Diacetone-D-mannitol CAS 1707-77-3 NrCov qauv qauv: C12H22O6 yog cov hmoov dawb crystalline, melting point yog 120-122℃(lit.), kev sib hloov kho qhov muag yog 6º (c=5, Chloroform), boiling point yog 382.0 ± 32.0℃(Predicted), ntom yog 1.175gm (so Predicted) ± 0.3cm 100mg / mL), acidity coefficient (pKa) yog 12.98 ± 0.20 (Predicted). Nws yog ib tug neeg sawv cev ntawm polyhydroxy compounds, uas yog ib tug tshiab chav kawm ntawv ntawm chiral xaiv tus neeg saib xyuas nrog yooj yim kev npaj thiab tsis muaj nqi, thiab nws yuav siv tau los cais ntau yam chiral tshuaj nyob rau hauv NACE nrog zoo sib cais nyhuv. Nws yog siv los ua ib qho nruab nrab hauv kev lag luam tshuaj vim nws cov qauv tshuaj tshwj xeeb.
Raws li ib tug tshiab chiral xaiv tus neeg sawv cev, bisacetone-D-mannitol ua lub luag haujlwm tseem ceeb hauv kev sib cais thiab kev lees paub. Nws lub chaw chiral tuaj yeem tsim cov complexes ruaj khov nrog cov khoom sib cais, yog li paub txog kev sib cais chiral zoo. Nrog rau kev txhim kho txuas ntxiv ntawm kev tshawb fawb thiab thev naus laus zis, nws daim ntawv thov kev lag luam yuav nthuav dav dua.
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C.F |
C12H22O6 |
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E.M |
262 |
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M.W |
262 |
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m/z |
262 (100.0%), 263 (13.0%), 264 (1.2%) |
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E.A |
C, 54.95; H, 8.45; O, 36.60 |
Diacetone-D-mannitol (tseem hu ua D-mannitol diketone) yog tsim los ntawm ntau txoj hauv kev, thiab cov hauv qab no yog qee qhov kev sib xyaw tseem ceeb thiab lawv cov yam ntxwv:
Synthesis catalyzed los ntawm molten zinc chloride:
Lub unsaturated ester 20 d-mannitol yog ntxiv rau cov tshuaj tov ntawm acetone qhuav nrog molten zinc chloride.
stirring tau txuas ntxiv mus txog thaum d-mannitol tau yaj tag (kwv yees li 22 teev).
Cov tshuaj tiv thaiv sib tov yog poured rau hauv ib tug stirred thiab txias aqueous tov ntawm poov tshuaj carbonate.
Lub precipitate raug tshem tawm los ntawm kev pom thiab ntxuav kom huv si nrog dichloromethane (DCM).
Lub aqueous filtrate tau evaporated kom tshem tawm acetone thiab muab rho tawm los ntawm DCM.
Cov organic ntxuav thiab rho tawm tau ntxuav nrog dej txias, qhuav nrog magnesium sulfate, evaporated mus rau cov khoom seem, thiab recrystallized kom muab bisacetone-D-mannitol.
Synthesized siv pyridine ntsev catalyst:
Cov tshuaj tiv thaiv ntawm D-mannitol thiab 2,2-dimethoxypropane hauv dioxane hnyav tau ua nyob rau hauv lub xub ntiag ntawm pyridine ntsev catalyst.
Txoj kev hluavtaws no muaj qhov zoo ntawm kev xaiv siab rau cov khoom, tuaj yeem zam thiab txo cov tiam ntawm cov khoom los ntawm -, txhim kho tus nqi hloov pauv ntawm cov khoom siv raw, thiab muaj cov txiaj ntsig ntawm cov khoom lag luam siab thiab purity.
Lwm cov txheej txheem hluavtaws:
Cov txheej txheem siv cov kuab tshuaj sib xyaw ntawm acetone lossis acetone qis cawv, magnesium sulfate absorbent, thiab poov tshuaj bisulfate raws li catalyst kuj suav nrog.
Kuj tseem muaj txoj hauv kev siv p-toluenesulfonic acid lossis stannous chloride ua cov khoom siv hauv DMSO lossis DMF cov kuab tshuaj, tab sis cov txheej txheem no raug kev txom nyem los ntawm cov teeb meem ntawm acidity, uas nyiam hloov cov khoom rau monoacetonide los ntawm - cov khoom thiab txo cov khoom zoo.
Diacetone-D-mannitol yog cov hmoov dawb crystalline hmoov uas muaj lub cev thiab tshuaj lom neeg. Nws cov ntsiab lus melting yog 120{15}}122 ° C, kev hloov kho qhov muag tshwj xeeb yog 6 º (c=5, Chloroform), boiling point yog 382.0 ± 32.0 ° C, qhov ceev yog 1.175 ± 0.06g / cm3, thiab refractive index (6.1 CH 2 ° C) Tsis tas li ntawd, diacetone{16}}D-mannitol muaj cov kua dej ntau hauv methanol, nrog rau acidity coefficient (pKa) ntawm 12.98 ± 0.20. Cov khoom no muab lub hauv paus rau nws daim ntawv thov hauv kev kho mob.
Daim ntawv thov hauv kev kho mob
1. Kev sib cais thiab kev txheeb xyuas cov tshuaj chiral
Raws li tus neeg sawv cev sib xyaw ntawm polyhydroxy compounds, ib daim ntawv thov tseem ceeb hauv kev lag luam tshuaj yog raws li chiral selector. Kev ua tau zoo thiab cov metabolism hauv cov tshuaj chiral hauv cov kab mob muaj sia feem ntau muaj feem cuam tshuam nrog lawv peb - cov qauv, yog li kev sib cais thiab kev tshuaj xyuas ntawm cov tshuaj chiral yog qhov tseem ceeb txuas hauv kev tsim tshuaj thiab cov txheej txheem tsim khoom. Vim qhov tseeb tias nws ob lub enantiomers feem ntau pom cov tshuaj sib txawv, tshuaj pharmacokinetic, thiab tshuaj lom neeg, nws tuaj yeem siv tsis yog -aqueous capillary electrophoresis (NACE) los cais ntau cov tshuaj chiral nrog kev sib cais zoo. Cov yam ntxwv no ua rau nws muaj kev thov dav dav hauv thaj chaw ntawm chiral tshuaj cais thiab tshuaj xyuas.
2. Pharmaceutical excipients thiab additives
Txawm hais tias nws cov ntawv thov tseem ceeb hauv kev lag luam tshuaj yog raws li chiral selectors thiab tshuaj synthesis intermediates, nws lub peev xwm ua tshuaj excipients thiab additives tsis tuaj yeem tsis quav ntsej. Vim nws cov khoom tshwj xeeb ntawm lub cev thiab tshuaj lom neeg, nws tuaj yeem siv los ua cov stabilizer, thickener, dispersant, thiab lwm yam rau cov tshuaj, txhim kho lawv cov stability thiab bioavailability. Tsis tas li ntawd, vim nws saj qab zib, nws kuj tseem siv tau los ua cov khoom qab zib rau cov piam thaj tsis muaj qab zib lossis cov piam thaj qis kom tau raws li cov kev xav tau ntawm cov neeg mob tshwj xeeb (xws li cov neeg mob ntshav qab zib).
3. Kev tsim cov tshuaj tshiab
Nrog rau qhov tob ntawm kev tshawb fawb ntawm nws, tib neeg tau pom tias nws kuj muaj peev xwm loj hauv kev tsim cov tshuaj tshiab. Piv txwv li, Petrosiols A-E tuaj yeem koom nrog hauv kev sib txuas ntawm cov khoom sib txuas nrog lub peev xwm los kho Alzheimer's disease thiab Parkinson's syndrome. Tsis tas li ntawd, nws kuj tuaj yeem siv los ua ke (-) Orthodiffenes A-C compounds nrog cov haujlwm zoo los tiv thaiv- qog nqaij hlav, uas ua rau muaj kev cuam tshuam tseem ceeb tiv thaiv qog noj ntshav xws li HL-60 thiab Jurkat. Cov kev tshawb fawb no qhia txog kev siv dav dav hauv kev tsim tshuaj tshiab.
Cov ntaub ntawv tshwj xeeb hauv kev kho mob
1. tshuaj ntshav qab zib
Mob ntshav qab zib yog ib hom kab mob metabolic, thiab nws txoj kev kho mob yuav tsum tau noj tshuaj ntev -. Raws li qhov nruab nrab hauv cov tshuaj synthesis, nws tuaj yeem koom nrog hauv kev sib xyaw ntawm cov tebchaw nrog cov teebmeem hypoglycemic. Piv txwv li, los ntawm inhibiting lub decomposition ntawm daim siab glycogen nyob rau hauv lub siab thiab txhawb kev siv cov piam thaj nyob rau hauv peripheral cov ntaub so ntswg, cov tshuaj nws tus kheej los yog nws derivatives yuav txo tau cov suab thaj nyob rau hauv lub cev, yog li txhim kho cov ntshav qab zib cov neeg mob. Tsis tas li ntawd, vim nws cov calories tsawg, tsis yooj yim ua rau cov ntshav qab zib hloov pauv thiab lwm yam ntxwv, nws kuj tuaj yeem siv los ua cov khoom noj khoom haus rau cov neeg mob ntshav qab zib kom ua tau raws li lawv cov kev xav tau qab zib thaum tsis txhob muaj cov piam thaj hloov pauv.
3. Cov tshuaj tiv thaiv kab mob
Cov kab mob kis xws li AIDS thiab mob khaub thuas ua rau muaj kev hem thawj rau tib neeg kev noj qab haus huv. Muaj peev xwm koom nrog hauv kev sib txuas ntawm cov tebchaw nrog kev ua haujlwm antiviral. Piv txwv li, sulfur-muaj fused tetracyclic nitrogen- muaj cov piam thaj derivatives yog synthesized los ntawm lawv los yog lawv cov derivatives, uas muaj zog inhibitory cuam tshuam rau tus kab mob HIV. Los ntawm kev tshawb fawb ntxiv thiab kev ua kom zoo, cov tebchaw no xav tias yuav dhau los ua ib tiam tshiab ntawm cov tshuaj tiv thaiv kab mob, muab kev xaiv ntau dua rau kev kho cov kab mob kis.
4. Cov tshuaj rau kev kho mob ntawm lub paj hlwb
Cov kab mob neurological xws li Alzheimer's disease thiab Parkinson's syndrome cuam tshuam rau lub neej zoo ntawm cov neeg mob. tuaj yeem koom nrog hauv kev sib txuas ntawm cov tshuaj sib txuas nrog lub peev xwm los kho cov kab mob neurological. Piv txwv li, Petrosiols A-E yog synthesized los ntawm nws los yog nws cov derivatives, thiab cov tebchaw no muaj tej yam kev kho mob rau cov kab mob neurological xws li Alzheimer's kab mob thiab Parkinson's syndrome. Los ntawm kev tshawb fawb ntxiv thiab kev ua kom zoo, cov ntsiab lus no yuav tsum dhau los ua ib tiam tshiab ntawm cov tshuaj kho mob rau cov kab mob neurological, nqa cov txiaj ntsig zoo rau cov neeg mob.
Chiral polyhydroxy compounds yog polyhydroxy compounds uas muaj ob lossis ntau pawg hydroxyl hauv lawv cov qauv molecular (xws li D/L-tartaric acid, series D/L-tartrate esters, D-gluconic acid, D/L-sorbose, D{4}}}mannitol, etc.). Diacetone-D-mannitol yog ib qho chaw sawv cev ntawm hom polyhydroxy compound, uas yog ib qho tshiab chiral selector nrog kev npaj yooj yim thiab tus nqi qis. Nws tuaj yeem siv tau hauv NACE txhawm rau cais ntau yam tshuaj chiral nrog kev sib cais zoo, tab sis nws daim ntawv thov kev tshawb fawb hauv cov qauv sib cais thiab kev tshuaj xyuas tseem txwv.
Feem ntau vim yog qhov tseeb tias ob lub enantiomers ntawm diacetone-D-mannitol feem ntau pom muaj cov tshuaj sib txawv, tshuaj pharmacokinetic, thiab tshuaj lom neeg, feem ntau hais lus, (R) - enantiomer plays lub luag haujlwm tseem ceeb hauv kev kho mob, thaum (S) - enantiomer muaj kev ua haujlwm tsis zoo, tsis muaj tshuaj lom lossis tsis zoo.
Yog li ntawd, txhawm rau txhim kho kev ua tau zoo ntawm cov tshuaj chiral xws li diacetone-D-mannitol, txo cov kev mob tshwm sim lom, tsim kom muaj ib txoj hauv kev yooj yim thiab muaj txiaj ntsig rau kev sib cais thiab tshawb xyuas cov tshuaj chiral, thiab ua ib qho kev tshawb fawb enantiomer kom nkag siab txog lawv cov kev ua haujlwm ntawm lub cev thiab cov tshuaj pharmacological, nws tseem ceeb heev kom ua tiav, nyab xeeb thiab siv tau zoo. Txhawm rau kom ua tiav kev nyab xeeb thiab muaj txiaj ntsig ntawm kev siv tshuaj chiral, ua kom cov tshuaj ruaj khov thiab zoo ib yam, thiab ua tau raws li cov kev xav tau ntawm cov tshuaj, nws yog ib qho tsim nyog yuav tsum ua raws li kev tswj hwm tshuaj zoo, thiab kev txiav txim siab ntawm cov ntsiab lus enantiomer yog ib qho tseem ceeb ntawm kev tswj xyuas.
Diacetone-D-mannitol yog ib qho tseem ceeb ntawm cov organic sib xyaw nrog cov nqi siv dav hauv kev lag luam tshuaj, zaub mov, thiab tshuaj lom neeg. Raws li ib qho derivative ntawm D-mannitol, nws cov qauv tshuaj tshwj xeeb tso cai rau nws nrog cov khoom tshwj xeeb thiab kev ua haujlwm. Qhov kev tshawb pom ntawm D-mannitol tuaj yeem taug qab rov qab mus rau kev tshawb fawb txog kev cog qoob loo nyob rau xyoo 19th.
Nyob rau hauv 1806, Fabkis chemist Louis Nicolas Vauquelin thawj zaug cais cov khoom qab zib no los ntawm honeydew (manna, exudate los ntawm Fraxinus ornus). Cov khoom ntuj no tau hu ua "mannite" vim nws cov keeb kwm, thiab tom qab ntawd hloov lub npe "mannitol" (mannitol). German chemist Joseph Louis Gay Lussac tau kawm ntxiv txog cov khoom no hauv xyoo 1811 thiab txiav txim siab nws cov khoom tseem ceeb.
Tom qab ntawd, xyoo 1826, lwm tus kws tshawb fawb Fab Kis Fab Kis Henri Braconnot tau ua tiav cais mannitol los ntawm nceb, algae, thiab lwm yam nroj tsuag, paub meej tias nws muaj nyob hauv qhov xwm txheej. Nrog rau kev txhim kho cov txheej txheem tshuaj lom neeg txoj kev xav, cov kws tshawb fawb tau pib tshawb nrhiav cov qauv molecular ntawm mannitol nyob rau hauv ib nrab ntawm lub xyoo pua 19th.
German chemist Justus von Liebig thawj synthesized acetone nyob rau hauv 1832 thiab kawm nws cov khoom. Nrog rau txoj kev loj hlob ntawm cov organic chemistry, acetone tsis yog tsuas yog siv los ua cov kuab tshuaj, tab sis kuj maj mam dhau los ua ib qho tseem ceeb reactant thiab hluavtaws intermediate.
Xyoo 1870, German chemist Emil Fischer tau pib kawm cov qauv ntawm cov khoom carbohydrate, uas thaum kawg tau txais nws qhov Nobel nqi zog hauv Chemistry xyoo 1902. Fischer txiav txim siab los ntawm cov tshuaj lom neeg ntse uas mannitol yog rau 6 carbon qab zib cawv nrog cov qauv tshuaj molecular C ₆ H ₁id ₆ ster .
Thaum pib ntawm lub xyoo pua 20th, nrog rau kev nce qib ntawm cov organic synthetic chemistry, chemists tau tsim ntau txoj hauv kev rau kev sib xyaw mannitol. Qhov tseem ceeb tshaj plaws yog cov txheej txheem ntawm kev npaj mannitol los ntawm D-glucose lossis D-fructose los ntawm kev txo qis hydrogenation. Cov txheej txheem hluavtaws no tau tsim lub hauv paus rau kev tshawb fawb tom ntej ntawm mannitol derivatives.
Acetone, raws li ib qho yooj yim thiab tseem ceeb organic hnyav thiab reagent, tau dav kawm thiab siv nyob rau hauv nruab nrab-19th caug xyoo.
Diacetone-D-mannitol yog ib qho kev sib xyaw ua ke uas muaj peev xwm tseem ceeb hauv kev tshuaj, chromatography, thiab organic synthesis. Nws cov khoom tshwj xeeb physicochemical, ua ke nrog kev tshawb fawb tsis tu ncua hauv ntsuab chemistry thiab nanotechnology, tso nws ua cov khoom tseem ceeb rau kev siv yav tom ntej. Raws li qhov kev thov rau chiral compounds thiab cov txheej txheem ruaj khov nce, DADM tau npaj los ua lub luag haujlwm tseem ceeb hauv kev txhim kho tshuaj lom neeg thiab kev tsim tshuaj.
Cim npe nrov: diacetone-d-mannitol cas 1707-77-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom