Raws li kev kho mob metabolic hloov zuj zus mus, cov tebchaw tsom rau kev tswj hwm lub zog ntawm tes qhia kev cog lus.5 ib 1mq peptide txhaj tshuaj tau nyiam kev tshawb fawb txog kev txhim kho cov roj metabolism los ntawm inhibiting nicotinamide N-methyltransferase (NNMT). Kev ua haujlwm siab NNMT degrades methyl pawg thiab nicotinamide xav tau rau NAD + ntau lawm, txo cov cellular zog efficiency thiab txhawb cov rog. Qhov kev txhaj tshuaj no thaiv NNMT kev ua haujlwm, cuam tshuam rau ntau txoj hauv kev metabolic nrog rau lipolysis thiab metabolic yooj. Kev tshawb fawb thaum ntxov qhia tias NNMT kev hloov pauv tuaj yeem cuam tshuam rau ob qho tib si ncaj qha rog rog thiab nthuav dav metabolic adaptation, lav kev tshawb nrhiav ntxiv.
5-amino-1mq Txhaj
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Txhaj tshuaj
(4) Capsules
(5) Qhov ncauj poob
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-3-113
5-amino-1MQ\\NNMTi\\5-amino-1-methylquinolinium\\5-Amino-1-methylquinolinium chloride CAS 42464-96-0
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Peb muab 5 amino 1mq peptide, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/oem-odm/injection/5-amino-1mq-injection.html
Dab tsi yog 5ib 1mq peptide txhaj tshuajthiab Nws Ua Haujlwm li cas ntawm Qib Enzyme?
Molecular Structure thiab Enzymatic Target
5-amino-1-methylquinolinium acts as a small-molecule inhibitor targeting NNMT, which uses S-adenosylmethionine to methylate nicotinamide. The quinolinium ring structure mimics nicotinamide, competitively binding the active site without undergoing methylation. Research-grade material requires >98% purity rau cov txiaj ntsig rov ua dua. Inhibitory tsis tu ncua qhov tseem ceeb qhia tau hais tias muaj kev cuam tshuam kev sib koom ua ke ua kom muaj koob tshuaj - nyob ntawm NNMT kev hloov kho. Cov pab pawg tshawb fawb biotechnology vam khom cov khoom zoo sib xws thaum kawm txog cov teebmeem metabolic hauv qab.
Inhibition Mechanism thiab Methylation Pathway Disruption
NNMT hloov nicotinamide mus rau N1-methylnicotinamide thaum noj SAM, depleting cellular methyl pas dej ua ke tseem ceeb rau DNA methylation, hloov histone, thiab phosphatidylcholine ntau lawm. Nce NNMT qhia nyob rau hauv metabolically dysfunctional adipose cov ntaub so ntswg qhia hais tias ntau tshaj kev ua si yuav ua rau cov metabolic tej yam kev mob . 5-amino-1-methylquinolinium slows nicotinamide methylation, redirecting nicotinamide rau NAD + cawm txoj kev ntawm NAMPT. Kev tuav pov hwm nicotinamide txhawb nqa NAD + qib, cuam tshuam rau mitochondrial kev ua haujlwm thiab kev siv lub zog.
Kev faib tawm cov ntaub so ntswg thiab kev txiav txim siab ntawm cov tshuaj
NNMT kev qhia txawv ntawm cov ntaub so ntswg, nrog rau qib siab tshaj plaws hauv cov ntaub so ntswg adipose thiab daim siab, qhia cov ntaub so ntswg - tshwj xeeb cov teebmeem metabolic ntawm inhibition. Kev txhaj tshuaj pub rau kev tswj hwm kev tswj hwm nrog cov kev txwv pharmacokinetic. Kev tshawb fawb xav tau cov ntaub ntawv txheeb xyuas dav dav suav nrog HPLC purity profiles, kev pom zoo ntawm huab hwm coj spectrometry, thiab kev ruaj ntseg specifications. Cov kws tshuaj ntsuam xyuas cov tshuaj ntsuam xyuas cov tshuaj tiv thaiv kab mob metabolic yuav tsum nkag siab txog kev sib khi kinetics, kev xaiv, thiab tawm ntawm - cov teebmeem. Quinolinium qauv yuav tsum ua kom pom kev txaus NNMT xaiv tshaj lwm yam methyltransferases rau kev tshawb fawb txog biochemical muaj txiaj ntsig.
Yuav ua li cas 5ib 1mq txhaj tshuajTxhawb NAD + Preservation thiab Cellular Energy Production?
NAD + Salvage Pathway Connection
NAD + yog qhov tseem ceeb rau kev tsim hluav taws xob ntawm tes los ntawm cov tshuaj tiv thaiv redox hauv glycolysis, lub voj voog citric acid, thiab oxidative phosphorylation. Txoj kev khaws cia rov ua dua nicotinamide rov qab rau NAD + los ntawm cov kauj ruam enzymatic. Kev ua haujlwm siab NNMT cuam tshuam nicotinamide los ntawm txoj hauv kev no, hloov mus rau N1-methylnicotinamide rau kev tso tawm . 5-amino-1-methylquinolinium inhibits NNMT, nce nicotinamide muaj rau NAMPT hloov dua siab tshiab rau NMN, uas yog tom qab ntawd adenylated rau NADtor +{7} sspiral remitation ntawm tes. sirtuin enzyme ua haujlwm.
Mitochondrial Function thiab Energy Expenditure
Vim tias mitochondria tas li siv NAD + thaum lub tshuab xa hluav taws xob thauj khoom ua haujlwm, lawv tau nkag siab zoo rau kev hloov pauv ntawm NAD + muaj. Hauv cov chaw tshawb fawb metabolic, cov kev tshawb fawb tau pom tias thaiv NNMT yog txuas rau cov kev ua pa ntawm mitochondrial ntau dua thiab siv oxygen ntau dua. Cov kev hloov pauv no taw qhia rau lub peev xwm siab dua los ua cardio ATP, uas tuaj yeem hloov pauv ntau npaum li cas cov neeg siv feem ntau.Direct NAD + precursor supplementing cov tswv yim txawv ntawm cov5 ib 1mq peptide txhaj tshuajtxoj kev ua kom NAD + qib siab.
Es tsis txhob ntxiv cov substrate, nws txo qis cov metabolism hauv dej uas los ntawm nicotinamide methylation ntau dhau. Endogenous metabolic pathways tau khaws cia ciaj sia los ntawm cov txheej txheem no, uas tseem cia cov hlwb tswj hwm qib NAD +. Cov tuam txhab biotechnology uas ua rau cov khoom noj qab haus huv metabolic tau dhau los paub txog qhov tseem ceeb npaum li cas los cuam tshuam nrog cov dej ntws ntawm cov enzyme bottlenecks es tsis txhob tsuas yog ntxiv rau cov dej hauv qab molecules.
Sirtuin Activation thiab Metabolic Regulation
NAD+-dependent sirtuin deacetylases tswj cov noob qhia, kho DNA, thiab hloov pauv metabolic.
NNMT inhibition indirectly txhawb sirtuin muaj nuj nqi hla cov ntaub so ntswg los ntawm kev tswj NAD + muaj. SIRT1 modulates transcriptional programs tswj lipid metabolism, mitochondrial biogenesis, thiab insulin rhiab heev. Kev tshawb fawb- qib 5 amino 1mq peptide txhaj ua kom tswj tau txoj kev tshawb fawb ntawm NAD+-sirtuin- metabolism kev sib txuas. Cov kws kho mob nruab nrab yuav tsum muab cov khoom sib xyaw nrog cov ntaub ntawv pov thawj purity thiab cov impurity cov ntsiab lus kom ntseeg tau tias cov txiaj ntsig kev sim rov tsim dua.
Fat Metabolism Ua kom dhau los ntawm 5ib 1mq: Vim li cas NNMT Inhibition Influences Lipid Siv?
Adipose ntaub so ntswg NNMT nthuav qhia thiab Metabolic Phenotype
Kev ua haujlwm siab NNMT tuaj yeem cuam tshuam lipolysis thiab rog oxidation, tsim cov txheej txheem metabolic nyiam khaws cia. Mechanisms koom nrog SAM depletion txo phosphatidylcholine synthesis, cuam tshuam lipid droplet dynamics thiab VLDL sib dhos. Txo NAD + txwv NAD+-dependent enzymes hauv beta- oxidation txoj hauv kev suav nrog cov dehydrogenases tseem ceeb. Cov xwm txheej no sib sau ua ke tsim ib puag ncig metabolic nyiam cov rog cia dhau kev siv.
Beta{0}}Oxidation Enhancement thiab Fatty Acid Flux
Beta{0}}oxidation yuav tsum tau NAD + ua cofactor nyob rau hauv ntau cov kauj ruam, ua rau nws rhiab heev rau cellular NAD + muaj. NNMT inhibition tswj NAD + qib, ua kom muaj txiaj ntsig beta - oxidation tus nqi thiab fatty acid flux los ntawm txoj kev oxidative. Kev ua sirtuin cuam tshuam rau PPAR- kev qhia thiab lub hom phiaj cov noob encoding fatty acid thauj thiab oxidation enzymes. Cov txheej txheem kev hloov pauv no nthuav tawm cov teebmeem metabolic ntawm nce NAD +, tsim cov kev hloov pauv ruaj khov hauv lipid tuav peev xwm. Cov tshuaj cuam tshuam rau ntau qib kev tswj hwm yuav ua rau muaj kev cuam tshuam zoo dua li ib qho - cov txheej txheem modulators.
Cellular Lipid Droplet Dynamics
Adipocytes khaws triacylglycerols hauv lipid droplets, uas yog cov qauv tshwj xeeb. Qhov loj thiab tus nqi ntawm kev hloov pauv ntawm cov tee dej no qhia tias lipogenesis thiab lipolysis sib npaug li cas. Lub tsho tiv no protein nyob ib ncig ntawm cov tee dej no muaj cov enzymes thiab cov txheej txheem tswj hwm uas tswj kev txav ntawm lipids. Cov kws tshawb fawb tau pom tias thaiv NNMT tuaj yeem hloov cov proteins uas tsim cov lipid tee thiab cov haujlwm ntawm lipases uas ua rau triacylglycerol.Hormone-rhiab lipase thiab adipose triglyceride lipase tawg triacylglycerols rau hauv cov roj fatty acids dawb thiab glycerol thaum cov hlwb tau txais cov lus siv khaws cia.
Thaum cov fatty acids no dawb lawm, lawv mus dhau ntawm beta -oxidation los yog nkag mus rau hauv cov hlab ntsha kom lwm cov hlwb siv tau. Cov5 ib 1mq peptide txhaj tshuajtxoj kev thaiv NNMT tuaj yeem txhim kho qhov lipolytic cascade los ntawm kev ua NAD+- nyob ntawm qhov taw qhia zoo dua thiab txhim kho txoj haujlwm ntawm txoj kev methylation. Cov tuam txhab tshuaj ua haujlwm ntawm kev kho mob metabolic tau paub ntau ntxiv tias kev hloov pauv tus cwj pwm ntawm cov lipid tee yog ib txoj hauv kev ua haujlwm sib txawv dua li kev siv tus qauv thermogenic.
5 ib 1mq txhaj tshuajthiab lub cev Recomposition: Hloov qhov sib npaug ntawm Fat Storage thiab Lean Mass Efficiency
Metabolic Partitioning ntawm lub zog substrates
Lub cev tsis tu ncua muab cov as-ham rau oxidation, cia li glycogen lossis rog, lossis hloov mus rau cov txheej txheem protein. Qhov kev faib tawm no nyob ntawm cov cim hormonal, muaj cov khoom noj muaj txiaj ntsig, thiab lub zog ntawm tes. Kev ua NNMT cuam tshuam rau qhov sib npaug no los ntawm NAD + metabolism thiab methylation pathway flux. Qhov siab NNMT tuaj yeem hloov pauv kev faib tawm mus rau qhov chaw cia, thaum inhibition txhawb oxidative pov tseg. Lub cev recomposition yuav tsum muaj cov ntaub so ntswg- tshwj xeeb substrate tuav ua kom muaj roj poob thaum khaws cia cov nqaij ntshiv los ntawm kev sib koom ua ke ntawm kev hloov pauv hauv metabolic.
Lub cev nqaij daim tawv Energy Efficiency thiab Performance
Thaum ib tug neeg yog lean, skeletal leeg yog lub ntsiab metabolic cheeb tsam. Cov leeg no kuj hloov tau yooj yim heev thiab tuaj yeem teb cov kev hloov pauv hauv kev noj zaub mov thiab tshuaj. Cov leeg nqaij mitochondria siv NAD + thaum lawv ua oxygen ATP thiab thaum lawv rov qab los ntawm lactate- ua kom siab - siv zog. Los ntawm kev thaiv NNMT, cov leeg nqaij NAD + cov khoom yuav raug tswj xyuas, uas yuav pab tau ntev - lub sij hawm contractile muaj nuj nqi thiab sai kho ntawm workouts.The5 ib 1mq peptide txhaj tshuajmechanism indirectly pab cov leeg nqaij ua haujlwm los ntawm kev ua kom yooj yim dua.
Insulin Sensitivity thiab Nutrient Handling
NNMT inhibition-vim kev hloov pauv hauv metabolic tuaj yeem cuam tshuam rau cellular insulin signaling teb. NAD+- cov txheej txheem nyob ntawm kev cuam tshuam cov insulin txoj hauv kev ntawm ntau lub ntsiab lus, suav nrog sirtuin-kev sib haum xeeb deacetylation ntawm cov teeb liab intermediates. Txhim kho cov tshuaj insulin rhiab heev ua rau muaj txiaj ntsig zoo ntawm cov piam thaj hauv cov qib insulin qis, txo qis pancreatic beta cell xav tau thiab insulin-tsav adipose cia. Cov tswv yim txog kev txwv cov kab mob hauv nruab nrab tuaj yeem ua rau muaj txiaj ntsig zoo dua - lub sij hawm ntev dua li cov kev taw qhia ncaj qha rau hauv kev tsim tshuaj.
Metabolic Adaptation Nrog 5ib 1mq: Yuav ua li cas Cellular Zog Efficiency hloov lub sij hawm?
Transcriptional Reprogramming thiab Metabolic Gene Expression
Ntev NNMT inhibition induces transcriptional adaptations rau hloov NAD + muaj thiab methylation txoj kev flux. Gene expression profiling nthuav tawm cov teebmeem ntawm kev ua haujlwm mitochondrial, kev siv lipid, thiab kev ntxhov siab teb cov noob. Cov ntaub so ntswg adipose qhia tau hais tias muaj zog tshaj kev hloov nrog upregulated oxidative metabolism noob thiab downregulated lipogenic txoj kev. Lub siab cov ntaub so ntswg teb nrog hloov kho gluconeogenesis thiab lipid export noob. Cov ntaub so ntswg- cov lus teb tshwj xeeb sib sau ua ke rau kev hloov pauv hauv cov txheej txheem metabolic sib sau ua ke thaum lub sijhawm tswj hwm kev sib koom ua ke.
Mitochondrial Biogenesis thiab Oxidative Capacity
Nce mitochondrial huab hwm coj thiab kev ua haujlwm sawv cev rau kev hloov pauv tseem ceeb rau kev txhawb nqa NNMT inhibition. Nce NAD + thiab txhim kho sirtuin signaling pab mitochondrial biogenesis los ntawm PGC-1 ua kom. Sirtuins tswj los ntawm NAD + tswj qhov kev hloov pauv ntawm coactivator, tig rau mitochondrial noob qhia. Qhov no cascade tsim cov mitochondria tshiab nrog ua tiav electron thauj chains
thiab beta{0}} tshuab oxidation, ua kom tag nrho cov cellular oxidative muaj peev xwm.
Metabolic Flexibility thiab Substrate Switching
Metabolic yooj yog lub peev xwm ntawm cov hlwb thiab cov ntaub so ntswg los hloov tus nqi uas lawv hlawv roj raws li cov khoom ntawm cov substrates thiab lawv lub zog xav tau. Cov neeg uas metabolically nruj, uas yog ib qho cim qhia ntawm metabolic tsis ua haujlwm, muaj teeb meem hloov pauv ntawm cov piam thaj thiab rog. Vim tias qhov nruj no, cov txheej txheem oxidation tsis tiav, thiab cov lipid intermediates tsim, uas nres cov tshuaj insulin los ntawm kev sib txuas lus kom raug.Cov kev hloov uas tshwm sim thaum NNMT raug thaiv rau lub sijhawm ntev zoo li txhim kho metabolic yooj nyob rau hauv ntau tshaj ib txoj kev.
Ntau mitochondria txhais tau hais tias txhua hom substrates tuaj yeem oxidized zoo dua. Ntau NAD + ua kom paub tseeb tias muaj cov cofactors txaus, txawm tias cov txheej txheem oxidation yuav mus li cas.Cov tshuaj insulin zoo dua tso cai rau lub cev tshem tawm cov piam thaj ntau dua thaum nws muaj cov carbohydrates ntau, thiab zoo dua lipolysis thiab beta -oxidation pab lub cev siv roj thaum nws tsis muaj zog lossis yoo mov.Cov kev hloov pauv ua ke no ua rau cov qauv metabolic uas tuaj yeem tswj cov substrates zoo nyob rau hauv ntau yam khoom noj khoom haus. 5 amino 1mq peptide txhaj txoj kev ua rau cov kev hloov pauv no txawv heev ntawm kev kho mob uas tsav qee lub xeev metabolic.
Xaus
Saib rau hauv5 ib 1mq peptide txhaj tshuaj(5-amino-1-methylquinolinium) raws li tus neeg sawv cev ntawm cov metabolic qhia kev sib txuas ntawm kev tswj cov enzymes, lub zog qauv ntawm cov hlwb, thiab kev tuav cov substrates thoob plaws hauv lub cev. Cov tshuaj no hloov pauv txoj hauv kev methylation flux thiab NAD + metabolism los ntawm kev thaiv NNMT hauv ib txoj kev. Qhov no muaj kev cuam tshuam ntxiv rau hauv kab uas cuam tshuam rau ntau qhov chaw ntawm cov cell ua haujlwm li cas. Khaws NAD + pab mitochondrial oxidative muaj peev xwm, sirtuin-mediated gene tswj, thiab zoo dua fatty acid oxidation, tag nrho cov uas ua rau ntau metabolic flexibility.Lub peev xwm los nkag siab txog cov txheej txheem no muab cov kws tshawb fawb thiab tuam txhab uas muag ua cov tshuaj muaj txiaj ntsig zoo rau kev txhim kho kev noj qab haus huv metabolic. Txoj kev NNMT tau hais tawm hauv cov ntaub so ntswg sib txawv thiab cov kev hloov pauv uas tshwm sim maj mam thaum nws raug thaiv qhia tias tsom mus rau metabolic reprogramming tuaj yeem ua tau. Raws li kev tshawb fawb ntau ntxiv kom nkag siab txog NNMT cov feem hauv cov metabolism, cov tshuaj xws li 5-amino-1-methylquinolinium tuaj yeem pab los nrog txoj hauv kev tshiab los kho cov teeb meem metabolic thiab txhim kho lub cev muaj pes tsawg leeg.
FAQ
1. Dab tsi yog 5ib 1mq peptide txhaj tshuajuas ua rau nws txawv ntawm lwm yam tshuaj lom neeg?
Nws qhov tshwj xeeb zoo yog tias nws lub hom phiaj NNMT enzyme kev ua haujlwm hauv txoj kev tshwj xeeb. Hloov chaw ncaj qha nce thermogenesis lossis nres qee qhov receptors, nws kho qhov teeb meem ua ntej hauv cov txheej txheem metabolic los ntawm kev ua kom NAD + muaj thiab txoj hauv kev ua haujlwm methylation. Qhov no cia cov hlwb txhim kho lawv tus kheej cov txheej txheem biochemical es tsis txhob thawb qee qhov txiaj ntsig los ntawm kev ua kom txoj hauv kev ncaj qha.
2. Feem ntau nws yuav siv sij hawm ntev npaum li cas kom pom cov kev hloov pauv hauv cov metabolism thaum NNMT raug thaiv?
Kev hloov pauv metabolic tshwm sim nyob rau ntau lub sijhawm. Cov teebmeem ntawm kev ua haujlwm enzyme tshwm sim tsuas yog ob peb teev tom qab kev tswj hwm, thaum hloov pauv hauv cov kab mob metabolic tshwm sim ob peb hnub. Tom qab lub lis piam ntawm kev sib cuag tas mus li, cov kev hloov sib sib zog nqus uas cuam tshuam nrog kev tsim mitochondrial thiab ntev - kev hloov pauv nyob rau hauv substrate oxidation qauv feem ntau tshwm sim. Txhawm rau kom tau txais cov duab meej ntawm ntau yam kev hloov pauv, cov kev tshawb fawb uas sim cov tshuaj no feem ntau yuav kav ntev tshaj li ib lub lis piam.
3. Dab tsi yog qhov tseem ceeb tshaj plaws uas yuav tsum tau nrhiav hauv 5ib 1mq peptide txhaj tshuajrau kev kawm?
Purity ntau dua 98% tseem tsim nyog, thiab qhov no tuaj yeem ua pov thawj siv HPLC thiab cov cuab yeej ntsuas raug. Mass spectrometry paub meej makNws paub tseeb tias cov tshuaj lom neeg yog qhov tseeb thiab qhia tau tias muaj cov qauv isomers lossis cov khoom tawg. Cov kws tshawb fawb tuaj yeem taug qab txhua yam kab mob uas tuaj yeem hloov pauv cov txiaj ntsig ntawm kev sim los ntawm kev siv cov ncauj lus kom ntxaws impurity. Lub zog thaiv lub zog yuav raug tswj xyuas thoob plaws lub sijhawm kawm ua tsaug rau cov ntaub ntawv ruaj khov khaws cia nyob rau hauv cov xwm txheej sib txawv. Kev sau tag nrho ntawm kev tshuaj ntsuam pab ua raws li cov cai thiab rov ua qhov kev sim.
Koom Tes Nrog BLOOM TECH: Koj Trusted 5ib 1mq peptide txhaj tshuajTus neeg muab khoom
Thaum koj lub koom haum xav tau kev nkag siab zoo rau kev tshawb fawb- qib metabolic compounds, BLOOM TECH muab qhov zoo, sib xws, thiab kev tswj hwm kev txhawb nqa uas cov kws tsim tshuaj thiab cov koom haum tshawb fawb biotechnology xav tau. Raws li kev paub5 ib 1mq peptide txhaj tshuajtus neeg muag khoom, peb tuav GMP-cov chaw tsim khoom tau lees paub los ntawm US-FDA, EU, JP, thiab CFDA cov tub ceev xwm, kom ntseeg tau tias txhua pawg ua tau raws li qhov nruj purity thiab analytical qauv tseem ceeb rau daim ntawv thov kev tshawb fawb metabolic.
Peb pab neeg tshwj xeeb muab kev pab txhawb nqa thoob plaws hauv koj txoj kev txhim kho, los ntawm kev tshawb fawb thawj zaug -qib kom muaj nuj nqis mus rau scalable bulk manufacturing. Nrog rau ntau tshaj 12 xyoo ntawm kev paub hauv cov organic synthesis thiab kev tsim tshuaj nruab nrab, peb nkag siab qhov tseem ceeb ntawm cov khoom sib xws, cov ntaub ntawv qhia ntxaws ntxaws, thiab cov khoom siv sib txuas. Txawm hais tias koj tab tom ua qhov kev tshawb fawb ua ntej enzyme inhibition lossis nce mus rau kev soj ntsuam kev soj ntsuam, BLOOM TECH muaj kev lees paub zoo, kev tswj hwm kev txawj ntse, thiab cov kev pabcuam teb uas ua rau koj cov haujlwm mus tom ntej.
Txuas nrog peb pab neeg los tham txog koj cov kev xav tau tshwj xeeb rau 5-amino-1-methylquinolinium thiab tshawb pom tias peb txoj kev pabcuam ib leeg ua kom yooj yim rau kev yuav khoom thaum tswj hwm cov qauv zoo tshaj plaws. Tiv tauj peb hnub no ntawmSales@bloomtechz.comthov kom paub meej cov khoom specifications, analytical cov ntaub ntawv, thiab customized quotations uas ua raws li koj cov kev tshawb fawb ncua sij hawm thiab nyiaj txiag xav tau.
Cov ntaub ntawv
1. Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown tiv thaiv kev noj haus-kev rog rog. Xwm . 2014;508(7495):258-262.
2. Ulanovskaya OA, Zuhl AM, Cravatt BF. NNMT txhawb nqa kev hloov kho epigenetic hauv kev mob qog noj ntshav los ntawm kev tsim cov metabolic methylation dab dej. Nature Chemical Biology. 2013;9(5):300-306.
3. Komatsu M, Kanda T, Urai H, et al. Kev ua kom NNMT tuaj yeem pab txhawb kev txhim kho cov kab mob rog rog los ntawm kev hloov kho NAD + cov metabolism. Kev Tshaj Tawm Txog Kev Tshawb Fawb . 2018; 8(1): 8637.
4. Pissios P. Nicotinamide N-methyltransferase: Ntau tshaj li vitamin B3 clearance enzyme. Trends in Endocrinology & Metabolism. 2017;28(5):340-353.
5. Brachs S, Polack J, Brachs M, thiab al. Genetic nicotinamide N-methyltransferase (Nnmt) deficiency hauv txiv neej nas txhim kho insulin rhiab heev hauv kev noj zaub mov- ntxias rog tab sis tsis cuam tshuam rau kev ua rau cov piam thaj. Mob ntshav qab zib mellitus . 2019; 68(3): 527-542.
6. Rejano-Gordillo CM, Marín-Aguilar F, Castejón-Vega B, et al. NNMT: Kev Tshawb Fawb Txog Cov Qauv thiab Kev Kho Mob. Medicinal Chemistry tam sim no. 2021;28(18):3602-3620.