Pterostilbene, ib txwm tshwm sim stilbenoid, yog ib qho chaw muab tau los ntawm ntau yam nroj tsuag, nrog rau cov ntsiab lus tseem ceeb hauv blueberries, pterocarpus hom (ib hom ntoo sov), thiab tshwj xeeb tshaj yog nplua nuj nyob rau hauv Indian tshuaj ntsuab.Jujube(Ziziphus jujuba). Nws belongs rau ib chav kawm ntawm polyphenols paub txog lawv cov antioxidant thiab muaj peev xwm txhawb kev noj qab haus huv.
Kev rho tawm ntawm pterostilbene feem ntau koom nrog ntau cov txheej txheem pib nrog kev sau cov khoom cog, feem ntau cov txiv hmab txiv ntoo, noob, lossis tawv ntoo, nyob ntawm qhov chaw. Thaum cov khoom tiav lawm, cov khoom siv ziab kom qhuav kom tshem tawm cov dej noo ntau dhau, ua raws li kev sib tsoo los yog hmoov txheej kom ua rau thaj chaw kom muaj txiaj ntsig zoo.
Cov kuab tshuaj rho tawm feem ntau yog ua haujlwm, siv cov kuab tshuaj organic xws li ethanol, methanol, lossis acetone, uas muaj peev xwm ua kom yaj pterostilbene zoo. Cov txheej txheem no yuav xav tau cua sov los txhim kho solubility thiab extraction efficiency. Tom qab rho tawm, cov kuab tshuaj uas muaj pterostilbene yog concentrated thiab purified los ntawm cov tswv yim xws li distillation, chromatography, los yog crystallization kom cais thiab cais pterostilbene los ntawm lwm cov nroj tsuag constituents.
Tsis ntev los no, kev nce qib hauv cov thev naus laus zis thev naus laus zis tau coj mus rau kev txhim kho ntau txoj hauv kev zoo ib puag ncig thiab siv tau zoo, suav nrog kev siv cov pa roj carbon dioxide supercritical carbon dioxide (CO2) extraction, uas muaj cov kuab tshuaj tsis muaj kuab lom thaum khaws cia cov khoom siv bioactivity.
Thaum kawg, cov refined pterostilbene extract yog tau raws li ib tug hmoov los yog kua concentrate, npaj rau siv nyob rau hauv kev noj haus tshuaj, tshuaj pleev ib ce, los yog kev tshawb fawb ntxiv rau nws cov txiaj ntsig kev noj qab haus huv.
Peb muab Pterostilbene Powder CAS 537-42-8, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Antioxidant Properties
Ib qho ntawm cov cwj pwm tseem ceeb tshaj plaws ntawm Pterostilbene yog nws cov kev ua haujlwm antioxidant muaj zog. Antioxidants ua lub luag haujlwm tseem ceeb hauv kev sib ntaus sib tua oxidative kev nyuaj siab, uas tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov pa oxygen reactive (ROS) thiab lub cev lub peev xwm los detoxify cov reactive intermediates los yog kho cov kev puas tsuaj. Pterostilbene zoo tshem tawm ntau yam dawb radicals, suav nrog DPPH, ABTS, hydroxyl, superoxide, thiab hydrogen peroxide. Qhov kev ua no yog nyob ntawm koob tshuaj, txhais tau hais tias ntau dua ntawm Pterostilbene nthuav tawm cov txiaj ntsig antioxidant ntau dua.
Cov kev tshawb fawb hauv vitro tau pom tias Pterostilbene muaj peev xwm txo qis lipid peroxides thiab hydroperoxides, txo cov protein carbonyl pawg, thiab rov qab cov protein sulphydryl pawg tom qab kev puas tsuaj los ntawm tert-butyl hydroperoxide (TBHP) thiab arsenite-hlau (As-Fe2+). Cov kev tshawb pom no qhia tias Pterostilbene tsis tsuas yog ncaj qha nruab nrab ROS nkaus xwb tab sis kuj tseem pab tiv thaiv cov cellular proteins los ntawm kev hloov pauv oxidative, yog li khaws cia lawv cov kev ua haujlwm zoo.
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Anti-inflammatory teebmeem
Pterostilbene's anti-inflammatory zog yog qhov tseeb noteworthy. Kev mob ntev ua rau lub luag haujlwm tseem ceeb hauv ntau yam kab mob, xws li mob qog noj ntshav, kab mob plawv, thiab ntshav qab zib. Kev tshawb fawb tau pom tias Pterostilbene zoo inhibits zus tau tej cov inflammatory cytokines thiab chemokines, uas yog ib qho tseem ceeb yam tseem ceeb nyob rau hauv pib thiab tswj cov inflammatory teb.
Hauv cov kev tshawb fawb tsiaj tsim los ua qauv o, thaum Pterostilbene tau muab tshuaj ntawm 30 milligrams ib kilogram ntawm lub cev hnyav, txhua hnub, rau lub sijhawm 21 hnub, nws txo qis kev tsim cov tshuaj Reactive Oxygen (ROS). ROS yog cov reactive molecules uas tuaj yeem ua rau cov hlwb thiab cov ntaub so ntswg puas, yog li ua rau cov txheej txheem inflammatory. Los ntawm inhibiting ROS ntau lawm, Pterostilbene pab txo qhov mob.
Cov kev tshawb pom no qhia tias Pterostilbene tuaj yeem muaj peev xwm siv tau hauv kev kho mob lossis kev tswj cov kab mob ntev. Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias thaum kev tshawb fawb tsiaj muab kev nkag siab zoo, kev ua tau zoo thiab kev nyab xeeb ntawm Pterostilbene hauv tib neeg yuav txawv thiab xav tau kev sim tshuaj ntxiv kom paub meej.
Anticancer Potential
Cov haujlwm tiv thaiv kab mob ntawm Pterostilbene tau txais kev saib xyuas tseem ceeb hauv xyoo tas los no. Cov tshuaj no nthuav tawm los tiv thaiv kev loj hlob ntawm ntau yam kab mob qog noj ntshav, suav nrog HeLa hlwb. Cov kev tshawb fawb hauv vitro tau pom tias Pterostilbene inhibits kev loj hlob ntawm HeLa hlwb nrog IC50 qhov tseem ceeb ntawm 101.2 μM thiab 65.9 μM ntawm 24 thiab 48 teev, feem. Tsis tas li ntawd, Pterostilbene induces apoptosis (programmed cell tuag) nyob rau hauv cov qog nqaij hlav cancer, qhia nws lub peev xwm ua tus neeg sawv cev kho mob hauv kev kho mob qog noj ntshav.
Lub tshuab uas Pterostilbene siv nws cov tshuaj tiv thaiv kab mob ntau yam. Nws tsom mus rau ntau txoj hauv kev qhia txog kev cuam tshuam hauv cell proliferation, ciaj sia taus, thiab metastasis. Piv txwv li, Pterostilbene inhibits kev ua kom muaj zog ntawm nuclear factor-κB (NF-κB), ib qho kev hloov pauv uas ua lub luag haujlwm tseem ceeb hauv kev mob thiab kev mob qog noj ntshav. Tsis tas li ntawd, Pterostilbene hloov kho qhov kev qhia ntawm cov noob cuam tshuam nrog kev tswj lub voj voog ntawm tes, kho DNA, thiab apoptosis.
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Antidiabetic thiab Anti-obesity Effects
Kev nce ntxiv ntawm hom 2 mob ntshav qab zib thiab rog rog ua rau muaj kev noj qab haus huv tseem ceeb thoob ntiaj teb. Pterostilbene tau tshwm sim los ua tus neeg sib tw muaj txiaj ntsig rau kev tswj hwm cov kab mob metabolic no. Los ntawm kev txhim kho insulin rhiab heev thiab qabzib metabolism, Pterostilbene pab txo cov ntshav qabzib thiab txo cov kev pheej hmoo ntawm cov teeb meem ntshav qab zib.
Ntxiv mus, Pterostilbene nthuav tawm los tiv thaiv kev rog los ntawm kev hloov pauv cov roj metabolism thiab kev siv hluav taws xob. Nws inhibits qhov sib txawv thiab kev loj hlob ntawm adipocytes (cov rog rog), yog li txo cov rog. Cov kev tshawb fawb tsiaj tau pom tias Pterostilbene supplementation tuaj yeem txo lub cev hnyav thiab rog rog hauv cov nas rog rog, tsis cuam tshuam rau kev noj zaub mov. Cov kev tshawb pom no qhia tias Pterostilbene yuav muaj txiaj ntsig zoo hauv kev kho mob rog thiab muaj feem cuam tshuam txog cov kab mob metabolic.
Cov txiaj ntsig ntawm Cardiovascular
Cov kab mob plawv kuj tseem muaj txiaj ntsig los ntawm Pterostilbene cov kev tiv thaiv. Los ntawm inhibiting qhov tsim ntawm oxidized low-density lipoprotein (ox-LDL), Pterostilbene txo qhov kev pheej hmoo ntawm atherosclerosis, ib qho mob uas tshwm sim los ntawm kev tsim cov quav hniav hauv cov hlab ntsha. Ox-LDL yog ib qho tseem ceeb rau kev ua haujlwm ntawm endothelial dysfunction, o, thiab kev loj hlob ntawm cov kab mob plawv.
Tsis tas li ntawd, Pterostilbene tau pom tias yuav txhim kho endothelial muaj nuj nqi thiab ua rau kom cov nitric oxide (NO), ib tug molecule uas dilates cov hlab ntsha thiab txhawb cov ntshav khiav. Cov teebmeem no ua rau muaj kev saib xyuas kev noj qab haus huv ntawm cov hlab plawv thiab tuaj yeem pab tiv thaiv qhov pib ntawm cov kab mob plawv.
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Cov teebmeem Neuroprotective
Cov khoom tiv thaiv neuroprotective ntawm Pterostilbene yog lwm thaj chaw ntawm kev tshawb fawb nquag. Cov kab mob neurodegenerative, xws li Alzheimer's disease thiab Parkinson's disease, yog tus cwj pwm los ntawm kev loj hlob ntawm kev ua haujlwm neuronal thiab kev tuag. Pterostilbene tau pom tias tiv thaiv cov hlwb neuronal los ntawm oxidative kev nyuaj siab thiab o, ob tug tseem ceeb tsav tsheb ntawm neurodegeneration.
Los ntawm inhibiting qhov tsim ntawm amyloid-plaques thiab tau tangles, uas yog cov yam ntxwv ntawm Alzheimer's kab mob, Pterostilbene yuav ua rau qeeb qhov kev loj hlob ntawm tus kab mob no. Tsis tas li ntawd, Pterostilbene txhim kho kev ua haujlwm ntawm cov enzymes antioxidant hauv lub hlwb, yog li tiv thaiv neurons los ntawm kev puas tsuaj oxidative. Cov kev tshawb pom no qhia tias Pterostilbene tuaj yeem tuav cov lus cog tseg ua tus neeg sawv cev kho mob hauv kev kho cov kab mob neurodegenerative.
Xaus
Hauv kev xaus, Pterostilbene yog ntau yam sib xyaw nrog ntau hom kev siv kho mob. Nws cov antioxidant, tiv thaiv inflammatory, anticancer, antidiabetic, anti-obesity, hlab plawv, thiab neuroprotective zog ua rau nws yog ib tug zoo neeg sib tw rau kev kho mob thiab kev tiv thaiv ntawm ntau yam kab mob. Raws li kev tshawb fawb txuas ntxiv mus tshem tawm cov txheej txheem hauv qab Pterostilbene ntau yam kev ua ub no lom neeg, qhov sib xyaw no yuav ua rau muaj lub luag haujlwm tseem ceeb hauv kev kho mob thiab kev kho mob.
Thaum cov ntaub ntawv preclinical ntawm Pterostilbene tau cog lus tseg, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias tib neeg kev tshawb fawb tseem xav tau kom paub meej tias nws txoj kev nyab xeeb thiab ua tau zoo hauv chaw kho mob. Tsis tas li ntawd, qhov kev noj qab haus huv zoo tshaj plaws thiab kev tsim ntawm Pterostilbene rau kev siv tshuaj kho mob tseem raug txiav txim siab.