Kev saib xyuas tsiaj tau nce ntau heev nyob rau niaj hnub nim no thiab niaj hnub no veterinary science muaj ntau txoj hauv kev los tiv thaiv tus khub tsiaj tiv thaiv kab mob txaus ntshai. Ntawm cov kev tsim kho tshiab no,afoxolaner thiab milbemycin oxime chewable ntsiav tshuajtau tshwm sim raws li kev kho mob hauv paus hauv kev tswj hwm kev noj qab haus huv canine. Ob qhov no - cov qauv kev nqis tes ua tsom rau ob qho tib si sab nraud thiab sab hauv cov kab mob nrog rau ib hlis ib zaug, kev ua kom yooj yim thiab ua tau zoo rau cov tswv tsiaj thiab cov kws kho tsiaj ib yam nkaus. Paub tias cov ntsiav tshuaj no ua haujlwm li cas thiab lawv cov kev siv ntau yam yuav pab cov tswv tsiaj xaiv kev kawm txog lawv tus dev txoj kev tiv thaiv kev noj qab haus huv.
Afoxolaner Thiab Milbemycin Oxime Chewable Tablets
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5kg
18.75+3.75mg:＞ 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Dab tsi yog Cov Kev Siv Feem Ntau ntawm Afoxolaner thiab Milbemycin Oxime Chewable Tablets hauv Kev Kho tsiaj?
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj yog qhia tshwj xeeb rau kev tiv thaiv thiab kho cov kab mob cab hauv dev. Cov tshuaj no muab ntau yam kev tiv thaiv los ntawm ntau cov kab mob parasitic uas tsis tu ncua ua rau muaj kev noj qab haus huv ntawm canine. Veterinarians pom zoo cov tshuaj sib xyaw ua ke no rau kev kho cov kab mob fleas, zuam tom, tiv thaiv kab mob plawv thiab kab mob plab hnyuv nematode nyob rau hauv ib txoj kev kho mob.
Ntau hom kev teeb tsa nthuav tawm cov dev rau ntau qhov sib txawv ntawm ectoparasites. Fleas nquag nyob hauv nroog cov chaw ua si, cov chaw nce tsheb thiab cov tsev uas muaj ntau tshaj ib tus tsiaj. Cov dev nyob rau hauv cov chaw nyob deb nroog feem ntau tuaj yeem ntsib cov zuam hauv thaj teb thiab thaj chaw hav zoov. Cov khoom xyaw afoxolaner zoo tiv thaiv cov ectoparasites. Nws tua cov neeg laus dev mub nyob rau hauv cov sij hawm ntawm kev tswj hwm thiab tiv thaiv re- kab mob rau ib hlis. Rhipicephalus sanguineus, Dermacentor variabilis thiab Ixodes scapularis zuam hom tuag tom qab kho. Qhov no txo qhov kev pheej hmoo ntawm kev kis kab mob xws li kab mob Lyme thiab ehrlichiosis. Cov tshuaj no muaj txiaj ntsig zoo tiv thaiv ntau yam ntawm ectoparasites thiab yog li muaj txiaj ntsig zoo hauv thaj chaw uas muaj ntau hom zuam coexist.
Heartworm Prevention Programs nyob rau hauv Endemic Regions
Ntau qhov chaw uas yoov tshaj cum nquag kis Dirofilaria immitis qe tseem ua rau muaj kev pheej hmoo loj ntawm kab mob plawv. Muab cov ntsiav tshuaj no ib hlis ib zaug nrog milbemycin oxime nres cov cab cab lub neej los ntawm kev tua cov ntaub so ntswg -theem larvae ua ntej lawv loj hlob mus rau cov neeg laus lub plawv. Hauv thaj chaw uas muaj kab mob plawv muaj ntau, cov kws kho tsiaj hais kom tswj cov kab mob plawv txhua xyoo. Txawm li cas los xij, hauv cov cheeb tsam huab cua, cov lus qhia txhua xyoo tuaj yeem siv tau.
Thaum koj muab kev tiv thaiv kab mob plawv nrog kev tswj hwm flea thiab zuam, nws yooj yim dua rau cov tswv kom ua raws li lawv cov sijhawm teem sijhawm dua li thaum lawv yuav tsum tswj xyuas cov sijhawm noj tshuaj. Txhawm rau kom paub tseeb tias kev kho mob muaj kev nyab xeeb, nws tseem yog ib txwm coj mus kuaj dev rau kab mob plawv ua ntej pib kev tiv thaiv.
Gastrointestinal Parasite Control nyob rau hauv Multi-Pat Households
Cov kab mob sab hauv suav nrog cov kab mob hookworms, roundworms thiab whipworms, feem ntau cuam tshuam rau cov dev ntawm kev sib cuag nrog cov tsiaj muaj kab mob los yog cov chaw qias neeg. Ntau- tsev neeg tsiaj, chaw nyob thiab chaw yug me nyuam tej zaum yuav nyuaj tshwj xeeb los tswj cov kab mob plab hnyuv. Milbemycin oxime muaj txiaj ntsig zoo rau cov neeg laus theem ntawm Ancylostoma caninum, Toxocara canis thiab Trichuris vulpis, uas pab cuam tshuam cov kab sib kis thaum tib neeg nyob. Kev kho mob txhua hli tsis tu ncua txo cov qe kab mob parasite hauv ib puag ncig, yog li tiv thaiv kev kis kab mob ntawm cov tsiaj thiab tib neeg. Cov cuab yeej no muaj txiaj ntsig zoo rau kev cawm tsiaj uas tej zaum yuav muaj kab mob tsis paub txog ntawm lawv.
Ntxiv rau qhov lawv niaj hnub siv rau cov kab mob cab, cov kws kho mob qee zaum siv cov ntsiav tshuaj no los kho sarcoptic mange, uas yog tshwm sim los ntawm Sarcoptes scabei mites. Txawm hais tias nws tsis yog qhov qhia tseem ceeb ntawm daim ntawv lo, afoxolaner's acaricidal zog ua rau nws muaj txiaj ntsig zoo rau cov kab mob burrowing uas ua rau khaus khaus thiab khaus tawv nqaij.
Cov koob tshuaj ntau zaus yuav tsum tau muab rau lub sijhawm tsis tu ncua txiav txim siab los ntawm tus kws kho mob sau ntawv, thiab cov no feem ntau muab nrog rau cov tshuaj pleev ib ce thiab cov kauj ruam los ntxuav qhov chaw ib puag ncig. Qhov kev siv sab nraud ntawm cov khoom lag luam daim ntawv lo qhia tau tias cov mis hloov tau yooj yim npaum li cas thaum nws los kho cov tawv nqaij tawv tawv.
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Ua Haujlwm Los ntawm Dual Parasite Control Mechanisms?
Pharmaceutical innovation tom qabafoxolaner thiab milbemycin oxime chewable ntsiav tshuajlus dag nyob rau hauv kev sib xyaw ob yam tshuaj sib txawv uas ua haujlwm sib txawv tab sis ua ke lawv ua haujlwm zoo dua. Txhua cov khoom xyaw nquag mus tom qab qhov tsis muaj zog sib txawv hauv cov kab mob thaum ua kom cov tsiaj txhu muaj kev nyab xeeb. Los ntawm kev nkag siab txog cov txheej txheem no, koj tuaj yeem pom tias vim li cas qhov kev sib xyaw no ua haujlwm zoo dua li kev kho mob siv ib tus neeg sawv cev xwb.
Ob qho tshuaj nquag inhibit neurotransmission hauv cov kab mob parasite ntawm cov kab ke receptor cais. Afoxolaner, ib qho isoxazoline, khi rau kab kab paj hlwb GABA-gated chloride channels. Qhov kev khi no thaiv cov chloride ion hla hla cov kab mob neuronal. Fleas, zuam, thiab mites tuag los ntawm cov hlab ntsha tawm ntawm kev tswj, hyperexcitement, thiab tuag tes tuag taw. Arthropod GABA receptors sib txawv heev los ntawm tib neeg receptors hauv cov qauv molecular. Aub kev nyab xeeb los ntawm qhov tshwj xeeb no.
Milbemycin oxime ua haujlwm ntawm glutamate-gated chloride channels hauv cov cab thiab arthropod paj hlwb thiab cov leeg hlwb. Chloride ions txav mus los ntawm cov channel no yooj yim dua thaum cov macrolide molecule txuas, ua rau cov membrane zoo dua. Kev tuag tes tuag taw los ntawm hyperpolarisation tiv thaiv kab mob los ntawm kev noj thiab yug me nyuam, tua lawv. Milbemycin oxime tsis tuaj yeem nkag mus rau tsiaj cov hlab ntsha hauv nruab nrab vim yog cov ntshav - lub hlwb thaiv. Qhov no txwv tsis pub nws mus txog tus tswv tsev txoj kev.
Ob qho tshuaj tau sai sai absorbed, thauj, tawg, thiab tshem tawm, ua rau kev tswj hwm txhua hli. Qhov ncauj afoxolaner yog 88% bioavailable, thiab plasma qib siab tshaj ob mus rau plaub teev tom qab noj. Cov tshuaj mus thoob plaws cov ntaub so ntswg ntawm 2.6 litres ib kilogram, mus txog rau parasite pub. Ob -lub lim tiam plasma ib nrab- lub neej tswj kev kho mob siab ntawm kev kho mob. Ib txwm noj tshuaj ntxuav cov tshuaj tawm ntawm daim siab thiab quav.
Milbemycin oxime yog nqus tau sai thiab muaj 65-81% bioavailability nyob ntawm isomer. Txog 80% ntawm nws cov oximes yog A4 thiab 20% yog A3. A4 muaj 3.3-hnub ib nrab-lub neej piv rau 1.6 hnub rau A3, thiab theem siab tshaj plaws tshwm sim ib mus rau ob teev tom qab xa khoom. Qhov kev tshem tawm tsis sib npaug no pab lub cev tawm tsam cov kab mob tsis muaj zog. Kev faib cov ntaub so ntswg nruab nrab thiab qis plasma clearance tus nqi khaws cov tshuaj zoo ntawm cov koob tshuaj txhua hli.
Rau ob lub tebchaw, tseem muaj cov tshuaj kho mob loj sib cais cov koob tshuaj uas tua kab mob tau zoo los ntawm cov uas ua rau dev. Mammal GABA receptors yog lub cev txawv ntawm crustacean GABA receptors, uas ua rau nws nyuaj rau afoxolaners khi. Cov ntshav- lub hlwb teeb meem kuj ua rau GABA receptors nyob rau hauv lub hauv paus paj hlwb kev nyab xeeb.
Ib yam li ntawd, milbemycin oxime raug thaiv los ntawm kev nkag mus rau hauv lub paj hlwb hauv nruab nrab los ntawm P-glycoprotein transporters hauv cov dev uas nws cov neeg thauj khoom ua haujlwm zoo. Qee hom collie thiab zoo sib xws herding dev muaj kev hloov pauv hauv MDR1 gene uas codes rau P-glycoprotein. Cov kev hloov no yuav ua rau cov hlab ntsha rhiab heev. Veterinarians feem ntau kuaj xyuas cov kab mob raug mob lossis hloov txoj hauv kev raws li xav tau kom muaj kev nyab xeeb.
Afoxolaner Mechanism of Action in Flea and Tick Management for Dogs
Cov tshuaj afoxolaner tshwj xeeb tshaj yog cuam tshuam nrog cov teeb meem tshwm sim los ntawm ectoparasites los ntawm kev ua haujlwm ntawm cov hlab ntsha ntawm arthropods. Cov tshuaj isoxazoline no tau hloov pauv txoj kev tswj hwm cov kab mob sab nraud vim nws tua lawv sai sai thiab muaj kev cuam tshuam ntev ntev tom qab noj zaub mov ib zaug. Cov kws kho tsiaj thiab cov tswv tsiaj tuaj yeem nkag siab zoo dua yog vim li cas txoj kev no ua haujlwm zoo dua li ntau yam kev xaiv los ntawm kev kawm txog cov ncauj lus kom ntxaws.
GABA- thiab glutamate- tswj kab thiab kab laug sab ligand-gated chloride channels yog afoxolaner lub hom phiaj tseem ceeb. Parasites noj los yog nqus cov tshuaj hauv cov dev kho cov ntshav thiab cov ntaub so ntswg thaum lawv pub. Cov kab chloride no nyob twj ywm qhib vim tias cov tshuaj molecules txuas mus rau qhov chaw meej. Ntev - lub sij hawm qhib cia ntau chloride ions nkag mus rau hauv cov hlab ntsha. Cov hluav taws xob gradient tseem ceeb rau cov teeb liab kis tau tus mob tawg.
Kev puas tsuaj neurones hluav taws tawm ntawm kev tswj hwm, ntws tawm lub zog thiab tiv thaiv cov leeg nqaij sib koom ua ke. Parasites tshee, poob, tuag tes tuag taw, thiab tuag hauv ib teev.
Cov kev hloov pauv me me hauv cov pob txha thiab cov tsiaj txhu receptor proteins ua rau arthropod channels xaiv ntau dua. Afoxolaner khi cov kab mob GABA receptors 300 npaug zog dua tib neeg. Qhov kev xaiv ntawm cov paj no ntxiv rau cov tshuaj nyuaj hla cov ntshav- lub hlwb teeb meem txhais tau tias tsuas yog cuam tshuam rau cov kab mob cab, tsis yog dev lub paj hlwb.
Cov kev sim tshuaj pom tau tias afoxolaner tua cov dev mub 4 teev tom qab kev tswj hwm qhov ncauj thiab zoo tshaj plaws tom qab 8 teev. Feem ntau cov dev mub yuav tsum pub 24 teev los tsim cov qe; Yog li, qhov kev txiav txim tam sim no tiv thaiv kev tsim tawm. Kev txwv tsis pub yug me nyuam ntxov ua kom huv huv ib puag ncig thiab tiv thaiv tsiaj ntau dhau hauv tsev thiab kennels. Flea qe thiab larvae nyob rau hauv ib puag ncig loj hlob tuaj thiab dhau qhov cuam tshuam tsis tu ncua, qhov chaw lawv tuag ua ntej yug me nyuam.
Tib txoj kev tua cov kab mob hookworms hauv 48 teev thiab nres cov ntawv txuas tshiab thoob plaws qhov kev noj tshuaj txhua hli.afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Afoxolaner ntev ib nrab-lub neej ua kom cov ntshav siab tshaj qhov tsawg kawg nkaus kom muaj nuj nqis rau plaub lub lis piam. Lub voj voog txhua hli tiv thaiv cov dev feem ntau. Lub sijhawm yuav txawv raws li huab cua, kev ua haujlwm dev, thiab kev hloov pauv hauv metabolic. Qhov kev ua haujlwm ntev no tiv thaiv cov khoom siv tshuaj pleev ib ce tiv thaiv dej thiab tshem tawm.
Afoxolaner ua haujlwm tawm tsam ntau dua li cov yoov thiab zuam; nws kuj ua hauj lwm tawm tsam ntau hom mites uas thab dev. Sarcoptes scabiei, mite uas ua rau sarcoptic mange, yog qhov yooj yim rau kev sib xyaw ntawm cov teebmeem neurotoxic. Demodex mites, uas ua rau demodectic mange nyob rau hauv cov dev uas tsis muaj zog tiv thaiv kab mob, feem ntau yuav kho thiab. Vim tias cov ntsiav tshuaj no ua haujlwm ntawm ntau hom arthropods, lawv tuaj yeem pab tswj tau ntau yam kab mob tib lub sijhawm lossis kho cov tawv nqaij tawv nqaij uas xav tau kev pab ntau.
Milbemycin Oxime muaj nuj nqi hauv kev txhawb nqa Internal Parasite Prevention Program
Lub milbemycin oxime ib feem tawm tsam cov kab mob uas nyob hauv cov dev thiab ua phem rau lawv txoj kev noj qab haus huv. Cov tshuaj macrolide no tsom cov kab mob thiab qee cov kab mob, txwv tsis pub lawv loj hlob thiab tshem tawm cov kab mob uas twb muaj lawm. Txoj kev nws ua haujlwm yog qhov txawv ntawm qhov ua haujlwm ntawm afoxolaner, uas ua rau cov ntawv qhia ua ke muaj kev tiv thaiv ntau dua.
Nws khi rau nematode paj hlwb thiab nqaij glutamate -gated chloride channels. Kev ua haujlwm neuromuscular ib txwm nyob ntawm cov channel no. Lawv tswj cov kab mob 'cov leeg nqaij contraction thiab so cycles rau txav thiab noj. Thaum milbemycin molecules khi rau cov kab no, chloride ions hla yooj yim dua, ua rau muaj ntau dhau. Raws li cov ntaub so ntswg loj hlob ntau dua, cov hlwb neuron thiab cov leeg hlwb ua rau tsis zoo rau cov stimuli. Cov kab mob nereids ua rau tuag tes tuag taw thiab tsis tuaj yeem hla cov ntaub so ntswg lossis cov hnyuv. Kab yuav tuag thiab tawm hauv lub cev los ntawm kev tshem tawm.
Kev nyab xeeb ntawm cov tsiaj yog muab los ntawm ntau qhov chaw. Glutamate-gated chloride channels feem ntau muaj nyob rau hauv cov tsiaj thiab muaj ob peb cov txheeb ze muaj txiaj ntsig hauv cov tsiaj txhu. Milbemycin khi tsis zoo vim qhov sib txawv ntawm cov qauv. Cov ntshav- lub hlwb thaiv kev tiv thaiv cov tshuaj tiv thaiv kom tsis txhob mus txog qhov tshwj xeeb hauv nruab nrab paj hlwb. P-glycoprotein transporters nquag tshem tawm milbemycin los ntawm cov cheeb tsam neural raug mob. Tsuas yog rau cov dev uas tsis muaj peev xwm thauj khoom tsis txaus, qhov no tswj kev nyab xeeb.
Heartworm Lifecycle cuam tshuam
Heartworm parasite Dirofilaria immitis hlob nyob rau hauv ib txoj kev nyuaj nrog kev pab ntawm yoov tshaj cum thiab dev. Thaum yoov tshaj cum noj ntshav, lawv nteg qe thib peb - theem qe. Tsis pub dhau ob lub lis piam, cov larvae yuav moult mus rau plaub -theem larvae tom qab tsiv los ntawm subcutaneous cov ntaub so ntswg thiab cov leeg. Thaum lub sij hawm no rhiab heev, muab milbemycin ib hlis ib zaug tua cov larvae loj hlob ua ntej lawv mus rau hauv cov hlab ntsws thiab lub plawv, qhov twg cov neeg laus kab mob ua rau kab mob. Muaj qee qhov kev ua si tawm tsam thawj thib tsib- theem larvae, tab sis tsis ntau npaum li muaj tawm tsam thib peb- thiab plaub- theem larvae.
Kev noj txhua lub hlis tsim kev tiv thaiv ntev tshaj li ib lub hlis, ua kom paub tseeb tias txhua tus kab mob uas kis tau ntawm cov tshuaj mus txog qhov muaj tshuaj tuag. Txoj kev no txwv tsis pub 6-hli txheej txheem ntawm kev loj hlob uas ua rau kev tsim cov kab laug sab laus. Vim lub sij hawm ntev ua ntej larvae mus txog theem uas lawv tsis muaj kev tiv thaiv ntxiv lawm, txawm tias koj tsis tau koob tshuaj ib zaug, koj tseem yuav tsum tau tiv thaiv. Kev ntsuam xyuas ib xyoos ib zaug rau cov kab mob plawv hauv cov ntshav tau lees paub tias kev tiv thaiv ua haujlwm thiab pom muaj kab mob tshiab uas xav tau kev kho mob sib txawv.
Gastrointestinal Nematode Control
Toxocara canis thiab Toxascaris leonina yog ob hom kab mob plab kab mob uas tuaj yeem kho nrog milbemycin ntawm cov tshuaj tiv thaiv kab mob. Cov menyuam dev feem ntau tau txais cov ascarids los ntawm cov placenta los yog mis nyuj, uas ua rau kev loj hlob tsis zoo, raws plab, thiab mob. Cov neeg laus dev tau kab mob los ntawm kev noj qe hauv ib puag ncig. Milbemycin tua cov cab neeg laus thiab lawv cov menyuam yaus, uas txiav cov qe qe uas tuaj yeem ua rau tsev thiab cov vaj tsev qias neeg. Vim tias qee hom Toxocara tuaj yeem kis kab mob rau cov tsiaj, qhov kev tswj hwm no tseem ceeb tshwj xeeb hauv cov tsev nrog cov menyuam yaus uas yuav kov cov av tsis huv.
Hookworms, tshwj xeeb tshaj yog Ancylostoma caninum, pub rau thiab txuas rau cov phab ntsa hauv plab hnyuv, uas ua rau ntshav poob. Anemia los ntawm cov mob hnyav yog qhov txaus ntshai tshwj xeeb rau cov tsiaj hluas lossis cov tsiaj uas tsis muaj lub cev tiv thaiv kab mob. Milbemycin ua haujlwm zoo rau cov neeg laus cov kab mob hookworms, uas pab tswj kev kis kab mob hauv qhov chaw uas lawv muaj. Whipworms (Trichuris vulpis) nyob rau hauv lub plab loj thiab ua rau raws plab uas yog mucusy los yog ntshav. Whipworm naj npawb tuaj yeem txo qis los ntawm kev muab cov tshuaj milbemycin ib hlis ib zaug, tab sis nws yuav siv sij hawm ntev dua kom tshem tawm tag nrho cov qe vim lawv nyob hauv ib puag ncig.
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Txhawb Kev Npaj Kev Noj Qab Haus Huv Zoo
Ntxivafoxolaner thiab milbemycin oxime chewable ntsiav tshuajrau lwm hom kev kho mob txhim kho kev noj qab haus huv ntawm dev tag nrho. Vim tias cov ntsiav tshuaj no yooj yim siv, yooj yim ua raws, thiab npog ntau hauv av, lawv yog qhov tseem ceeb ntawm kev npaj tshuaj tiv thaiv. Tsis yog tsuas yog kho tus kab mob thaum nws tshwm sim, kev xyaum kho tsiaj niaj hnub no tau hais tias kev tswj cov kab mob parasite yog ib feem tseem ceeb ntawm kev noj qab haus huv.
Simplifying Multi-Kev Tiv Thaiv Kab Mob Kab Mob
Yav dhau los, cov tswv tsiaj yuav tsum taug qab cov khoom sib txawv rau cov dev mub, zuam, kab mob plawv, thiab kab mob plab hnyuv. Qhov no ua rau nws yooj yim kom tsis txhob noj tshuaj, tsis meej pem txog thaum yuav coj lawv, thiab muaj qhov sib txawv ntawm kev tiv thaiv. Muab ob peb txoj haujlwm ntawm ib lub ntsiav tshuaj uas tau noj txhua hli ua rau kev mloog lus yooj yim dua. Cov tswv tsiaj tsuas yog yuav tsum nco ntsoov ib hnub ib hlis es tsis txhob taug qab ntau qhov kev npaj. Cov mis nyuj qab zib ua rau nws yooj yim dua rau cov tib neeg coj nws ntawm lawv tus kheej, uas tshem tawm cov teeb meem uas tuaj nrog cov ntawv siv tshuaj pleev ib ce lossis cov tshuaj tsis txaus siab rau qhov ncauj. Kev ua tau zoo dua ncaj qha ua rau muaj kev tiv thaiv zoo dua thiab tsawg dua ntawm cov kab mob parasitic.
Txo cov kab mob sib kis hauv ntau-Cov tsiaj ib puag ncig
Cov neeg uas muaj ntau dua ib tus dev yuav kis tau kab mob. Kev sib koom thaj chaw nrog tus tsiaj muaj kev cuam tshuam tuaj yeem kis tau cov qe fleas, worm larvae, lossis ua zes rau cov zuam. Los ntawm muab tag nrho cov dev nyob rau hauv ib lub tsev tiv thaiv tag nrho, koj tsim ib tug barrier uas txwv tsis pub cov cab los tuav. Fleas tsis tuaj yeem ua tiav lawv lub neej voj voog yog tias txhua tus tswv tsev tau kho tau zoo. Thaum txhua tus tsiaj tau txais kev kho mob anthelmintic tsis tu ncua, kab mob plab hnyuv tsis tuaj yeem ua kom cov kab mob kis mus. Qhov kev tiv thaiv ntawm cov pejxeem no ua haujlwm zoo dua li kev kho txhua tus tsiaj sib cais.
Txhawb nqa ntev -Lub Sijhawm Noj Qab Haus Huv Los Ntawm Kev Tiv Thaiv Kab Mob
Cov kab mob parasitic ntev ua rau muaj teeb meem kev noj qab haus huv uas tsis pom tseeb thaum xub thawj tab sis txhim kho lub sijhawm. Cov kab mob plab hnyuv sib tua nrog lwm cov kab mob rau cov khoom noj, uas tuaj yeem ua rau cov tsiaj hluas loj hlob qeeb thiab ua rau cov neeg laus tsis haum. Hookworms uas noj ntshav tsis tu ncua poob hlau, uas tuaj yeem ua rau subclinical anemia thiab qis zog thiab lub zog. Cov kab mob plawv ua mob rau lub plawv thiab lub ntsws thaum lub sijhawm, txawm tias ua ntej lawv pom cov tsos mob pom tseeb. Flea allergic dermatitis ua rau khaus thiab mob uas kav ntev thiab ua rau lub neej tsis zoo. Cov kab mob kis los ntawm cov zuam tuaj yeem ua rau muaj mob hnyav sai sai thiab muaj kev cuam tshuam ntev -.
Kev koom ua ke nrog Routine Veterinary Care
Kev kuaj xyuas kev noj qab haus huv tau ua ib xyoos ib zaug lossis txhua rau lub hlis muab sijhawm rau kws kho mob los xyuas seb qhov kev tiv thaiv kab mob ua haujlwm zoo npaum li cas thiab hloov pauv raws li xav tau. Veterinarians saib cov kev hloov hauv lub cev qhov hnyav uas yuav txhais tau tias cov koob tshuaj yuav tsum tau hloov. Cov xwm txheej ntawm thaj chaw muaj kev pheej hmoo raug coj mus rau hauv tus account, thiab cov lus pom zoo hloov pauv nyob ntawm seb thaj chaw puas muaj kab mob plawv- mob lossis tsis. Hauv qee thaj chaw, xyoo-ib puag ncig vs. kev tiv thaiv raws caij nyoog yog raws li tib neeg ua li cas thaum qee lub sijhawm ntawm lub xyoo. Los ntawm saib faeces, txhua yam kab mob plab hnyuv tshiab uas xav tau kev pab ntxiv tuaj yeem pom.
Xaus
Veterinary parasitology tau nce nrog kev txhim kho ntawmafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, uas tiv thaiv cov kab mob sab nraud thiab sab hauv. Cov kab mob txhua hli no, zuam, kab mob plawv, thiab kev kho mob plab nematode yog yooj yim ua raws. To taub yuav ua li cas afoxolaner cuam tshuam rau arthropod paj hlwb thiab milbemycin oxime cuam tshuam cov kab mob neuromuscular muaj nuj nqi piav qhia vim li cas qhov kev sib xyaw no ua haujlwm tau zoo. Cov tshuaj no yog ib qho tseem ceeb rau kev tiv thaiv kev saib xyuas tam sim no vim tias lawv muaj kev nyab xeeb rau cov dev feem ntau thiab ua kom muaj kev noj tshuaj txhua hli. Ob -hauv- ib qho qauv no tau nrov dua hauv cov kws kho tsiaj vim tias cov kab mob cab tuaj yeem tiv taus cov tshuaj qub thiab cov tswv tsiaj xav tau kev kho mob yooj yim, zoo. Cov kws kho tsiaj thiab cov chaw muag tshuaj yog qhov tseem ceeb hauv kev muab cov tshuaj tiv thaiv kab mob no rau cov dev, uas txhim kho tib neeg- tsiaj sib txuas.
FAQ
1. Qhov hnyav npaum li cas ua qhov sib txawv ntawm afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj npog?
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Txoj kev formulation muaj tsib specs uas yog tsim rau cov dev ntawm qhov hnyav sib txawv. Rau cov dev ntawm 2 thiab 3.5 kg, 9.375 mg +1.875 mg ntsiav tshuaj yog qhov zoo tshaj plaws, thiab rau cov dev ntawm 3.5 thiab 7.5 kg, 18.75 mg +3.75 mg ntsiav tshuaj yog qhov zoo tshaj. Rau cov dev ntawm 7.5 kg thiab 15 kg, 37.5 mg +7.5 mg ntsiav tshuaj yog rau lawv, thiab 75 mg +15 mg ntsiav tshuaj yog rau dev ntawm 15 kg thiab 30 kg. Cov ntsiav tshuaj 150 mg +30 mg yog rau cov dev loj uas hnyav 30 kg txog 60 kg. Cov kws kho tsiaj sib xyaw cov koob tshuaj zoo rau cov dev uas hnyav tshaj 60 kg kom tau txais cov koob tshuaj afoxolaner zoo ntawm 2.5 txog 6.9 mg / kg thaum khaws cov milbemycin oxime ratios kom raug.
2. Cov tshuaj afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj puas tuaj yeem muab rau cov dev cev xeeb tub lossis cov neeg laus?
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Tsis muaj ntau daim ntawv ceeb toom txog kev nyab xeeb txog kev muab rau cov poj niam cev xeeb tub lossis pub niam mis, yog li cov kws kho tsiaj yuav tsum txiav txim siab raws li txhua tus neeg txoj kev pheej hmoo - kev tshuaj xyuas cov txiaj ntsig. Cov kev tshawb fawb tswj tau tseem tsis tau paub meej tias kev nyab xeeb npaum li cas ntawm cov tsev me nyuam no. Ntau tus kws kho tsiaj yuav zoo siab pib lossis txuas ntxiv kev tiv thaiv hauv cov dev cev xeeb tub thiab cov neeg laus thaum muaj kev pheej hmoo ntawm cov kab mob parasitic siab dua li cov kev mob tshwm sim ntawm cov tshuaj, tshwj xeeb tshaj yog nyob rau hauv cov chaw uas muaj kab mob plawv. Hauv cov chaw uas muaj kev pheej hmoo tsawg, lwm txoj hauv kev tiv thaiv tus kab mob yuav xav txog. Tham nrog tus kws kho mob hais txog koj qhov xwm txheej tshwj xeeb yog txoj hauv kev zoo tshaj plaws los xyuas kom meej tias koj xaiv txoj cai thaum nws los txog rau kev sib txuas cov kev xav tau los tiv thaiv cov kab mob nrog kev pheej hmoo ntawm kev loj hlob teeb meem.
3. Kev hloov caj ces hauv qee hom dev yuav cuam tshuam li cas rau kev nyab xeeb ntawm milbemycin oxime?
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MDR1 noob, uas cov lej rau P-glycoprotein transporters, tej zaum yuav muaj kev hloov pauv hauv Collie yug tsiaj, Australian Shepherds, thiab lwm yam tsiaj yug dev. Feem ntau, cov neeg thauj khoom no txwv tsis pub cov tshuaj nkag mus rau hauv lub hlwb thiab tus txha caj qaum. Cov dev uas tsis muaj P-glycoprotein txaus yog feem ntau raug rau cov tshuaj uas cuam tshuam rau lub paj hlwb, uas tuaj yeem ua rau muaj kev phom sij ntawm qhov qub. Kev ntsuam xyuas caj ces pom cov neeg raug cuam tshuam, uas cia cov kws kho tsiaj hloov lawv cov txheej txheem. Milbemycin oxime koob tshuaj siv los tiv thaiv kab mob plawv feem ntau muaj kev nyab xeeb rau MDR1-mutant dev, tab sis ntau dua cov tshuaj siv los kho lwm yam mob yuav tsum tau siv nrog kev saib xyuas. Ivermectin ua rau muaj kev pheej hmoo ntau dua rau cov tsiaj no, yog li milbemycin yog qhov kev xaiv macrolide zoo dua thaum tsis paub txog caj ces.
Koom tes nrog BLOOM TECH raws li koj qhov kev ntseeg siab Afoxolaner thiab Milbemycin Oxime Chewable Tablets Supplier
BLOOM TECH stands li koj txhim khu kev qhaafoxolaner thiab milbemycin oxime chewable ntsiav tshuajtus neeg muag khoom, muab cov tshuaj- qib cov khoom tsim hauv GMP- cov chaw muaj ntawv pov thawj uas ua tau raws li US-FDA, EU-GMP, thiab CFDA cov qauv. Nrog rau ntau tshaj 12 xyoo ntawm kev txawj ntse nyob rau hauv cov organic synthesis thiab veterinary kws tshuaj intermediates, peb muab kev ruaj ntseg zoo los ntawm triple -txheej txheem txheej txheem kuaj, xyuas kom meej cov khoom specifications. Peb cov qauv nqi sib tw tswj hwm cov nyiaj tau los ruaj khov thaum hla cov nqi txuag ncaj qha rau cov neeg koom tes, thiab peb ERP- kev sib koom ua ke logistics platform muab cov sij hawm ua tau zoo nrog rau tag nrho cov ntaub ntawv rau seamless kev lis kev cai clearance. Txawm hais tias koj xav tau API ntau, cov ntsiav tshuaj tiav hauv cov qauv tshwj xeeb, lossis kho OEM / ODM cov kev daws teeb meem rau kev tshawb fawb thiab kev tsim kho lub hom phiaj, peb pab neeg ua haujlwm koom tes nrog koj cov kev xav tau tshwj xeeb. Hu rau peb pab neeg muag khoom ntawmSales@bloomtechz.comlos tham txog koj qhov kev xav tau, thov daim ntawv pov thawj ntawm kev tshuaj xyuas, lossis tau txais cov lus qhia ntxaws ntxaws rau koj cov khoom siv tshuaj kho tsiaj.
Cov ntaub ntawv
1. Toutain, CE, Seewald, W., and Jung, M. (2018). Pharmacokinetics ntawm afoxolaner tom qab txhaj tshuaj thiab qhov ncauj hauv cov dev. Veterinary Parasitology, 251, 98-102.
2. Snyder, DE, Wiseman, S., and Bowman, DD (2019). Kev ua tau zoo ntawm afoxolaner thiab milbemycin oxime qhov ncauj ntsiav tshuaj rau kev kho thiab tswj cov plab hnyuv nematodes hauv dev. Veterinary Parasitology: Regional Studies and Reports, 17, 100314.
3. Shoop, WL, Hartline, EJ, and Gould, BR (2020). Sib piv neurotoxicity ntawm isoxazoline tebchaw: afoxolaner selectivity rau arthropod GABA receptors. Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, 43(3), 214-223.
4. Becskei, C., Fias, D., and Mahabir, SP (2017). Kev ua tau zoo thiab kev nyab xeeb ntawm afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj tiv thaiv dev mub thiab zuam hauv cov neeg siv khoom- cov dev. Parasites & Vectors, 10(1), 525-536.
5. Prichard, RK, Menez, C., thiab Lespine, A. (2021). Milbemycin oxime mechanisms ntawm kev txiav txim thiab tsis kam nyob rau hauv cov kab mob veterinary: kev pom los ntawm glutamate-gated chloride channels. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, 15, 23-34.
6. American Heartworm Society (2020). Cov Lus Qhia Txog Canine tam sim no rau Kev Tiv Thaiv, Kev kuaj mob, thiab kev tswj hwm kev mob plawv hauv cov dev. American Heartworm Society Symposium Proceedings, Wilmington, Delaware.