Thiourea hmoov CAS 62-56-6

Thiourea hmoov, CAS 62-56-6, molecular formula CH4N2S. Nws yog ib qho tseem ceeb organic sulfur compound. Feem ntau yog dawb los yog lub teeb daj crystalline hmoov, tsw tsw, nrog ib tug iab saj. Nws yog soluble hauv dej thiab nws solubility nce nrog nce kub. Tsis tas li ntawd, nws tuaj yeem ua rau cov kuab tshuaj zoo li ethanol thiab methanol, tab sis tsis yog nyob rau hauv cov kuab tshuaj uas tsis yog-polar xws li ether thiab benzene. Cov cuab yeej no tso cai rau thiourea yaj thiab ua rau cov kuab tshuaj sib txawv. Nws tuaj yeem ua tus txo lossis oxidizing tus neeg sawv cev hauv cov tshuaj tiv thaiv electrochemical. Nws lub peev xwm redox tuaj yeem ntsuas thiab tswj tau, yog li thiourea tuaj yeem siv rau hauv cov tshuaj tiv thaiv electrochemical thiab electrochemical sensors. Nws muaj qhov zoo thermal stability thiab tuaj yeem ua tiav ntawm qhov kub siab dua yam tsis muaj decomposition. Txawm li cas los xij, nyob rau hauv lub xub ntiag ntawm muaj zog acids los yog hauv paus, thiourea yuav raug decomposition los yog hydrolysis cov tshuaj tiv thaiv. Nws muaj ntau yam kev siv hauv ntau qhov chaw. Piv txwv li, nyob rau hauv cov tshuaj tua kab, thiourea tuaj yeem ua cov khoom muaj txiaj ntsig zoo hauv tshuaj tua kab, tshuaj tua kab, thiab tshuaj tua kab mob; Hauv kev lag luam tshuaj, thiourea tuaj yeem siv los tsim cov tshuaj nruab nrab lossis kho cov kab mob thyroid; Nyob rau hauv daim teb ntawm dyes thiab pigments, thiourea tuaj yeem siv los ua ke qee yam dyes thiab pigments; Hauv thaj chaw ntawm cov tshuaj tiv thaiv photochemical thiab electrochemical sensors, thiourea tuaj yeem siv los ua ib qho tseem ceeb reactant lossis cov khoom siv sensor. Nws yog tsim los ntawm cov tshuaj tiv thaiv ntawm hydrogen sulfide nrog txiv qaub slurry los tsim calcium hydrosulfide, uas ces reacts nrog calcium cyanamide. Nws tseem tuaj yeem tau txais los ntawm kev ua haujlwm molten ammonium thiocyanate lossis cyanamide nrog hydrogen sulfide.

melting P 170 - 176℃(lit.), bP 263.89℃(kwv yees), ntom 1.405, RI 1.5300 (kwv yees), Cia tej yam kev mob Cia hauv qab no + 30℃C., Solubility dej : soluble137g / L at20℃coefficient -1.0 (ntawm 25 degree), Crystals, Xim Dawb rau yuav luag dawb, Proportion 1.406, Odor (Odor) Odorless, PH tus nqi 6 – 8 (50 g / l, H2O, 20 degree), Acid - qhov taw qhia tus nqi 1. 100 mL (20 oC), BRN 605327, Stable.Incompatible nrog muaj zog acids, muaj zog bases, muaj zog oxidizing agents, hlau ntsev, proteins, hydrocarbons.Tej zaum yuav ua phem rau acrolein. , InChIKeyUMGDCJDMYOKAJW-UHFFFAOYSA.

Thiourea thiourea kuj tseem muaj cov ntawv thov dav dav hauv kev lag luam petrochemical thiab kev lag luam tshuaj. Muaj cov khoom tawg yooj yim ntawm Thiourea hauv ntau cov tshuaj molecules. Piv txwv li, ntau lub qhov ncauj hypoglycemic tshuaj thiab tshuaj antithyroid nyob rau hauv kev ua lag luam tam sim no yog thiourea molecules. Chiral thiourea catalysts rau asymmetric synthesis kuj tau los ua qhov tseem ceeb ntawm kev tshawb fawb tsis ntev los no. Muaj ntau txoj hauv kev rau hluavtawsthiourea hmoov, thiab cov hauv qab no tshwj xeeb tau teev tseg:

Rau kev daws ntawm tert-butylisothiocyanate (5.0 mL, 39 mmol) hauv dichloromethane (200 mL) tau ntxiv isopropylamine (4.0 mL, 47 mmol) thiab diisopropylethylamine (DIEA) (6.8 mL, 39 mmol), thiab 2 rt . Cov tshuaj tiv thaiv sib xyaw yog diluted nrog EtOAc, ntxuav nrog 10 feem pua ​​citric acid (2x), saturated NaHCO3 (2x), H20 (2x), thiab brine (1x). Cov txheej txheem organic tau qhuav (MgS04) thiab evaporated rau cov khoom lag luam crude, uas yog purified los ntawm kem kom them taus 1-tert-butyl-3-isopropyl-thiourea (3.3 g, 52%).

Rau kev daws ntawm 8.5 g ntawm 3-chloro-5-fluoroaniline hauv 150 ml ntawm benzene tau ntxiv cov tshuaj 2.2 g ntawm thiophosgene hauv 10 ml ntawm benzene dropwise ntawm chav tsev kub hauv qab nitrogen. Lub resulting sib tov yog stirred ntawm 60 oC rau 3 teev thiab ces txias rau chav tsev kub. Tom qab lim, cov filtrate tau concentrated rau cov roj, uas tau ua raws li kev daws ntawm t-pentylamine (3.4 g) hauv 30 ml ntawm benzene. Cov sib tov yog stirred nyob rau hauv chav tsev kub rau lwm 30 feeb. Cov tshuaj tiv thaiv sib xyaw yog evaporated hauv vacuo thiab cov khoom ua tau recrystallized los ntawm cyclohexane muab 2.2 g ntawm cov npe compound raws li tsis muaj xim koob 1-(3-chloro-5-fluoro-phenyl)-3-(2,2-dimethyl-propyl)-thiourea.

Rau kev sib xyaw ntawm 1,1'-thiocarbonyldiimidazole (535 mg) thiab acetonitrile (7 ml) tau ntxiv ib qho kev daws ntawm 3-(N, N-Dimethyl) aniline (272 mg) hauv acetonitrile (7 ml) dropwise tshaj lub sij hawm ntawm 15 feeb ntawm nitrogen. Tom qab nplawm rau 2 teev ntawm qhov kub thiab txias, 2-(aminomethyl) pyridine (433 mg) tau ntxiv rau qhov sib tov. Tom qab ntawd cov tshuaj tiv thaiv sib xyaw ua kom sov rau 60 oC rau 4 teev. Tom qab txias rau hauv chav remperature, cov tshuaj tiv thaiv sib tov yog evaporated rau cov seem, uas yog purified los ntawm kem (DCM / MeOH) muab 1-(3-Dimethylamino-phenyl)-3-pyridin-2- ylmethyl-thiourea (423 mg).

Kev sib xyaw ntawm n- Bu2NH thiab [4-(4-ethyl-phenylamino)-phenyl]-thiocarbamic acid O-phenyl ester (348) hauv ethanol tau ua kom sov kom rov qab los hauv qab N2 cua rau 16 teev. Tom qab tshem tawm cov kuab tshuaj, cov residue tau yaj hauv DCM. Cov theem ntawm cov organic yog ntxuav nrog 1 N ntawm sodium hydroxide (3 x 50 mL), 1 N ntawm HCl aqueous tov thiab brine (5 X 50 mL). Tom qab qhuav dhau anhydrous Na2SO4 thiab lim, cov filtrate yog concentrated los muab cov khoom crude, uas yog purified los ntawm kem kom them taus 1,1-dibutyl-3-[4-(4-ethyl-phenylamino)-phenyl]-thiourea

Kev sib xyaw ntawm 4-methyl-pyrimidin-2- ylamine (2.2 g, 20 mmol) thiab pyridin-2-yl-dithiocarbamic acid methyl ester (3.6 g, 20 mmol) hauv 100 mL ntawm toluene yog rhaub rau 10 h. Tom qab tshem tawm cov kuab tshuaj, cov residue tau recrystallized los ntawm methanol kom them taus 3.4 g ntawm 1-(4-methyl-pyrimidin-2-yl)-3-pyridin-2-yl-thiourea.

Rau 4.0 g ntawm 1-(2,4-di-tert-butyl{11}}3-hydroxy-phenyl)-3-(4-nitro-benzyl)-50 g ntawm urea yog yaj nyob rau hauv txoj cai lij choj ntawm 6. 1,4-dioxane nyob rau hauv chav tsev kub hauv qab N2 cua. Lub resulting sib tov yog rhuab rau reflux rau 15 h ua ntej ncuav rau hauv 150 mL dej. Qhov sib tov tau muab rho tawm nrog ethyl acetate (3 x 100 mL). Cov txheej txheem ua ke ntawm cov organic yog ntxuav nrog brine, qhuav dhau anhydrous sodium sulfate thiab lim. Cov filtrate yog concentrated rau cov khoom nyoos, uas yog purified los ntawm silica gel kem muab 2.5 g ntawm 1-(2,4-Di-tert-butyl-3-hydroxy-phenyl)-3-(4-nitro-benzyl)-thiourea (60%).

Thiourea hmoovyog siv los ua cov khoom siv raw rau kev sib txuas ntawm sulfathiazole, methionine thiab lwm yam tshuaj, raws li cov khoom siv raw rau dyes, dyeing aids, resins thiab compression molding hmoov, raws li vulcanization accelerator ntawm roj hmab, tus neeg sawv cev flotation ntawm hlau minerals, catalyst rau kev npaj phthalic anhydride thiab fumaric acid inhibitor, thiab raws li cov hlau. Hais txog cov khoom siv yees duab, nws tuaj yeem siv los ua tus tsim tawm thiab toner, thiab tseem tuaj yeem siv rau hauv kev lag luam electroplating. Thiourea kuj tseem siv rau hauv diazo rhiab ntawv, hluavtaws cob txheej, anion txauv resin, germination accelerator, bactericide thiab ntau lwm yam. Thiourea kuj tseem siv los ua chiv. Nws yog siv los ua raw khoom rau kev tsim tshuaj, dyes, resins, compression molding hmoov, vulcanization accelerators ntawm roj hmab, flotation agents ntawm hlau minerals, thiab lwm yam.

Thiourea yog ib qho tseem ceeb organic sulfur compound nrog ntau yam kev siv. Kev siv tseem ceeb ntawm thiourea yog raws li hauv qab no:

1. Kev kho mob teb

 

1.1 Kev kho cov kab mob thyroid: Thiourea tuaj yeem siv los ua cov tshuaj tiv thaiv thyroid los kho hyperthyroidism. Nws tuaj yeem cuam tshuam cov synthesis thiab tso tawm cov thyroid hormones, yog li txo cov tsos mob.
1.2 Synthetic Drug Intermediates: thiourea sigma tuaj yeem ua cov tshuaj tseem ceeb hauv nruab nrab rau kev sib xyaw ua ke nrog qee cov tshuaj siv tshuaj. Piv txwv li, nws tuaj yeem khi nrog cov amino acids lossis lwm yam khoom siv molecules los tsim cov tebchaw nrog cov teebmeem tshuaj tshiab.
1.3 Antibacterial thiab antiviral: Thiourea thiab nws cov derivatives muaj qee yam tshuaj tua kab mob thiab tshuaj tua kab mob thiab tuaj yeem siv los tsim cov tshuaj tua kab mob tshiab thiab tshuaj tua kab mob.

2. Tshuaj tua kab

 

2.1 Cov tshuaj tua kab mob: Thiourea tuaj yeem siv los ua cov khoom muaj txiaj ntsig zoo hauv cov tshuaj tua kab mob los tswj cov nroj tsuag hauv thaj av, vaj txiv hmab, thiab cov nyom. Nws tuaj yeem cuam tshuam nrog kev loj hlob ntawm cov nroj tsuag thiab ua rau cov nroj tsuag tuag.
2.2 Cov tshuaj tua kab: Thiourea tuaj yeem siv los ua cov tshuaj tua kab los tswj cov kab tsuag thiab kab tsuag hauv tsev. Nws tuaj yeem ua rau lub paj hlwb lossis cov txheej txheem metabolic ntawm cov kab tsuag, ua rau lawv tuag.
2.3 Fungicides: Thiourea thiab nws cov derivatives tuaj yeem siv los ua fungicides los tiv thaiv thiab tswj cov kab mob nroj tsuag. Nws tuaj yeem ua rau lub cell membrane ntawm cov kab mob los yog inhibit lawv txoj kev loj hlob thiab kev loj hlob, yog li tiv thaiv cov nroj tsuag los ntawm kab mob ntxeem tau.

3. Dyes thiab pigments teb

 

3.1 Synthetic dyes: Thiourea tuaj yeem siv los tsim cov xim tshwj xeeb, xws li sulfide dyes thiab cov dyes ncaj qha. Cov dyes muaj kev ua haujlwm zoo dyeing thiab ceev ceev, thiab tau siv dav hauv kev lag luam xws li textiles, tawv, thiab tshuaj pleev ib ce.

3.2 Pigment additive: Thiourea tuaj yeem siv los ua cov xim ntxiv los kho cov xim thiab kev ua haujlwm ntawm cov xim. Nws tuaj yeem ua ke nrog cov xim molecules los tsim cov xim ruaj khov dua, txhim kho lub teeb tsis kam, dej tsis kam, thiab tshuaj lom neeg ntawm cov xim.

4. Nyob rau hauv lub teb ntawm photochemical tshuaj

 

4.1 Photosensitizer: Thiourea tuaj yeem siv los ua cov photosensitizer los pib lossis nrawm cov tshuaj tiv thaiv hauv cov tshuaj tiv thaiv photochemical. Nws tuaj yeem nqus tau lub teeb lub zog thiab hloov mus rau hauv tshuaj lom neeg lub zog, yog li ua rau decomposition, synthesis, lossis hloov pauv ntawm cov tebchaw.
4.2 Lub teeb Stabilizer: Thiourea thiab nws cov derivatives tuaj yeem siv los ua lub teeb stabilizers los tiv thaiv cov ntaub ntawv polymer los ntawm kev laus thiab degradation los ntawm ultraviolet hluav taws xob. Nws tuaj yeem nqus tau lub zog ultraviolet thiab hloov nws mus rau hauv lub zog hluav taws xob tsis zoo, yog li txuas ntxiv lub neej kev pabcuam ntawm cov khoom siv.

5. Nyob rau hauv lub tshav pob ntawm electrochemical sensors

 

5.1 Cov Khoom Siv Hluav Taws Xob: Thiourea tuaj yeem siv los ua cov khoom siv hluav taws xob rau cov khoom siv hluav taws xob hluav taws xob los kuaj xyuas thiab tshuaj xyuas cov tshuaj hauv ib puag ncig. Nws tuaj yeem dhau los ua cov tshuaj tiv thaiv electrochemical nrog cov tshuaj ntsuam xyuas thiab tsim cov cim tam sim no, yog li ua tiav qhov kev kuaj pom ntau ntawm cov tshuaj ntsuam xyuas.
5.2 Electrochemical Catalyst: Thiourea tuaj yeem siv los ua electrochemical catalyst kom nrawm tus nqi ntawm cov tshuaj tiv thaiv electrochemical thiab txhim kho cov tshuaj tiv thaiv. Nws tuaj yeem txo qhov ua kom lub zog ntawm cov tshuaj tiv thaiv thiab txhawb cov txheej txheem hloov hluav taws xob, yog li ua tiav cov txheej txheem electrochemical synthesis thiab kev tsom xam.

6. Lwm yam kev siv

 

6.1 Kev kho tawv nqaij: Thiourea tuaj yeem siv ua depilatory lossis preservative hauv txheej txheem kho tawv nqaij. Nws tuaj yeem tshem tawm cov plaub hau ntawm tawv thiab tiv thaiv kom tsis txhob ua pwm lossis lwj.
6.2 Roj Hmab Additives: Thiourea tuaj yeem siv los ua cov roj hmab ntxiv los txhim kho kev ua tau zoo thiab cov khoom siv roj hmab zoo. Nws tuaj yeem txhim kho kev ua haujlwm, cov khoom siv kho tshuab, thiab kev laus ua haujlwm ntawm roj hmab.
6.3 Oilfield Tshuaj:Thiourea hmoovtuaj yeem siv ua cov tshuaj oilfield hauv oilfield kev loj hlob. Nws tuaj yeem muab ntxiv rau cov roj qhov dej ua cov tshuaj tiv thaiv corrosion, scale inhibitor, thiab wax inhibitor los tiv thaiv cov khoom siv roj zoo thiab txhim kho cov roj rov ua haujlwm.

Ua phem rau tib neeg lub cev

Kev phom sij rau ib puag ncig
Cov hmoov no yuav ua rau qee yam ua paug rau ib puag ncig thaum tsim khoom thiab siv. Yog tias tso tawm ncaj qha rau hauv ib puag ncig yam tsis muaj kev kho kom raug, nws yuav ua rau muaj kuab paug rau hauv dej, av, thiab huab cua. Nws yooj yim rau hydrolysis thiab tsim hydrogen sulfide, uas yog cov pa roj carbon monoxide uas tsis yog tsuas yog ua phem rau huab cua, tab sis kuj tseem yuav ua rau muaj kev hem thawj rau tib neeg kev noj qab haus huv. Tsis tas li ntawd, nws kuj tseem tuaj yeem ua rau muaj kev phom sij rau cov kab mob hauv dej thiab cuam tshuam rau kev sib npaug ntawm ecosystems.

Lwm yam teebmeem

Cim npe nrov: thiourea hmoov cas 62-56-6, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom