Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm myristoyl hexapeptide-23 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo myristoyl hexapeptide-23 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Myristoyl Hexapeptide-23yog cationic lipopeptide synthesized los ntawm cov khoom -theem txoj kev. Raws li biomimetic hluavtaws lipopeptide, nws ua haujlwm los ntawm ntau yam kev sib koom ua ke xws li tsom cov kab mob tua kab mob, tswj sebum, soothing o, thiab txhawb kev tsim collagen. Bloomtechz leverages nws tus kheej synthesis kab, mature quality control systems, and global supply chain capabilities to provide global cosmetics formulators, skincare brands, and raw material distributors with a -stop peptide raw material solution, from sample test and me-scale customization to large-scale supply.
Peb Cov Khoom Muag Khoom
Myristoyl Hexapeptide-23COA
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| Certificate of Analysis | ||
| Compound npe | Myristoyl Hexapeptide-23 | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | N/A | |
| Ntau | 18g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.58% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.65% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.68% |
| Ib qho impurity | <0.8% | 0.74% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 188 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Raws li ib qho kev ywj pheej peptide synthesis hom, Bloomtechz tuav tag nrho cov txheej txheem ntawmMyristoyl Hexapeptide-23nyob rau hauv -tsev, los ntawm cov amino acid raw khoom input, solid-theem coupling, N-terminal myristoylation, multi-step HPLC purification, sterilizing filtration, low-kub lyophilization, mus rau qhov kawg ntim. Peb tsis outsource synthesis lossis purification, thiab peb tuaj yeem hloov pauv txhua yam los ntawm cov qauv R & D me me mus rau loj - nplai kev lag luam. Ntxiv rau, peb suav nrog 'C. acnes antibacterial bioactivity 'nyob rau hauv peb batch tso system, uas yog ib tug tshwj xeeb muaj peev xwm haum rau daim ntawv thov no.
C. pob txuv yog ib qho facultative anaerobic Gram- cov pas nrig zoo uas nyob hauv ib puag ncig anaerobic ntawm cov plaub hau follicle sebaceous qog. Nws cov cell membrane phospholipids, tshwj xeeb tshaj yog cov tsis zoo them phosphatidylglycerol thiab cardiolipin, muaj nyob rau hauv ntau dua proportions piv rau cov tawv nqaij commensals xws li Staphylococcus epidermidis thiab coagulase -negative staphylococci. Nyob rau hauv sib piv, cov cell membrane ntawm S. epidermidis yog nplua nuj nyob rau hauv zwitterionic phospholipids, thiab nws daim nyias nyias muaj tsawg dua net tsis zoo nqi tshaj cov kab mob C. acnes hom. Gram- cov kab mob zoo tsis muaj cov txheej txheem sab nrauv, yog li cov cell membrane raug pom ncaj qha, thiab daim nyias nyias ntawm cov nqi them ncaj qha txiav txim siab qhov pib electrostatic adsorption zog ntawm cationic lipopeptides.
Cov tshuaj no lub peptide qaum yog nqa peb lysine residues, uas yog protonated ntawm physiological pH, muab lub molecule ib tug siab zoo nqi ceev. Thaum cov lipopeptide nkag mus rau hauv cov follicle microenvironment, nws nyiam qhov chaw nres nkoj ntawm electrostatic attraction mus rau qhov chaw tsis zoo ntawm C. acnes membrane. Txij li thaum S. epidermidis daim nyias nyias muaj tsawg tus nqi tsis zoo, qhov pib khi ntawm electrostatic adsorption qis dua, thiab lipopeptide molecules tsis tshua muaj ntau ntawm cov commensal membrane. Qhov no ua raws li thawj txheej ntawm kev tshuaj ntsuam xyuas thiab kuj yog ib qho kev sib txawv uas ntau yam lipopeptides tsis muaj.
Qhov thib ob txheej ntawm kev lees paub los ntawm 'membrane lipid theem hloov thiab hydrophobic insertion pib.'
C. pob txuv tau hloov zuj zus mus ua neej nyob ntev -lub sij hawm nyob rau hauv sebaceous follicles nplua nuj nyob rau hauv glycerides thiab dawb fatty acids, yog li nws cov cell membrane muaj ib tug ntau saturated fatty acid cov ntsiab lus, siab dua theem hloov pauv kub, thiab ntau rigid membrane. Lub myristoyl (C14) fatty saw muaj txoj cai hydrophobic ntev los ntxig rau hauv cov tawv phospholipid bilayer ntawm C. acnes. Cov saw luv luv (C10, C12) tsis muaj lub zog txaus hydrophobic kom ruaj khov rau hauv daim nyias nyias, thaum cov saw ntev ntev (C16 stearoyl hloov kho) txo qis lipopeptide dej solubility, ua rau nag lossis daus hauv cov dej formulations thiab ua rau nws nyuaj rau nkag mus rau hauv dej -lipid microenvironment ntawm follicles. Qhov no yog lub hauv paus ntsiab lus ntawm kev xaiv C14 myristoyl kev hloov kho- tsis yog los txhim kho cov tawv nqaij nkag mus, tab sis kom haum raws li qhov kev nkag siab ntawm cov dej nkag ntawm C. acnes cell membrane.
Tom qab cov khoom khi rau C. acnes cell membrane, myristoyl saw ntawm lipopeptide ntxig rau hauv phospholipid bilayer, hloov cov txheej txheem ntawm daim nyias nyias lipids thiab tsim ib ntus, tsis yog - mus tas li transmembrane ion channels, ua rau hydrogen thiab potassium ions tuaj yeem hla daim nyias nyias, uas ua rau PMF sai. Thaum PMF poob lawm, C. acnes 'lub zog metabolism hauv tuag tes tuag taw. Txawm hais tias cov kab mob tsis tuaj yeem lyse thiab tuag tam sim ntawd, lawv tsis tuaj yeem sib txuas, thauj, lossis tso cov kab mob phem xws li lipases thiab proteases. Yog tias tsis muaj peev xwm zais cov tshuaj tiv thaiv kab mob no, lawv tsis tas yuav txhawb nqa follicular keratinocytes, txiav tawm qhov chaw ntawm cov teeb liab inflammatory.
Cov txheej txheem no piav qhia txog qhov tshwm sim tshwm sim nyob rau hauv qee cov qauv: hauv kev sim suav hauv vitro colony, cov kab mob txo qis, tab sis hauv cell co- qauv kab lis kev cai, kev tso tawm ntawm pro- cov kab mob inflammatory uas tshwm sim los ntawm C. pob txuv tau txo qis. Lub hauv paus ua rau yog qhov sub-MIC qib ntawmMyristoyl Hexapeptide-23inhibit cov kab mob virulence tso zis ntau dua li ncaj qha tua tag nrho cov kab mob.
Thaum lub concentration ntawm lipopeptides nyob rau hauv lub zos follicle nce thiab nce mus txog lub MBC (tsawg kawg bactericidal concentration) pib, ntau npaum li cas ntawm lipopeptides accumulates nyob rau hauv daim nyias nyias, cuam tshuam lub phospholipid bilayer nyob rau hauv ib tug 'cov ntaub pua plag qauv' txoj kev. Cov txheej txheem membrane poob nws qhov txuas ntxiv, tsim cov lipid tsis xws luag, thiab cov poov tshuaj ions intracellular, ATP, thiab nucleic acids tawm hauv ntau. Cov kab mob tsis tuaj yeem tswj hwm kev ruaj ntseg thiab thaum kawg tuag irreversibly.
Khoom Description
Bloomtechz tsim siv tag nrho cov khoom-theem peptide synthesis nrog N-terminal myristoylation, multi-theem thim rov qab-theem HPLC purification, thiab qis-kub lyophilization. Cov lus hauv qab no muab ib sab -los ntawm- sab piv ntawm ntau yam peptides thoob plaws ntau qhov ntev, suav nrog lub hom phiaj ua haujlwm, cuam tshuam rau C. acnes, biofilm inhibition, cuam tshuam rau ntawm daim tawv nqaij microbiome, impurity risk, formulation compatibility, zoo tswj logic, ntau lawm, thiab kev pab txhawb. Qhov no pab R&D pab pawg tshawb nrhiav qhov sib txawv sai sai thiab muab cov ntaub ntawv ua tiav rau kev xaiv cov khoom xyaw rau cov neeg laus pob txuv thiab oily- cov qauv ntawm daim tawv nqaij rhiab heev. Cov ntaub ntawv ntawm no tsuas yog siv rau kev siv xwb.
| Sib piv Dimension | Bloomtechz | Myristoyl Tetrapeptide-4 | Palmitoyl Tripeptide-8 (Classic Anti-Inflammatory Peptide) | Salicylic Acid (BHA) |
|---|---|---|---|---|
| Core Molecular Structure | Myristoyl-Ala-Lys-Lys-Leu-Lys-Leu-NH₂; tag nrho covalently bonded C14 myristoyl pawg, amphipathic cationic lipopeptide | luv peptide qaum nrog C14 myristoyl hloov kho, cationic lipopeptide nrog cov amino acid sib lawv liag | Palmitoyl- hloov kho tripeptide, signaling peptide,tsis muaj daim nyias nyias -lysing bacteriostatic kev ua haujlwm | Me me molecule organic acid, tsis muaj peptide saw |
| Mechanism tawm tsamC. pob txuv | 1. Electrostatic targeting thiab adsorption mus rau siab -tsis zoo- nqiC. pob txuvcell daim nyias nyias; 2. Ntawm sub-MIC concentration, dissipates PMF nyiam thiab suppresses secretion ntawm virulence yam xws li lipase thiab protease;3. Membrane perturbation thiab bacteriostasis saum MBC; 4. Inhibits cov kab mob planktonic thiab cuam tshuam nrog biofilm colonization | Membrane pore tsim los tua planktonicC. pob txuv; kev tswj tsis muaj zog ntawm cov xwm txheej virulence, nruab nrab nkag mus rau hauv biofilm matrix | Tsis muaj kev ua bacteriostatic ncaj qha; tsuas yog downregulates pro-inflammatory cytokines hauv keratinocytes, tsis tuaj yeem ua ncaj qha rauCov kab mob ntawm daim tawv nqaij | Lipophilic follicular keratin exfoliation, indirectly txo cov kab mob colonization; tsis ncaj qha rau cov kab mob membrane |
| C. pob txuvBiofilm Inhibition | Penetrates polysaccharide matrix, inhibits tshiab biofilm tsim thiab txo virulence secretion ntawm embedded kab mob; haum rau cov neeg laus mob pob txuv | Tsuas yog inhibits nascent biofilm, txwv kev ua tau zoo ntawm kev paub tab biofilm | Tsis muaj biofilm inhibition muaj peev xwm | Tsuas yog exfoliates keratin, tsis tuaj yeem ncav cuag cov kab mob hauv biofilm |
| Kev cuam tshuam rau daim tawv nqaij Microbiome | Xaiv lub hom phiaj rauC. pob txuv; tsawg heev cuam tshuam rau commensal zoo kab mob xws liStaphylococcus epidermidis, preserves haiv neeg daim tawv nqaij flora tshuav nyiaj li cas | Cov tshuaj tua kab mob dav dav; muaj zog inhibition ntawm cov kab mob zoo ntawm daim tawv nqaij | Tsis yog -bactericidal, tsuas yog modulates cellular o, tsis muaj kev cuam tshuam rau cov kab mob | High concentration ua rau daim tawv nqaij barrier thiab indirectly cuam tshuam daim tawv nqaij microbiome |
| Risk ntawmC. pob txuvKev tiv thaiv | Tsawg heev; lub hom phiaj yog lub cev lipid qauv ntawm cov kab mob cell membrane, nyuaj los tsim kev tiv thaiv ntawm ib qho - taw tes noob hloov | Tsawg tsis kam tiv thaiv vim membrane- lub hom phiaj mechanism; broad - spectrum cov cuab yeej ua rau muaj kev xaiv siab rau ntawm daim tawv nqaij flora | Tsis muaj kab mob tsis zoo (tsis yog -bactericidal) | Tsis muaj kab mob tiv thaiv kab mob; daim tawv nqaij barrier kam rau siab poob lub sij hawm |
| Pom zoo Formulation Dosage | 0.001% - 0.05%, muaj zog ntawm tus nqi qis | 0.005%–0.1% | 0.001%–0.02% | 0.5% - 2% (kev tswj xyuas kom zoo nkauj sab sauv) |
| Optimal Formulation pH Range | 4.0–7.0, zoo tshaj plaws ntawm 4.5–6.5, sib piv cov follicle pH | 4.0–7.0 | 4.0–7.5 | 3.0-4.0 (acidic system) |
| Formulation Compatibility Risks | Tsis txhob muaj siab concentration anionic polymers / anionic surfactants; synergistic nrog zinc ntsev thiab kho peptides | Tsis txhob anionic systems; siab dua lipophilicity, kev pheej hmoo ntawm nag lossis daus hauv siab - roj formulations | Compatibility zoo heev, yuav luag tsis muaj electrostatic complexation txaus ntshai | Tsis tuaj yeem ua ke nrog siab -cov tshuaj tiv thaiv antioxidants; txaus ntshai ntawm additive irritation |
| Ntsiab impurity Control | Kev tswj nruj ntawm de-myristoylated impurities, uas ploj lawm / truncated peptides;Kev txheeb xyuas cov khoom muaj feem xyuam ntawm tus kheej ntawm HPLC ib pawg;C. pob txuvMIC kev soj ntsuam lom neeg rau kev tso tawm batch | Kev tswj ntawm truncated peptides thiab acylation byproducts nyob ntawm cov chaw tsim tshuaj paus synthesis; impurity profile tsis meej rau repacked mov | Ob peb impurities, mature synthetic txoj kev, byproducts yooj yim tshem tawm | Yooj yim me me molecule impurities, tsawg purification nyuaj |
| Daim tawv nqaij Irritation & Phototoxicity | Tsawg khaus ntawm qhov pom zoo noj; tsis yog -photosensitive, tsis muaj kev tiv thaiv tshav ntuj | Me ntsis irritating tshaj qhov tshuaj no | Kev khaus khaus qis heev, tsis yog -photosensitive | Keratin exfoliation nyhuv, redness thiab tev ntawm siab concentration; tsis yog -photosensitive |
| Cov txiaj ntsig ua haujlwm ntxiv | Thaum inhibitingC. pob txuv, activates fibroblasts, upregulates hom I / III collagen, zawm lax pores, xa tawm los tiv thaiv - kev laus pab rau cov neeg laus pob txuv | Bacteriostasis thiab tiv thaiv - mob nkaus xwb, tsis muaj qhov tseem ceeb ntawm collagen stimulation los yog pore tightening | Anti-inflammatory soothing thiab txhawb collagen,tsis muaj roj tswj lossis cov nyhuv bacteriostatic | Roj tswj thiab keratin unclogging, tsis muaj collagen boosting nyhuv |
| Manufacturing Model & Peev xwm | Bloomtechz nyob rau hauv-tsev khoom-theem synthesis, myristoylation, multi-theem HPLC purification thiab lyophilization Rhiav; muaj peev xwm hloov tau: mg lab kuaj → gram- nplai kev sim → kg pilot batches → puas-kg ntau lawm; muaj peev xwm reservation muaj | Ob qhov chaw: nyob rau hauv - tsev synthesis / luam repacking; muab kev ruaj ntseg sib txawv los ntawm tus neeg muag khoom | mature peptide, huab hwm coj- tsim los ntawm ntau lub Hoobkas, khoom ruaj khov | Cov khoom siv tshuaj lom neeg ntau, khoom siv txaus |
| Cov ntaub ntawv qhia txog kev xa tuaj | COA (nrog rau cov khoom muaj feem xyuam), TDS, MSDS; xaiv tauC. pob txuvMIC, strain selectivity thiab biofilm hauv - vitro test reports; formulation technical support, compatibility ntsuam xyuas, ua raws li kev thov kev sab laj | Cov ntaub ntawv yooj yim; Qee tus neeg muag khoom tsuas yog muab cov planktonic MIC, tsis muaj cov ntaub ntawv biofilm | Cov ntaub ntawv pov thawj peptide tag nrho; tsis muaj ntaub ntawv qhia txog kev kuaj bacteriostatic | Cov ntaub ntawv raw khoom ruaj ntseg |
| Ntiaj teb no ua raws li kev txhawb nqa | Txhawb REACH, TSCA thiab txawv teb chaws kev tswj cov ntaub ntawv npaj; pab cov neeg muas zaub nrog formulation thov kev soj ntsuam kev pheej hmoo | Cov ntaub ntawv yooj yim, tsis ua raws li cov kev pabcuam zoo thoob plaws cov neeg muag khoom | Thoob ntiaj teb lees txais cov khoom siv tshuaj pleev ib ce, cov ntaub ntawv paub tab | Dav siv thoob ntiaj teb, cov ntaub ntawv sau npe paub tab |
Cov ntaub ntawv siv
1. Zhang, Y., et al. (2021). Amphipathic Lipopeptide Modulation ntawm Cutibacterium acnes Membrane Potential thiab Virulence Factor Secretion. Phau ntawv Journal of Cosmetic Dermatology, 20(8), 2560-2568.
2. Lee, J., Park, S. (2022). Membrane Lipid Specificity of Cutibacterium acnes: Basic for Selective Targeting los ntawm Cationic Lipopeptides. Phau ntawv Journal of Bacteriology, 204(12), e00321-22.
3. Tshuaj pleev ib ce Raw Material Safety & Technical Specification
Personal Care Products Council (PCPC). (2023). Cov Lus Qhia Txog Kev Nyab Xeeb Kev Nyab Xeeb ntawm Myristoyl Peptide Cov Khoom Siv Ua Haujlwm. Washington: PCPC Xov Xwm Xov Xwm.
4. Kim, H., et al. (2022). Anti-Biofilm Kev Ua Haujlwm ntawmMyristoyl Hexapeptide-23Tawm tsam yeeb tshuaj-Resistant Cutibacterium acnes Isolates. Daim tawv nqaij Pharmacology thiab Physiology, 35(4), 210-218.
Cov lus nug nquag
Q1: Puas yog Bloomtechz Myristoyl Hexapeptide-23 txhawb nqa cov kev pabcuam ntim me me?
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A: Yog lawm, peb muab cov ncauj lus kom ntxaws kev ntim cov kev xaiv nrog cov pob me me ntawm 1g, 5g, thiab 10g, haum rau R & D kuaj thiab cov qauv kev txhawb nqa. Tag nrho cov txheej txheem yog sterile kom muaj kev ruaj ntseg ntawm cov khoom xyaw.
Q2: Yuav ua li cas qis - qhov kub thiab txias peptides nyob ruaj khov thaum hla - ciam teb shipping?
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A: Rau cov peptide no, uas xav tau 2-8℃cia, peb siv qhov kub thiab txias txias ntim ntim, nrog rau lub teeb - pov thawj thiab ya raws- pov thawj tiv thaiv, los tiv thaiv kev ua haujlwm poob vim qhov kub hloov pauv lossis lub teeb raug. Tag nrho cov txheej txheem yog traceable thiab haum rau hla - ciam teb shipping.
Q3: Cov khoom puas tuaj yeem ua tau zoo - kho kom haum rau cov qauv pH sib txawv?
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A: Yog lawm, peb tuaj yeem hloov kho thiab kho kom zoo kom haum rau qhov zoo tshaj plaws kev tu tawv nqaij pH ntau ntawm 4.5–6.5, zoo - kho cov txheej txheem purification los txhim kho cov dej solubility thiab formula compatibility, thiab tsis txhob inactivation los yog layering teeb meem.
Q4: Koj ua li cas kom ntseeg tau qhov sib xws hauv kev ua haujlwm thiab purity thaum lub sijhawm ntau lawm?
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A: Kev vam khom rau tus qauv peptide ntau lawm kab, peb txhim kho synthesis thiab lyophilization tsis. Txhua batch los nrog COA thiab TDS daim ntawv qhia, nruj me ntsis tswj purity thiab kev ua si kom tshem tawm batch sib txawv.
Q5: Koj puas muab kev pabcuam tshwjxeeb rau kev siv cov qauv?
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A: Yog lawm, peb muab ib qho - ntawm- ib qho kev txhawb nqa, qhia txog kev khaws cov khoom xyaw, qhov sib ntxiv, thiab kev txwv kev sib raug zoo, pab cov qauv kev tu tawv nqaij xws li pob txuv thiab roj- tswj cov khoom kom ua tau zoo thiab txo qis kev tsim khoom.
Cim npe nrov: myristoyl hexapeptide-23, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom