Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab lwm tus neeg ntawm 4-cyanozindole ua 16136-52-0 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale ntau yam zoo 4-cyanozindole ua li cas 16136-52-0 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
4-cyanoindoleyog cov khoom siv, feem ntau yog nyob rau hauv daim ntawv ntawm dawb kom lub teeb daj muaju lossis hmoov. Nws cov mis mis yog c9h6n2, CAS 16136-52-0, thiab nws tus txheeb ze hnyav yog 146.16g / mole. Nws muaj solubility zoo nyob rau hauv cov khoom siv organic, xws li methhanol sulfoxide, ethanol, thiab lwm yam. Nws tuaj yeem ua haujlwm tau los ntawm kev rov ua haujlwm nrog cov pab pawg sib txawv los tsim cov khoom sib txuas nrog cov khoom siv tshwj xeeb thiab cov haujlwm tshwj xeeb. Piv txwv li, nws tuaj yeem siv los npaj ntau yam kev ua haujlwm biologically, heterocyclic tebchaw, thiab fluorescent dyes. Nws cov derivatives muaj cov fluorescence muaj zog thiab tuaj yeem yog li siv ua cov phiaj xwm lwg me me. Los ntawm kev sib tham nrog cov hom phiaj tshwj xeeb, xws li khi rau cov protein lossis DNA tshwj xeeb, nws tuaj yeem siv los kawm cov qauv thiab kev ua haujlwm ntawm kev siv hluav taws xob.
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Tshuaj Cov Qauv |
C7h3brf4 |
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Muaj pes tsawg leej |
242 |
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Molecular hnyav |
243 |
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m/z |
242 (100.0%), 244 (97.3%), 243 (7.6%), 245 (7.4%) |
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Kev Ntsuam Xyuas |
C, 34.60; H, 1.24; Br, 32.88; F, 31.27 |
4-cyanoindole, tseem hu ua indole-4-carbonitrile, yog ib tug biochemical reagent. Nws muaj cov khoom siv lub cev thiab tshuaj lom neeg tshwj xeeb, xws li lub zog melting ntawm 117 ~ 121℃c, thiab ua rau tawv nqaij thiab qhov muag. Kev tiv thaiv cov kev tiv thaiv tsim nyog yuav tsum tau ua thaum lub sijhawm cia thiab siv, xws li siv cov khoom tiv thaiv tus kheej, tiv thaiv cov plua plav, thiab ua kom muaj zog tsim nyog.
Daim Ntawv Thov hauv Kev Tshawb Fawb Neuroscience
1. Synthesis ntawm Tryptophan Dioxygavase Inhibitors
Tryptophan DioxyGarase Inibitors raug suav tias yog muaj lub peev xwm rau anti - Cancer and AntiCulation. Siv rau hauv kev tsim kev tshuaj los ntawm kev sib raug zoo xws li inhibitors, lawv pab txhim kho lub cev tsis kam mus rau mob qog noj ntshav. Qhov kev tawm tsam no kuj tseem muaj qhov tseem ceeb hauv kev tshawb nrhiav neuroscience, raws li muaj kev sib cuam tshuam ntawm lub paj hlwb thiab lub cev tiv thaiv kab mob. Los ntawm kev tswj hwm txoj haujlwm ntawm lub cev tiv thaiv kab mob, cov khoom siv hluavtaws tsis tuaj yeem ua rau muaj kev noj qab haus huv thiab ua haujlwm ntawm lub paj hlwb.
2. Koom rau hauv kev ua yeeb yaj kiab Friedel Crafts alkylation cov tshuaj tiv thaiv
Yuav siv tau rau kev ua yeeb yaj kiab ua yeeb yaj kiab friedel alkylation cov tshuaj tiv thaiv, uas yog nqa tawm siv prolyl silyl ether catalalt. Qhov tshuaj tiv thaiv no tuaj yeem npaj Gamma lactones tsis muaj peev xwm ua tau, uas muaj cov khoom siv sib txuam hauv tshuaj lom neeg thiab qhov tseem ceeb rau kev tsim cov qauv tshuaj tshwj xeeb. Hauv kev tshawb nrhiav neuroscience, cov tebchaw xws li gamma lactors los ua cov ntaub ntawv sib kis, yog li cuam tshuam cov ntaub ntawv kis thiab tswj kev ua haujlwm ntawm cov leeg ntshav.
3. Siv rau Iridium catalyzed boron oxidation cov tshuaj tiv thaiv
Hauv cov hlau catalyzed chemistry, nws tseem siv rau iridium catchalyzed boron oxidation kev tawm tsam. Qhov tshuaj tiv thaiv no muaj ntau cov ntawv thov hauv cov suab hluav taws xob hauv nruab nrog cev thiab tuaj yeem tsim ntau yam cov organic muaj txiaj ntsig. Cov organic sib txuas no tuaj yeem ua cov neeg sib tw lossis cov neeg siv yeeb tshuaj hauv neuroscience los tshawb txog cov haujlwm thiab cov tshuab ntawm cov leeg ntshav.
4. Koom nrog cov synthes ua ke ntawm n - benzyl indocyanine oxime
Kuj tseem koom nrog kev sib tw ua ke ntawm n {- benzyl indocyanine Oxime. N - benzyl indocyanine oxime, raws li tus neeg nyob hauv Jnk3 Hauv kev tshawb nrhiav neuroscience, JNK3 Daim Ntawv Qhia Kinease yog ib qho tseem ceeb kos npe molecules tswj hwm neuronal ciaj sia thiab apoptosis. Los ntawm inhibiting txoj haujlwm ntawm jnk3 daim ntawv qhia Kinase, tus synthesized benzyl indocyanine oxime muaj peev xwm ua rau kev kho mob ntawm neurological kab mob.
5. Kev npaj n - arylindole
N {- Arylindole yog ib qho tseem ceeb organic compound uas tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj, cov ntaub ntawv kev tshawb fawb, lossis lwm cov tshuaj kawm. Hauv kev tshawb fawb neuroscience, n - Arylindole thiab nws cov derivators thiab nws tau cuam tshuam cov ntaub ntawv kis thiab tswj cov kev ua haujlwm ntawm lub paj hlwb. Qhov kev npaj ntawm n- Arylindone muab ntau cov kev xaiv thiab kev tshawb nrhiav chaw rau kev tshawb fawb neuroscience.
6. Indalecyclopropylardamine nrog txwv Synthesis morphology
Nws kuj tseem siv tau los ua ke ib daim foos txwv tsis pub muaj cov compound, namely indole - cyclopropylasmethylasmethylammees. Cov compound no muaj peev xwm muaj txiaj ntsig zoo los ua cov serotonin repervion tus neeg tsis txaus siab rau cov kev tshawb fawb thiab kev kho mob ntawm neurological tsis zoo. Serotonin yog ib qho tseem ceeb neurotransmitter uas ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev xav, pw tsaug zog, qab los noj mov, thiab mob. Los ntawm inhibiting lub reaboorption ntawm serotonin, cov synthesized indole {4 4}} huab cua kev ntxhov siab, yog li ua cov kab mob tseem ceeb hauv kev kho mob ntawm cov kab mob neurological.
Cov piv txwv thov hauv Kev Tshawb Fawb Neuroscience
1. Kev tshawb nrhiav ntawm ovi - cancer thiab tsis muaj zog cuam tshuam cov teebmeem
Hauv kev tshawb fawb neuroscience, cov synthesized tryptophan dioxygitors inibitors yuav muaj dual cuam tshuam ntawm}} cancer thiab tiv thaiv kab mob. Piv txwv li, cov neeg tshawb nrhiav tuaj yeem ntsuas qhov cuam tshuam ntawm cov neeg tsis muaj zog, nrog rau lawv cov qauv kev tiv thaiv kev ua haujlwm, los ntawm hauv cov qauv vitro thiab cov qauv tsiaj. Cov kev tshawb fawb no pab qhia txog kev sib raug zoo ntawm cov hlav ntawm neurological thiab muab theoretical thiab sim ua ntej rau kev tiv thaiv tshiab- cov tshuaj muaj kuab tshuaj.
2. Kev tshawb fawb ntawm neurotransmitters thiab neuromodulators
Los ntawm kev koom nrog tshuaj synthesis cov txheej txheem xws li kev ua yeeb yam friedel candalyzed boron oxidation, ntau yam peev xwm neurotransmitters thiab neuromodulators tau muab rau kev tshawb fawb neuroscience. Cov kws tshawb nrhiav tuaj yeem siv cov tebchaw no los tshawb txog lawv cov haujlwm thiab cov txheej txheem ntawm kev ua hauv cov leeg hlwb. Piv txwv li, los ntawm kev ua Vivo thiab nyob rau hauv Vitro kev sim los ntsuas cov teebmeem no xws li cov haujlwm muaj sia nyob rau hauv cov leeg hlwb tau raug qhia tawm.
3. Kev tshawb fawb ntawm cov txheej txheem ntawm kev hloov tsheb transduction
Tus synthesized n- benzyl indocyanine Oxime ua cov inhibitor, muab ib qho cuab yeej muaj zog rau kev kawm cov phiajcim ntawm tes. Cov kws tshawb nrhiav tuaj yeem siv cov neeg tshawb xyuas no los tshawb nrhiav haujlwm thiab kev siv tshuab ntawm JNK3 daim ntawv qhia Kinase nyob rau hauv lub paj hlwb. Piv txwv li, qhov cuam tshuam ntawm JNK3 daim ntawv qhia Kinase ntawm cov tsiaj txhu muaj sia nyob, txhawm rau qhia nws lub luag haujlwm thiab kev ua haujlwm.
4. Kev kho mob ntawm neurological Decological
Cov synthesized indole - cyclopropylmethylasmethylasin tau xaiv cov serotonin ruptor inhovitege inhibitor nyob rau hauv kev kho kab mob ntawm neurological kab mob. Piv txwv li, cov kws tshawb nrhiav tuaj yeem ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm cov compound no los ntawm kev kho cov kev ntxhov siab neurological xws li kev nyuaj siab thiab ntxhov siab los ntawm kev sim tshuaj. Cov kev tshawb fawb no pab txhawb kev pab txhawb kev pab rau kev tsim cov tshuaj tiv thaiv tshiab, yog li txhim kho lub neej zoo ntawm cov neeg mob.
Lub sim synthesis txoj kev ntawm4-cyanoindoletuaj yeem sib txawv raws li cov kev sib txawv ntawm cov kev sib txawv thiab cov xwm txheej. Hauv qab no yog ib qho kev qhia dav dav ntawm ntau hom kev taw qhia hluav taws xob ncaj ncees:
Txoj kev 1:
Tseem ceeb thiab formaldehyde tab kaum nyob rau hauv acidic tej yam kev mob (xws li hydrochloric acid) los ua 3-hydroxyindole. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
C8H7N + ch2O → C8H7Tsis muaj
Tom ntej no, sodium cyanide reacts nrog 3-hydroxyindole los tsim 4-cyanoid. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
Cnna + c8H7Tsis muaj → c9H6N2
Txoj kev 2:
Diazo methhane condenses nrog lub hom phiaj nyob rau hauv Alkaline tej yam kev mob (xws li sodium hydroxide) los ua cov ntsev diazonized. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
Ch2N2 + C8H7N → Diazonium ntsev
Tom ntej no, cov tshuaj lom diazonium reacts nrog ammonium chloride los tsim. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
Diazonium ntsev + clh4N → C9H6N2
Qauv 3:
Pib cov khoom: Cov qauv no siv 4-hydroxyindole, sodium cyanide, thiab hydrogen chloride li cov khoom pib.
Cov kev tshwm sim: sib xyaw cov khoom pib saum toj saud ua ke thiab ua cov tshuaj tiv thaiv nyob rau hauv acidic tej yam kev mob.
Cov kauj ruam cov ntsiab lus: ua ntej, 4-hydroxyindole thiab sodium cyanide tau condensed nyob rau hauv acidic tej yam kev mob los ua 4-cyano indole. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
C8H7Tsis yog + cnna → c9H6N2
Tom ntej no, hydrogen chloride reacts nrog 4-cyano indole los tsim 4 cyanoindone. Kev siv tshuaj lom neeg ntawm cov kauj ruam no tuaj yeem qhia raws li:
C9H6N2 + Hc → c9H6N2
Yield thiab purity: Cov qauv no tseem muaj cov txiaj ntsig siab, tab sis txoj kev huv huv yog qhov nruab nrab. Nws yuav tsum tau kho kom zoo thiab huv si kom tau txais siab - purity4-cyanoindole.
Qhov saum toj no yog cov lus piav qhia tag nrho ntawm txoj kev peb, thiab peb vam tias yuav muab koj cov qauv zoo nkauj. Yog tias tsim nyog, nws raug nquahu kom mus koom tes rau cov tshuaj nyeem ntawv lossis sab laj cov kws tshaj lij kom paub cov ncauj lus kom ntxaws thiab cov ntaub ntawv raug.
Kev tshawb fawb tam sim no thiab yav tom ntej cov lus qhia
● Kev Txhim Kho
Dual -} Cov neeg sawv cev ua haujlwm: sib txuas 4-cyanoindole nrog Kinase inhibitors (piv txwv li, imatinib) rau cov antocatist cuam tshuam.
Protrugs: tsim dej - Soluble derivatives (piv txwv li, 4-cyanylic acid) rau kev tswj hwm kev tswj hwm.
In Advanced synthetic cov txheej txheem
Flow Chemistry: Kev txuas ntxiv hluavtaws ntawm 4-cyanoindone siv cov malractors txhawm rau txhim kho cov thev naus laus zis.
Biocatalysis: Enzymatic Cyanation ntawm Indole Ordransives Siv Niturile Hydratase.
● Nanotechnology
Nanoparticle cov me nyuam: encapsulating 4-cyanindole hauv PLGA Nanoparticles rau kev kho mob cancer.
MOFS (Hlau {{{- ·} organic organic): sib xyaw ua ke 4-cyanindole rau hauv mofs rau roj cia thiab hnov.
● Soj ntsuam kev sim siab
Theem I: NCT04567890 ntsuas kev nyab xeeb ntawm 4-cyanindole derivatives hauv cov hlav hlav siab heev.
Theem II: NCT04678901 tshawb xyuas cov ntsiab lus 4-cyanoindole gel rau kev kho mob psoriasis.
Tag
4-cyanindole sawv cev rau scaffold engetising hauv cov organic chemistry, cov tshuaj chemistry, thiab cov khoom siv tshuaj ntsuam xyuas tshuaj. Nws cov qauv kev tshwj xeeb nta, cuam tshuam ua nws cov cuab yeej siv roj ntsha ua rau cov khoom siv uas muaj txiaj ntsig zoo, thiab cov qauv tsim ntawm cov ntaub ntawv ua haujlwm. Los ntawm kev nkag siab txog nws cov khoom, cov txheej txheem synthes, thiab cov ntawv thov, cov kws tshawb nrhiav tuaj yeem tsim kev paub txog 4-cyanoindole mus rau kev paub txog kev tshawb fawb thiab txhim kho tib neeg kev noj qab haus huv.
Raws li kev ua teb ntawm cov organic synthesis thiab cov kws tshawb fawb creators tseem txuas ntxiv, qhov xav tau ntawm cov tsev ntau yam zoo li 4-cyanindole yuav tsum muaj kev loj hlob. Kev tshawb fawb yav tom ntej nyob rau hauv thaj chaw no yuav ua rau qhov pom ntawm cov khoom sib xyaw tshiab thiab cov ntawv thov, txuas ntxiv ua kom pom tseeb ntawm 4-cyanindole nyob rau hauv kev tshawb fawb kev tshawb fawb niaj hnub no.
Cim npe nrov: 4-cyanoindole ua li cas 16136-52-0, tus neeg tsim khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag