub so ntswg. Nws yog ib qho tseem ceeb ntawm cov endogenous analgesic system nyob rau hauv lub cev.
Peb cov khoom tsim
Leucine Enkephalin COA
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| Certificate of Analysis | ||
| Compound npe | Leucine Enkephalin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 58822-25-6 | |
| Ntau | 60g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090035 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Chemical Formula: | C28H37N5O7 |
| Exact Mass: | 555 |
| Molecular Luj: | 556 |
| m/z: | 555 (100.0%), 556 (30.3%), 557 (2.7%), 556 (1.8%), 557 (1.7%), 557 (1.4%) |
| Elemental Analysis: | C, 60.53; H, 6.71; N, 12.60; O, 20.16 |
Leucine enkephalin, raws li ib qho tseem ceeb ntawm cov endogenous opioid peptide system, yog dav faib nyob rau hauv nruab nrab thiab peripheral khaus systems thiab koom nyob rau hauv cov kev cai ntawm ntau yam physiological thiab pathological txheej txheem los ntawm kev cuam tshuam nrog μ - thiab δ - opioid receptors. Nyob rau hauv xyoo tas los no, nws siv nyob rau hauv qhov mob mechaism tsom xam, neuro circuit efficiency tshawb xyuas, thiab kev xav thiab lub siab mob qauv tau txuas ntxiv mus, thiab nws tau dhau los ua ib qho tseem ceeb soj ntsuam cov cuab yeej hauv thaj tsam ntawm neuroscience.
1. Taw qhia
Lub endogenous opioid peptide system plays lub luag haujlwm tseem ceeb hauv kev tswj hwm neuro homeostasis, tswj kev mob kev xav, thiab cuam tshuam rau kev xav. Raws li ib qho ntawm cov tswv cuab tseem ceeb ntawm cov kab ke no, nws tau siv dav hauv kev tshawb xyuas neuroscience vim nws cov qauv meej, kev faib dav dav, thiab muaj zog receptor tshwj xeeb. Cov peptide no ua rau Gi / o protein txuas nrog opioid receptors, inhibits adenylate cyclase kev ua, thiab tswj cov ion channel, yog li cuam tshuam rau neuronal excitability thiab neurotransmitter tso tawm.
Nrog rau kev tshawb xyuas tob zuj zus, nws siv tau nthuav dav los ntawm kev tshawb nrhiav thawj zaug rau ntau qhov chaw xws li kev tswj hwm neuro circuit, kev txawj ntse tshawb nrhiav, thiab kev tshuaj xyuas mechaism ntawm kev mob hlwb. Yog li ntawd, kev sib koom ua ke nrog nws cov kev siv tshwj xeeb hauv kev tshawb nrhiav sib txawv yog qhov tseem ceeb rau kev nkag siab txog nws cov txiaj ntsig thiab nthuav dav nws txoj kev siv.
2. Siv nyob rau hauv tshuaj tua kab mob thiab kev tswj mob
Kev siv nyob rau hauv qhov mob tshawb xyuas spans ntau theem, ob qho tib si hauv nruab nrab thiab peripheral, nrog rau nws lub hom phiaj tseem ceeb yog los piav qhia cov txheej txheem tswj hwm ntawm endogenous analgesic system. Nyob rau theem qaum qaum, tshwj xeeb tshaj yog nyob rau thaj tsam dorsal horn, qhov peptide no tau siv dav los kawm cov txheej txheem kev sib koom ua ke ntawm cov teeb liab nociceptive. Ntau qhov kev sim tau pom tias los ntawm kev ua yeeb yam ntawm presynaptic opioid receptors, nws muaj peev xwm inhibit qhov tso tawm ntawm glutamate thiab tshuaj P los ntawm kev hnov qab cov paj hlwb, yog li txo qhov excitability ntawm kev ua haujlwm neurons.
Qhov kev ua tau zoo no ua rau nws yog ib qho cuab yeej tseem ceeb rau kev kawm "pain gating mechaism" (Fields HL, 2004). Hauv kev sim electrophysiological, exogenous siv cov peptide lossis kev tswj hwm ntawm nws qhov kev tso tawm endogenous tuaj yeem hloov pauv cov qauv hluav taws xob neuronal, uas tuaj yeem siv los ntsuas cov kev hloov pauv hauv kev sib kis ntawm synaptic.
Nyob rau theem brainstem, nws yog dav siv los kawm txog kev tswj lub luag hauj lwm ntawm descending analgesic system. Cov teeb meem grey nyob ib puag ncig cov dej hauv dej thiab ventromedial medulla ua ib txoj hauv kev qis qis qis.
Thiab cov peptide no koom nrog hauv kev tswj hwm kev ua haujlwm neuronal hauv cov cheeb tsam no. Kev tshawb xyuas tau pom tias nws tuaj yeem txhim kho cov haujlwm ntawm inhibitory neurons, yog li txo qis kev sib kis ntawm cov teeb liab raug mob mus rau cov chaw siab dua. Qhov kev siv no muaj nuj nqis tseem ceeb hauv kev ntxhov siab analgesia qauv thiab kev tswj xyuas neuro tswj, thiab tau siv los piav qhia ntau yam tsis yog tshuaj kho mob analgesic tshwm sim.
Hauv kev kawm txog kev mob inflammatory, nws lub ntsiab yog siv cov lus dag hauv kev tsom xam ntawm kev sib cuam tshuam ntawm lub cev tiv thaiv kab mob thiab kev mob siab. Hauv cov qauv mob ntev xws li mob caj dab rheumatoid,
Cov kev tshawb fawb tau pom tias lub cev tiv thaiv kab mob tuaj yeem tso tawm enkephalins ntawm qhov chaw ntawm qhov mob thiab tsim cov tshuaj tua kab mob los ntawm kev ua kom opioid receptors nyob rau hauv cov hlab ntsha peripheral. Qhov kev tshawb pom no ua rau nws yog ib qho tseem ceeb molecule rau kev kawm 'peripheral opioid system' (Stein, 2016). Tsis tas li ntawd, nyob rau hauv lub postoperative mob thiab cov ntaub so ntswg puas qauv, no peptide yog siv los soj ntsuam cov tswv yim analgesic hauv zos, muab ib tug theoretical hauv paus rau txo cov kev phiv ntawm central opioid tshuaj.
Hauv kev tshawb nrhiav qhov mob neuropathic, nws tau siv dav los tshuaj xyuas cov txheej txheem molecular hauv qab qhov tshwm sim thiab kev kho mob ntev.
Hauv cov qauv kev raug mob neuro thiab mob ntshav qab zib neuropathy, cov kev tshawb fawb tau pom tias qhov txo qis ntawm enkephalin qhia yog ze rau qhov mob rhiab heev.
Qhov tshwm sim no qhia tau hais tias dys kev ua tau zoo ntawm endogenous analgesic system plays lub luag haujlwm tseem ceeb hauv kev mob ntev. Yog li ntawd, cov peptide no yog siv los ntsuas kev hloov pauv hauv neuroplasticity thiab qhov ua tau zoo ntawm cov kab mob analgesic. Tsis tas li ntawd, nyob rau hauv tus qauv mob cancer,leucine enkephalinyog siv los kawm txog kev tswj hwm kev tswj hwm kev noj qab haus huv hauv cov qog microenvironment, tshwj xeeb tshaj yog nyob rau hauv lub xub ntiag ntawm cov kab mob inflammatory, thiab nws cov kev tso tawm hauv zos muaj qhov cuam tshuam rau qhov mob nyem.
3. Nws siv nyob rau hauv regulating khaus system muaj nuj nqi
Nws muaj ntau yam kev siv nyob rau hauv txoj kev tshawb fawb ntawm kev nruj kev tswj hwm kev ua tau zoo. Nyob rau hauv lub basal ganglia system, qhov peptide no feem ntau yog qhia nyob rau hauv neurons ntawm striatal indirect txoj kev, ua rau nws yog ib qho tseem ceeb rau kev kawm tswj lub cev muaj zog thiab neuro circuit regulation. Hauv cov qauv kab mob Parkinson, kev hloov pauv hauv cov theem qhia tau siv los cuam tshuam txog kev ua haujlwm ntawm txoj hauv kev tsis ncaj. Kev tshawb xyuas tau qhia tias nyob rau hauv cov xwm txheej ntawm dopamine deficiency, qhov kev qhia ntawm no peptide yog upregulated, li no pab txhawb inhibitory tso zis thiab ua rau impaired lub cev muaj zog efficiency.
Yog li ntawd, qhov peptide no tseem ceeb siv hauv kev txiav txim siab cov txheej txheem ntawm lub cev muaj zog.
Nws tau dav siv nyob rau hauv cov qauv kev qaug dab peg hauv kev kawm txog kev tswj hwm neuro excitability. Hauv kev tshawb nrhiav kev qaug dab peg, peptide no txo qis kev sib koom ua ke ntawm neuro networks ntau dhau los ntawm inhibiting excitatory synaptic kis tau tus mob thiab txhim kho inhibitory neuro kev ua. Qhov kev siv no ua rau nws yog ib qho tseem ceeb molecule rau kev kawm kev ruaj ntseg ntawm neuro networks.
Tsis tas li ntawd, los ntawm kev soj ntsuam cov txiaj ntsig ntawm cov peptide no ntawm neuronal firing zaus thiab synaptic kis tau tus mob, lub mechaism ntawm kev qaug dab peg tuaj yeem ua tau ntxiv.
Hauv hippocampus, qhov peptide no tuaj yeem cuam tshuam rau cov txheej txheem ntawm lub sijhawm ntev - lub sijhawm muaj zog thiab ntev - lub sijhawm inhibition, yog li tswj cov ntaub ntawv khaws cia thiab rho tawm. Kev tshawb xyuas tau pom tias nws muaj kev cuam tshuam loj rau kev paub txog kev ua tau zoo los ntawm kev tswj hwm glutamate receptor kev ua thiab kev tso tawm neurotransmitter. Yog li ntawd, no peptide yog dav siv nyob rau hauv kev txawj ntse neuroscience soj ntsuam.
Hauv kev tshawb nrhiav neuroprotective, nws yog siv los tshuaj xyuas cov txheej txheem tiv thaiv tom qab raug mob paj hlwb. Hauv cov qauv mob stroke thiab mob hlwb raug mob, cov peptide no nthuav tawm qee yam kev tiv thaiv neuroprotective los ntawm inhibiting cell apoptosis, txo cov lus teb inflammatory, thiab txo qis oxidative kev ntxhov siab. Qhov kev siv no ua rau nws yog ib qho tseem ceeb ntawm cov cuab yeej molecular rau kev ntsuam xyuas cov tswv yim neuroprotective.
Daim ntawv thov hauv kev kawm txog kev xav thiab kev mob hlwb
Hauv kev kawm txog kev xav thiab kev mob hlwb, nws lub hom phiaj tseem ceeb yog tswj hwm qhov khoom plig thiab kev coj cwj pwm. Nyob rau hauv cov qauv kev nyuaj siab, qhov poob ntawm kev ua tau zoo ntawm enkephalin system yog ze ze rau kev poob siab. Los ntawm kev kho nws cov qib thiab soj ntsuam cov kev hloov pauv ntawm tus cwj pwm tsiaj, kev tshawb nrhiav tuaj yeem siv los txheeb xyuas cov txheej txheem ntawm kev kho mob ntshav siab (Nestler & Carlezon, 2006). Cov peptide no tswj cov dopamine tso tawm hauv thaj av nucleus accumbens, yog li cuam tshuam rau kev nkag siab txog nqi zog.
Hauv kev tshawb nrhiav kev ntxhov siab, kev xav tau raug tswj los ntawm kev ua ntawm amygdala thiab prefrontal cortex. Nws tuaj yeem cuam tshuam ntau dhau ntawm neuro excitement, yog li txo qis tus cwj pwm ntxhov siab. Lub hom phiaj no tseem ceeb heev rau kev nkag siab txog kev tswj hwm kev xav.
Hauv kev tshawb nrhiav kev quav tshuaj, qhov peptide no tau siv dav los txheeb xyuas cov teebmeem kev txhawb zog thiab cov txheej txheem kev hloov kho neuro.
Nyob rau hauv tus qauv opioid dependence, lub dopamine system nyob rau hauv lub nucleus accumbens yog tswj kom koom nyob rau hauv tus txheej txheem ntawm nqi zog thiab dependence tsim (Shippenberg li al., 1987). Tsis tas li ntawd, nws kuj tau siv rau hauv kev kawm txog cawv thiab lwm yam tshuaj tiv thaiv los tshuaj xyuas cov kev hloov pauv hauv neuro circuits.
Hauv kev tshawb nrhiav kev ntxhov siab, nws yog siv los tswj cov lus teb neuroendocrine, tshwj xeeb tshaj yog hypothalamic pituitary adrenal axis. Los ntawm kev cuam tshuam rau cortisol tso tawm, peptide no koom nrog hauv lub cev txoj kev hloov mus rau kev ntxhov siab (Drolet li al., 2001).
Leucine enkephalinmuaj qhov dav thiab ntau- theem siv hauv kev tshawb nrhiav neuroscience. Cov peptide no ua lub luag haujlwm tseem ceeb hauv ntau qhov kev tshawb nrhiav, los ntawm kev tswj xyuas qhov mob mus rau kev tsom xam ntawm neuro circuit efficiency, thiab tom qab ntawd mus rau kev kawm txog kev xav thiab kev puas siab puas ntsws. Raws li ib qho tseem ceeb molecule txuas cov khaus, tiv thaiv kab mob, thiab endocrine systems, nws tsis tsuas yog muab ib tug tseem ceeb cov cuab yeej rau kev tshawb nrhiav yooj yim, tab sis kuj muab lub hauv paus tseem ceeb rau kev nkag siab tob txog cov txheej txheem ntawm cov kab mob.
Cov ntaub ntawv
1. Xwm
2. Phau ntawv Journal of Neuroscience
3. Kev tshawb fawb lub hlwb
4. Kev Tshawb Fawb Txog Tshuaj Kho Mob
5. Kev tshuaj xyuas endocrine
6. Hughes J et al., 1975
7. Field HL, 2004
8. Stein C, 2016
9. Gerfen CR et al., 1990
10. Shippenberg TS et al., 1987
11. Drolet G et al., 2001
12. Nestler EJ & Carlezon WA, 2006
FAQ
Leucine enkephalin yog dab tsi?
Leu-enkephalin txhais tau tias yogtsib amino acid endogenous peptide uas ua raws li agonist ntawm opioid receptors. Nws yog ib qho ntawm thawj zaug pom endogenous opioid peptides, nrog rau nws cov congener Met-enkephalin.
Puas yog leu-enkephalin yog tshuaj tua kab mob?
Leucine-enkephalin (Leu-ENK), lub endogenous delta opioid receptor agonist, tswj qhov mob thiab mus ob peb vas thiabtsim muaj zog analgesianrog txo cov teebmeem tsis zoo piv rau cov tshuaj opioids.
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