Phloroglucinol hmoov, tseem hu ua 1,3,5-trihydroxybenzene, yog ntau yam organic compound teej tug mus rau tsev neeg phenol. Qhov no zoo, dawb mus rau lub teeb xim av hmoov nthuav tawm cov khoom siv tshuaj lom neeg uas ua rau nws muaj cov khoom tseem ceeb hauv ntau yam kev lag luam thiab kev tshawb fawb.
Nws cov yam ntxwv tseem ceeb yog nyob rau hauv nws lub peev xwm los tsim muaj zog hydrogen bonds, tso cai rau nws los ua ib qho khoom pib rau kev sib txuas ntawm ntau cov molecules complex. Hauv kev lag luam kws tshuaj, nws ua haujlwm ua ntej rau kev tsim cov tshuaj, vim nws cov tshuaj tiv thaiv thiab kev ua haujlwm ntau yam.
Tsis tas li ntawd, nws pom daim ntawv thov nyob rau hauv kev lag luam dyeing, qhov twg nws pab txhawb rau txoj kev loj hlob ntawm colorants nrog txhim khu kev ruaj ntseg thiab ceev ceev. Nws siv nyob rau hauv analytical chemistry yog ib qho tseem ceeb sib npaug, vim nws ua hauj lwm raws li ib tug reagent rau kev kuaj pom muaj tej pab pawg neeg nyob rau hauv cov organic tebchaw.
Tsis tas li ntawd, nws nthuav tawm cov khoom siv tshuaj tua kab mob thiab tshuaj tua kab mob, ua rau nws muaj peev xwm sib tw rau cov khoom noj khoom haus thiab tshuaj pleev ib ce. Cov kws tshawb fawb tseem tab tom tshawb nrhiav nws lub peev xwm hauv thaj tsam ntawm nanotechnology, qhov twg nws cov khoom tshwj xeeb tuaj yeem ua rau kev txhim kho cov ntaub ntawv tshiab.
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Tshuaj Formula |
C6H6O3 |
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Exact Mass |
126.03 |
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Molecular Luj |
126.11 |
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m/z |
126.03 (100.0%), 127.04 (6.5%) |
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Elemental Analysis |
C, 57.14; H, 4.80; O, 38.06 |
Phloroglucinol hmoovyog cov organic compound nrog cov qauv tshuaj tshwj xeeb, nrog cov qauv molecular C6H6O3, tsim los ntawm peb pawg hydroxyl hloov cov hydrogen atoms ntawm txoj haujlwm 1, 3, thiab 5 ntawm lub nplhaib benzene. Raws li myophilic, tsis yog atropine, uas tsis yog papaverine smooth nqaij antispasmodic tshuaj, phloroglucinol tau ua kom pom kev siv nyiaj ntau hauv cov tshuaj kho mob, kev lag luam tshuaj, thiab kev tshawb fawb tshawb fawb.
1. Kev kho cov kab mob digestive
Los ntawm kev ua ncaj qha rau ntawm cov nqaij ntshiv ntawm lub plab zom mov, kev cog lus ntau dhau yog inhibited, yog li txo qhov mob spasmodic. Nws cov kev xaiv antispasmodic muaj kev cuam tshuam tsawg heev rau cov leeg nqaij ib txwm, tsis txhob muaj kev phiv xws li qhov ncauj qhuav thiab cem quav los ntawm cov tshuaj antispasmodic (xws li atropine).
Mob plab hnyuv thiab chim siab plob tsis so tswj syndrome: tuaj yeem txo qhov mob plab thiab tsam plab tshwm sim los ntawm txoj hnyuv, thiab txhim kho txoj hnyuv. Piv txwv li, hauv cov neeg mob uas mob plab hnyuv, qhov mob tau txo qis hauv 30 feeb tom qab txhaj tshuaj phloroglucinol, thiab tsis muaj kev phiv xws li nce plawv dhia lossis ntshav siab.
Cov kab mob ntawm cov kab mob biliary: Rau cov mob spasmodic los ntawm biliary colic, cholecystitis, thiab gallstones, phloroglucinol relaxes cov nqaij mos ntawm lub biliary ib ntsuj av, txhawb cov kua tsib excretion, thiab txo qhov mob. Cov kev tshawb fawb soj ntsuam tau pom tias tag nrho cov txiaj ntsig zoo ntawm kev siv tshuaj tua kab mob ua ke rau biliary colic yog 92%, uas yog qhov zoo dua li kev kho tshuaj tua kab mob yooj yim.
Functional dyspepsia: tuaj yeem tswj cov kev sib txuam ntawm cov nqaij ntshiv plab, txhim kho cov tsos mob xws li tsam plab thiab belching. Ib qho kev sim tshuaj ntsuam xyuas uas suav nrog 200 tus neeg mob tau pom tias cov tsos mob ntawm cov tshuaj phloroglucinol pab pawg kho mob yog 35% siab dua li ntawm pawg tswj hwm.
2. Kev kho mob ntawm cov kab mob urinary thiab kev ua me nyuam
Cov nyhuv antispasmodic ntawm cov leeg du ntawm cov kab mob urogenital ua rau nws yog ib qho ntawm cov tshuaj nyiam rau kev kho mob ntsig txog.
Lub raum colic thiab zais zis spasm: Nyob rau hauv mob raum colic tshwm sim los ntawm ureteral pob zeb los yog cystitis, so ntawm cov nqaij mos ntawm lub ureter txhawb pob zeb tshem tawm thaum alleviating urinary zaus thiab ceev los ntawm lub zais zis spasm. Piv txwv li, ib qho kev tshawb fawb ntau ntawm cov neeg mob lub raum colic tau pom tias lub sijhawm kho mob hauv pab pawg kho nrog cov tshuaj antispasmodics yog 50% luv dua li ntawm kev siv tshuaj antispasmodics ib leeg.
Gynecological spasmodic mob:Phloroglucinol hmoovdav siv rau kev kho mob ntawm dysmenorrhea, endometriosis, thiab uterine contractions. Nws cov txheej txheem ntawm kev ua muaj xws li inhibiting ntau contraction ntawm uterine du nqaij thiab txo prostaglandin synthesis. Cov ntaub ntawv kho mob qhia tau hais tias tom qab siv phloroglucinol hauv cov neeg mob dysmenorrhea, qhov pom kev sib piv ntawm qhov ntsuas (VAS) rau qhov mob tau txo qis los ntawm 7.2 cov ntsiab lus mus rau 2.8 cov ntsiab lus, thiab tsis muaj kev cuam tshuam hauv nruab nrab ntawm lub paj hlwb xws li kiv taub hau thiab tsaug zog.
3. Kev siv tshuaj tua kab mob hauv cov xwm txheej tshwj xeeb
Cov xwm txheej tsis muaj yees thiab kev nyab xeeb ntawm lub plawv ntawm triphenylphenol muab nws qhov tshwj xeeb zoo hauv cov chaw kho mob tshwj xeeb.
Kev rho menyuam tawm thiab kev phais hysteroscopic: tuaj yeem so cov leeg nqaij ntawm lub ncauj tsev menyuam, txo qhov mob thiab kev puas tsuaj ntawm ncauj tsev menyuam los ntawm cov txheej txheem phais. Piv txwv li, hauv kev rho menyuam tsis muaj mob, kev txhaj tshuaj ua ntej ntawm phloroglucinol tuaj yeem txo lub sijhawm ntawm ncauj tsev menyuam los ntawm 40% thiab txo qis los ntshav los ntawm 25%.
Kev pab tus me nyuam: Thaum lub sij hawm thawj theem ntawm kev ua hauj lwm, lub tsev me nyuam cov leeg nqaij so yog siv los txhawb lub ncauj tsev menyuam dilation thiab ua kom luv luv. Ib txoj kev tshawb fawb uas muaj 500 tus poj niam primiparous tau pom tias qhov nruab nrab lub sij hawm nquag ntawm cov pab pawg phloroglucinol tau luv luv los ntawm 1.2 teev piv rau pawg tswj hwm, thiab qhov seem ntawm qhov chaw phais raug txo los ntawm 15%.
Postoperative colic tiv thaiv: Tom qab phais plab, nws tuaj yeem tiv thaiv qhov mob spasmodic los ntawm txoj hnyuv adhesions thiab txhawb kev ua haujlwm ntawm plab hnyuv. Cov kev soj ntsuam soj ntsuam tau pom tias cov neeg mob uas siv phloroglucinol nyob rau hauv lub sij hawm postoperative thaum ntxov muaj lub sij hawm rov qab los ntawm lub plab zom mov los ntawm 18 teev thiab lub sij hawm luv luv ntawm qhov quav los ntawm 24 teev.
1. Chemical synthesis intermediates
Nws yog ib qho tseem ceeb raw khoom rau synthesizing ntau yam tshuaj thiab dyes. Piv txwv li:
Tshuaj synthesis: Nws tuaj yeem ua ke los ntawm Hoesch cov tshuaj tiv thaiv los tsim Braun (ib qho tshuaj tiv thaiv kab mob peptic ulcer) lossis hnov mob nrog acetonitrile los tsim 2-acetyl triphenylphenol (siv hauv kev txhim kho tshuaj tiv thaiv kab mob).
Kev lag luam dyeing: Derivatives ntawm triphenylphenol (xws li 1,3,5-trimethoxybenzene) tuaj yeem siv los ua cov plaub hau dyes thiab siab -kawg dyes, thiab lawv cov tshuaj ruaj khov ua rau lawv muaj txiaj ntsig zoo hauv cov txheej txheem dyeing kub.
2. Kev tshuaj xyuas thiab tshawb xyuas cov tshuaj reagents
Cov khoom siv tshuaj lom neeg tshwj xeeb ua rau nws ua rau muaj ntau yam kev tshawb nrhiav:
Kev kuaj pom carbohydrate: cua sov pentose (xws li ribose) hauv cov ntsiab lus hydrochloric acid los tsim cov xim liab rau kev txiav txim siab txog DNA / RNA cov ntsiab lus.
Kev txheeb xyuas cov hlau ion: Nws cov tshuaj hydrochloric acid tuaj yeem hnov mob nrog Pine bark aldehyde pawg hauv lignin los tsim cov xim liab, uas yog siv rau cov nroj tsuag fiber ntau tsom xam; Nws tsim cov txiv kab ntxwv liab tebchaw nrog formaldehyde nyob rau hauv alkaline tej yam kev mob thiab yog siv los soj ntsuam formaldehyde cov ntsiab lus nyob rau hauv textiles.
Kev tswj hwm tshuaj zoo: siv los ua tus qauv rau kev txiav txim siab cov ntsiab lus ntawm lwm cov tshuaj antispasmodics los ntawm siab -kev ua tau zoo kua chromatography (HPLC) txoj kev.
3. Tshawb nrhiav cov cuab yeej molecules
Hauv kev tshawb nrhiav neuroscience,phloroglucinol hmoovyog siv los tshawb txog cov txheej txheem molecular ntawm cov leeg nqaij leeg. Piv txwv li, los ntawm kev tsim ib tus qauv ntawm cov nqaij mos ntawm tes raug ntxias los ntawm phloroglucinol, cov kws tshawb fawb tuaj yeem soj ntsuam cov kev hloov pauv hauv calcium ion channels thiab Rho kinase txoj hauv kev, muab lub hauv paus theoretical rau kev txhim kho cov tshuaj antispasmodic tshiab.
biocatalytic synthesis
Dilute lub cell mus rau ib qho concentration, tom qab ntawd muab cov tshuaj tua kab mob thiab ntxiv rau cov tshuaj sib xyaw ntawm NaNO2 tov thiab HAC-NaAC buffer tov, thiab kab lis kev cai los ntawm co hauv da dej ntawm li 37 degree. Ntxiv rau lawv rau hauv Na2HPO4 tsis haum tshuaj, sib tov kom zoo, smear rau ntawm lub phaj uas muaj LiCl, thiab cog rau hauv qhov tsaus ntuj ntawm li 37 degree.
Cov genomic DNA ntawm cov kab mob Pseudomonas fluorescens Pf-5 tau muab rho tawm, thiab cov noob polyketone synthase (phlD) tau txais los ntawm PCR amplification; Lub mutant noob phlD1 tau txais los ntawm qhov chaw qhia mutagenesis. Lub hom phiaj tawg tau zoo los ntawm cov khoom siv gel rov qab. Lub hom phiaj tawg tau zom los ntawm qhov sib thooj txwv enzyme ntawm 37℃rau 3-4 teev. Lub hom phiaj tawg tau purified los ntawm ethanol nag lossis daus; Lub prokaryotic qhia vector pET-30a (+) tau zom nrog tib yam kev txwv enzyme, thiab cov khoom siv rov qab gel tau siv rau kev rov ua kom huv thiab huv; Lub prokaryotic qhia vector pET-phlD1 tau tsim thaum qhov sib piv ntawm vector mus rau exogenous fragment yog 1: 3-10, thiab nws tau txuas thaum hmo ntuj ntawm txog 16 degree; Lub tsev recombinant plasmid tau hloov mus ua anti phloroglucinol Escherichia coli los ntawm tshav kub poob ntawm 42 degree, thiab qhov zoo recombinant strain tau los ntawm enzyme digestion identification, PCR qhia thiab sequencing soj ntsuam; - Cov lim tau khaws cia ntawm li 80 degree.
Inoculate cov kab mob engineered rau hauv LB kua kab lis kev cai nruab nrab (nrog rau 30-50μG·mL -1 kanamycin), thaum OD600 yog li ntawm 0.4-0.6 ntawm 37 degree, inducer IPTG tau ntxiv rau cov tshuaj tua kab mob, thiab tom qab ntawd lub hom phiaj protein yog induced qhia ntawm 37℃rau 3 - 5 teev; Tshem tawm cov tshuaj tiv thaiv kab lis kev cai, nqa cov av thiab ntxuav nws nrog phosphate tsis, thiab tom qab ntawd tshem tawm cov hlwb nrog qhov tsis sib xws ntawm qhov sib piv ntawm 1:10 (w / v). Ntxiv 2 × SDS-PAGE loading buffer, boiling, SDS-PAGE electrophoresis nrhiav kom tau, qhov sib thooj fusion protein bands tuaj yeem kuaj pom.
Fermentation ntawmphloroglucinol hmoovNpaj fermentation nruab nrab, sterilize, thiab ua aseptic inoculation thaum txias. Raws li qhov ua tau zoo ntawm kev sim orthogonal, thawj kab lis kev cai nruab nrab, los ntawm qhov induction ntawm kub electrode thiab pH electrode, yuav kho qhov kub thiab txias pH ntawm fermentation kua, thiab do cov kab lis kev cai fermentation.
Isophloroglucinol los ntawm cov fermentation supernatant tau muab rho tawm los ntawm ethyl acetate, ces ethyl acetate tau zoo tu qab tso thiab concentrated nyob rau hauv txo siab kom tau phloroglucinol.
FAQ
Dab tsi yog phloroglucinol siv rau?
Nws tiv thaiv spasms (contractions). Cov khoom siv tshuaj no yog qhia raukev kho mob spasmodic ntawm txoj hnyuv, biliary ib ntsuj av, zais zis thiab uterus.
Puas yog phloroglucinol siv rau lub sijhawm mob?
Antispasmodics: Phloroglucinol-raws li tshuaj antispasmodictuaj yeem ua tau zoo los txo qhov mob cuam tshuam nrog uterine contractions.
Cov tshuaj Spasfon siv rau dab tsi?
Nws yog siv nyob rau hauv kev kho mob ntawm spasms ntawm digestive (spasmodic colitis), biliary (hepatic colic), urological (lub raum colic) thiab gynecological (mob lub sij hawm thiab contractions ntawm lub tsev menyuam thaum cev xeeb tub).
Puas yog phloroglucinol tiv thaiv - mob?
Phloroglucinol muaj cov tshuaj tiv thaiv - kev ua ub nolos ntawm kev tswj hwm AMPK/Nrf2/HO-1 txoj kev taw qhia hauv LPS-stimulated RAW264.
Dab tsi yog cov kev phiv los ntawm phloroglucinol?
Cov tshuaj no tsis tshua muaj kev phiv loj heev, txawm li cas los xij, cov neeg mob tseem yuav tsum tau saib xyuas lub cev cov kev mob tshwm sim thaum noj cov tshuaj xws likhaus, pob khaus, Quincke's edema, arterial hypotension, thiab txawm tias tshuaj poob siabkom hu rau tus kws kho mob tam sim ntawd.
Spasfon puas tuaj yeem ua rau koj tsaug zog?
Txawm li cas los xij,Hauv qee cov neeg mob nws yuav ua rau muaj kev phiv xws li xeev siab, ntuav, kub siab, raws plab, tsis qab los noj mov, qhuav qhov ncauj, tsis muaj zog, tsaug zog.thiab lwm yam kev mob tshwm sim tsis tshua muaj tshwm sim. Yog tias koj ntsib teeb meem tsis tu ncua thaum noj cov tshuaj no, qhia rau koj tus kws kho mob sai li sai tau.
Cim npe nrov: Phloroglucinol CAS 108-73-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom