Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov kws tshaj lij manufacturers thiab cov chaw muag khoom ntawm n-boc-n'-nitro-l-arginine cas 2188-18{10}}3 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale tej khoom zoo n-boc-n'-nitro-l-arginine cas 2188-18-3 rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
N-Boc-N'-nitro-L-arginineyog ib tug compound teej tug mus rau qeb ntawm arginine derivatives. Cov yam ntxwv ntawm qhov sib xyaw no yog nws cov xim dawb mus rau dawb crystalline hmoov zoo li, nrog qhov ceev ntawm kwv yees li 1.4 ± 0.1 g / cm³. Nws muaj cov ntsiab lus melting ntawm 257℃C thiab soluble hauv DMSO (hauv me me) thiab methanol (kub me ntsis). Nws yuav tsum tau muab khaws cia rau hauv qhov chaw kaw thiab qhuav ntawm qhov kub thiab txias (2-8 degree), nyiam dua nyob rau hauv ib lub thawv tiv thaiv roj inert. Lub compound yog ruaj khov thiab tsis yooj yim deteriorated, thiab yuav tsum tau zam los ntawm kev sib cuag nrog oxides. Raws li kev tsim qauv, nws muaj Boc (tert butoxycarbonyl) tiv thaiv pawg ntawm N-terminus ntawm arginine molecules thiab ib pawg nitro (- NO2) txuas rau sab saw guanidine nitrogen (N '). Qhov kev hloov kho tshwj xeeb no tso cai rau cov tshuaj tiv thaiv tshwj xeeb thiab kev sib cuam tshuam.
Nyob rau hauv cov nqe lus ntawm nws daim ntawv thov, nws yog siv nyob rau hauv ntau yam kev tshawb fawb chaw vim nws cov yam ntxwv tshuaj. Nws tau pom tias muaj kev cuam tshuam cov tshuaj hormones hauv metabolic, kev siv roj thaum lub sijhawm ua haujlwm, kev ua haujlwm ntawm lub hlwb thaum muaj kev ntxhov siab-txoj haujlwm, thiab kev tiv thaiv kev tawm dag zog- ua rau cov leeg nqaij puas tsuaj. Cov amino acid derivatives no kuj tau ua lag luam ua lub zog ntxiv, lees paub rau lawv cov txiaj ntsig zoo li ergogenic tshuaj.
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Tshuaj Formula |
C11H21N5O6 |
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Exact Mass |
319.15 |
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Molecular Luj |
319.32 |
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m/z |
319.15 (100.0%), 320.15 (11.9%), 320.15 (1.8%), 321.15 (1.2%) |
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Elemental Analysis |
C, 41.38; H, 6.63; N, 21.93; O, 30.06 |
- Nws ua haujlwm raws li chiral organic synthesis nruab nrab.
- Nws feem ntau yog siv los ua cov pob txha molecular hauv kev sib txuas ntawm chiral tshuaj molecules thiab bioactive molecules.
- Vim nws qhov xwm txheej chiral, nws pom cov ntawv thov hauv kev txhim kho cov tshuaj tshiab.
- Nws Boc tiv thaiv pab pawg thiab pab pawg nitro muab cov chaw tshwj xeeb rau kev hloov kho ntxiv thiab koom ua ke rau hauv cov neeg sib tw tshuaj.
- Hauv kev tsim cov khoom sib txuas tshwj xeeb, nws yog siv los ua cov khoom pib.
- Piv txwv li, nws yog ua hauj lwm nyob rau hauv kev npaj ntawm Agatroban intermediates, ib tug txheej txheem uas muaj xws li ib tug - kauj ruam cov tshuaj tiv thaiv nrog txhim kho yield thiab purity.
- Amino acids thiab lawv cov derivatives, suav nrogN-Boc-N'-nitro-L-arginine, yog siv rau hauv kev tshawb fawb los kawm txog lawv cov teebmeem ntawm cov tshuaj hormones metabolic, kev siv roj, kev puas siab puas ntsws, thiab kev tiv thaiv cov leeg nqaij.
- Cov tebchaw no tau ua lag luam ua cov khoom siv hluav taws xob, vim lawv cov txiaj ntsig ergogenic.
pharmacological teebmeem
Cov teebmeem pharmacological ntawmN-Boc-N'-nitro-L-argininetsis yog cov ntaub ntawv ncaj qha nyob rau hauv cov ntaub ntawv uas tau muab, vim nws feem ntau yog cov tshuaj siv tshuaj siv nyob rau hauv kev tshawb fawb chaw es tsis yog tus neeg saib xyuas tshuaj ncaj qha. Txawm li cas los xij, raws li cov khoom siv dav dav ntawm arginine thiab nws cov derivatives, peb tuaj yeem nthuav tawm qee qhov muaj peev xwm pharmacological ntawm nws, txawm hais tias cov no yuav tsum tau txiav txim siab xav txog kom txog thaum kev tshawb fawb ntxiv.
Muaj peev xwm tiv thaiv kab mob plawv
Arginine, niam txiv compound ntawm nws, paub tias yuav ua rau kom nitric oxide ntau lawm hauv lub cev. Nitric oxide yog vasodilator, txhais tau tias nws pab nthuav cov hlab ntsha, txhim kho cov ntshav khiav thiab muaj peev xwm txo cov ntshav siab. Yog li ntawd, raws li ib tug derivative ntawm arginine, tej zaum yuav pom zoo xws li cov hlab plawv tiv thaiv.
Antioxidant Kev Ua Haujlwm
Arginine tau pom tias txhim kho antioxidant muaj peev xwm hauv cov ntshav, uas tuaj yeem pab tiv thaiv kev loj hlob ntawm cov kab mob ntev xws li ntshav qab zib. Txawm hais tias cov teebmeem antioxidant tshwj xeeb tsis paub, nws muaj peev xwm hais tias nws muaj peev xwm muaj cov tshuaj antioxidant zoo sib xws vim nws txoj kev sib raug zoo nrog arginine.
Txiv neej Fertility Support
Arginine tau raug tshawb xyuas rau nws lub peev xwm los txhim kho txiv neej fertility los ntawm kev nce cov phev suav thiab motility. Txawm hais tias qhov cuam tshuam ncaj qha rau txiv neej fertility tsis paub, nws cov qauv zoo sib xws rau arginine qhia tias nws yuav muaj txiaj ntsig zoo sib xws hauv cheeb tsam no.
Exercise Performance Enhancement
Raws li cov amino acid derivative, nws yuav siv tau los ua ib qho kev pab ergogenic los txhim kho kev tawm dag zog. Txawm li cas los xij, cov txheej txheem tshwj xeeb thiab qhov twg ntawm qhov cuam tshuam no tseem yuav raug tshawb xyuas.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov txiaj ntsig tshuaj muaj peev xwm no yog kwv yees thiab tsis tau sim tshuaj xyuas rau nws. Kev tshawb fawb ntxiv yog xav tau los txiav txim qhov tseeb pharmacological kev ua ntawm no compound. Tsis tas li ntawd, nws tsis yog cov tshuaj pom zoo rau kev siv tshuaj kho mob thiab tsuas yog yuav tsum tau siv rau hauv kev tshawb fawb chaw nyob hauv kev saib xyuas ntawm cov kws tshaj lij.
Cov txheej txheem synthesis
Lub synthesis ntawmN-Boc-N'-nitro-L-arginineFeem ntau suav nrog kev tiv thaiv cov amino pawg ntawm N'-nitro-L-arginine nrog Boc (tert-butoxycarbonyl) pawg. Nov yog cov ncauj lus kom ntxaws txog cov txheej txheem hluavtaws:
Pib Khoom: Cov synthesis pib los ntawm N'-nitro-L- arginine, uas tuaj yeem tau txais los ntawm ntau txoj hauv kev, xws li nitration ntawm L-arginine lossis kev sib txuas los ntawm L-arginine hydrochloride.
Cov tshuaj tiv thaiv nrog Boc Anhydride: N'-nitro-L- arginine yog ces reacted nrog di-tert-butyl dicarbonate (Boc2O), los yog Boc anhydride, nyob rau hauv lub xub ntiag ntawm lub hauv paus los tiv thaiv cov amino pawg nrog ib pab pawg neeg Boc. Lub hauv paus, xws li carbonate poov tshuaj (K2CO3), ua raws li ib tug scavenger rau liberated hydrogen chloride (HCl) thaum lub sij hawm cov tshuaj tiv thaiv.
Cov xwm txheej tshwm sim: Cov tshuaj tiv thaiv feem ntau yog nqa tawm hauv cov kuab tshuaj organic xws li dimethylformamide (DMF) lossis dichloromethane (DCM). Cov tshuaj tiv thaiv sib tov yog nplawm ntawm qhov ntsuas kub rau qee lub sijhawm kom ntseeg tau tias kev hloov pauv tiav.
Kev huv huv: Tom qab ua tiav cov tshuaj tiv thaiv, cov khoom raug cais tawm los ntawm cov txheej txheem xws li pom, rho tawm, thiab crystallization. Qhov no tshem tawm cov khoom siv uas tsis muaj kev cuam tshuam, cov khoom sab nraud, lossis cov kuab tshuaj.
Cim xeeb: Lub purity thiab tus kheej ntawm cov khoom kawg, tau lees paub los ntawm ntau yam kev tshuaj ntsuam xyuas, suav nrog nyias - txheej chromatography (TLC), nuclear magnetic resonance (NMR) spectroscopy, thiab siab - daws teeb meem loj spectrometry (HRMS).
Environmental phom sij
Dej ib puag ncig kev phom sij
Raws li nitrifying amino acid tshuaj, nws ua rau muaj kev hem thawj rau cov dej ib puag ncig. Tsis txhob tso cai rau cov khoom tsis muaj tshuaj lom los yog ntau ntau los rau hauv cov dej hauv av, cov dej hauv dej, lossis cov kav dej phwj tuaj.
Cia tej yam kev mob
Txhawm rau txo nws qhov cuam tshuam rau ib puag ncig, nws yuav tsum tau muab cia rau hauv qhov chaw kaw thiab qhuav ntawm qhov kub thiab txias (feem ntau yuav tsum tau 2-8 degrees), nyiam dua nyob rau hauv lub thawv ntim roj inert.
Tshuaj stability
Tam sim no, cov ntaub ntawv qhia tau hais tias cov compound muaj cov tshuaj ruaj khov, tsis yooj yim deteriorated, thiab zam kev sib cuag nrog oxides. Tsis muaj lus ceeb toom txog nws qhov tshwj xeeb reactivity, thiab nws tsis decompose nyob rau hauv ib txwm muaj xwm txheej, tsis muaj kev txaus ntshai tshwm sim.
Kev pov tseg pov tseg
Nyob rau hauv cov nqe lus ntawm pov tseg, cov khoom yuav tsum tau soluble los yog tov nrog flammable solvents thiab hlawv nyob rau hauv ib tug chemical incinerator nruab nrog tom qab combustion kev kho mob thiab ntxuav lub luag hauj lwm, los yog cov seem thiab unrecovered daws yuav tsum muab xa mus rau lub tuam txhab kho mob.
Qhov cuam tshuam rau plab microbiota
1.Npaum plab hnyuv o
Nyob rau hauv tus qauv nas hypertensive tshwm sim los ntawm L-NAME (N ω - nitro-L-arginine methyl ester, tsis muaj synthase inhibitor), pom muaj kev nce hauv plab hnyuv.
2.Microcirculation thiab nruj junction protein txo
Hauv cov qauv nas kho, qhov txo qis hauv microcirculation thiab nruj junction proteins kuj tau pom.
3.Microbial zej zog hloov
Hauv cov nas uas raug mob siab, cov zej zog microbial tau hloov pauv, uas tau cuam tshuam nrog cov hom triglycerides (TAG) thiab fatty acids (FA).
4. Muaj peev xwm mechanisms
Kev tshawb fawb pom tau hais tias qhov induction ntawm daim siab puas nyob rau hauv hypertensive nas los ntawm cov tshuaj no yog ib tug ua ke nyhuv ntawm txawv txav fatty acid metabolism thiab microcirculatory ntshawv siab nyob rau hauv lub siab. Tsis tas li ntawd, kev hloov pauv hauv plab microbiota thiab fatty acid beta oxidation (ACOX, CPT1), desaturation (SCD-1), thiab synthesis (FAS) tej zaum yuav yog cov txheej txheem hauv qab ntawm cov roj fatty acid metabolism.
Dose hauv kev sim
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Kev tshawb nrhiav cytotoxicity
Hauv kev tshawb fawb txog cov nyhuv ntawm cov tshuaj no ntawm DU145 tib neeg prostate mob qog noj ntshav cell kab, nws IC50 rau DU145 hlwb yog 12.2 mM, uas txhais tau hais tias hauv kev sim, nws ib nrab inhibitory concentration (xws li cov concentration uas inhibits cell loj hlob los ntawm 50%) yog 12.2 mM.
Kev tshawb fawb txog tus qauv ntawm Pre eclampsia
Hauv lwm txoj kev tshawb fawb, nws tau siv los ua kom muaj tus kab mob ua ntej eclampsia zoo li tus qauv nas, nrog rau cov koob tshuaj qis dua - koob L-NAME (40 mg / kg lub cev hnyav / hnub) thiab siab - koob L-NAME (75 mg / kg lub cev hnyav / hnub lossis 125 mg / kg lub cev hnyav / hnub) pib txij hnub 9 ntawm cev xeeb tub.
Kawm txog cov qauv nas hypertensive
Nyob rau hauv ib lub sij hawm ntev - tus qauv kab mob ntshav siab tau kho nrog nws, koob tshuaj 40 mg / kg lub cev hnyav / hnub tau siv rau 8 lub lis piam.
Kev tshawb nrhiav metabolic
Nyob rau hauv cov tshuaj metabolomics txoj kev tshawb fawb ntawm cov nas hypertensive tshwm sim los ntawm nws, cov nas raug ntxias kom tsim cov ntshav siab los ntawm kev haus dej tsis muaj menyuam uas muaj 0.5 g·L^-1 ntawm cov khoom. Kev hloov ntshav siab ntawm cov nas tau saib xyuas txhua hnub rau 4 lub lis piam sib law liag.
Cov lus qhia rau kev siv: Kev ua haujlwm siab ntawm cov tshuaj no feem ntau yog 10-100 µ M. Muaj tsawg zaus, qhov concentration ntawm 500 µ M lossis txawm 5mM yuav tsum tau saib xyuas cov teebmeem tseem ceeb. Qhov kev ua haujlwm zoo tshaj plaws yuav tsum tau tshawb xyuas raws li cov kev sim tshwj xeeb, thiab peb qhov concentration ntawm 10, 30, thiab 100 µ M tuaj yeem sim ua ntej.
Thaum kawg
N-Boc-N'-nitro-L-arginine, ib qho nruab nrab hauv chiral organic synthesis, tau khaws cov kev tshawb fawb tseem ceeb vim nws cov ntawv siv ntau yam hauv kev sib xyaw ntawm cov tshuaj chiral thiab cov tshuaj lom neeg lom neeg. Nws cov qauv molecular tshwj xeeb, tus yam ntxwv los ntawm pawg Boc thiab nitro kev ua haujlwm, muaj sijhawm rau kev hloov kho ntxiv thiab kev hloov pauv.
Kev tshawb fawb ntawm nws feem ntau tsom rau kev tshawb nrhiav cov txheej txheem hluavtaws tshiab los txhim kho cov txiaj ntsig thiab purity. Qhov no suav nrog kev ua kom zoo dua cov tshuaj tiv thaiv xws li hnyav, qhov kub thiab txias, thiab xaiv lub hauv paus kom ua tiav qhov ua tau zoo tshaj plaws. Tsis tas li ntawd, cov kev tshawb fawb tau ua los tshawb xyuas qhov reactivity ntawm pawg Boc thiab nitro, ua rau kev txhim kho cov khoom siv tshiab nrog cov khoom zoo.
Tsis tas li ntawd, daim ntawv thov hauv kev tshawb nrhiav tshuaj thiab kev tshawb fawb tshuaj yog thaj tsam ntawm kev tshawb nrhiav nquag. Nws lub peev xwm ua ib qho molecular scaffold nyob rau hauv cov synthesis ntawm chiral tshuaj neeg sib tw tau raug tshawb nrhiav, aiming los tsim kho tshiab nrog kev txhim kho bioactivity thiab selectivity.
Hauv cov ntsiab lus, kev tshawb fawb suav nrog kev tsim kho cov txheej txheem hluavtaws, kev tshawb fawb txog kev rov ua haujlwm, thiab kev siv hauv kev tshawb nrhiav tshuaj. Cov kev siv zog no tsom mus siv cov khoom tshwj xeeb ntawm no chiral intermediate rau kev nce qib ntawm kev tshawb fawb tshuaj.
Controllable Energy Release Mechanism of N-Boc-N '- nitro-L-arginine Binding rau Myosin
Hauv thaj chaw ntawm biochemistry thiab bioenergy, kev tshawb fawb txog kev cuam tshuam ntawm biomolecules thiab cov txheej txheem ntawm lub zog tso tawm ib txwm yog lub ntsiab lus kub. Myosin, ua cov protein tseem ceeb rau cov leeg nqaij, ua lub luag haujlwm tseem ceeb hauv kev txav thiab lub zog hloov pauv ntawm cov kab mob. Thiab N-Boc-N '- nitro-L-arginine, raws li kev sib xyaw nrog cov qauv tshuaj tshwj xeeb, nws txoj kev khi nrog myosin tuaj yeem ua rau muaj kev tswj hwm lub zog tshiab.
Kev sib khi mechanism ntawm N-Boc-N '- nitro-L-arginine thiab myosin
Kev sib xyaw ua ke
Kev khi ntawm N-Boc-N '- nitro-L-arginine rau myosin tej zaum yuav yog ib qho txheej txheem ntau- kauj ruam. Ua ntej, vim yog thermal txav ntawm cov molecules hauv cov tshuaj, N-Boc-N '- nitro-L-arginine molecules yuav mus rau ntawm qhov chaw ntawm myosin. Tom qab ntawd, los ntawm kev sib cuam tshuam tsis zoo ntawm cov molecules xws li van der Waals rog, electrostatic kev sib cuam tshuam, thiab hydrogen bonds, N-Boc-N '- nitro-L-arginine undergoes preliminary adsorption ntawm kuv cheeb tsam. Raws li kev sib txuas ua tiav, nws tuaj yeem koom nrog kev hloov kho kom haum rau kev sib khi ntawm ob qho tib si nruj thiab ruaj khov, thaum kawg tsim kom muaj kev ruaj khov.
Cov chaw sib khi
Kev txheeb xyuas qhov chaw sib khi ntawm N-Boc-N '- nitro-L-arginine ntawm myosin yog qhov tseem ceeb rau kev nkag siab txog kev sib khi. Molecular docking simulations thiab nuclear magnetic resonance (NMR) cov tswv yim tuaj yeem siv los kwv yees thiab txheeb xyuas qhov chaw khi. Cov chaw muaj peev xwm khi tau muaj xws li ATP khi hnab tsho ze ntawm lub taub hau myosin, qhov chaw sib khi ntawm actin, thiab qee thaj tsam hydrophobic. Kev khi ze ntawm ATP lub hnab ris yuav cuam tshuam rau cov txheej txheem hydrolysis ntawm ATP; Kev khi ze ntawm qhov chaw sib txuas ntawm actin tuaj yeem cuam tshuam kev cuam tshuam ntawm myosin thiab actin; Thiab kev khi rau hauv thaj chaw hydrophobic ntawm qhov chaw tuaj yeem cuam tshuam kev cuam tshuam thiab kev ua haujlwm ntawm myosin nrog rau lwm cov molecules los ntawm kev hloov nws cov khoom nto.
Analysis ntawm kev sib khi quab yuam
Lub zog khi ntawm N-Boc-N '- nitro-L-arginine thiab myosin feem ntau suav nrog van der Waals rog, electrostatic kev sib cuam tshuam, hydrogen bonding, thiab hydrophobic kev sib cuam tshuam. Van der Waals quab yuam yog qhov tsis muaj zog ntawm kev sib cuam tshuam uas ua lub luag haujlwm hauv kev ruaj khov ntawm cov txheej txheem sib khi. Kev sib cuam tshuam ntawm electrostatic yog tshwm sim los ntawm kev sib nrig sib attraction los yog repulsion ntawm N-Boc-N '- nitro-L- arginine thiab pawg nrog sib txawv nqi ntawm myosin. Qhov tsim ntawm hydrogen bonds muaj qhov cuam tshuam loj rau qhov tshwj xeeb thiab kev ruaj ntseg ntawm kev khi, piv txwv li, cov amino lossis carbonyl pawg hauv N-Boc-N '- nitro-L-arginine tuaj yeem tsim cov hydrogen bonds nrog hydroxyl lossis carbonyl pawg ntawm myosin. Hydrophobic kev sib cuam tshuam feem ntau tshwm sim ntawm pawg hydrophobic. Thaum cov hydrophobic feem ntawm N-Boc-N '- nitro-L-arginine los rau hauv kev sib cuag nrog thaj tsam hydrophobic ntawm myosin, nws txhawb nqa lawv txoj kev khi kom txo tau qhov chaw sib cuag ntawm pawg hydrophobic thiab dej.
Cov lus nug nquag
Yuav ua li cas thaum koj noj L-arginine txhua hnub?
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Kev noj L-arginine txhua hnub tuaj yeem txhim kho cov ntshav khiav, muaj peev xwm txo cov ntshav siab thiab txhim kho kev tawm dag zog, tab sis nws yuav ua rau muaj teeb meem hauv plab hnyuv (mob plab, raws plab, xeev siab), mob hawb pob / ua xua, thiab ua rau muaj kab mob herpes, yuav tsum tau ceev faj thiab kev sab laj kev kho mob vim muaj kev cuam tshuam nrog cov tshuaj xws li ntshav siab.
Dab tsi yog qhov tsaus ntuj ntawm L-arginine?
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Txawm li cas los xij, L-arginine kuj muaj sab tsaus;nws potentiates neuroinflammation thiab nitric oxide (NO) ntau lawm, ua rau kev puas tsuaj rau theem nrab. Yog li, kev hloov pauv L-arginine metabolism yog qhov nyuaj vim tias ob qho tib si cuam tshuam thiab muaj txiaj ntsig zoo yog nyob ntawm qhov no semi- tseem ceeb amino acid.
Leej twg yuav tsum zam arginine?
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Cov neeg uas yuav tsum tsis txhob arginine suav nrog cov uas nyuam qhuav mob plawv, muaj kab mob herpes nquag, mob raum lossis mob siab, ntshav siab, lossis cev xeeb tub / pub niam mis; nws kuj cuam tshuam nrog cov ntshav thinners, ntshav qab zib, thiab cov tshuaj ntshav siab, yog li kev sab laj tus kws kho mob yog qhov tseem ceeb, tshwj xeeb tshaj yog ua ntej kev phais.
Puas yog kas fes siab hauv arginine?
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Puas yog kas fes siab hauv arginine?Tsis yog, brewed kas fes tsis siab hauv arginine. Ib qho 6-ounce noj ntawm brewed kas fes muaj zoo tsis muaj arginine. Arginine yog ib qho amino acid uas lub cev xav tau los tsim cov protein, thiab qhov pom zoo noj txhua hnub yog li 2 mus rau 3g rau cov neeg laus noj qab haus huv.
Puas yog arginine cuam tshuam rau kev pw tsaug zog?
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Ntawm qhov tod tes, kev tswj hwm ntawm L-arginine lossis SIN-1 thaum lub sijhawm tsaus ntujnce qeeb yoj pw tsaug zog thiab txo qis waking thaum thawj 4 teev ntawm lub sijhawm kaw. Lub sij hawm siv sai - qhov muag - txav pw tsaug zog (REMS) tsis tau hloov pauv loj.
Cim npe nrov: n-boc-n'-nitro-l-arginine cas 2188-18-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom