Thaum cov kws kho tsiaj pom zoo kom tiv thaiv kab mob rau cov dev, kev nkag siab txog kev tshawb fawb tom qab kev kho mob ua rau txhua qhov sib txawv. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj sawv cev rau txoj hauv kev zoo tshaj plaws rau kev tswj cov kab mob parasite, ua haujlwm los ntawm ob txoj hauv kev ntawm lub paj hlwb kom tshem tawm cov kab mob sab nraud thiab sab hauv. Qhov no dual - cov qauv kev ua haujlwm tau hloov pauv cov kws kho tsiaj cov kab mob los ntawm kev tsom mus rau cov paj hlwb tshwj xeeb uas muaj nyob hauv cov kab mob tab sis ua haujlwm sib txawv hauv cov tsiaj. Cia peb tshawb nrhiav seb cov tshuaj no cuam tshuam cov kab mob hauv lub paj hlwb li cas thaum tswj kev nyab xeeb rau koj tus khub canine.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization: Peb yuav sib tham ib tus zuj zus, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Peb muab Afoxolaner Thiab Milbemycin Oxime Chewable Tablets, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/oem-odm/tablet/afoxolaner-thiab-milbemycin-oxime-chewable.html
Yuav Ua Li Cas Afoxolaner cuam tshuam rau Parasite Nervous System Signals?
Thaiv GABA-Gated Chloride Channels hauv Arthropod Parasites
Afoxolaner yog ib qho isoxazoline compound, uas yog ib lub tswv yim tshiab nyob rau hauv daim teb ntawm parasitology hauv cov tsiaj. Cov khoom xyaw no ua haujlwm los ntawm kev tsom mus rau gamma-aminobutyric acid (GABA)-gated chloride channels. Cov no yog qhov tseem ceeb ntawm yuav ua li cas arthropods xws li fleas, zuam, thiab mites xa cov paj hlwb. Thaum afoxolaner khi rau cov kab no, nws nres cov tshuaj chloride ions los ntawm kev txav ib txwm hla cov paj hlwb. Qhov teeb meem no ua rau muaj kev tsim cov paj hlwb, uas ua rau cov neurons hluav taws tsis muaj kev tswj hwm. Qhov no hu ua hyperexcitation.
Qhov system no zoo nkauj heev vim nws tuaj yeem xaiv thiab xaiv yuav ua li cas. Txawm hais tias ob leeg cab thiab tib neeg muaj GABA receptors, afoxolaner khi ntau zog rau daim ntawv arthropod ntawm cov kab no. Vim tias qhov kev xaiv molecular no, afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj tuaj yeem tua cov kab mob uas tsis muaj qhov cuam tshuam zoo ib yam rau cov dev cov hlab ntsha. Cov khoom no nce mus txog qib siab tshaj plaws hauv cov ntshav hauv ob mus rau plaub teev tom qab noj los ntawm qhov ncauj. Nws bioavailability yog ib qho amazing 88%, uas txhais tau hais tias nws ua hauj lwm sai heev tiv thaiv pub kab mob.
Kev Tiv Thaiv Zoo Los Ntawm Kev Txuas Ntxiv Ib Nrab -Lub Neej
Txoj kev afoxolaner ua haujlwm hauv lub cev yog qhov ua rau nws txawv ntawm lwm yam tshuaj tua kab ntawm nws lub hnub nyoog. Nrog ib nrab - lub neej ntawm li ob lub lis piam hauv cov ntshav, cov tshuaj no nyob twj ywm hauv cov hlab ntsha ntawm cov qib kho mob ntev txaus los tua kab mob ntawm cov koob tshuaj txhua hli. Vim tias lub sijhawm ntev dua, cov yoov lossis cov zuam uas nyuam qhuav ntes tau yuav tuaj rau hauv cov tshuaj tua kab mob ua ntej lawv tuaj yeem ua tiav kev noj zaub mov lossis kis kab mob - ua rau cov kab mob. Vim tias nws ua haujlwm ntev, afoxolaner- muaj cov qauv tsim muaj txiaj ntsig zoo hauv qhov chaw uas zuam - kis kab mob yog qhov txaus ntshai rau cov dev.
Kev xaiv uas ua kom muaj kev nyab xeeb ntawm Canine
Kev nyab xeeb profile ntawm afoxolaner yog ua raws li cov qauv sib txawv ntawm cov hlab ntsha ntawm cov pob txha thiab cov vertebrates. Ntawm cov koob tshuaj kho mob, afoxolaner tsis cuam tshuam ntau nrog cov tsiaj txhu GABA receptors, tshwj xeeb tshaj yog cov ntshav qab zib - hlwb teeb meem. Cov kev tshawb fawb hauv cov dev tau pom tias qhov sib xyaw ua ke feem ntau nyob hauv txheej txheej ntawm lub cev cov ntaub so ntswg thiab tsis nkag mus rau hauv lub hauv nruab nrab lub paj hlwb ntau heev. Vim tias cov khoom siv tshuaj no, afoxolaner tuaj yeem pom hauv cov ntshav ntawm qib uas ua rau cov kab mob tuag taus tab sis tsis nyob rau theem uas yuav cuam tshuam rau tus dev lub hlwb ua haujlwm.
Yuav Ua Li Cas Milbemycin Oxime Influence Parasite Ion Channels rau Internal Parasite Control?
Ua kom Glutamate-Gated Chloride Channels
Milbemycin oxime ua haujlwm nyob rau hauv ib txoj kev sib txawv kiag li ntawm lub paj hlwb. Nws tsom mus rau glutamate-gated chloride channels uas feem ntau pom nyob rau hauv cov hlab ntsha thiab cov leeg hlwb ntawm cov cab thiab lwm yam kab mob sab hauv.
Cov tshuaj macrolide no muaj ob ntu: milbemycin A3 (20%) thiab A4 (80%). Cov khoom no ua hauj lwm ua ke los tua cov kab mob plawv, cov kab mob hookworms, roundworms, thiab whipworms.
Milbemycin oxime txuas mus rau cov glutamate receptors thiab xa cov tshuaj chloride ions mus rau hauv cov kab mob cab cov paj hlwb, uas ua rau lawv raug nqi ntau dua.
Qhov no hyperpolarisation yog qhov txawv ntawm qhov tshwm sim hauv arthropods thaumafoxolaner thiab milbemycin oxime chewable ntsiav tshuajsiv. Tsis txhob ua rau cov paj hlwb zoo siab heev, milbemycin oxime ua rau lawv tsis teb rau qhov kev xav tsis tu ncua.
Parasites uas raug rau cov khoom no maj mam poob peev xwm siv lawv cov kev noj mov thiab cov leeg nqaij, uas nws thiaj li ua rau lawv raug tshem tawm ntawm lawv tus tswv tsev.
Cov khoom no nce mus txog qib siab tshaj plaws hauv cov ntshav hauv ib mus rau ob teev tom qab noj los ntawm qhov ncauj. Qhov no txhais tau hais tias nws ua haujlwm sai sai los tua cov kab mob plawv thiab cov neeg laus plab kab mob.
Kev faib tawm txawv thiab Mammalian kev nyab xeeb
Milbemycin oxime muaj kev nyab xeeb rau cov dev vim nws muaj ntau yam kev nyab xeeb. Cov ntshav- lub hlwb teeb meem ua rau mammalian glutamate-gated chloride channels feem ntau nyob rau hauv nruab nrab lub paj hlwb.
Raws li lub substrate ntawm P-glycoprotein, lub twj tso kua mis efflux uas nquag tshem tawm cov tshuaj los ntawm lub hlwb, milbemycin oxime muaj kev cuam tshuam me ntsis ntawm lub hauv paus paj hlwb hauv cov dev uas P-glycoprotein ua haujlwm ib txwm.
Qhov no yog vim li cas cov tshuaj tuaj yeem ncav cuag qib siab txaus los tua cov kab mob hauv cov ntshav thiab lwm yam kua hauv lub cev yam tsis muaj kev cuam tshuam rau dev lub hlwb ua haujlwm.
Milbemycin A3 thiab A4 muaj cov tshuaj pharmacokinetic zoo ib yam, tab sis lawv ib nrab -lub neej yog 1.6 thiab 3.3 hnub, raws li. Cov qauv pov tseg tib yam no ua kom paub tseeb tias cov nyhuv antiparasitic nyob twj ywm tib yam thaum lub sijhawm noj tshuaj.
Cov kev tshawb fawb bioavailability qhia tau hais tias milbemycin A3 yog absorbed 81% ntawm lub sij hawm thiab A4 yog absorbed 65% ntawm lub sij hawm. Ob qho ntawm cov qib no yog siab txaus los ua kom muaj txiaj ntsig zoo tiv thaiv kab mob uas ua rau raug mob.
Targeting Heartworm Microfilariae thiab Larval Stages
Ib qho tseem ceeb tshaj plaws txog milbemycin oxime hauv tshuaj yog tias nws tua cov kab mob plawv. Muab cov tshuaj no ib hlis ib zaug nres qhov kev loj hlob ntawm Dirofilaria immitis nyob rau theem L3 thiab L4 larval, txwv tsis pub lawv los ua tus neeg laus kab mob uas tuaj yeem ua rau lub plawv thiab tua tus tswv tsev.
Vim hais tias cov tshuaj tsis tau tshem ntawm cov neeg laus cov kab mob plawv uas twb muaj nyob rau hauv cov hlab ntsha pulmonary, qhov kev tiv thaiv no yuav tsum tau ua txhua hli.
Hauv cov chaw uas muaj kab mob plawv, cov kev tiv thaiv txhua hli yog cov qauv vim tias milbemycin oxime tuaj yeem ua rau cov paj hlwb puas ntawm cov theem kev loj hlob no.
Afoxolaner thiab Milbemycin Oxime Mechanism: Nkag siab Dual Neuroactive Parasite Targeting
Complementary Receptor Systems for Comprehensive Protection
Cov qauv tshuaj ntawm afoxolaner thiab milbemycin oxime qhia cov pab pawg tseem ceeb uas pab lawv khi rau receptors. Afoxolaner muaj lub nplhaib isoxazoline, uas yog tsib - koom nrog heterocycle nrog nitrogen thiab oxygen atoms. Qhov system no yog dab tsi khi rau GABA receptors. Ntxiv cov nplhaib uas muaj ntxhiab ntau dua thiab cov khoom siv halogen hloov pauv lipophilic thiab khi li cas -affine cov molecule, uas txhim kho nws cov txiaj ntsig thiab cov tshuaj pharmacokinetic zoo. Qhov tseeb tias afoxolaner thiab milbemycin oxime yog ob qho tib si hauv tib qho kev sib xyaw qhia tau hais tias tsim tshuaj ntse. Ob cov tshuaj no ua haujlwm ntawm ob hom receptors: GABA-gated channels hauv arthropods thiab glutamate-gated channels hauv cov cab.
Qhov no txhais tau tias lawv tuaj yeem tswj cov kab mob sab nraud thiab sab hauv tib lub sijhawm yam tsis muaj kev sib tw rau kev khi lossis ua haujlwm tsis zoo. Vim tias ob cov tshuaj no ua haujlwm ua ke, ib koob tshuaj txhua hliafoxolaner thiab milbemycin oxime chewable ntsiav tshuajtua txhua yam kab mob hauv dev. Los ntawm kev xav txog kev kho mob, ob - cov txheej txheem no ua rau kev tiv thaiv kab mob yooj yim dua. Cov kws kho tsiaj tsis tas yuav muab ob yam tshuaj sib txawv kom tshem tawm cov yoov, zuam, kab mob plawv, thiab kab mob plab hnyuv; lawv tsuas muaj peev xwm muab tau ib ntsiav tshuaj chewable uas ua tau ob qho tib si. Cov kev tshawb fawb txog kev ua raws cai tau pom tias ua cov txheej txheem yooj yim ua raws li pab cov tswv tsiaj lo rau lawv ntau zaus, uas txhim kho tag nrho cov kab mob parasites hauv cov dev.
Molecular Selectivity Raws li Evolutionary Divergence
Qhov sib txawv ntawm cov noob caj noob ces loj ntawm arthropods, worms, thiab tsiaj txhu tau ua rau muaj qhov sib txawv loj hauv cov qauv ntawm lawv cov neurotransmitter receptors. Vim tias qhov sib txawv no, cov tshuaj siv tshuaj tuaj yeem siv cov chaw sib khi tshwj xeeb uas muaj cov kab mob cab tab sis sib txawv txaus hauv cov tsiaj txhu kom tsis txhob muaj qhov phem. Milbemycin oxime cov haujlwm tshwj xeeb tawm tsam nematode glutamate channels thiab afoxolaner qhov kev xaiv affinity rau arthropod GABA receptors ob qho tib si qhia tau hais tias lub paj hlwb tau hloov pauv ntau lab xyoo.
Cov qauv siv lead ua kev tshawb fawb ntawm cov receptor proteins tau pom qhov sib txawv me me tab sis tseem ceeb hauv cov duab ntawm lub hnab ntawv khi, cov amino acid pleev, thiab cov proteins muaj peev xwm hloov cov duab. Cov kws kho mob tuaj yeem ua cov tshuaj sib xyaw nrog cov tshuaj kho mob siab (qhov sib piv ntawm cov tshuaj lom thiab cov koob tshuaj zoo) los ntawm kev pom qhov sib txawv ntawm qib molecular. Qhov ntsuas kev kho mob no siab rau ob qho tib si afoxolaner thiab milbemycin oxime, muab lub qhov rais loj loj thaum siv raws li cov qauv kev kho mob.
Yuav ua li cas cov khoom xyaw nquag cuam tshuam Parasite Neural Function los ntawm txoj kev sib txawv
Afoxolaner's Hyperexcitation Versus Milbemycin Oxime's Paralysis
Cov teebmeem sib txawv uas ob yam tshuaj no muaj rau ntawm lub paj hlwb -hyperexcitation tiv thaiv tus tuag tes tuag taw- yog vim qhov sib txawv receptors lawv khi rau thiab cov teebmeem ntawm tes ua raws li.
Yog tias afoxolaner nres GABA-gated chloride channels los ntawm kev ua haujlwm ntawm cov hma los yog zuam, nws nres cov lus uas feem ntau tswj cov hlab ntsha.
Yog tias tsis muaj kev tswj hwm no, cov hlab ntsha hluav taws xob txhua lub sijhawm, ua rau lub xeev ntawm kev tswj tsis tau zoo uas siv cov khoom siv hluav taws xob sai sai thiab tua cov kab mob hauv cov sij hawm noj ntshav.
Milbemycin oxime, ntawm qhov tod tes, thaiv nematodes tob los ntawm kev qhib glutamate-gated chloride channels. Cov paj hlwb thiab cov leeg nqaij muaj lub sijhawm nyuaj mus txog qib rau kev ua kom muaj peev xwm tsim tau vim tias muaj cov tshuaj chloride ntau dhau los.
Cov kab mob uas cuam tshuam los ntawm cov txheej txheem no tsis tuaj yeem ua rau cov leeg nqaij sib koom ua ke lawv xav tau noj lossis nyob hauv qhov chaw hauv tus tswv tsev txoj kev zom zaub mov, yog li lawv raug pov tseg.
Qhov chaw -Kev nqis tes tshwj xeeb txo qis tawm-Cov txiaj ntsig ntawm lub hom phiaj
Thaum nws los txog rau kev nyab xeeb, ob lub tebchaw yog zoo heev ntawm tsuas yog khi rau cov chaw tshwj xeeb. Afoxolaner txav mus los ntawm lub cev lub cev, tab sis nws tsuas yog tua kab thaum cov cab noj nws thaum lawv pub ntshav.
Qhov no txhais tau hais tias cov tshuaj tsis tas yuav tsum tau concentrated hauv daim tawv nqaij lossis plaub hau txhawm rau tiv thaiv ectoparasites. Nws tsuas yog yuav tsum tau nyob hauv cov hlab ntsha.
Cov ntaub ntawv pharmacokinetic uas qhia txog qhov ntim ntawm 2.6 L / kg qhia tias cov tshuaj tau kis thoob plaws hauv ntau cov ntaub so ntswg, yog li cov kab mob yuav tuaj rau hauv kev sib cuag nrog nws txawm tias lawv txuas mus rau tus dev twg.
Milbemycin oxime kuj pom muaj thoob plaws hauv lub cev, tab sis nws feem ntau pom nyob rau hauv cov ntaub so ntswg uas cab cab nyob los yog txav mus. Thaum cov tshuaj mus txog qib kho nyob rau hauv lub plab hnyuv phab ntsa thiab lumen, nws pib tua kab mob uas nyob rau hauv lub digestive ib ntsuj av.
Txhawm rau tiv thaiv kab mob plawv ua haujlwm, milbemycin oxime yuav tsum tau nyob hauv cov hlab ntsha thaum yoov tshaj cum- kis tau tus kab mob mus rau hauv cov ntaub so ntswg thiab mus rau lub plawv thiab lub ntsws.
Qhov sib xyaw ua ke cov ntshav plasma clearance tus nqi-75 ml / h / kg rau A3 thiab 41 ml / h / kg rau A4- khaws cov concentrations ntawm qib zoo rau tag nrho lub hli.
Resistance Considerations thiab Dual Mechanism Benefits
Muab ob qho khoom xyaw ua ke uas ua haujlwm sib txawv muaj txiaj ntsig ntxiv: nws pab tswj kev tiv thaiv. Thaum cov kab mob kis mus rau ntau lub tebchaw uas lub hom phiaj sib txawv ntawm txoj kev lom neeg nyob rau tib lub sijhawm, lawv tsis tshua muaj peev xwm tiv taus.
Ib qho kev hloov caj ces uas yuav ua rau tus kab mob resistant rau afoxolaner's GABA receptor binding yuav tsis tiv thaiv nws los ntawm milbemycin oxime qhov ua kom cov glutamate channel, thiab tib yam mus rau lwm txoj hauv kev.
Lub tswv yim no tau zoo-paub nyob rau hauv kev saib xyuas cov tshuaj tua kab mob, thiab nws kuj ua haujlwm rau cov txheej txheem uas tshem tawm cov kab mob.
Molecular Insights Rau Afoxolaner thiab Milbemycin Oxime Action Tawm tsam Parasites
Cov yam ntxwv zoo uas pab kom Receptor Binding
Cov qauv tshuaj ntawm afoxolaner thiab milbemycin oxime qhia cov pab pawg tseem ceeb uas pab lawv khi rau receptors. Afoxolaner muaj lub nplhaib isoxazoline, uas yog tsib - koom nrog heterocycle nrog nitrogen thiab oxygen atoms. Qhov system no yog dab tsi khi rau GABA receptors. Ntxiv cov nplhaib uas muaj ntxhiab ntau dua thiab cov khoom siv halogen hloov pauv lipophilic thiab khi li cas -affine cov molecule, uas txhim kho nws cov txiaj ntsig thiab cov tshuaj pharmacokinetic zoo.
Raws li macrolide, milbemycin oxime muaj lub nplhaib loj macrocyclic lactone uas yog dai kom zoo nkauj nrog ntau pawg ua haujlwm. Cov tshuaj xws li ivermectin thiab moxidectin, uas nyob hauv tib chav kawm molecular, tau pom tias muaj kev vam meej tshwj xeeb tiv thaiv kab mob. Milbemycin oxime khi xaiv rau nematode glutamate-gated chloride channels thiab tsis muaj kev cuam tshuam nrog cov tsiaj txhu receptors vim nws qhov tshwj xeeb stereochemistry thiab cov qauv hloov pauv.
Pharmacokinetic Properties uas txhawb kev noj txhua hli
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajua haujlwm zoo tshaj plaws raws li kev tiv thaiv txhua hli thaum lawv muaj cov tshuaj pharmacokinetic zoo. Ib nrab ntawm - lub neej ntawm afoxolaner yog ob lub lis piam, uas txhais tau hais tias kev tiv thaiv kev tiv thaiv ntev ntev tom qab lub sijhawm noj txhua hli. Qhov no ua rau muaj qhov tsis zoo rau kev ncua me me hauv kev tswj hwm. Nws yuav zoo li tsis muaj txiaj ntsig zoo tias milbemycin oxime muaj ib nrab luv dua - lub neej ntawm 1.6 mus rau 3.3 hnub, tab sis qhov no yog qhov txaus kom tsis txhob muaj kab mob plawv vim tias cov tshuaj tsuas yog yuav tsum muaj nyob rau lub sijhawm luv luv uas cov larvae tuaj yeem cuam tshuam los ntawm nws.
Ob lub tebchaw ua rau lub siab metabolism. Afoxolaner feem ntau raug tshem tawm los ntawm faeces, thaum milbemycin oxime tuaj yeem tshem tawm los ntawm ob lub plab thiab zis. Cov kev tshem tawm cov pov tseg no ua rau muaj kev ntxhov siab tsawg tshaj plaws ntawm txhua lub cev thiab ntxiv rau qhov kev nyab xeeb dav dav. Cov ntaub ntawv bioavailability -88% rau afoxolaner thiab 65-81% rau milbemycin oxime Cheebtsam-qhia tau tias cov ntsiav tshuaj tau zoo nqus los ntawm lub plab zom mov, tshwj xeeb tshaj yog thaum lawv noj nrog zaub mov.
Clinical Implications of Mechanism-Raws Li Kev Kho Mob
Cov kws kho tsiaj thiab cov tswv tsiaj tuaj yeem txiav txim siab zoo dua txog kev tswj cov kab mob parasite thaum lawv paub tias afoxolaner thiab milbemycin oxime ua haujlwm li cas ntawm lub paj hlwb. Afoxolaner tua cov yoov sai sai (hauv 4 teev) thiab zuam (hauv 24 txog 48 teev). Qhov no yog vim nws tau sai sai absorbed thiab kis tau, muab kev pab sai sai ntawm cov kab mob. Kev ua haujlwm tas li tawm tsam cov kab mob tshiab uas tau txais thoob plaws lub hli txwv tsis pub muaj kab mob tshwm sim dua thiab txo cov kab mob hauv ib puag ncig.
Txhawm rau tiv thaiv kab mob plawv, qhov tseem ceeb tshaj plaws yog khaws cov tshuaj txhua lub hlis thaum lub caij yoov tshaj cum (lossis txhua xyoo hauv qhov chaw uas muaj kab mob plawv). Tus txheej txheem ntawm milbemycin oxime xav tau cov tshuaj kom muaj nyob rau thaum cov larvae txav los ntawm cov ntaub so ntswg, uas tshwm sim li ib hlis tom qab kis kab mob. Yog tias koj tsis noj tshuaj, cov larvae tuaj yeem loj hlob dhau ntawm qhov chaw uas lawv muaj peev xwm kis kab mob plawv. Yog li, lub hauv paus paj hlwb ntawm kev tswj cov kab mob ncaj qha cuam tshuam rau txoj hauv kev zoo tshaj plaws kom tsiaj noj qab haus huv.
Xaus
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajua hauj lwm ntawm complex neurological systems. Qhov no qhia tau hais tias cov tshuaj tam sim no rau cov tsiaj ua kom zoo dua ntawm qhov sib txawv ntawm cov kab mob thiab cov tswv tsev hloov zuj zus. Thaum afoxolaner lub hom phiaj GABA-gated chloride channels, nws sai sai overexcites thiab tua arthropod parasites. Ntawm qhov tod tes, thaum milbemycin oxime qhib glutamate-gated channels, nws ua rau tuag tes tuag taw thiab tua cov nematodes sab hauv. Qhov ob - cov txheej txheem no, nrog rau nws cov tshuaj pharmacokinetic zoo thiab cov ntsuas kev kho mob siab, tau ua qhov sib xyaw no yog ib feem tseem ceeb ntawm kev tiv thaiv kab mob ua kom tiav rau dev. Thaum cov kws kho tsiaj thiab cov tswv tsiaj nkag siab txog cov txheej txheem no, lawv tuaj yeem nkag siab zoo dua tsis yog cov tshuaj no ua li cas, tab sis kuj yuav tiv thaiv tsiaj li cas los ntawm kev sib cuam tshuam ntawm molecular.
FAQ
1. Dab tsi ua rau kev sib xyaw ua ke ntawm afoxolaner thiab milbemycin oxime zoo dua li ib qho - cov khoom siv kho kab mob parasite?
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Qhov sib tov tiv thaiv tag nrho lawv los ntawm kev mus tom qab ob txoj hauv kev sib txawv ntawm cov kab mob hauv cov kab mob sib txawv. Cov kab mob sab nraud zoo li dev mub thiab zuam tuaj yeem tua los ntawm afoxolaner los ntawm kev thaiv GABA receptors. Ntawm qhov tod tes, cov kab mob plawv thiab lub plab nematodes tuaj yeem tua los ntawm milbemycin oxime los ntawm kev ua kom cov glutamate channels. Qhov no dual mechanism tau tshem ntawm qhov xav tau ntawm ntau yam tshuaj sib txawv thiab ua rau muaj kev tiv thaiv tsis tshua muaj tshwm sim, txij li cov kab mob yuav tsum tau hloov ob lub tshuab receptor tib lub sijhawm kom muaj sia nyob kho.
2. afoxolaner thiab milbemycin oxime pib ua haujlwm sai npaum li cas tom qab kev tswj hwm?
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Afoxolaner tau txais nws qib siab tshaj plaws hauv cov ntshav hauv ob mus rau plaub teev tom qab siv. Nws pib tua hma nyob rau hauv plaub teev thiab zoo tshaj plaws tiv thaiv zuam nyob rau hauv nees nkaum- plaub mus rau yim caum- yim teev. Milbemycin oxime nce mus txog qhov siab tshaj plaws txawm tias sai dua, ib mus rau ob teev tom qab kev tswj hwm, thiab pib tua cov kab mob plawv thiab cov kab mob hauv cov neeg laus tam sim ntawd. Ob lub tebchaw yog absorbed sai sai los ntawm cov ntaub ntawv chewable ntsiav tshuaj, uas tua cov kab mob sai sai thaum ua kom koj muaj kev nyab xeeb los ntawm kev xaiv lub hom phiaj receptors.
3. Puas muaj cov dev uas yuav tsum tau saib xyuas tshwj xeeb thaum siv cov khoom sib xyaw no?
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Collies thiab zoo sib xws herding hom uas muaj kev hloov nyob rau hauv MDR1 noob yuav tsum tau ua tib zoo kuaj xyuas ua ntej muab milbemycin oxime. Qhov no yog vim qhov kev hloov pauv hloov txoj kev P-glycoprotein ua haujlwm thiab tuaj yeem ua rau cov tshuaj nkag mus tob rau hauv lub paj hlwb. Cov kws kho tsiaj feem ntau qhia txog kev kuaj caj ces rau cov tsiaj txhu uas muaj kev pheej hmoo lossis hloov cov sijhawm noj kom haum rau cov kev xav tau. Afoxolaner's kev ruaj ntseg profile tsis yog raws li P-glycoprotein txwv, thiab nws feem ntau tsis ua teeb meem ntau npaum li cas rau qee yam tsiaj. Cov menyuam dev hnub nyoog qis dua 8 lub lis piam lossis hnyav dua 2 kg yuav tsum tsis txhob noj cov tshuaj no kom txog thaum lawv muaj hnub nyoog thiab qhov hnyav.
Koom Tes Nrog BLOOM TECH rau Hwm Afoxolaner thiab Milbemycin Oxime Chewable Tablets
Bloom Tech yog lub chaw tsim khoom tsim nyogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Lawv muaj ntau tshaj 12 xyoo ntawm kev paub nyob rau hauv cov tshuaj intermediates thiab veterinary active cov khoom xyaw, yog li lawv muaj peev xwm muab tau zoo thiab kev pab cuam. Teb Chaws Asmeskas -FDA, PMDA, thiab EU cov koom haum tswj hwm tau ua tib zoo tshuaj xyuas peb cov GMP- cov chaw tsim khoom muaj ntawv pov thawj, ua kom txhua pawg ua tau raws li cov qauv thoob ntiaj teb siab tshaj plaws. Peb lub tuam txhab muab tag nrho cov kev pab cuam customization rau API, tiav cov ntsiav tshuaj nyob rau hauv sib txawv zog (9.375+1.875mg rau 150+30mg), thiab tshuaj pleev cov tshuaj uas yuav siv tau los ntawm dev ntawm tag nrho cov luj. Peb cov qauv tsim nqi meej, muaj kev ruaj ntseg zoo nrog peb theem ntawm kev sim, thiab kev tswj xyuas cov saw hlau raug tag nrho ua haujlwm ua ke kom paub tseeb tias koj tau txais cov khoom raug raws sijhawm. Peb pab pawg kws tshaj lij muab cov ntaub ntawv tag nrho rau kev ua raws cai thiab kev lis kev cai tshem tawm, txawm tias koj xav tau API ntau rau kev tsim lossis ua tiav cov ntawv ntau npaum li cas rau kev faib tawm. Email peb cov neeg ua haujlwm paub txog ntawmSales@bloomtechz.comtham txog koj cov kev xav tau tshwj xeeb thiab nrhiav seb BLOOM TECH tuaj yeem dhau los ua koj li -ntev tus khub hauv kev muab tshuaj kho tsiaj.
Cov ntaub ntawv
1. Shoop, WL, et al. (2014). "Discovery thiab hom kev ua ntawm afoxolaner, tus tshiab isoxazoline parasiticide rau dev." Veterinary Parasitology, 201(3-4), 179-189.
2. Prichard, R., Ménez, C., & Lespine, A. (2012). "Moxidectin thiab avermectins: Consanguinity tab sis tsis yog tus kheej." International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, 2, 134-153.
3. Bowman, DD, et al. (2016). "Kev sib piv kev ua tau zoo ntawm afoxolaner thiab peb lwm yam isoxazoline parasiticides tiv thaiv Ixodes scapularis." Veterinary Parasitology, 224, 37-40.
4. Taenzler, J., et al. (2015). "Kev ua tau zoo ntawm qhov ncauj afoxolaner ntxiv rau milbemycin oxime chewables tiv thaiv plaub hom zuam uas kis tus dev hauv Europe." Parasitology Research, 114(Suppl 1), S193-S200.
5. Njiro, SM & Kidane, FA (2017). "Lub luag haujlwm ntawm glutamate-gated chloride channels hauv cov tshuaj tiv thaiv kab mob thiab tiv thaiv." Tam sim no Pharmaceutical Design, 23(7), 1019-1025.
6. Wolstenholme, AJ & Rogers, AT (2005). "Glutamate-gated chloride channels thiab hom kev ua ntawm avermectin/milbemycin anthelmintics." Parasitology, 131 (Suppl), S85-S95.