Hydroxyzine dihydrochloride, tseem hu ua Hydroxyzine 2HCl, yog ntau yam tshuaj siv tshuaj nrog ntau yam kev siv kho mob. Qhov no benzodiazepine antihistamine ua raws li qhov ncauj qhov ncauj nquag histamine H1 receptor thiab serotonin antagonist, muab cov txiaj ntsig kho mob tseem ceeb hauv ntau qhov chaw kho mob. Kab lus no yog tsom rau kev txheeb xyuas thiab sib tham txog kev siv tshuaj kho mob ntawm Hydroxyzine dihydrochloride kom ntxaws.
Peb muab Hydroxyzine Dihydrochloride CAS 2192-20-3, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
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Chemical Properties thiab Stability
Hydroxyzine dihydrochloride, nrog rau CAS tus naj npawb ntawm 2192-20-3, nthuav tawm cov khoom siv tshuaj lom neeg thiab cov yam ntxwv ruaj khov. Cov tshuaj no, tseem hu ua 2-[2-[4-(4-chlorophenyl)benzyl-1-piperazinyl]ethoxy]ethanol dihydrochloride, muaj cov mis mos molecular ntawm C21H27ClN2O2 2HCl thiab qhov hnyav molecular ntawm kwv yees li 447.83 g / mol.
Nyob rau hauv cov nqe lus ntawm nws cov khoom siv tshuaj, hydroxyzine dihydrochloride zoo nkaus li ib qho dawb, tsis muaj ntxhiab crystalline hmoov. Nws melts nyob rau hauv qhov ntau ntawm 190-192 degree, tab tom decomposition nyob rau hauv cov txheej txheem no. Cov compound yog soluble hauv qee cov kuab tshuaj, txawm hais tias cov ntaub ntawv solubility tshwj xeeb yuav txawv.
Hais txog kev ruaj ntseg, hydroxyzine dihydrochloride feem ntau suav hais tias ruaj khov nyob rau hauv ib txwm muaj. Txawm li cas los xij, zoo li ntau yam tshuaj, nws yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav kom tsis txhob raug ya raws, tshav kub, thiab tshav ntuj ncaj qha, uas tuaj yeem ua rau cov khoom sib xyaw. Tsis tas li ntawd, cov cuab yeej tiv thaiv tus kheej tsim nyog yuav tsum tau hnav thaum tuav cov tshuaj no los tiv thaiv daim tawv nqaij thiab qhov muag.
Pharmacological Actions
Hydroxyzine dihydrochloride belongs rau qeb ntawm non-sedating antihistamines tab sis kuj qhia tau tias tsis muaj zog anxiolytic zog. Qhov kev ua ob no ua rau nws muaj txiaj ntsig zoo rau kev kho mob rau ntau yam mob. Cov tshuaj pharmacological tseem ceeb ntawm Hydroxyzine dihydrochloride suav nrog:
Antihistamine Action
Raws li H1 receptor antagonist, Hydroxyzine dihydrochloride thaiv cov histamine receptors, yog li inhibiting kev tsis haum tshuaj. Qhov kev txiav txim no tshwj xeeb tshaj yog muaj txiaj ntsig zoo hauv kev kho mob tsis haum xws li mob urticaria, dermatitis, thiab histamine-mediated pruritus.
Tsis muaj zog Anxiolytic Action
Los ntawm inhibiting lub hauv paus paj hlwb, Hydroxyzine dihydrochloride ua rau cov nyhuv sedative, muaj zog dua diphenhydramine. Qhov kev ua no yuav pab daws cov tsos mob ntawm kev ntxhov siab, ntxhov siab, thiab kev ntxhov siab.
Antiemetic thiab Antispasmodic teebmeem
Hydroxyzine dihydrochloride kuj nthuav tawm cov khoom siv tshuaj tiv thaiv, ua rau nws muaj txiaj ntsig zoo li cov tshuaj tiv thaiv ntuav. Tsis tas li ntawd, nws cov tshuaj antispasmodic pab hauv kev kho mob spasms thiab lwm yam mob.
Cov teebmeem plawv
Los ntawm kev txo qis adrenergic pressor kev ua ub no, Hydroxyzine dihydrochloride nthuav tawm quinidine-zoo li antiarrhythmic teebmeem, txawm hais tias nws txoj kev siv tseem ceeb hauv cov hlab plawv yog txwv.
Kev siv tshuaj kho mob
Kev kho mob ntawm kev ua xua
Hydroxyzine dihydrochloride yog dav siv nyob rau hauv kev kho mob ntawm kev tsis haum tshuaj xws li mob urticaria, dermatitis, thiab pruritus. Nws lub peev xwm los thaiv cov histamine receptors zoo txo cov kev tsis haum tshuaj thiab muab kev pab ntawm cov tsos mob xws li khaus, liab, thiab o. Cov kev tshawb fawb tau pom tias Hydroxyzine dihydrochloride muaj txiaj ntsig tshwj xeeb hauv kev kho mob urticaria tshwm sim los ntawm kev mob khaub thuas lossis dag zog.
Kev ntxhov siab thiab Neuropsychiatric Disorders
Hydroxyzine dihydrochloride yog tshuaj rau kev tswj kev ntxhov siab, ntxhov siab, thiab cuam tshuam txog neuropsychiatric mob. Nws cov khoom tsis muaj zog anxiolytic ua rau nws yog qhov kev xaiv tsim nyog rau cov neeg mob uas muaj kev ntxhov siab me me mus rau nruab nrab. Nws tuaj yeem siv los ua kev kho mob monotherapy lossis ua ib qho ntxiv rau lwm cov tshuaj psychotropic hauv kev kho mob ntawm kev ntxhov siab, kev ntxhov siab, thiab kev puas siab puas ntsws.
Adjuvant Therapy hauv Psychiatry
Hauv kev puas siab puas ntsws, Hydroxyzine dihydrochloride ua haujlwm raws li kev kho mob ntxiv, txhawb cov teebmeem ntawm thawj cov tshuaj psychotropic. Nws sedative thiab anxiolytic zog pab nyob rau hauv calming agitated cov neeg mob thiab txhim kho lawv tag nrho kev koom tes nrog kev kho mob. Tsis tas li ntawd, Hydroxyzine dihydrochloride tuaj yeem siv los ua kev kho mob ua ntej kom txo cov kev ntxhov siab ua ntej thiab ua kom ntev cov tshuaj loog ntawm ketamine.
Kev Tswj Kev Mob
Txawm hais tias tsis tau qhia tshwj xeeb rau kev tswj qhov mob, Hydroxyzine dihydrochloride tau qhia txog cov txiaj ntsig zoo hauv cheeb tsam no. Nws lub peev xwm los txo kev ntxhov siab thiab muab sedation tuaj yeem txhim kho qhov mob siab thiab txhim kho tag nrho cov txheej txheem tswj kev mob zoo. Cov kev tshawb fawb tshawb fawb txog nws txoj kev siv ua ke nrog lwm cov tshuaj analgesics tau tshaj tawm cov txiaj ntsig zoo, qhia tias nws muaj peev xwm ua rau kev kho mob ntxiv.
Cov tshuaj sib cuam tshuam thiab kev phiv
Thaum Hydroxyzine dihydrochloride raug tswj hwm ib txhij nrog lwm cov kev ntxhov siab hauv nruab nrab hauv lub paj hlwb, xws li benzodiazepines, barbiturates, opioids, lossis cawv, qhov kev pheej hmoo ntawm kev ntxhov siab ntau dhau, tsaug zog, thiab ua pa nyuaj siab tuaj yeem nce ntxiv. Yog li ntawd, kev siv ib txhij yuav tsum tau zam los yog ua tib zoo saib xyuas.
Hydroxyzine dihydrochloride kuj tuaj yeem cuam tshuam nrog cov tshuaj anticholinergic, vim tias ob hom tshuaj tuaj yeem cuam tshuam rau acetylcholine system. Qhov no tuaj yeem ua rau muaj kev phiv tshuaj anticholinergic, xws li qhov ncauj qhuav, qhov muag tsis pom kev, thiab cem quav.
Tsis tas li ntawd, Hydroxyzine dihydrochloride tuaj yeem cuam tshuam nrog monoamine oxidase inhibitors (MAOIs), ua rau nce qib ntawm serotonin thiab muaj peev xwm serotonin syndrome. Cov tsos mob no tshwm sim los ntawm cov tsos mob xws li tsis meej pem, ntxhov siab, thiab hyperthermia.
Nws tsim nyog sau cia tias Hydroxyzine dihydrochloride kev sib cuam tshuam nrog lwm cov tshuaj kuj tseem nyob ntawm cov khoom xws li kev noj ntau npaum li cas, cov metabolism hauv tus kheej, thiab muaj lwm yam mob. Yog li ntawd, nws yog ib qho tseem ceeb rau cov neeg mob kom qhia rau lawv cov kws kho mob txog txhua yam tshuaj, tshuaj, thiab tshuaj ntsuab uas lawv noj kom txo tau qhov kev pheej hmoo ntawm kev phiv tshuaj.
Cov kev mob tshwm sim feem ntau cuam tshuam nrog Hydroxyzine dihydrochloride muaj xws li qaug zog, qhov ncauj qhuav, kiv taub hau, thiab qaug zog. Tsawg dua tab sis cov kev mob tshwm sim loj dua tuaj yeem suav nrog sedation, ataxia, tsis meej pem, thiab hypotension. Kev siv Hydroxyzine dihydrochloride mus ntev tuaj yeem ua rau muaj kev vam khom, tshwj xeeb tshaj yog rau cov tib neeg uas muaj keeb kwm ntawm kev tsim txom tshuaj yeeb dej caw. Yog li ntawd, kev saib xyuas lub siab ua haujlwm tsis tu ncua thiab suav cov qe ntshav dawb raug pom zoo thaum lub sijhawm kho ntev.
Kev ceev faj tshwj xeeb
Hydroxyzine dihydrochloride yuav tsum tau siv nrog ceev faj rau cov neeg mob uas muaj kab mob siab lossis lub raum tsis zoo, nrog rau cov neeg ua pa tsis txaus. Vim nws cov khoom sedative, cov neeg mob yuav tsum tsis txhob tsav tsheb lossis ua haujlwm ntawm lub tshuab thaum noj cov tshuaj no. Tsis tas li ntawd, kev haus cawv yuav tsum tau zam thaum kho kom tsis txhob muaj kev phiv ntau dhau.
Kev tshawb fawb thiab cov lus qhia yav tom ntej
Kev tshawb fawb tsis ntev los no tau nthuav dav cov peev txheej kho mob ntawm Hydroxyzine dihydrochloride tshaj nws cov kev siv ib txwm siv. Cov kev tshawb fawb tab tom tshawb nrhiav nws lub luag haujlwm hauv kev tswj cov kev puas siab puas ntsws, kev ntxhov siab, thiab kev tswj qhov mob. Tsis tas li ntawd, kev tshawb fawb txog kev kho mob sib xyaw ua ke txhawm rau txhim kho kev kho mob thiab txo cov kev mob tshwm sim.
Ib qho chaw tseem ceeb ntawm kev tshawb fawb yog kev siv Hydroxyzine dihydrochloride hauv cov neeg mob hauv cov menyuam yaus uas tau phais strabismus. Hauv ib qhov muag tsis pom kev, kev soj ntsuam kev soj ntsuam yav tom ntej, kev kho mob ua ntej nrog kev sib xyaw ntawm Hydroxyzine dihydrochloride thiab midazolam tau pom tias txo qis qhov tshwm sim ntawm oculocardiac reflex piv rau premedication nrog midazolam ib leeg. Qhov kev tshawb pom no qhia tias Hydroxyzine dihydrochloride tuaj yeem txhim kho cov tshuaj loog thiab sedative teebmeem ntawm midazolam, ua rau nws muaj txiaj ntsig ntxiv rau cov tshuaj premedication rau kev phais.
Ntxiv mus, kev tshawb fawb kuj tau tshawb xyuas lub peev xwm ntawm Hydroxyzine dihydrochloride ua ke nrog lwm cov tshuaj rau kev tswj hwm kev ntxhov siab, insomnia, thiab lwm yam kev puas siab puas ntsws. Cov kev tshawb fawb ua ntej qhia tau hais tias nws yuav muaj kev sib koom ua ke thaum siv nrog kev xaiv serotonin reuptake inhibitors lossis benzodiazepines, txhim kho lawv cov txiaj ntsig kho.
Kev tshawb pom ntawm cov hom phiaj tshuaj kho mob tshiab thiab kev txhim kho cov qauv tshiab yog kev siv zog txuas ntxiv los txhim kho cov kev kho mob ntawm Hydroxyzine dihydrochloride. Cov kev nce qib no tau cog lus rau kev siv dav dav thiab siv tau zoo dua yav tom ntej.
Xaus
Hydroxyzine dihydrochloride yog ib qho tshuaj sib xyaw ua ke nrog ntau yam kev siv tshuaj kho mob. Nws cov tshuaj antihistamine thiab anxiolytic zog ua rau nws txoj kev kho mob zoo rau kev ua xua, kev ntxhov siab, thiab cov mob neuropsychiatric. Txawm hais tias nws muaj peev xwm ua rau muaj kev phiv thiab kev cuam tshuam ntawm cov tshuaj, kev saib xyuas kom raug thiab ua raws li cov tshuaj noj tshuaj yuav ua kom muaj kev nyab xeeb thiab siv tau zoo. Nrog rau kev tshawb fawb thiab kev loj hlob tsis tu ncua, Hydroxyzine dihydrochloride tau npaj los ua lub luag haujlwm tseem ceeb hauv cov tshuaj niaj hnub, muab kev pab rau cov neeg mob uas muaj ntau yam kev xav tau kev kho mob.