Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm 3,4,5-trimethoxyphenylboronic acid cas 182163-96-8 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo 3,4,5-trimethoxyphenylboronic acid cas 182163-96-8 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
3,4,5-Trimethoxyphenylboronic acid(3,4,5-trimethoxyphenyl boronic acid) yog cov organic compound. Nws yog xim tsis muaj xim lossis dawb. Nws tuaj yeem muaj nyob rau hauv cov ntaub ntawv siv lead ua sib txawv, xws li rab koob zoo li cov muaju, cov ntawv zoo li cov muaju, thiab lwm yam. Nws yog cov khoom siv hluav taws xob uas tuaj yeem hlawv hauv qhov qhib nplaim taws lossis cua sov. Cov qauv muaj xws li benzene nplhaib, boric acid pawg thiab peb pawg methoxy. Cov pab pawg boric acid txuas nrog lub nplhaib benzene, thaum pawg methoxy nyob ntawm txoj haujlwm 3, 4 thiab 5 ntawm lub nplhaib benzene. Nws muaj cov yam ntxwv ntawm Phenylboronic acid thiab tuaj yeem siv los ua cov ligand los koom nrog cov tshuaj tiv thaiv hlau catalytic, xws li Suzuki Coupling cov tshuaj tiv thaiv. Nws kuj tuaj yeem siv los ua ke rau lwm cov organic tebchaw, xws li tshuaj, khoom siv, thiab lwm yam.
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C.F |
C9H13BO 5 |
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E.M |
212 |
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M.W |
212 |
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m/z |
212 (100.0%), 211 (24.8%), 213 (9.7%), 212 (2.4%), 214 (1.0%) |
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E.A |
C, 50.99; H, 6.18; B, 5.10; O, 37.73 |
3,4,5-Trimethoxyphenylboronic acidtau txais txiaj ntsig tseem ceeb hauv kev tshawb fawb txog kev tshawb fawb vim nws lub peev xwm zoo kawg nkaus rau kev paub txog carbohydrate thiab khi. Cov txheej txheem tshuaj lom neeg no ua rau nws muaj kev cuam tshuam tshwj xeeb nrog diol- muaj cov molecules, xws li cov suab thaj thiab glycosylated proteins, tsim cov complexes ruaj khov los ntawm cov nyiaj rov qab covalent. Cov cuab yeej no muaj txiaj ntsig tshwj xeeb hauv kev txhim kho cov cuab yeej siab tshaj plaws thiab kev sojntsuam tsim los txhawm rau txheeb xyuas thiab ntsuas cov suab thaj tshwj xeeb lossis glycosylated biomolecules nrog siab rhiab heev thiab xaiv.
Nyob rau hauv lub realm ntawm analytical chemistry, lub compound lub peev xwm los khi diols tau harnessed rau affinity chromatography daim ntaub ntawv. Los ntawm kev muab nws tso rau hauv chromatographic resins, cov kws tshawb fawb tuaj yeem ua kom huv si glycoproteins thiab lwm yam diol - nplua nuj biomolecules los ntawm cov sib tov sib xyaw. Cov txheej txheem no leverages lub compound xaiv binding affinity, tso cai rau kev sib cais ntawm lub hom phiaj molecules nrog siab purity thiab tawm los.
1. Nto hloov:
TMPBA tuaj yeem siv los ua qhov hloov pauv saum npoo los hloov cov khoom ntawm cov khoom nto los ntawm kev sib koom ua ke nrog cov khoom nto. Piv txwv li, qhia TMPBA mus rau saum npoo ntawm nanoparticles tuaj yeem txhim kho lawv cov kev sib raug zoo nrog cov matrix, txhim kho qhov tawg thiab ruaj khov ntawm nanoparticles. Tsis tas li ntawd, TMPBA kuj tseem siv tau los tswj tus cwj pwm ntawm cov tee dej ntawm cov khoom siv, xws li tswj lub kaum sab xis ntawm cov tee dej thiab inhibiting droplet evaporation.
2. Interface los ua ke:
TMPBA tuaj yeem siv rau hauv cov txheej txheem ntawm kev sib dhos sib dhos. Los ntawm kev sib koom tes nrog lwm cov molecules lossis cov pab pawg ua haujlwm saum npoo av, kev teeb tsa kom zoo thiab tus kheej - sib dhos ntawm cov molecules sib txawv tuaj yeem ua tiav. Cov tshuaj tiv thaiv kev sib koom ua ke no tuaj yeem tsim cov qauv kev sib txuas ruaj khov, xws li ib qho - txheej zaj duab xis, ntau- txheej zaj duab xis, thiab lwm yam. Cov yam ntxwv ntawm TMPBA tuaj yeem siv los tsim kev sib txuas nrog cov qauv tshwj xeeb thiab kev ua haujlwm, xws li cov khoom siv hluav taws xob molecular, Photoelectrochemical cell, thiab lwm yam.
3. Interface catalyst:
TMPBA tuaj yeem siv los ua tus thawj coj rau kev sib txuas catalysts los tsim kev sib txuas nrog cov catalytic kev ua tau zoo. Los ntawm kev qhia TMPBA rau saum npoo ntawm cov catalyst, nws cov kev cuam tshuam nrog cov substrate tuaj yeem txhim kho, txhim kho kev ua haujlwm thiab kev xaiv ntawm cov tshuaj tiv thaiv catalytic. Qhov no interface catalyst yuav siv tau rau ntau yam organic synthesis tshuaj thiab cov txheej txheem tseem ceeb catalytic.
4. Interface sensor:
Vim muaj kev sib koom tes thiab tshuaj muaj zog ntawm TMPBA, nws tuaj yeem siv los tsim cov khoom sib txuas. Kev paub txog Molecular rhiab heev thiab kev kuaj pom tuaj yeem ua tiav los ntawm kev cuam tshuam TMPBA nrog cov kev ntsuas tshwj xeeb. Cov interface sensors no tau siv dav hauv thaj chaw xws li kev saib xyuas ib puag ncig, kev nyab xeeb zaub mov, thiab biomedicine.
5. Cov khoom siv roj rhiab heev
TMPBA muaj cov khoom redox siab thiab tuaj yeem hnov mob nrog oxygen molecules. Yog li ntawd, TMPBA feem ntau yog siv los ua ib qho chaw ua haujlwm rau cov khoom siv roj. Los ntawm kev qhia TMPBA rau hauv cov pa roj carbon monoxide lossis cov yeeb yaj kiab, cov ntaub ntawv nkag siab rau cov pa oxygen lossis lwm cov pa roj tuaj yeem npaj tau. Cov ntaub ntawv no tuaj yeem siv rau hauv thaj chaw xws li roj av sensors, kev saib xyuas ib puag ncig, thiab tshawb nrhiav biochemical.
6. High tech kev lag luam:
Vim yog kev siv TMPBA hauv kev tshawb fawb ntawm cov ntaub ntawv tshawb fawb thiab cov khoom siv fluorescent, cov cheeb tsam uas siab -tech industries sib sau ua ke kuj yog ib qho ntawm nws lub khw tseem ceeb. Cov cheeb tsam no suav nrog Silicon Valley hauv Tebchaws Meskas, Shenzhen hauv Suav teb, thiab Seoul hauv Kaus Lim Qab Teb.
7. Kev lag luam kws tshuaj:
TMPBA muaj ntau yam kev siv hauv kev lag luam kws tshuaj, tshwj xeeb tshaj yog nyob rau hauv cov tshuaj synthesis. Yog li ntawd, cov cheeb tsam tseem ceeb ntawm kev lag luam feem ntau yog cov teb chaws lossis thaj chaw uas tsim kev lag luam tshuaj, xws li Tebchaws Meskas, Tebchaws Europe (xws li lub teb chaws Yelemees, Switzerland thiab United Kingdom), thiab cov tebchaws Esxias (xws li Nyiv, Tuam Tshoj thiab Is Nrias teb).
8. Kev tsim tshuaj tua kab:
TMPBA kuj tseem siv rau kev siv tshuaj tua kab, ua rau thaj chaw ua liaj ua teb hnyav ib qho ntawm nws lub khw tseem ceeb. Cov cheeb tsam no suav nrog cov teb chaws ua liaj ua teb loj xws li Tebchaws Meskas, Tebchaws Europe, Brazil, thiab Tuam Tshoj. TMPBA muaj ntau yam kev siv, thiab cov khoom siv raw khoom txaus. Raws li kev txheeb xyuas keeb kwm thiab kev txhim kho kev txheeb xyuas ntawm lub ntiaj teb thiab Suav TMPBA kev lag luam, lub ntiaj teb kev lag luam loj ntawm TMPBA yuav ncav cuag billion yuan (RMB) hauv 2022, thaum lub lag luam loj ntawm Tuam Tshoj yuav ncav cuag billion yuan.
Functionalization and Drug Candidate Synthesis
Taw qhia ntawm Cov Neeg Siv Khoom
Cov pab pawg trimethoxyphenyl tuaj yeem hloov kho ntxiv los ntawm ntau yam tshuaj hloov pauv. Piv txwv li, cov pab pawg methoxy tuaj yeem raug cleaved los yog hloov mus rau hauv lwm pab pawg ua haujlwm, xws li hydroxyl, amines, lossis halides, uas tuaj yeem siv los ua haujlwm rau kev sib txuas ntxiv. Qhov no tso cai rau kev qhia txog ntau yam kev hloov pauv, suav nrog alkyl, aryl, heteroaryl, thiab cov pab pawg ua haujlwm muaj nitrogen, oxygen, lossis sulfur.
Diversification of Drug Candidates
Los ntawm leveraging lub functionalization muaj peev xwm ntawm TMPBA, chemists muaj peev xwm tsim ib tug ntau yam array ntawm cov neeg sib tw tshuaj. Cov tebchaw no tuaj yeem nthuav tawm cov haujlwm lom neeg sib txawv, xws li enzyme inhibition, receptor binding, lossis kev hloov pauv ntawm cellular signaling pathways. Lub peev xwm los tsim sai sai thiab soj ntsuam ntau cov analogs yog qhov tseem ceeb hauv cov txheej txheem tshawb nrhiav tshuaj, vim nws ua rau muaj feem ntau ntawm kev txheeb xyuas cov tshuaj txhuas nrog cov khoom siv tshuaj uas xav tau.
Daim ntawv thov hauv Pharmaceutical Synthesis
Anticancer Agents
Nws tau raug siv nyob rau hauv cov synthesis ntawm anticancer agents, qhov twg cov pab pawg neeg trimethoxyphenyl yuav pab tau rau lub compound lipophilicity thiab daim nyias nyias permeability, txhim khu nws muaj peev xwm mus cuag intracellular lub hom phiaj.
Antimicrobial Compounds
Lub compound kuj tau pom cov ntawv thov hauv kev sib txuas ntawm cov tshuaj tua kab mob, qhov twg cov kev qhia tshwj xeeb tuaj yeem hloov kho qhov sib xyaw ua haujlwm tawm tsam cov kab mob, kab mob, lossis fungi.
Central Nervous System (CNS) Cov Tshuaj
Hauv thaj tsam ntawm CNS tshuaj nrhiav pom, nws tuaj yeem siv los tsim cov tshuaj sib txuas uas lub hom phiaj neurotransmitter receptors lossis hloov kho neuronal signaling txoj hauv kev, muaj peev xwm ua rau kev txhim kho cov kev kho tshiab rau cov kab mob neurological.
TMPBA yog ib qho tshuaj tseem ceeb nrog ntau yam kev siv, feem ntau yog cov tshuaj nruab nrab. Nws txoj kev lag luam faib thoob plaws ntau thaj chaw thoob ntiaj teb, qhia txog nws txoj kev siv dav hauv kev lag luam tshuaj thiab tshuaj.
Hauv Asia, cov teb chaws xws li Tuam Tshoj thiab Is Nrias teb yog cov tseem ceeb hauv kev tsim khoom thiab siv cov khoom sib xyaw no. Tuam Tshoj, tshwj xeeb, muaj ntau lub tuam txhab thiab cov chaw muag khoom, muab cov khoom lag luam sib txawv purities thiab ntim ntau thiab tsawg los ua kom haum rau ntau yam kev lag luam xav tau. Cov neeg muag khoom no feem ntau muaj kev sib faib khoom muaj zog ob leeg hauv tsev thiab txawv teb chaws.
North America, tshwj xeeb yog Tebchaws Meskas, yog lwm lub khw tseem ceeb. Lub cheeb tsam cov chaw lag luam thiab tshuaj muaj zog muaj zog tsav qhov kev thov rau qhov sib xyaw no hauv kev tshawb fawb thiab kev tsim kho, nrog rau kev tsim khoom ntawm ntau yam tshuaj thiab tshuaj.
Teb chaws Europe kuj txhawb kev lag luam, nrog rau cov teb chaws xws li lub teb chaws Yelemees thiab United Kingdom yog cov neeg siv khoom tseem ceeb. Lub teb chaws qhov tseem ceeb ntawm kev tshawb fawb tshuaj lom neeg thiab cov qauv kev tswj hwm nruj kom ntseeg tau qhov kev thov tsis tu ncua rau siab - cov khoom nruab nrab zoo li3,4,5-Trimethoxyphenylboronic acid.
Tsis tas li ntawd, cov cheeb tsam xws li South America thiab thaj chaw ntawm Africa yog cov lag luam tawm tshiab, qhov twg kev loj hlob ntawm kev lag luam kws tshuaj tau ua rau muaj kev xav tau ntawm qhov sib xyaw no. Cov neeg muag khoom feem ntau muab cov nqi sib tw thiab kev txiav txim siab kom muaj nuj nqis los coj mus rau hauv cov kev lag luam loj hlob no.
Kev puas tsuaj rau qhov muag
Nws yog khaus thiab tuaj yeem ua rau lub qhov muag, ua pa, thiab tawv nqaij. Tshwj xeeb tshaj yog, thaum cov tshuaj no nkag mus rau hauv lub qhov muag, nws yuav ua rau raug mob hauv qab no:
Tshuaj hlawv
Vim nws cov khoom siv tshuaj lom neeg, cov khoom no tuaj yeem ua rau cov tshuaj tua hluav taws ncaj qha rau ntawm qhov muag, ua rau cov tsos mob xws li liab, o, mob, thiab kua muag ntawm lub qhov muag.
Kev raug mob pob txha
Lub sij hawm ntev los yog siab concentration yuav ua rau puas corneal epithelial hlwb, thiab nyob rau hauv cov mob hnyav yuav cuam tshuam rau lub zeem muag.
Kab mob thiab kab mob
Tom qab qhov muag raug mob, nws yog ib qho yooj yim ua rau lub qhov muag o thiab kab mob, ntxiv exacerbating tsis xis nyob thiab puas rau lub qhov muag.
Cov ntaub ntawv kev nyab xeeb & kev tiv thaiv
Txhawm rau txo qhov muag puas, yuav tsum tau ua ntau yam kev nyab xeeb thiab kev tiv thaiv.
Dangerous khoom cim Xn
Qhia tau tias cov khoom yog ib yam khoom uas muaj kev phom sij.
Risk lub sij hawm R36/37/38
Qhia tau hais tias cov khoom no muaj kev cuam tshuam rau lub qhov muag, ua pa, thiab tawv nqaij.
Risk lub sij hawm R22
Qhia tau hais tias kev noj cov tshuaj no yog teeb meem.
Cov tsom iav tiv thaiv
Thaum tuav, cov neeg ua haujlwm yuav tsum hnav cov tsom iav tiv thaiv kom tsis txhob muaj tshuaj lom los ntawm qhov muag.
Hnab looj tes
Siv cov hnab looj tes tsim nyog los tiv thaiv cov tawv nqaij ncaj qha nrog cov khoom.
Cov khaub ncaws tiv thaiv
Hnav khaub ncaws tiv thaiv kom tsis txhob raug lwm qhov ntawm lub cev.
Kev saib xyuas kev noj qab haus huv & kev kho mob
Rau ntev -cov neeg ua haujlwm tiv tauj mus ntev, kev saib xyuas kev noj qab haus huv tsis tu ncua, suav nrog kev kuaj qhov muag, yuav tsum tau ua kom sai sai thiab daws teeb meem kev noj qab haus huv.
Thaum ntsib qhov muag, tam sim ntawd yaug qhov muag nrog dej kom ntau thiab nrhiav kev kho mob sai li sai tau. Qhov no yog ib kauj ruam tseem ceeb heev uas yuav pab txo qhov kev puas tsuaj ntawm cov tshuaj rau lub qhov muag. Thaum yaug lub qhov muag, xyuas kom cov dej ntws los ntawm lub kaum sab xis ntawm lub qhov muag mus rau sab nraud ntawm lub qhov muag kom tsis txhob muaj kev cuam tshuam ncaj qha rau ntawm lub qhov muag thiab tsis txhob ua rau muaj kev raug mob hnyav.
Nws yuav tsum tau muab cia rau hauv qhov chaw kaw, txias, qhov cua thiab qhuav, tsis txhob sib cuag nrog oxides. Thaum lub sij hawm kev thauj mus los, nws yog ib qho tsim nyog los xyuas kom meej tias lub thawv ntim tau zoo kom tsis txhob xau thiab ib puag ncig muaj kuab paug.
Cov lus nug nquag
Vim li cas nws thiaj li purity tshaj 100%? Qhov no puas tsim nyog?
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Tsim nyog, qhov no yog "ib txwm illusion" txiav txim los ntawm txoj kev titration. Ntau tus neeg muag khoom tau sau nws cov purity li 97.0 txog 110.0% (txoj kev nruab nrab titration). Qhov no tsis yog qhov yuam kev, tab sis vim tias cov khoom muaj qhov tsis txaus ntseeg ntawm anhydride - boric acid yog qhov ua rau lub cev qhuav dej thaum lub sijhawm khaws cia, ua rau cov txiaj ntsig titration ntau dua. Qhov tseeb purity yuav tsum tau txiav txim siab los ntawm kev sib xyaw HPLC thiab kev txiav txim siab noo noo.
Vim li cas thiaj muaj ntau qhov kev sib cav txog nws qhov melting point? Qhov twg yog qhov tseeb?
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Vim tias muaj qhov tsis meej pem ntawm "decomposition temperature" thiab "melting temperature". Qee cov ntaub ntawv qhia txog qhov kub siab tshaj 230 ° C, thaum lwm qhov yog qhov tseeb txog 247 ° C (dec.). Qhov kev pom zoo yog tias nws decomposes ntawm qhov kub thiab txias ntau dua li melting, thiab yog li ntawd -hu ua melting point yog qhov tseeb decomposition point, uas fluctuates vim yog cov ntsiab lus ntawm anhydride.
Puas yog nws khaws cia ntawm "chav kub" lossis "txias"? Vim li cas thiaj muaj cov lus qhia tsis sib haum?
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Qhov no yog qhov kev ua si ntawm 'zoo tagnrho vs kev muaj tiag'. Hauv txoj kev xav, nws yuav tsum tau muab tso rau hauv tub yees (2-8 ° C) thiab tiv thaiv nrog nitrogen los tiv thaiv lub cev qhuav dej, acid anhydride tsim, lossis kev nqus dej tsis zoo. Txawm li cas los xij, cov neeg muag khoom xws li TCI daim ntawv lo rau chav tsev kub (<15 ° C) as cool and dark, which is a compromise based on short-term stability - in a well sealed, dry and cool environment, short-term storage at room temperature is acceptable, but long-term storage is still recommended to be refrigerated.
Dab tsi lwm yam kab mob tuaj yeem "hla" kho dua li cov tshuaj tiv thaiv Suzuki?
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Nws tuaj yeem "lub hnub qub" hauv kev tiv thaiv - mob qog noj ntshav thiab tshuaj kho mob. Nws cov derivatives muaj ntau yam kev ua ub no: lawv tuaj yeem ua raws li microtubule polymerization inhibitors (tsom mus rau qhov chaw colchicine) los ua kom mob qog noj ntshav ntawm tes apoptosis; Nws kuj tseem tuaj yeem txo cov tsos mob tshem tawm morphine hauv cov nas los ntawm kev khi rau serotonin 5-HT1A receptors. Tsis tas li ntawd, nws cov thiothiazole derivatives muaj kev xaiv toxicity rau cov tshuaj tiv thaiv kab mob qog noj ntshav.
Puas yog nws peb pawg methoxy 'décor'? Nws ua lub luag haujlwm dab tsi hauv cov tshuaj tiv thaiv?
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Lawv yog "electronic regulators" thiab "site protectors". Peb pawg methoxy yog cov muaj zog electron pub dawb pab pawg uas tuaj yeem qhib lub nplhaib benzene thiab txhim kho cov reactivity ntawm boric acid hauv Suzuki coupling; Lub caij no, lawv tuav 3, 4, thiab 5 txoj haujlwm, yuam cov kev sib txuas lus tsuas yog tshwm sim ntawm 1- txoj hauj lwm (cov pab pawg boronic acid), ua kom tiav cov regioselectivity meej. Cov cuab yeej no yog qhov tseem ceeb hauv kev sib txuas ntawm cov analogues ntawm cov tshuaj tiv thaiv kab mob Combretastatin A-4.
Cim npe nrov: 3,4,5-trimethoxyphenylboronic acid CAS 182163-96-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom