O-tert-Butyl-L-threonine, tseem hu uaH-THR(TBU)-OH, yog ib tug compound nrog ib tug tshwj xeeb tshuaj architecture thiab cov khoom. CAS 4378-13-6, Cov mis mos molecular C8H17NO3 feem ntau tshwm li cov hmoov dawb los yog khoom. Raws li ib tug derivative ntawm threonine, nws muaj cov yam ntxwv ntawm cov amino acids thiab muaj dav daim ntawv thov kev cia siab nyob rau hauv teb xws li biochemistry thiab organic chemistry. Piv txwv li, nws tuaj yeem ua cov amino acid tiv thaiv monomer rau synthesis ntawm peptides thiab nurish; Nws tseem tuaj yeem siv los ua cov khoom siv nruab nrab rau lwm cov organic molecules, rau kev npaj tshuaj thiab biomarkers. Nrog rau kev txhim kho txuas ntxiv ntawm kev tshawb fawb thiab thev naus laus zis, nws daim ntawv thov kev lag luam yuav nthuav dav ntxiv, thiab nws cov txiaj ntsig muaj peev xwm hauv thaj chaw xws li tshuaj, biotechnology, thiab matrials tshiab yuav raug tshawb nrhiav ntxiv thiab siv.
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Tshuaj Formula |
C8H18ClNO3 |
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Exact Mass |
211.10 |
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Molecular Luj |
211.69 |
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m/z |
211.10 (100.0%), 213.09 (32.0%), 212.10 (8.7%), 214.10 (2.8%) |
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Elemental Analysis |
C, 45,39; H, 8,57; Yog ', 16,75; N, 6,62; 22.67 Nws |
H-THR(TBU)-OH, raws li ib qho tseem ceeb amino acid deriative, muaj dav daim ntawv thov kev cia siab nyob rau hauv ntau yam teb xws li biochemistry, organic chemistry, thiab kws tshuaj tshawb fawb thiab kev loj hlob.
Biochemistry Field
(1) Synthesis ntawm Peptides thiab Nurish
Nws tuaj yeem siv los ua cov amino acid tiv thaiv monomer rau kev sib txuas ntawm peptides thiab nurish. Nyob rau hauv cov txheej txheem ntawm peptide synthesis, pawg hydroxyl ntawm threonine yog tiv thaiv los ntawm tert butyl, yog li tsis txhob cuam tshuam rau sab tsis tsim nyog thiab txhim kho cov efficiency thiab purity ntawm synthesis. Los ntawm kev qhia meej txog kev tswj xyuas qhov ntev thiab qhov sib lawv liag ntawm polypeptide chains, peptides thiab tu nrog cov dej num tshwj xeeb tuaj yeem npaj tau.
(2) Kev npaj ntawm biomarkers
Biomarkers yog cov khoom siv los kuaj xyuas, saib xyuas, lossis ntsuas cov txheej txheem biolgical lossis kab mob. Nws tuaj yeem siv los ua ib qho nruab nrab rau kev sib txuas biomarkers, thiab los ntawm kev qhia cov pab pawg tshwj xeeb lossis cov cim, biomarkers nrog siab rhiab heev, muaj zog tshwj xeeb, thiab kev ruaj ntseg zoo tuaj yeem npaj tau. Cov biomarkers no muaj cov txiaj ntsig tseem ceeb hauv kev kuaj kab mob, kev ntsuas kev ua tau zoo, kev txhim kho tshuaj, thiab lwm yam.
(3) Kev tshawb fawb hauv biochemistry
Nws kuj tseem tuaj yeem siv rau kev tshawb fawb biochemical yooj yim, xws li kawm txog cov txheej txheem metabolic thiab cov txheej txheem kev ua haujlwm ntawm cov amino acids hauv cov kab mob. Los ntawm kev qhia nws, peb tuaj yeem simulate cov txheej txheem amino acid metabolism hauv cov kab mob, saib xyuas nws cov kev cuam tshuam ntawm kev ua haujlwm biolgical, thiab nthuav tawm cov haujlwm thiab cov txheej txheem ntawm cov amino acids hauv kab mob.
Hauv Kev Ua Haujlwm Ntawm Organic Chemistry
(1) Organic synthesis intermediates
Muaj cov khoom siv tshuaj lom neeg tshwj xeeb thiab cov khoom siv, nws tuaj yeem ua ib qho tseem ceeb nruab nrab ntawm cov organic synthesis. Los ntawm kev qhia nws, cov organic tebchaw nrog cov qauv tshwj xeeb thiab cov khoom tuaj yeem ua ke, uas muaj cov ntawv thov dav dav hauv thaj chaw xws li tshuaj, tshuaj tua kab, tshuaj pleev xim, thiab lwm yam.
(2) Kev tsim tshuaj
Hauv cov txheej txheem ntawm kev tsim tshuaj, nws tuaj yeem ua tus qauv hloov kho lossis cov khoom siv nruab nrab rau cov tshuaj molecules. Los ntawm kev qhia txog nws, lub spatial architecture thiab biolgical kev ua haujlwm ntawm cov tshuaj molecules tuaj yeem hloov pauv, yog li ua kom zoo dua cov khoom ntawm kev siv tshuaj, pharmacokinetics, thiab tshuaj stability. Tsis tas li ntawd, nws tseem tuaj yeem siv los npaj cov tshuaj nrog cov txiaj ntsig zoo, txhim kho cov tshuaj tshwj xeeb thiab kho tau zoo.
(3) Organic catalytic cov tshuaj tiv thaiv
Nws tseem tuaj yeem ua tus catalyst lossis co catalyst rau cov organic catalytic repercussions. Los ntawm kev qhia nws, tus nqi ntawm cov organic repercussions tuaj yeem nrawm dua, thiab cov txiaj ntsig thiab kev xaiv ntawm qhov cuam tshuam tuaj yeem txhim kho. Tsis tas li ntawd, nws kuj tseem siv tau rau asymmetric catalytic repercussions los npaj cov organic tebchaw nrog chiral architectures.
Pharmaceutical Research Thiab Development Field
(1) Synthesis ntawm tshuaj molecules
Ua lub luag haujlwm tseem ceeb hauv kev sib txuas ntawm cov tshuaj molecules. Los ntawm kev qhia nws, cov tshuaj molecules nrog cov tshuaj pharmacological thiab biolgical kev ua ub no tuaj yeem ua ke. Cov tshuaj molecules no muaj kev siv dav dav hauv thaj chaw xws li qog nqaij hlav, kab mob plawv, thiab kab mob neurodegenerative.
(2) Kev hloov kho tshuaj
Nws kuj tseem siv tau rau kev tshawb fawb txog tshuaj kho mob. Los ntawm kev qhia cov tshuaj no, cov solubility, stability, bioavailability, thiab lwm yam khoom ntawm cov tshuaj yuav hloov, yog li optimizing cov kev kho mob nyhuv ntawm cov tshuaj. Tsis tas li ntawd, nws tseem tuaj yeem siv los npaj cov kev tso tawm kom ruaj khov - tso tawm, tswj kev tso tawm thiab lwm yam tshuaj, txhim kho cov nyhuv tso tawm ntawm cov tshuaj thiab kev nplij siab ntawm tus neeg mob.
(3) Kev tshawb fawb tshuaj metabolism
Nws kuj tseem siv tau rau kev tshawb fawb txog tshuaj metabolism. Los ntawm kev qhia nws, nws muaj peev xwm simulate cov txheej txheem metabolic ntawm cov tshuaj hauv lub cev, saib xyuas lawv cov teebmeem ntawm cov tshuaj metabolizing enzymes, thiab nthuav tawm cov txheej txheem metabolic thiab cov tshuaj metabolites hauv lub cev. Cov ntaub ntawv no muaj cov txiaj ntsig tseem ceeb rau kev soj ntsuam kev nyab xeeb ntawm tshuaj, kev tshawb fawb txog kev siv tshuaj, thiab lwm yam.
Lwm yam teb
(1) Kev lag luam zaub mov
Nws kuj muaj qee yam kev siv hauv kev lag luam zaub mov. Nws tuaj yeem siv los ua zaub mov ntxiv los txhim kho saj, tsw, thiab khoom noj muaj txiaj ntsig ntawm cov khoom noj. Los ntawm kev qhia cov khoom xyaw no, cov ntsiab lus amino acid ntawm cov zaub mov tuaj yeem nce ntxiv, txhim kho nws cov khoom noj muaj txiaj ntsig; Nyob rau tib lub sijhawm, nws tseem tuaj yeem siv los ua khoom noj khoom haus kom ntev lub neej txee ntawm zaub mov.
(2) Hauv kev ua liaj ua teb
Kuj tseem muaj qee qhov peev xwm rau kev thov hauv kev ua liaj ua teb. Nws tuaj yeem ua tus tswj kev loj hlob ntawm cov nroj tsuag, txhawb cov nroj tsuag kev loj hlob thiab kev loj hlob. Los ntawm kev qhia O-tert-butyl-L-threonine, qhov kev nyuaj siab, kev tiv thaiv kab mob, thiab cov qoob loo ntawm cov nroj tsuag tuaj yeem txhim kho; Nyob rau tib lub sijhawm, nws tseem tuaj yeem siv los npaj biopesticdes, txo kev siv tshuaj tua kab, thiab txo qis ib puag ncig.
(3) Kev tiv thaiv ib puag ncig
Nws kuj muaj qee qhov kev cia siab rau hauv kev tiv thaiv ib puag ncig. Nws tuaj yeem siv los ua tus neeg sawv cev biodegradable rau kev kho cov organic pov tseg thiab cov dej paug hauv lub cev. Los ntawm kev qhia O-tert-butyl-L-threonine, qhov decomposition thiab degradation ntawm cov organic pov tseg tuaj yeem nrawm dua, txo cov pa phem ib puag ncig; Nyob rau tib lub sijhawm, nws tseem tuaj yeem siv los npaj cov khoom siv biolgical tshem tawm cov hlau hnyav ions thiab cov kuab paug organic los ntawm lub cev dej.
H-THR(TBU)-OH, raws li ib qho tseem ceeb amino acid deriative, muaj ntau yam kev siv nyob rau hauv teb xws li biochemistry, organic chemistry, thiab kev tshawb fawb tshuaj thiab kev loj hlob. Kev xaiv thiab kev ua kom zoo ntawm nws txoj kev sib xyaw ua ke yog qhov tseem ceeb rau kev txhim kho cov txiaj ntsig, txo cov nqi, thiab ua tau raws li cov ntawv thov tshwj xeeb. Cov hauv qab no yog cov ncauj lus kom ntxaws nthuav dav thiab piav qhia ntawm ob peb O-tert-butyl-L-threonine synthesis txoj kev hais saum toj no.
Isobutene yog ib qho tseem ceeb chemical raw matrial nrog lub cus ciav ob daim ntawv cog lus architecture, ua rau nws yooj yim rau undergo tshuaj repercussions xws li ntxiv thiab polymerization. Cov txheej txheem ntawm kev sib txuas O-tert-butyl-L-threonine siv isobutene feem ntau suav nrog cov kauj ruam hauv qab no:
Raw matrial npaj:
Ua ntej, nws yog ib qho tsim nyog los npaj ib qho nyiaj tsim nyog ntawm isobutene, L-threonine, los yog lawv cov derivatives thaum pib matrials. Nyob rau tib lub sijhawm, auxiliary matrials xws li catalysts thiab cov kuab tshuaj yuav tsum tau npaj.
Ntxiv cov tshuaj tiv thaiv:
Nyob rau hauv qhov ntsuas kub thiab siab, isobutene raug rau qhov cuam tshuam ntxiv nrog L-threonine lossis nws cov derivatives. Cov kauj ruam no feem ntau yuav tsum tau ua nyob rau hauv lub xub ntiag ntawm ib tug catalyst kom nce tus nqi repercussion thiab tawm los. Cov xwm txheej tshwj xeeb ntawm qhov kev cuam tshuam ntxiv (xws li temprature, siab, hom catalyst thiab ntau npaum li cas) yuav tsum tau ua kom zoo raws li qhov kev sim thiab cov kev xav tau ntawm cov khoom lag luam.
Tshaj tawm - kev ua haujlwm:
Tom qab qhov kev cuam tshuam ntxiv tiav lawm, kev tshaj tawm - cov kauj ruam ua tiav yuav tsum tau cais thiab ntxuav cov khoom lag luam. Qhov no feem ntau suav nrog kev ntxuav, ziab, recrystallization thiab lwm yam kev ua haujlwm kom tshem tawm impurities thiab txhim kho qhov purity ntawm cov khoom.
Product validation:
Thaum kawg, cov khoom lag luam raug lees paub los ntawm kev tshuaj ntsuam xyuas tshuaj xws li nuclear magnetic resonance, infrared spectroscopy, huab hwm coj spectrometry, thiab lwm yam, kom ntseeg tau tias nws cov qauv tsim thiab purity ua tau raws li qhov yuav tsum tau ua.
Nws yuav tsum tau muab sau tseg tias vim yog lub reactivity ntawm isobutene thiab rhiab heev ntawm repercussion condtions, no synthesis txoj kev yuav nthuav tej yam kev cov nyom nyob rau hauv lub tswv yim ua hauj lwm. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum nruj me ntsis tswj qhov cuam tshuam qhov tshwm sim, ua kom zoo dua qhov kev xaiv thiab ntau npaum li cas ntawm cov catalysts, txhawm rau txhim kho cov txiaj ntsig thiab cov khoom zoo.
Fmoc (9-fluorenylmethoxycarbonyl) yog ib hom tshuaj amino acid tiv thaiv pawg nrog cov yam ntxwv ntawm kev tshem tawm yooj yim thiab ruaj khov zoo. Cov txheej txheem ntawm kev sib txuas O-tert-butyl-L-threonine siv Fmoc-O-tert-butyl-L-threonine ua ib qho nruab nrab feem ntau suav nrog cov kauj ruam hauv qab no:
1. Raw khoom npaj:
Npaj ib qho nyiaj tsim nyog ntawm Fmoc-L-shreonine los yog nws cov derivatives thaum pib matrials. Nyob rau tib lub sijhawm, auxiliary matrials xws li tert butanol thiab catalysts yuav tsum tau npaj.
2. Cov tshuaj tiv thaiv Esterification:
Raws li qhov ntsuas kub thiab qhov ntsuas kub tsim nyog, Fmoc-L-shreonine lossis nws cov derivatives yog esterified nrog tert butanol. Lub hom phiaj ntawm cov kauj ruam no yog los tiv thaiv pawg hydroxyl ntawm threonine thiab tsis txhob muaj kev cuam tshuam sab nraud hauv kev cuam tshuam tom qab.
3. Txo cov tshuaj tiv thaiv:
Tom qab esterification repercussion tiav lawm, yuav tsum muaj kev txo qis rov qab los tshem tawm cov pab pawg tiv thaiv Fmoc. Cov kauj ruam no feem ntau yog ua los ntawm kev siv cov tshuaj txo qis (xws li hydrogen, sodium borohydride, thiab lwm yam) ntawm qhov kub thiab txias.
Tom qab qhov txo qhov cuam tshuam tiav lawm, kev tshaj tawm - cov kauj ruam ua tiav kuj tseem yuav tsum tau cais thiab ntxuav cov khoom lag luam. Qhov no suav nrog kev ntxuav, ziab, recrystallization thiab lwm yam kev ua haujlwm kom tshem tawm impurities thiab txhim kho cov purity ntawm cov khoom.
Product validation:
Thaum kawg, cov khoom lag luam raug lees paub los ntawm kev tshuaj xyuas tshuaj xyuas kom ntseeg tau tias nws cov qauv tsim thiab purity ua tau raws li qhov yuav tsum tau ua.
Nws yuav tsum raug sau tseg tias txoj kev sib txuas no suav nrog ntau cov kauj ruam thiab qhov tshwm sim tshwm sim, yog li kev tswj hwm nruj ntawm qhov tshwm sim thiab cov khoom lag luam zoo ntawm txhua kauj ruam yog xav tau hauv kev ua haujlwm. Lub caij no, vim muaj qhov tshwj xeeb txo qis uas yuav tsum tau ua rau kev tshem tawm ntawm Fmoc tiv thaiv pawg, kev ua tau zoo thiab cov txiaj ntsig ntawm cov kauj ruam no kuj tseem yuav cuam tshuam rau qee qhov.
Txhawm rau txhim kho cov synthesis efficiency thiab tawm los ntawmH-THR(TBU)-OH, nws yog ib qho tsim nyog los ua kom zoo thiab txhim kho cov txheej txheem synthesis. Nov yog qee cov lus qhia ua kom zoo tshaj plaws:
Xaiv thiab ntau npaum li cas ntawm catalyst:
Hom thiab ntau npaum li cas ntawm cov catalyst muaj qhov cuam tshuam loj rau kev sib xyaw ua haujlwm thiab tawm los. Yog li ntawd, nws yog ib qho tsim nyog los tshuaj xyuas cov catalysts tsim nyog thiab ua kom zoo dua lawv cov tshuaj kom txhim kho tus nqi cuam tshuam thiab tawm los.
Optimization ntawm cov tshuaj tiv thaiv tej yam kev mob:
Repercussion temprature, siab, hnyav, thiab lwm yam xwm txheej kuj tseem muaj feem cuam tshuam rau kev sib xyaw ua haujlwm thiab tawm los. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum ua kom zoo dua cov xwm txheej no kom pom qhov pom kev sib xyaw ua ke ntawm cov xwm txheej tshwm sim.
Kev txhim kho tom qab- cov kauj ruam ua tiav:
Kev ua tau zoo thiab kev coj dawb huv ntawm kev tshaj tawm- cov kauj ruam ua haujlwm muaj feem cuam tshuam rau qhov zoo ntawm cov khoom kawg. Yog li ntawd, nws yog ib qho tsim nyog los txhim kho cov ntawv tshaj tawm - cov kauj ruam ua haujlwm txhawm rau txhim kho qhov purity thiab tawm los ntawm cov khoom.
Kev xaiv thiab pretreatment ntawm raw khoom:
Qhov zoo thiab purity ntawm raw matrials kuj muaj tej yam kev cuam tshuam rau synthesis efficiency thiab yield. Yog li ntawd, nws yog ib qho tsim nyog los xaiv cov qib siab -cov khoom siv raw zoo thiab ua kom tsim nyog pretreatment los txhim kho qhov ua tau zoo thiab cov khoom zoo.
Daim ntawv thov ntawm ntsuab chemistry: Siv ntsuab chemistry cov hauv paus ntsiab lus hauv cov txheej txheem synthesis tuaj yeem txo cov pa phem ib puag ncig thiab txo cov nqi. Piv txwv li, siv cov uas tsis yog - tshuaj lom los yog cov kuab tshuaj toxicity tsawg, catalysts, thiab raw matrials.
Lub molecular configuration ntawm H-THR (TBU) - OH (O-tert-butyl-L-threonine) muaj cov yam ntxwv hauv qab no:
Cov mis molecular ntawm H-THR (TBU) - OH yog C ₈ H ₁ NO ∝, nrog rau qhov hnyav molecular ntawm 175.23 g / mol. Nws architecture yog tsim los ntawm kev hloov cov hydroxyl pawg ntawm threonine (Thr) nrog tert butyl (tBu), thiab nws belongs rau amino acid deriatives.
L-configuration: Raws li ib tug deriative ntawm L-amino acids, nws alpha carbon (cov pa roj carbon atom txuas cov amino thiab carboxyl pawg) ua hauj lwm raws li lub chiral center thiab muaj ib tug S-configuration (raws li txoj cai Cahn Ingold Prelog).
Tert butyl substituent: Tom qab cov pab pawg hydroxyl hloov los ntawm tert butyl (- C (CH3) H3), qhov loj ntawm tert butyl tuaj yeem cuam tshuam rau cov molecular steric hindrance, tab sis nws tsis cuam tshuam rau chiral centre ntawm - carbon.
Melting point: 244-247℃C. Lub siab melting point qhia tias muaj cov hydrogen bonds muaj zog ntawm cov molecules los yog ib tug nruj siv lead ua architecture, uas muaj feem xyuam rau cov niaj hnub kev npaj ntawm L-hom molecules.
Qhov ceev: Kwv yees li 1.1 g / cm³, qhia txog kev ua haujlwm molecular stacking, cuam tshuam los ntawm tert butyl substituents.
Solubility: Txawm hais tias tsis muaj cov ntaub ntawv tshwj xeeb, cov khoom siv zoo sib xws feem ntau tau txo cov solubility vim yog hydrophobicity ntawm tert butyl pawg thiab xav tau cov kuab tshuaj polar (xws li DMSO) rau kev sib cais.
Chemical structural formula:
Nws architecture tuaj yeem sawv cev raws li:
HOOC-CH(NH₂)-CH(O-tBu)-OH
Ntawm lawv, tert butyl (- O-tBu) hloov cov pawg hydroxyl (- OH) ntawm threonine sab saw, khaws cov - amino thiab carboxyl pawg, thiab tswj cov pob txha pob txha ntawm cov amino acids.
Application thiab Configuration Stability:
Peptide synthesis: Raws li kev tiv thaiv amino acid, tert butyl tiv thaiv pab pawg tuaj yeem tiv thaiv kev cuam tshuam ntawm cov saw hlau thaum lub sijhawm sib xyaw. Tom qab synthesis,H-THR(TBU)-OHraug tshem tawm nyob rau hauv acidic mob, tso tawm dawb hydroxyl pawg.
Configuration stability: L-configuration yooj yim lees paub los ntawm enzymes nyob rau hauv cov kab mob nyob, thiab tert butyl hloov tsis cuam tshuam rau alpha carbon chirality, tab sis yuav tswj cov molecular reactivity los ntawm steric hindrance.
Cim npe nrov: h-thr(tbu)-oh cas 4378-13-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom