Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm feem kev paub manufacturers thiab lwm tus neeg ntawm secretin peptide nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo secretin peptide muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Secretin Peptideyog thawj zaug pom lub plab zom mov polypeptide hormone, tus cwj pwm los ntawm cov qauv linear polypeptide muaj 27 amino acids. N-terminal cyclization thiab C-terminal amidation modifications endows with strong stability and specificity. Tsis zoo li lwm cov kev tswj hwm peptides, nws cov haujlwm tsom mus rau cov kev tswj hwm ntawm lub plab zom mov thiab nws muaj ob lub zog ntawm cov tshuaj hormones thiab neuropeptide, ua rau nws yog ib qho tseem ceeb polypeptide rau kev tswj lub xeev khov kho ntawm digestive thiab metabolic dab nyob rau hauv lub cev. Nws cov txheej txheem ntawm kev txiav txim siab yog tsom rau: nws feem ntau yog zais los ntawm plab hnyuv S hlwb, tshwj xeeb tshaj yog khi rau receptors hauv lub hom phiaj hauv nruab nrog cev xws li pancreas thiab gallbladder, thiab ncaj qha tswj cov kua dej hauv plab zom mov yam tsis muaj kev sib kho los ntawm hypothalamic-pituitary-gonadal axis. Nws tsis tsuas yog txhawb lub pancreatic secretion ntawm bicarbonate rau neutralize gastric acid thiab tiv thaiv cov hnyuv mucosa, tab sis kuj tswj cov kua tsib secretion thiab gastrointestinal peristalsis, txuam lub physiological atherosclerosis ntawm tib neeg digestion.
Peb cov khoom Form
Secretin COA
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| Certificate of Analysis | ||
| Compound npe | Secretin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 17034-35-4 | |
| Ntau | 45g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.32% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.17% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.8% |
| Ib leeg impurity | <0.8% | 0.54% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 90 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Tshuaj Formula | C130H220N44O41 | |
| Exact Mass | 3053.65 | |
| Molecular Luj | 3055.46 | |
| m/z | 3054.65(100.0%), 3053.65(71.1%), 3055.65(69.8%), 3056.66(23.9%), 3055.65(16.3%), 3056.65(9.3%), 3056.66(8.4%), 3056.66(8.3%), 3054.65(6.6%), 3057.66(6.0%), 3055.65(6.0%), 3057.66(5.9%), 3057.66(5.0%), 3054.65(5.0%), 3057.66(2.9%), 3055.66(2.5%), 3057.66(2.4%), 3058.67(2.3%), 3056.65(2.0%), 3058.66(2.0%), 3054.65(1.8%), 3056.66(1.8%), 3055.66(1.6%), 3057.65(1.4%), 3058.66(1.2%), 3054.65(1.1%), 3056.66(1.1%), 3056.65(1.1%) | |
| Elemental Analysis | C,51.10; H,7.26; N,20.17; O,21.47 | |
Stimulating pancreatic kua txiv secretion
Stimulating pancreatic kua txiv secretion yog qhov tseem ceeb tshaj plaws thiab thawj qhov kev ua haujlwm ntawm lub cevSecretin Peptide, nrog rau nws lub luag haujlwm tseem ceeb tshaj plaws hauv kev tswj hwm lub xeev khov kho ntawm lub plab zom mov. Txoj haujlwm no yog qhov tshwj xeeb thiab raug tswj hwm. Tsis zoo li lwm cov plab hnyuv polypeptides, nws ua ncaj qha rau ntawm exocrine pancreas, thiab nws cov kev tswj xyuas tau zoo heev rau lub cev cov kev xav tau ntawm digestive, ua ib qho tseem ceeb lav rau kev zom thiab nqus cov as-ham xws li cov rog thiab cov protein.
Nws cov txheej txheem ntawm kev ua haujlwm yog qhov tseeb thiab muaj txiaj ntsig: thaum cov zaub mov nkag mus rau hauv duodenum, tshwj xeeb tshaj yog thaum acidic chyme (pH 4.5) nkoos S hlwb ntawm txoj hnyuv mucosa, S hlwb secrete ntau ntawm nws. Tom qab nkag mus rau hauv cov ntshav ncig, cov peptide no tuaj yeem ceev ceev thiab tshwj xeeb khi rau secretin receptors ntawm qhov chaw ntawm cov kab mob epithelial hauv cov kab mob exocrine pancreas, qhib cov kev taw qhia hauv qab, thiab tom qab ntawd pib qhov tso tawm loj heev ntawm cov kua txiv kua txiv pancreatic.
Sib txawv los ntawm lwm yam tshuaj uas tswj cov kua txiv kua txiv kua txiv, cov kua txiv hmab txiv ntoo ua los ntawm cov khoom muaj qhov sib txawv ntawm cov khoom sib txawv - nws yog nplua nuj nyob rau hauv bicarbonate (HCO₃⁻) thiab muaj cov dej tsim nyog thiab cov enzymes digestive (xws li pancreatic amylase, pancreatic lipase, trypsinogen, thiab lwm yam). Cov concentration ntawm bicarbonate tuaj yeem ncav cuag ntau dua 10 npaug ntawm cov ntshav plasma, ua rau nws cov ntsiab lus tseem ceeb rau neutralizing gastric acid thiab tiv thaiv cov hnyuv mucosa.
Hauv cov xwm txheej ntawm lub cev, qhov kev ua haujlwm no muaj qhov ua tau zoo heev: thaum muaj cov kua qaub ntau dhau hauv duodenum, qhov tso tawm ntawm nws nce ntxiv, ua rau cov txiav ua kom zais cov pa roj carbon ntau, uas sai sai neutralizes gastric acid nkag mus rau hauv duodenum thiab kho cov hnyuv pH mus rau qhov haum ntawm 8.0-7.0. Qhov no tiv thaiv corrosion thiab kev puas tsuaj ntawm duodenal mucosa los ntawm acidic tshuaj thiab txo cov kev pheej hmoo ntawm gastritis thiab duodenal rwj. Lub caij no, cov dej hauv cov kua txiv pancreatic tuaj yeem dilute chyme, ua kom yooj yim rau kev nthuav dav ntawm cov as-ham thiab kev ua haujlwm ntawm digestive enzymes.
Cov enzymes digestive xws li pancreatic lipase thiab trypsinogen hauv nws tuaj yeem koom tes nrog cov kua tsib thiab cov kua dej hauv cov hnyuv los txhawb cov emulsification thiab decomposition ntawm cov rog thiab kev zom ua ntej ntawm cov protein, daws teeb meem xws li kev zom qeeb thiab nqus cov rog thiab plab zom mov.
Txhawb txoj kev zais zis
Kev txhawb nqa cov kua tsib tso kua mis yog ib qho tseem ceeb pabcuam kev ua haujlwm ntawm cov khoom. Qhov kev ua haujlwm no ua haujlwm hauv kev sib koom ua ke nrog "stimulating pancreatic kua txiv secretion" kom tiav kev zom thiab nqus cov rog. Nws ua rau cov kab mob hauv cov kab mob epithelial ntawm daim siab nrog cov kev tswj xyuas me me thiab meej, uas tsis ua rau cov kua tsib ntau dhau los yog ua tsis tau raws li qhov xav tau ntawm lub cev. Nws yog ib qho tseem ceeb embodiment ntawm lub synergistic nyhuv ntawm lub digestive system thiab tseem qhia txog tus nqi ntawm nws nyob rau hauv cov kev cai digestive.
Nws cov txheej txheem ntawm kev ua haujlwm yog ob qho tib si cuam tshuam thiab sib txawv los ntawm kev tswj hwm ntawm pancreatic kua txiv tso kua txiv: Cov khoom lag luam kuj ua rau lub hom phiaj ntawm lub cev los ntawm cov ntshav ncig, tab sis nws khi rau cov receptors tshwj xeeb rau ntawm cov kab mob siab ntawm cov kab mob siab epithelial hlwb es tsis txhob ua rau pancreatic receptors. Tom qab kev khi, nws tuaj yeem ua kom lub zais zais ntawm cov kab mob hauv cov kab mob hauv lub cev, feem ntau txhawb kev zais ntawm bicarbonate thiab dej hauv cov kua tsib, thaum tsis muaj kev cuam tshuam rau kev tso tawm ntawm cov khoom tseem ceeb xws li kua tsib ntsev thiab cov roj cholesterol hauv cov kua tsib. Cov yam ntxwv kev tswj hwm no ua kom muaj kev ncaj ncees ntawm cov kua tsib thiab tsis txhob cuam tshuam ntawm cov kua tsib.
Nyob rau hauv cov nqe lus ntawm lub cev muaj nuj nqi, qhov tseem ceeb ntawm cov nyhuv no yog nyob rau hauv pab kev zom cov rog: lub ntsiab ua haujlwm ntawm cov kua tsib yog emulsify cov rog, decomposing macromolecular fat particles rau hauv me me molecular fat droplets los pab txhawb kev txiav txim ntawm pancreatic lipase, yog li txhawb cov rog zom thiab nqus. Tom qabSecretin Peptidetxhawb nqa cov kua tsib, nws tuaj yeem ua kom tag nrho cov nyiaj thiab cov kua tsib kua tsib, nce cov kua tsib nyob rau hauv txoj hnyuv, thiab txhim kho cov roj emulsification nyhuv-qhov no yog tshwj xeeb tshaj yog haum rau kev zom zaub mov tom qab noj cov zaub mov muaj roj ntau, txo cov tsos mob ntawm plab zom mov xws li mob plab thiab mob plab, mob plab. emulsification.
Nyob rau tib lub sijhawm, kev nce bicarbonate hauv cov kua tsib tuaj yeem pab ntxiv rau hauv kev ua kom tsis zoo ntawm cov kua qaub nyob hauv duodenum, thiab ua haujlwm hauv kev sib koom ua ke nrog bicarbonate hauv cov kua txiv pancreatic los tsim kev tiv thaiv ob npaug rau cov hnyuv mucosa thiab tswj kev ruaj ntseg ntawm cov kua qaub - puag ncig hauv plab hnyuv.
Hauv daim ntawv thov kev kho mob, qhov haujlwm no tuaj yeem siv rau kev pabcuam kev kho mob ntawm cov kab mob ntsig txog cov kua tsib tsis txaus, xws li kab mob siab ntev thiab cov kua tsib tsis zoo tom qab kev phais mob biliary obstruction. Exogenous supplementation ntawm nws tuaj yeem txhawb lub siab kom tso tawm cov kua tsib txaus, txhim kho cov rog zom thiab nqus tau zoo, thiab txo cov tsos mob xws li anorexia thiab mob plab hauv cov neeg mob.
Tsis tas li ntawd, cov txiaj ntsig ntawm nws hauv kev txhawb nqa cov kua tsib tso tawm tuaj yeem ua rau kom cov kua tsib tso tawm, uas pab txhawb kev tawm ntawm cov metabolism hauv cov khoom pov tseg (piv txwv li, bilirubin) hauv lub cev, pab txhim kho cov tsos mob jaundice, thiab muab cov tswv yim tshiab rau kev pab kho cov kab mob hepatobiliary. Hauv kev tshawb fawb txog kev tshawb fawb, nws tseem tuaj yeem siv los kawm txog cov txheej txheem secretory ntawm cov kab mob siab ntawm cov kab mob hauv lub siab epithelial hlwb thiab tshawb nrhiav kev sib koom ua ke ntawm kev tswj hwm kev sib raug zoo ntawm hepatobiliary system thiab digestive system.
Inhibiting gastric acid secretion
Inhibiting gastric acid secretion yog lub luag haujlwm tseem ceeb ntawm nws hauv kev tswj cov kua qaub -paj tshuav ntawm txoj hnyuv. Ua ke nrog ob qho haujlwm saum toj no, nws tsim "triple tiv thaiv thaiv" ntawm lub plab zom mov. Nws hom kev ua yog kev tswj tsis ncaj: tsis zoo li polypeptides lossis tshuaj uas ncaj qha inhibit gastric acid secretion, nws ua tiav gastric acid secretion inhibition los ntawm kev tswj kev tso tawm ntawm gastrin. Nrog rau cov nyhuv me me thiab thim rov qab, nws tuaj yeem hloov kho kom haum rau lub cev lub cev ntawm lub cev zom zaub mov, zam kev zom zaub mov tsis zoo tshwm sim los ntawm kev txwv ntau dhau ntawm gastric acid, thiab qhia txog qhov zoo ntawm qhov tshwj xeeb thiab kev nyab xeeb hauv nws txoj cai polypeptide.
Nws cov txheej txheem tshwj xeeb ntawm kev ua yog raws li hauv qab no: Cov khoom nws tus kheej tsis ua ncaj qha rau ntawm parietal hlwb (cov hlwb tseem ceeb secreting gastric acid), tab sis inhibits qhov zais ntawm gastrin los ntawm G hlwb hauv plab antrum los ntawm kev tawm tswv yim tsis zoo. Gastrin yog qhov tseem ceeb ntawm cov tshuaj hormones txhawb lub plab acid secretion thiab tuaj yeem txhawb nqa parietal hlwb kom tso cov hydrochloric acid. Thaum lub secretion ntawm nws nce, nws tshwj xeeb inhibits kev ua ntawm G hlwb, txo qhov tso tawm ntawm gastrin, yog li indirectly inhibiting gastric acid secretion ntawm parietal hlwb, txo cov concentration ntawm hydrochloric acid nyob rau hauv lub plab, thiab tswj cov kua qaub -base tshuav nyiaj li cas ntawm lub plab.
Tib lub sijhawm,Secretin Peptidekuj tseem tuaj yeem ua rau cov ntsiab lus ntawm bicarbonate nyob rau hauv txoj hnyuv los ntawm kev txhawb nqa cov kua txiv hmab txiv ntoo thiab cov kua tsib, ua rau tsis ncaj ncees rau cov kua qaub ntawm lub plab, ua kom muaj kev tswj hwm ob hom ntawm "inhibiting secretion + neutralizing residue", thiab ntxiv stabilizing cov kua qaub - puag ncig ntawm gastrointest.
Nyob rau hauv cov xwm txheej ntawm lub cev, cov kev cai ntawm qhov kev ua haujlwm no muaj kev hloov pauv tau yooj yim: thaum cov zaub mov nkag mus rau hauv lub plab, qhov tso pa tawm ntawm gastrin nce ntxiv thiab cov kua qaub kua qaub nce ntxiv los pab kev zom zaub mov ua ntej; Thaum chyme nkag mus rau hauv duodenum thiab txhawb kev tso tawm ntawm nws, gastric acid secretion yog me ntsis inhibited, tsis txhob ntau gastric acid nkag mus rau hauv txoj hnyuv ua rau puas mucosa, thiab tsim ib qho chaw haum rau kev txiav txim ntawm pancreatic kua txiv thiab kua tsib. Cov yam ntxwv ntawm "ntawm-kev tswj hwm kev xav tau" tuaj yeem ua kom tsis txhob muaj ntau dhau lossis tsis txaus cov kua qaub kua qaub, tswj kev ua haujlwm ntawm lub plab zom mov, thiab txo qhov tshwm sim ntawm gastric acid- ntsig txog kab mob.
Hauv daim ntawv thov kev kho mob, txoj haujlwm no muaj txiaj ntsig zoo thiab tuaj yeem siv rau kev kho mob ntawm cov kab mob ntsig txog cov kua qaub ntau dhau, xws li kab mob gastroesophageal reflux, mob gastritis thiab duodenal ulcer. Rau cov neeg mob zoo li no, exogenous supplementation ntawm nws tuaj yeem txo qis gastric acid secretion los ntawm inhibiting gastrin tso tawm, txo cov tsos mob xws li acid regurgitation, kub siab thiab mob plab. Vim nws cov nyhuv me me thiab thim rov qab, nws yuav tsis ua rau muaj kev tsis txaus siab ntawm gastric acid secretion zoo li muaj zog acid-txo cov tshuaj, zam cov kev mob tshwm sim xws li plab zom mov, mob plab thiab vitamin B12 malabsorption, thiab tshwj xeeb tshaj yog haum rau lub sijhawm ntev - pab kho mob ntawm cov neeg mob uas muaj kua qaub ntau dhau.
Nyob rau hauv tas li ntawd, nyob rau hauv lub teb ntawm kev tshawb fawb, lub mechanism ntawm nws inhibiting gastric acid secretion yuav siv tau los kawm cov synergistic tswj network ntawm plab hnyuv cov tshuaj hormones, tshawb nrhiav qhov tsis zoo tawm tswv yim tswj kev sib raug zoo ntawm polypeptides xws li gastrin thiab nws, thiab muab ib qho tseem ceeb siv rau kev tshawb fawb ntawm pathogenesis ntawm gastric acid- cov tshuaj tshiab thiab kev loj hlob. Nyob rau tib lub sijhawm, nws tseem tuaj yeem siv los ua cov cuab yeej polypeptide los tshuaj xyuas cov tshuaj tshiab uas tswj cov kua qaub hauv plab, pab txhim kho kev tshawb fawb thiab txhim kho cov tshuaj digestive.
FAQ
Dab tsi yog secretin hormone peptide?
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Nws yogpeptide muaj 27-amino acids uas muaj kev sib raug zoo nrog glucagon, VIP thiab gastric inhibitory polypeptide (GIP). Nws yog secreted los ntawm S hlwb ntawm duodenum nyob rau hauv cov lus teb rau cov kua qaub thiab ua rau nkoos bicarbonate secretion; nws cov khoom tuaj yeem cuam tshuam los ntawm somatostatin.
Nws siv rau dab tsi?
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Nws muaj 3 lub luag haujlwm tseem ceeb:Kev tswj hwm ntawm gastric acid, kev tswj ntawm pancreatic bicarbonate, thiab osmoregulation.
Lub cev twg yog stimulated los ntawm nws?
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Secretin ua raupancreastso tawm cov kua dej uas muaj cov enzymes digestive. Cov enzymes no zom cov zaub mov thiab pab lub cev nqus cov as-ham. Qhov kev ntsuam xyuas secretin stimulation yog ua los xyuas seb lub plab zom mov ntawm cov txiav.
Cim npe nrov: secretin peptide, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom