Fleas yog ntau tshaj li kev ntxhov siab. Ib tus yoov tshaj cum tuaj yeem tso tau txog li 50 lub qe hauv ib hnub, ua rau muaj kab mob me me mus rau hauv tag nrho - teeb meem hauv tsev neeg tsis pub dhau lub lis piam. Rau cov tswv dev nrhiav kev ntseeg siab, kev tshawb fawb-rov qab tiv thaiv,afoxolaner thiab milbemycin oxime chewable ntsiav tshuajtau tshwm sim los ua ib qho ntawm cov kab ke tswj kev tswj hwm zoo tshaj plaws muaj hnub no. Qhov kev kho qhov ncauj txhua hli no tsis yog tsuas yog yoov xwb tab sis kuj zuam, kab mob plawv, thiab plab hnyuv nematodes - tag nrho hauv ib ntsiav tshuaj palatable koj tus dev yuav xav noj.
Txawm hais tias koj tswj hwm ib tus tsiaj hauv tsev ib leeg lossis saib xyuas kev ua haujlwm kennel loj dua, kev nkag siab yuav ua li cas ob txoj haujlwm no - qauv ua haujlwm tuaj yeem pab koj txiav txim siab paub ntau ntxiv txog koj tus dev txoj kev tiv thaiv kab mob cab.
Afoxolaner Thiab Milbemycin Oxime Chewable Tablets
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Target Fleas ntawm dev?
Lub luag haujlwm ntawm Afoxolaner hauv Flea Elimination
Afoxolaner yog ib qho isoxazoline, uas txhais tau hais tias nws tua cov kab tsuag thiab acari. Nws ua haujlwm los ntawm kev thaiv cov chloride ion channel uas tswj los ntawm GABA hauv cov hlab ntsha ntawm arthropods. Fleas uas tom tus dev uas tau kho nrog afoxolaner tau nkag mus rau hauv lawv lub cev, uas ua rau lawv cov hlab ntsha tsis ua haujlwm zoo. Cov neeg uas tau ntsib nrog qhov no feem ntau tuag nyob rau hauv ib teev, vim hais tias lawv cov neurons ua overexcited thiab tswj tsis tau.Dab tsi ua rau afoxolaner pab tau yog tias nws tuaj yeem xaiv tau qee yam. Rau qee qhov laj thawj, nws khi ntau zog rau GABA receptors hauv kab ntau dua li tib neeg receptors.Qhov no yog vim li cas nws thiaj li muaj kev nyab xeeb rau cov dev noj afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj raws li qhia. Yog tias koj noj afoxolaner los ntawm qhov ncauj, nws yuav yog qhov siab tshaj plaws hauv koj cov ntshav hauv ob mus rau plaub teev.
Qhov no ua rau nws ua haujlwm sai, tua cov dev ua ntej lawv tuaj yeem noj tau.
Vim li cas Systemic Action Matters for Flea Control
Cov khoom uas koj muab rau cov dev mub ua hauj lwm los ntawm sab nraud nyob rau hauv. Cov tshuaj zoo li no chewy ntsiav tshuaj uas koj noj los ntawm lub qhov ncauj ua hauj lwm los ntawm sab hauv. Thaum ib tug yoov tom ib tug dev uas tau kho nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, nws sai absorbs cov tshuaj los ntawm cov ntshav noj.
Nrog rau qhov no feature, fleas yuav tsum kov tus aub thiaj li yuav raug tua. Qhov no yog ib qho ntxiv thiab ib txoj hauv kev zoo heev los tshem tawm qhov teeb meem.Plasma ib nrab - lub neej rau afoxolaner yog li ob lub lis piam, thiab nws nyob twj ywm ntawm qhov muaj txiaj ntsig thaum lub hli - txog - lub hli noj. Hauv lwm lo lus, dev muaj kev nyab xeeb txhua lub sijhawm, tsis yog tom qab kev phais.
Kev sim tsiaj tau pom tias afoxolaner tua ntau dua 99% ntawm dev mub hauv 24 teev. Qhov no ua rau nws yog ib qho ntawm cov tshuaj flea uas ua haujlwm sai tshaj plaws thaum noj los ntawm qhov ncauj.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets rau Kev Ua Phem Lub Neej
Hais Txog Tus Neeg Laus Fleas thiab Ib puag ncig Re- kab mob
Muaj ntau cov dev mub nyob ntawd, tab sis tsuas yog nyob ib ncig ntawm 5 feem pua yog cov neeg laus. Lwm 95% yog kis tawm raws li qe, larvae, thiab pupae ntawm ntaub pua plag, txaj, thiab rooj tog. Cov neeg laus fleas ntawm tus dev raug tua sai sai los ntawm afoxolaner. Siv afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj ib hlis ib zaug txwv tsis pub qhov teeb meem tshwm sim dua los ntawm kev tua cov neeg laus ua ntej lawv tuaj yeem tso cov qe uas yuav hle.
Koj tuaj yeem kho koj tus dev ib hlis ib zaug, yog li dev mub yuav tsis muaj peev xwm nteg qe rau nws. Thaum cov yoov tau kho tsis tu ncua rau ob peb lub hlis,
Tus naj npawb ntawm cov yoov tshaj cum hauv tsev ib txwm poob qis vim tsis muaj cov theem tshiab ntawm lub neej raug coj los rau hauv. Cov kev cai ntawm qhov ncauj txhua hli yog ib lub sijhawm zoo dua - cov phiaj xwm ntau dua li qhov kev kho mob tsis zoo lossis rov ua haujlwm vim tias nws muaj qhov cuam tshuam uas ua rau lub sijhawm.
Yuav Ua Li Cas Milbemycin Oxime Pab Koom Tes rau Tag Nrho -Kev Tiv Thaiv Kab Mob Lub Cev
Qhov no yog ib qho tseem ceeb ntxiv tiv thaiv uas milbemycin oxime muab rau koj. Nws ua ntau tshaj li tua hma. Vim tias nws yog tshuaj tua kab macrolide, nws tua kab mob los ntawm kev txwv glutamate-gated chloride channels hauv lawv cov hlwb neuromuscular. Cov kab mob plague uas nyob hauv lub cev, xws li cov kab mob plawv thiab cov kab mob hauv plab, tau daig ntawm cov kab no thiab ua rau hyperpolarization. Lawv thiaj li tuag tes tuag taw.
Muaj milbemycin oxime nyob rau hauv qhov sib tov, yog li thaum afoxolaner tshem tawm cov kab mob sab nraud, milbemycin oxime tshem tawm cov teeb meem ntawm sab hauv tib lub sijhawm. Milbemycin oxime A4 muaj ib nrab ntawm - lub neej ntawm 3.3 hnub thiab yog qhov tseem ceeb tshaj plaws (nws ua rau 80% ntawm milbemycin).
Qhov A3, ntawm qhov tod tes, muaj ib nrab -lub neej ntawm 1.6 hnub. Lawv ua hauj lwm ua ke los tswj cov kab mob sab hauv thaum lub sij hawm siv tshuaj. Cov neeg uas nyob hauv qhov chaw uas muaj kab mob plawv yuav tau txais txiaj ntsig los ntawm kev tiv thaiv ob.
Dab tsi ua rau Afoxolaner thiab Milbemycin Oxime Chewable ntsiav tshuaj pab tau rau kev tswj flea?
Dav -Spectrum Kev Pabcuam hauv Ib Lub Hlis Ib Leeg
Covafoxolaner thiab milbemycin oxime chewable ntsiav tshuajzoo heev vim lawv tuaj yeem tua ntau dua ib kab ib zaug. Qhov no yog qhov zoo rau cov tswv tsiaj thiab vets ib yam nkaus. Hnyav, zuam, mites, kab mob plawv, thiab cov kab mob hauv plab tuaj yeem raug tua nrog ib koob tshuaj ntawm qhov ncauj ib hlis ib zaug. Yog li koj tsis tas yuav taug qab ib pawg ntawm cov tshuaj sib txawv uas yuav tsum tau noj nyob rau lub sijhawm sib txawv thiab tuaj yeem cuam tshuam nrog ib leeg.
Daim ntawv uas tuaj yeem zom tau yooj yim dua rau kev mloog. Cov tshuaj uas koj noj los ntawm qhov ncauj ib txwm muab tib yam rau koj lub cev tag nrho. Kev kho mob, ntawm qhov tod tes, yuav tsum tau ua tib zoo saib xyuas thiab hloov tau los ntawm kev da dej lossis da dej. Txoj kev muab tshuaj dev no yuav ua haujlwm zoo tshaj plaws rau cov neeg taug kev lossis ua luam dej rau lawv cov dev ntau heev.
Palatability Design thiab tus tswv ua raws
Qhov tseeb tias cov tshuaj tsw qab zoo tuaj yeem cuam tshuam loj npaum li cas nws ua haujlwm zoo. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj yog tsim nrog lub hauv paus uas feem ntau cov dev yuav zoo siab noj, los ntawm nws tus kheej los yog tov rau hauv lawv cov zaub mov. Ntau tus neeg ua raws li lawv hais lawv yuav ua ncaj qha kom tsis txhob yoov tshaj cum, uas yog qhov zoo dua rau ob tus dev thiab tsev nyob rau lub sijhawm ntev.Cov ntsiav tshuaj muaj 9.375 mg thiab hnyav ntawm 1.87 kg. Nws tuaj nyob rau hauv 150 mg thiab 30 mg nqi rau cov dev uas hnyav ntawm 30 kg thiab 60 kg.Ua kom txhua tus dev, los ntawm cov me me mus rau cov dev ua hauj lwm loj, tau txais cov nqi ntawm ob qho tib si active tshuaj rau lawv noj qab haus huv yog ib qho tseem ceeb heev.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets thiab Kev tshem tawm sai sai
Kev nrawm nrawm: Vim li cas Teev Teeb Meem
Cov tshuaj yuav tsum pib ua haujlwm tam sim ntawd yog tias koj tus dev twb muaj dev mub. Afoxolaner pib tua hma tom qab nws noj. Cov kws tshaj lij hauv thaj teb tau saib cov ntaub ntawv thiab pom tias ntau dua 99% ntawm cov dev mub raug tua tsis pub dhau 24 teev ntawm thawj koob tshuaj. Cov teebmeem tshwm sim tau 30 hnub tom qab txhua koob tshuaj.
Cov fleas tsis tuaj yeem tom, noj, lossis rov tsim dua tam sim vim qhov kev ua haujlwm ceev no. Cov dev uas muaj flea allergy dermatitis, ib qho kev tsis haum tshuaj loj rau cov qaub ncaug uas ua rau daim tawv nqaij khaus thiab o, tuaj yeem pib hnov zoo dua nyob rau hnub ntawm kev kho mob, vim cov dev mub ntawm tus dev yuav tsis nyob ntawd lawm.
Sustained Efficacy thoob plaws lub hli voj voog
Pharmacokinetic profile ntawm afoxolaner txhawb nqa kev tiv thaiv tus nqi tas li 30-hnub. Qhov no txawv ntawm qee cov tshuaj uas poob lawv cov txiaj ntsig tom qab lub sijhawm siv tshuaj tas. Afoxolaner nkag mus rau hauv lub cev cov ntaub so ntswg tob thiab nyob twj ywm nyob rau hauv ib theem uas ua hauj lwm los ntawm thawj koob mus rau hnub kawg ntawm lub voj voog. Nws yog bioavailable kiag li ntawm 88% thiab kis tawm hauv cov ntaub so ntswg ntawm tus nqi ntawm 2.6 L / kg.Vim cov feem pua nyob twj ywm tib yam, fleas uas kov ib tug dev uas tau kho nyob rau hnub 28 yog raug rau tib yam tshuaj lom li lawv nyob rau hnub 1.Ib yam tseem ceeb uas ua rau qhov version tshwj xeeb yog tias nws tsis muaj qhov nkhaus.
Xaiv Afoxolaner thiab Milbemycin Oxime Chewable Tablets rau dev nyob rau hauv Flea-Nyob ib puag ncig
Siab - Ib puag ncig txaus ntshai thiab Xyoo- Kev Tiv Thaiv Ib puag ncig
Cov dev uas nyob hauv qhov chaw sov, ntub dej, siv sij hawm ntau sab nraum zoov, los yog dai nrog lwm yam tsiaj muaj feem yuav tau yoov tshaj cum. Txhawm rau kom muaj kev nyab xeeb hauv cov cheeb tsam siab - cov kev pheej hmoo siab txhua xyoo, nojafoxolaner thiab milbemycin oxime chewable ntsiav tshuajyog ib tug ntse txav uas ua haujlwm. Lub caij flea tau ntev dua nyob rau ntau qhov chaw vim tias huab cua hloov pauv. Nws muaj peev xwm hais tias koj tus dev tuaj yeem muaj kev phom sij yog tias koj tsuas yog coj lawv mus rau kws kho tsiaj thaum koj xav tias yog lub hlis uas muaj neeg coob tshaj plaws.
Nws yog ib qho nyuaj heev kom ceev cov dev mub kom deb ntawm cov chaw nyob tsiaj, chaw pab, thiab cov tsev uas muaj ntau tshaj ib tus dev.
Nws yog ib qho kev xaiv zoo rau cov xwm txheej no vim tias cov mis no tuaj yeem tua cov yoov sai sai thiab tiv thaiv tag nrho lub cev ib hlis ib zaug. Nws ua kom fleas txav ntawm ib tus tsiaj mus rau lwm tus thiab txo qis cov dev mub nyob ib puag ncig lub sijhawm.
Kev txiav txim siab txog kev yug tsiaj thiab Veterinary Guidance
Qee hom, zoo li Collies thiab lwm cov dev herding, feem ntau yuav muaj MDR1 (ABCB1) gene variation. Cov tshuaj muaj lub sijhawm nyuaj nkag mus rau hauv lub hlwb vim qhov kev hloov pauv no. Tham nrog koj tus kws kho mob ua ntej koj pib kho cov tshuaj antihelmintic rau hom no. Milbemycin oxime ib feem khi rau P-glycoprotein,
thiab cov dev uas muaj kev hloov pauv hauv MDR1 yuav muaj teeb meem txog kev faib tshuaj li cas.
Cov menyuam dev uas muaj hnub nyoog qis dua 8 lub lis piam lossis tsawg dua 2 kg yuav tsum tsis txhob noj cov zaub mov no. Cov dev uas cev xeeb tub lossis laus yuav tsum tau txais kev kho mob tsuas yog raws li kev saib xyuas ncaj qha ntawm kws kho tsiaj. Qhov no yog vim tsis paub ntau txog kev nyab xeeb npaum li cas rau cov pab pawg dev no. Cov txiaj ntsig zoo tshaj plaws rau cov dev ntawm txhua lub hnub nyoog yog los ntawm kev siv nws lub luag haujlwm thiab ua raws li qhov hnyav tshaj - raws li kev noj tshuaj thiab cov lus qhia los ntawm kws kho tsiaj.
Xaus
Cov dev tuaj yeem nyob tau yoov -dawb nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, uas tau pom tias ua haujlwm los ntawm kev tshawb fawb. Milbemycin oxime tua ntau cov kab mob sab hauv, thiab afoxolaner tua cov neeg laus dev sai sai. Ua ke, lawv tsim ib lub phiaj xwm kev nyab xeeb txhua hli uas nyuaj rau kev sib tw nrog ib leeg - kev kho tus neeg sawv cev. Nws yog ib qho yooj yim rau tib neeg ua raws li cov lus qhia thiab tau txais txiaj ntsig zoo hauv kev kho mob vim tias cov khoom lag luam muaj cov tshuaj pharmacokinetic zoo, qhov hnyav yog- raws li kev noj tshuaj, thiab ib txoj hauv kev zoo los muab cov tshuaj.
Cov neeg uas xav tshem cov dev mub ntawm lawv cov dev, vets, thiab cov neeg ua haujlwm yuav tuaj yeem ntseeg cov khoom sib xyaw ua ke no ua haujlwm. Nws kuj ua tau raws li cov qauv kev tsim khoom siab.
Cov lus nug nquag
Q1: Yuav ua li cas sai sai afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj pib tua dev mub?
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Afoxolaner pib ua haujlwm sai li sai tau thaum nws noj. Kev tshawb fawb txog nws ua haujlwm tau zoo npaum li cas tau pom tias nws tshem tawm ntau dua 99% ntawm cov dev mub hauv 24 teev ntawm thawj koob tshuaj. Qhov no txhais tau tias cov dev uas tam sim no muaj kab mob tuaj yeem hnov zoo sai sai.
Q2: Cov tshuaj afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj puas tuaj yeem siv tau rau xyoo -ib puag ncig rau kev tiv thaiv dev mub?
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Yog lawm. Ib txwm kho cov dev mub ib hlis ib zaug, tab sis ntau zaus yog tias koj nyob qhov chaw sov lossis qhov chaw ntub dej uas lawv ua haujlwm sab nraum lub caij nyoog ib txwm muaj. Yog tias koj siv nws tsis tu ncua, nws txwv tsis pub cov dev mub rau cov neeg laus tsis muaj menyuam thiab maj mam txo cov dev mub nyob ib puag ncig koj.
Q3: Puas yog afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj muaj kev nyab xeeb rau txhua tus dev yug?
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Nws muaj kev nyab xeeb rau cov dev feem ntau yog tias tus nqi raug muab nyob ntawm lawv qhov hnyav. Nrog rau cov kev hloov pauv hauv cov tshuaj metabolized li cas, Collies thiab lwm cov dev herding nrog MDR1 noob hloov yuav xav tau kev kho mob ntau dua. Cov dev uas muaj hnub nyoog qis dua 8 lub lis piam lossis tsawg dua 2 kg yuav tsum tsis txhob muab cov khoom no.
Koom tes nrog Bloomtechz rau Kev Txhim Kho Afoxolaner thiab Milbemycin Oxime Chewable Tablets Supply
Ntawm Bloomtechz, peb paub tias tus nqi qis tsis txaus kom tau txais siab - cov khoom pib zoo thiab cov khoom tiav rau cov kws kho tsiaj. Nws kuj yuav tsum muaj peev xwm tswj tau qhov zoo, ua kom pom tseeb, thiab xa lawv raws sijhawm. Nws muaj kev nyab xeeb los yuavafoxolaner thiab milbemycin oxime chewable ntsiav tshuajlos ntawm Bloomtechz. Lawv muaj ib tsob nroj uas yog 100,000 square meters thiab yog GMP- ntawv pov thawj los ntawm US FDA, EU GMP, PMDA (Nyiv), thiab CFDA. Cov txheej txheem tswj kev ua haujlwm zoo rau peb lub tuam txhab muaj peb theem: ntawm theem cog, hauv peb tus kheej QA / QC department, thiab los ntawm cov cai sab nraud. Nws ua kom paub tseeb tias txhua batch ua tau raws li cov qauv siab tshaj plaws los ntawm tag nrho lub ntiaj teb.
Raws li cov khoom lag luam, peb kuj muab OEM / ODM kev xaiv uas tuaj yeem ua tau raws li qhov xav tau ntawm koj lub khw. Peb pab neeg tau npaj txhij los pab koj nrhiav qhov koj xav tau, txawm tias nws yog cov tshuaj ntau npaum li cas - cov ntaub ntawv qib lossis cov ntim tshwj xeeb rau txoj hauv kev hauv koj cheeb tsam. Sau ntawv rau peb ntawmSales@bloomtechz.com, thiab cia peb ua kom ntev - txuas ntxiv raws li kev ntseeg siab, kev ncaj ncees, thiab kev loj hlob rau peb ob leeg.
Cov ntaub ntawv
1. Ketsis, JK, et al. "Kev ua tau zoo ntawm afoxolaner tiv thaiv Ctenocephalides felis hauv kev simulated hauv tsev qauv." Veterinary Parasitology, vol. 201, no. 1–2, 2014, pp. 51–56.
2. Rufener, L., et al. "Pharmacology ntawm isoxazoline parasiticide afoxolaner: GABA-gated chloride channel phiaj thiab xaiv arthropod toxicity." International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, vol. 7, no. 3, 2017, pp. 362–370.
3. Bowman, DD, et al. "Kev ua tau zoo ntawm afoxolaner ntxiv rau milbemycin oxime chewable ntsiav tshuaj tiv thaiv induced infestations ntawm Ixodes scapularis thiab Rhipicephalus sanguineus zuam hauv dev." Veterinary Parasitology, vol. 222, 2016, pp. 43–47.
4. Hartmann, S., thiab Udall, D. "Milbemycin oxime: spectrum ntawm kev ua thiab pharmacological profile nyob rau hauv khub tsiaj tshuaj." Phau ntawv Journal of Veterinary Pharmacology and Therapeutics, vol. 34, no. 5, 2011, pp. 409–416.
5. Prichard, RK, thiab Geary, TG "Perspective on the utility of moxidectin and milbemycin oxime for sustainable parasite control." Veterinary Parasitology, vol. 186, no. 3–4, 2012, pp. 497–501.
6. European Medicines Agency (EMA). "Kev Ntsuam Xyuas Daim Ntawv Qhia: Afoxolaner thiab Milbemycin Oxime Combination Khoom rau dev." Pawg Neeg Saib Xyuas Kev Kho Mob rau Kev Siv Veterinary (CVMP), 2015.