Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm 1,10-phenanthroline hmoov cas 66-71-7 hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 1,10-phenanthroline hmoov cas 66-71-7 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
1,10-Phenanthroline hmoovyog ib qho tseem ceeb ntawm cov organic compound nrog cov mis molecular C₁₂H₈N₂ thiab CAS npe 66-71-7, nrog rau qhov hnyav molecular ntawm 180.21. Qhov sib xyaw no nthuav tawm dav dav ntawm cov tshuaj lom neeg thiab cov dej num, ua rau nws siv dav hauv ntau yam kev tshawb fawb thiab kev lag luam. Nyob rau hauv nws lub xeev ruaj khov, 1,10-phenanthroline feem ntau tshwm li tsis muaj xim lossis daj daj crystalline hmoov, nrog rau lub cev ruaj khov uas pab txhawb kev khaws cia thiab kev sim ua haujlwm.
Qhov sib xyaw no ua rau pom kev zoo solubility hauv ntau hom kuab tshuaj. Nws yog yooj yim soluble nyob rau hauv polar organic solvents xws li ethanol, acetone, thiab dimethyl sulfoxide (DMSO), thiab kuj yaj nyob rau hauv tej yam inorganic kuab tshuaj xws li dej thiab benzene. Nyob rau hauv sib piv, nws yuav luag insoluble nyob rau hauv non-polar solvents zoo li roj av ether. Tshwj xeeb tshaj yog, nws cov ntaub ntawv hydrated thiab anhydrous qhia cov yam ntxwv ntawm lub cev: cov monohydrate tshwm sim raws li cov hmoov dawb crystalline nrog lub melting point ntawm 93-94 degree, thaum lub anhydrous daim ntawv muaj ib tug siab melting point ntawm 117 degree. Xws li cov ntsiab lus zoo solubility thiab thermal zog zoo heev txhim kho nws txoj kev ua haujlwm hauv kev sim tshuaj niaj hnub, kev tshuaj ntsuam xyuas, thiab kev tsim khoom loj.
Nyob rau hauv hluavtaws chemistry, 1,10-phenanthroline feem ntau yog siv los ua ib qho tseem ceeb ntawm lub tsev thaiv rau kev tsim kho cov hlau macrocyclic complexes. Los ntawm kev sib koom tes thiab kev sib koom ua ke ntawm tus kheej nrog ntau hom hlau ions thiab cov pab pawg ligands, nws tuaj yeem koom nrog kev tsim cov hlau macrocyclic compounds nrog cov qauv zoo thiab cov haujlwm tshwj xeeb. Cov kev ua haujlwm zoo no qhia tau tias muaj kev cia siab rau daim ntawv thov hauv cov haujlwm tseem ceeb xws li homogeneous catalysis, tshuaj sensing, biological imaging, thiab tswj kev xa tshuaj.
Raws li classic bidentate chelating ligand, 1,10-phenanthroline tuaj yeem tsim kev sib koom ua ke ruaj khov nrog ntau qhov kev hloov pauv hlau ions. Ntawm cov no, cov complexes tsim nrog tooj liab ions thiab lawv cov derivatives tau nyiam tshwj xeeb vim lawv cov haujlwm lom neeg tshwj xeeb. Cov kev tshawb fawb pom tau hais tias xws li tooj liab-phenanthroline complexes muaj qhov pom tseeb DNA cleavage kev ua si thiab tuaj yeem ua raws li non-oxidative nucleolytic mimetic enzymes, yog li endowing lawv muaj peev xwm tiv thaiv kab mob.
Tsis tas li ntawd, 1,10-phenanthroline ua haujlwm raws li tus neeg sawv cev zoo ntawm cov hlau chelates, uas tuaj yeem tswj cov hlau ion tshuav nyiaj li cas thiab txo oxidative kev nyuaj siab. Nws tau raug tshaj tawm tias inhibit chromosomal aberrations induced los ntawm streptozotocin, qhia txog kev tiv thaiv ntawm caj ces stability. Cov khoom siv roj ntsha no txuas ntxiv nthuav dav nws cov nqi siv hauv kev tshawb fawb biochemical thiab kev tsim tshuaj.
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Tshuaj Formula |
C12H8N2 |
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Exact Mass |
180 |
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Molecular Luj |
180 |
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m/z |
180 (100.0%), 181 (13.0%) |
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Elemental Analysis |
C, 79.98; H, 4.47; N, 15.55 |
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1,10-Phenanthroline, nrog rau cov tshuaj formula C ₁₂ H ₈ N ₂, yog nitrogen-muaj bidentate ligand. Ob lub nitrogen atoms hauv nws cov qauv molecular tuaj yeem tsim cov chelates ruaj khov nrog ntau yam hlau ions. Txij li nws cov khoom siv dag zog, qhov sib xyaw no tau nthuav tawm cov nqi siv dav hauv thaj chaw xws li tshuaj xyuas tshuaj, organic synthesis, tsim tshuaj, cov ntaub ntawv tshawb fawb, thiab kev tshawb fawb ib puag ncig vim nws cov khoom siv hluav taws xob tshwj xeeb thiab kev sib koom tes.
1. Spectral tsom xam thiab kuaj pom hlau
1,10-Phenanthroline hmoovyog ib qho classic reagent rau kev kuaj cov hlau ions hauv spectroscopic tsom xam. Lub txiv kab ntxwv liab complex tsim ntawm nws thiab Fe ² ⁺ nthuav tawm qhov siab tshaj plaws nqus ncov ntawm lub wavelength ntawm 510nm, nrog rau qhov ruaj khov ntawm lgK=21.3 (20℃). Cov yam ntxwv no ua rau nws yog ib txoj hauv kev rau kev txiav txim siab ntawm kab hlau los ntawm pom lub teeb spectrophotometric. Piv txwv li, hauv kev saib xyuas ib puag ncig, cov ntsiab lus hlau hauv cov qauv dej tuaj yeem kuaj pom los ntawm cov tshuaj tiv thaiv colorimetric, nrog qhov rhiab heev ntawm 0.1 μ g / L.
Tsis tas li ntawd, lub ligand tseem tuaj yeem siv rau kev tshawb nrhiav cov hlau ions xws li tooj liab, palladium, thiab vanadium. Lub complex tsim nrog tooj liab ions nthuav tawm cov yam ntxwv quenching nyhuv hauv fluorescence spectra, uas tuaj yeem siv rau kev txheeb xyuas ntau ntawm tooj liab ions. Qhov kev kuaj pom muaj 4.0 × 10 ⁻⁷ txog 4.0 × 10 ⁻⁵ mol / L.
2. Redox qhov taw qhia
Hauv kev tsom xam titration, nws muaj qhov zoo tseem ceeb raws li oxidation -qhib qhia. Piv txwv li, nyob rau hauv cov txheej txheem ntawm titrating hlau ntsev nrog cerium sulfate, qhov taw qhia ortho phenanthroline Fe (II) (npaj los ntawm 1.485g ntawm ortho phenanthroline monohydrate thiab 0.695g ntawm FeSO ₄· 7H ₂ O) tuaj yeem qhia qhov tseeb ntawm qhov kev hloov pauv ntawm cov xim. Thaum Fe ² ⁺ yog oxidized rau Fe ³ ⁺, cov xim tov hloov los ntawm txiv kab ntxwv liab mus rau xim tsis muaj xim, thiab qhov kawg ntawm qhov kev txiav txim yuam kev yog tsawg dua 0.1%.
3. Catalytic photometry thiab kinetic tsom xam
Raws li cov nyhuv catalytic ntawm 1,10-phenanthroline, catalytic photometry tuaj yeem ua tiav kev soj ntsuam hauv qhov ntau ntawm 0-1.0 × 10 ⁻ ³ mol / L. Piv txwv li, nyob rau hauv molybdate catalytic system, lub ligand tuaj yeem ceev cov tshuaj tiv thaiv ntawm poov tshuaj bromate oxidizing txiv kab ntxwv IV, thiab cov kab mob molybdenum tuaj yeem txiav txim siab los ntawm kev saib xyuas cov kev hloov hauv absorbance. Cov txheej txheem kinetic siv qhov kev hloov pauv ntawm cov tshuaj tiv thaiv rau kev tsom xam, nrog rau kev tshawb pom ntau ntawm 1.0 × 10 ⁻⁸ txog 6.0 × 10 ⁻⁶ mol / L, tsim nyog rau kev kuaj pom cov qauv ultra-low concentration.
Catalytic thiab Coordination Functions hauv Organic Synthesis
1. Hloov cov hlau catalyzed cov tshuaj tiv thaiv
Raws li ib tug bidentate ligand,1,10-Phenanthroline hmoovplays lub luag haujlwm tseem ceeb hauv kev hloov pauv hlau catalysis. Nyob rau hauv cov organic boronic acid crosslinking cov tshuaj tiv thaiv catalyzed los ntawm Cu (II), nws muaj peev xwm sib koom ua ke tuaj yeem ruaj khov rau nruab nrab thiab txhim kho cov tshuaj tiv thaiv xaiv. Piv txwv li, nyob rau hauv kev tsim kho ntawm carbon nitrogen bonds nyob rau hauv guanidine derivatives, ib tug system siv cuprous iodide raws li ib tug catalyst, 1,10-phenanthroline raws li ib tug ligand, thiab cesium carbonate raws li lub hauv paus yuav nce yield los ntawm 58% mus rau 89%.
Hauv kev tsim cov pa roj carbon sulfur daim ntawv cog lus, cov ligand no kuj nthuav tawm qhov ua tau zoo. Noj cov tshuaj tiv thaiv kev sib txuas ntawm phenylthiophenol thiab iodobenzene ua piv txwv, hauv CuI / 1,10-phenanthroline catalytic system, trifluoromethyltrimethylsilane tuaj yeem siv los ua trifluoromethyl qhov chaw kom ua tiav trifluoromethylation lossis trifluoromethylthiolation ntawm lub nplhaib benzene nrog 75% yield.
2. C-H daim ntawv cog lus ua kom cov tshuaj tiv thaiv
Hauv cov tooj liab catalyzed cross coupling cov tshuaj tiv thaiv ntawm diazole thiab pentafluorobenzene, ua raws li ligand tuaj yeem txhim kho cov tshuaj tiv thaiv zoo. Qhov kev sim tau pom tias tom qab ntxiv 0.1 equiv ligand, lub sij hawm cov tshuaj tiv thaiv luv luv ntawm 24 teev mus rau 8 teev, thiab cov txiaj ntsig ntawm cov khoom lag luam tau nce los ntawm 63% mus rau 91%. Nws cov txheej txheem ntawm kev txiav txim yog nyob rau hauv stabilizing lub tooj liab active chaw los ntawm kev sib koom tes, txhawb lub activation thiab coupling ntawm C-H bonds.
3. Kev tshuaj xyuas ntawm alkyl lithium compounds
Hauv kev txiav txim siab ntawm cov organic lithium reagent cov ntsiab lus, nws tuaj yeem siv los ua xim reagent. Kev ua haujlwm tshwj xeeb yog coj 1mg ntawm cov qauv thiab hnov mob nrog ortho phenanthroline los tsim cov xim tsaus nti, thiab tom qab ntawd titrate nrog cawv kom txog thaum tsis muaj xim. Txoj kev no tuaj yeem txiav txim siab qhov concentration ntawm alkyl lithium nrog qhov yuam kev tsawg dua 2%, thiab siv dav rau lithium reagent calibration hauv tshuaj synthesis.
1. DNA cleavage kev ua
Lub complex tsim nrog tooj liab ions nthuav tawm tsis muaj oxidative nuclease zog. Cov kev sim tau pom tias Cu (II) - phenanthroline complexes tuaj yeem tshem DNA ob npaug ntawm cov kab ke tshwj xeeb, thiab qhov kev ua haujlwm ntawm kev sib cais yog qhov zoo sib xws nrog ligand concentration. Thaum lub ligand concentration yog 50 μ M, DNA cleavage tus nqi nce mus txog 87%, muab lub hauv paus theoretical rau kev txhim kho cov tshuaj tiv thaiv kab mob tshiab.
Kev tshawb nrhiav cytotoxicity:
Hauv kev tshuaj xyuas ntawm cov tshuaj tiv thaiv kab mob qog noj ntshav, phenanthroline hlau complexes muaj cov haujlwm tseem ceeb.
Piv txwv li, lub dichloroplatinum (II) complex tsim los ntawm 3,4,7,8-tetramethyl-1,10-phenanthroline thiab platinum muaj IC50 tus nqi ntawm 12.3 μ M rau tib neeg daim siab mob qog noj ntshav cell HepG2, txo qis dua cisplatin's 28.7 μ M. Nws cov txheej txheem ntawm kev txiav txim siab yuav ua rau cov tshuaj platinum rau hauv cov tshuaj tiv thaiv kab mob thiab cov kab mob ntawm cov cell.
3. Chromosomal aberration suppression
Raws li tus neeg sawv cev hlau chelating, nws tuaj yeem tiv thaiv chromosome aberrations induced los ntawm streptozotocin. Kev sim hauv vitro tau pom tias kev kho mob nrog 10 μ M phenanthroline tuaj yeem txo cov chromosome breakage zaus los ntawm 68%, qhia tias nws muaj peev xwm tiv thaiv kab mob.
Organic Light Emitting Diodes (OLEDs):
1,10-Phenanthroline thiab nws cov derivatives tuaj yeem ua lub qhov thauj txheej rau OLED cov ntaub ntawv vim lawv qhov sib txuas π - electron system. Piv txwv li, lub iridium complex nrog 3,4,7,8-tetramethyl-1,10-phenanthroline li ligand muaj ib tug electroluminescence efficiency ntawm 18.7cd / A thiab ib tug sab nraud quantum efficiency ntawm 7.2%, ho zoo dua li tsoos txhuas quinone ligand systems.
Organic solar cells:
Nyob rau hauv cov organic solar cells, 1,10-phenanthroline derivatives tuaj yeem ua cov khoom thauj lub qhov.
Cov kev sim tau pom tias qhov qhib hluav taws xob hluav taws xob ntawm lub polymer P3HT: PCBM system uas muaj ortho phenanthroline units nce los ntawm 0.58V mus rau 0.65V, qhov ntim tau nce ntawm 62% mus rau 71%, thiab lub zog hloov pauv mus txog 6.8%.
Kev txhim kho ntawm fluorescent probes:
Raws li cov khoom fluorescence ntawm 1,10-phenanthroline, nws cov derivatives tuaj yeem siv rau kev tshawb pom hlau ion. Piv txwv li, 2-hydroxy-1,10-phenanthroline tsim ib qho 1: 1 complex nrog Zn ² ⁺ nyob rau hauv ib tug pH 7.4 buffer tov, uas txhim kho fluorescence siv los ntawm 12 lub sij hawm thiab muaj ib tug nrhiav kom tau txwv ntawm 0.8 nM. Nws tuaj yeem siv rau intracellular zinc ion imaging.
Nrhiav kom pom cov ntsiab lus hlau hauv dej:
Txoj kev tshawb nrhiav sai rau cov ntsiab lus hlau hauv cov qauv dej tuaj yeem tsim los ntawm kev siv cov tshuaj tiv thaiv xim ntawm ortho phenanthroline Fe (II) complex. Raws li qhov xwm txheej ntawm pH=2-9, txoj kev no muaj qhov sib txawv ntawm 0.05-5.0mg / L rau kev kuaj pom ntawm Fe ² ⁺, nrog tus nqi rov qab ntawm 98% -102%. Nws yog dav siv los saib xyuas cov dej saum npoo av thiab cov dej khib nyiab.
Ua kom thiab degradation ntawm cov pa phem los ntawm persulfate:
1,10-Phenanthroline hmoovNws tuaj yeem siv los ua ib qho catalyst los qhib persulfate (PMS) thiab tsim cov pa oxygen reactive (ROS) kom degrade organic pollutants.Thaum 25 degree, lub 0.1mM phenanthroline thiab 2mM PMS system tuaj yeem degrade 10mg / L bisphenol A nyob rau hauv 30 feeb, nrog ib tug degradation lub sij hawm ntau dua 4.
Kev saib xyuas cov pa phem hlau hnyav:
Surface enhanced Raman spectroscopy (SERS) thev naus laus zis tuaj yeem siv rau kev kuaj pom cov hlau hnyav hauv dej. Piv txwv li, ntawm nano silver aggregate substrate, lub complex tsim los ntawm ortho phenanthroline thiab Cd ² ⁺ nthuav tawm tus yam ntxwv Raman ncov ntawm 1450 cm ⁻¹, nrog rau kev tshawb pom txwv ntawm 0.1 nM, muab txoj hauv kev tshiab rau kev saib xyuas ib puag ncig hnyav hlau.
Tsiaj fiber staining:
Yuav siv tau raws li ib tug dye additive rau tsiaj fibers. Cov txheej txheem tsim nrog cov hlau ions tuaj yeem kho rau ntawm qhov chaw ntawm cov protein fibers xws li ntaub plaub thiab txhob lo lo ntxhuav, txhim kho xim ceev. Kev sim tau pom tias qhov sib ntxiv ntawm 5% phenanthroline ua rau kom ceev ceev ntawm cov ntaub plaub ntawm qib 3 txog qib 4-5.
Electroplating additives:
Hauv kev lag luam electroplating, nws tuaj yeem siv los ua qhov ci ci. Piv txwv li, ntxiv 0.2g / L phenanthroline rau zinc nickel alloy electroplating kua tuaj yeem txo qhov roughness ntawm txheej ntawm Ra1.2 μ m rau Ra0.3 μ m, thaum txhim kho corrosion kuj.
Capillary chromatography kab hloov kho:
Kev sib xyaw ua ke ntawm chromatography kem nrog π - π kev sib cuam tshuam, hydrogen bonding, thiab electrostatic kev sib cuam tshuam tuaj yeem npaj tau los ntawm kev hloov kho saum npoo ntawm silica gel monolithic kem nrog 1,10-phenanthroline siv cov cuab yeej siv tshuaj lom neeg. Kev sib cais ua haujlwm ntawm kem no rau polycyclic aromatic hydrocarbons yog 3.2 npaug ntau dua li cov kab C18 ib txwm, ua rau nws tsim nyog rau kev soj ntsuam ntawm cov qauv nyuaj.
Tus txheej txheem ntawm kev kuaj xyuas 1,10-Phenanthroline los ntawm qhov chaw ua kom zoo nkauj Raman spectroscopy suav nrog cov kauj ruam hauv qab no:
(1) Kev npaj ntawm o-phenanthroline txheem kev daws teeb meem: ntxiv 50 ~ 650 rau txhua ntawm tsib txoj kev kawm tiav nyob rau hauv lem μ L 20 mg / L nano-silver solution, 50-200 μ L 0.2 mol/L disodium hydrogen phosphate-sphosphate dihydrate dihydrohydrate 5.8 - 7.8, sib tov zoo; Ntxiv 2.5 raws li μ L, 5 μ L, 10 μ L, 30 μ L, 40 μ L, 50 μ L 1.0 × 10 ⁻ ⁷ mol / L phenanthroline standard tov, thiab tom qab ntawd ntxiv 20 ~ 150 rau txhua lub raj ntsuas μ L 2.0 min mol / L tov rau 1 qhov chaw sib tov, sib tov sib xyaw NaCl. 2.0 mL nrog dej distilled, thiab sib tov zoo;
(2) Npaj cov kev daws teeb meem dawb paug yam tsis muaj o-phenanthroline txheej txheem kev daws teeb meem raws li cov txheej txheem hauv kauj ruam;
(3) Siv cov txheej txheem saum toj no thiab cov kev tswj tsis pub dawb thiab muab tso rau hauv quartz colorimetric phaj feem. Ntawm Raman spectrometer, teeb tsa cov ntsuas ntsuas, luam theej duab kom tau qhov saum npoo - txhim kho Raman spectrum, thiab ntsuas 1450 cm ⁻ ¹ Tus nqi siv zog ntawm qhov chaw- txhim kho Raman tawg paj ntawm lub ncov yog kuv, thiab tus nqi siv zog ntawm qhov chaw {{5} Ramaneak kev daws teeb meem=I - I0;
(4) Nrog Ua ib qho kev ua haujlwm nkhaus rau kev sib raug zoo ntawm o-phenanthroline;
(5) Npaj cov tshuaj ntsuam xyuas ntawm cov qauv mus kuaj raws li txoj hauv kev hauv kauj ruam (1), thiab hloov cov qauv kev daws teeb meem ntawm o-phenanthroline nrog cov qauv yuav tsum tau kuaj, thiab txiav txim siab saum npoo- txhim kho Raman emission siv tus nqi ntawm cov tshuaj ntsuam xyuas ntawm cov qauv yuav tsum tau kuaj raws li kuv cov qauv raws li cov qauv (I piv txwv) {5} cov qauv {5} - I0;
(6) Xam cov ntsiab lus ntawm o-phenanthroline hauv cov qauv kuaj raws li kev ua haujlwm nkhaus hauv kauj ruam.
Cov kev txiav txim siab ntawm o-phenanthroline feem ntau suav nrog catalytic spectrophotometric, fluorescence spectrometry thiab kinetic method. Txoj kev catalytic spectrum siv cov nyhuv catalytic ntawm o-phenanthroline, thiab qhov kev tshuaj ntsuam ntau yog 0 ~ 1.0 × 10⁻ ³ Mol / L; Phosphorescence quenching ntawm o-phenanthroline los ntawm fluorescence spectrometry tuaj yeem ua rau kev tsom xam ntau txog 4.0 × 10⁻⁷-4.0 × 10⁻⁵ mol / L; Txoj kev kinetic yog raws li kev hloov pauv ntawm cov tshuaj tiv thaiv, thiab nws qhov kev soj ntsuam ntau yog 1.0 × 10⁻⁸-6.0 × 10 ⁻ ⁶ mol / L. CN201210363302.6 muab ib txoj hauv kev rau kev kuaj pom ntawm o-phenanthroline los ntawm qhov chaw ua kom zoo nkauj Raman spectroscopy.Cov qauv no muaj qhov zoo ntawm kev xaiv zoo, yooj yim, ceev ceev thiab tus nqi qis, thiab muaj cov ntawv thov zoo hauv kev txiav txim siab ntawm o-phenanthroline. Cov kev daws teeb meem rau realizing lub invention yog:
Nyob rau hauv cov xwm txheej ntawm qhov kev tsim kho tam sim no, nano-silver tov yog nyob rau hauv sodium dihydrogen phosphate-sodium hydrogen phosphate buffer tov, thiab cov tshuaj sodium chloride tuaj yeem ua kom nws sib sau ua ke los ua lub hauv paus nquag ntawm nano{2}}silver aggregate. Thaum cov tshuaj o-phenanthroline ntxiv, cov1,10-Phenanthroline hmoovyog adsorbed rau saum npoo ntawm nano-silver aggregate thiab yog 1450 cm tuab ¹ Muaj ib qho chaw muaj zog-ua kom zoo Raman tawg ua rau lub ncov ntawm, thiab muaj kev sib raug zoo ntawm cov concentration ntawm o-phenanthroline thiab kev siv zog txhim kho tus nqi ntawm qhov chaw{{4}. Raws li qhov no, ib txoj kev tsom xam ntau rau kev txiav txim siab ntawm o-phenanthroline tuaj yeem tsim.
Cim npe nrov: 1,10-phenanthroline hmoov cas 66-71-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom