Lub hauv paus rau phau ntawv
Chlorpromazine hydrochloride, tseem hu ua Thenothine, yog ib lub luag haujlwm phepotiaz uas tau ua lub luag haujlwm tseem ceeb hauv keeb kwm ntawm kev siv hlwb ntawm psychopharmacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacation. Txij li thaum nws tshawb pom ntawm xyoo 1950, CLORPrromazine tau kawm ntau yam thiab siv hauv kev kho mob ntawm ntau yam kev mob hlwb. Kab lus no muab cov kev thov kho mob ntawm chlorpromazine hydrochloride, tsom mus rau nws txoj kev ua tau zoo, kev nyab xeeb, thiab kev tshawb fawb tam sim no.
Khoom Code: BM -2-5-123
Hmong npe Askiv: Chlorpromazine hydrochloride
CAS TSIS MUAJ.: 69-09-0
Molecular cov mis: C17H20Cl2n2s
Molecular hnyav: 355.33
Eineecs tsis muaj.: 200-701-3
MDL No.:MFCD00012654
HS code: 29173980
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab chlorpromazine hydrochloride hmoov cas 69-09-0}}}}}}}}}, thov saib cov vev xaib no kom paub cov ncauj lus kom ntxaws thiab cov ntaub ntawv.
Keeb Kwm Keeb Kwm
Chlorpromazineyog thawj synthesized nyob rau xyoo 1950 los ntawm tus Fabkis Chemist Paul Pillentier ntawm Rhône-Poulenc kuaj. Thaum pib, nws tau sim ua ib qho muaj peev xwm antihistamine, tab sis nws cov kev cuam tshuam sedative rau cov neeg mob LED cov kws tshawb nrhiav tshawb xyuas nws lub peev xwm hauv kev puas hlwb. Xyoo 1952, cov tshuaj tau qhia rau hauv kev coj ua ntawm kev tshawb fawb ntawm Pierre Deniker thiab Jean ncua hauv kev kho mob ntawm cov neeg mob ntxhov siab. Qhov no cim pib pib ntawm lub caij nyoog niaj hnub ntawm cov tshuaj tiv thaiv kab mob antipsychimtic.
Pharmacological cov zog
Chlorpromazine hydrochloride yog kev tawm tsam dopamine uas ua feem ntau los ntawm kev thaiv dopamine receptors hauv nruab nrab lub paj hlwb. Nws tseem muaj cov tseem ceeb los tiv thaiv clochergic, tiv thaiv histaminic, thiab tawm tsam adrengic cov yam ntxwv. Cov txiaj ntsig hluav taws xob pab txhawb rau nws cov spectrum dav ntawm kev kho cov kev ua, tab sis kuj ua rau muaj kev phiv ntau.
Mechanism ntawm Kev Ua
Chlorpromazine thawj mechanism ntawm kev nqis tes ua cuam tshuam nrog thaiv dopamine D2 txais hauv lub hlwb. Qhov kev ua no txo cov kev ua si ntau dhau uas ntseeg tau tias ntseeg tau tias muaj cov tsos mob hauv qab xws li ua kom zoo xws li kev ua kom zoo nkauj thiab delusions. Ib qho ntxiv, chlorpromazine lub anti-choti-chori-antiative cov khoom siv, thaum nws cov teebmeem kev ntseeg siab yuav ua rau nws cov kev tawm tsam emetic thiab sedation.
Cov Ntawv Thov Kev Kho Mob
Schizophrenia thiab lwm yam kev mob siab ntsws
Chlorpromazine yog feem ntau siv nyob rau hauv kev kho mob ntawm schizophrenia thiab lwm yam kev cuam tshuam ntawm lub hlwb. It has been shown to be effective in reducing positive symptoms such as hallucinations, delusions, and disorganized thinking. Hauv kev tshawb fawb thaj av hauv xyoo 1950, CLORPromazine tau pom tias ua tau zoo dua li cov khoom siv hluav taws xob ua rau cov neeg mob psybroics hauv cov neeg mob schizophrenia.
Niaj hnub nub tshuaj tiv thaiv, xws li risperidone thiab olanzapine, muaj ntau dua hloov chlorpromazine vim lawv sab kev txhim kho profiles. Txawm li cas los xij, chlorpromazine tseem siv qee kis, tshwj xeeb hauv cov neeg mob uas tsis teb cov tshuaj tshiab tshiab lossis tus neeg tsis tuaj yeem tiv thaiv lawv cov kev mob tshwm sim.
Kev puas siab bipolar
Chlorpromazine kuj tau siv nyob rau hauv kev kho mob bipolar puas tsuaj, tshwj xeeb hauv kev tswj hwm ntawm cov neeg mob maticodes. Nws cov kev sedative thiab tiv thaiv dopaminergic kev mob tuaj yeem pab txo kom muaj kev ntxhov siab, kev ua phem, thiab cov tsos mob psanicicic uas yuav nrog Mania. Txawm li cas los xij, vim nws lub peev xwm los ua kev nyuaj siab thiab nws qhov tshwm sim siab ntawm cov kev mob tshwm sim, CADRromazine tsis yog feem ntau yog ib qho kev kho mob thawj zaug rau kev puas siab ntsws bipolar.
Ntxhov siab vim muaj kev ntxhov siab
Chlorpromazine anti-ntxhov siab cov khoom tau ua rau nws siv nyob rau hauv kev kho mob ntawm kev ntxhov siab ntxhov siab thiab lwm yam kev ntxhov siab. Txawm li cas los xij, nws cov teebmeem tshwm sim thiab muaj peev xwm rau kev ntsuas txwv nws siv hauv cov ntsiab lus no. Benzodiazepines thiab xaiv serotonin ruptors (SSRIS) feem ntau nyiam rau kev kho mob ntawm kev ntxhov siab vim lawv cov txiaj ntsig zoo dua vim lawv cov txiaj ntsig zoo tshaj plaws.
Xeev siab thiab ntuav
Chlorpromazine yog cov tshuaj tiv thaiv zoo los tiv thaiv xeev siab thiab ntuav nrog ntau yam kev mob siab thiab ntuav (PONVING (PONVING (PIGNING (Pigraine-txuam nrog xeev siab. Nws cov txiaj ntsig tawm tsam yog ntseeg tias yog vim nws lub chaw hauv paus tiv thaiv dopaminergic thiab cov tshuaj tiv thaiv kab mob chotriergic.
Nyob rau hauv cov ntsiab lus ntawm cinv, chlorpromazine feem ntau siv hauv kev sib xyaw nrog lwm cov tshuaj tiv thaiv kab mob, kom muab kev tswj hwm ntawm xeev siab thiab ntuav.
Kev tswj hwm qhov mob
Chlorpromazine tau siv los ua kev sib tw hauv kev tswj hwm kev mob mob hnyav, tshwj xeeb hauv cov neeg mob mob qog noj ntshav. Nws cov txiaj ntsig sedative thiab tiv thaiv kev ntxhov siab tuaj yeem pab txo qis kev pom ntawm qhov mob thiab txhim kho tus neeg mob siab. Txawm li cas los xij, nws siv hauv kev tswj hwm qhov mob feem ntau yog txwv vim muaj cov tshuaj uas muaj txiaj ntsig zoo thiab tshwj xeeb.
Lwm Cov Ntawv Thov
Chlorpromazine tau kawm rau nws cov peev xwm siv nyob rau hauv ntau yam ntawm lwm yam kev mob, suav nrog Porphyria, Tetanus, thiab kev ua ntsos, thiab kev ua niam ua siab zoo. Txawm li cas los xij, nws siv nyob rau hauv cov ntsiab lus no feem ntau muaj kev txwv vim muaj ntau yam tshwj xeeb thiab kev kho zoo.
Kev phiv thiab kev cuam tshuam kev nyab xeeb
Txawm hais tias nws kho cov txiaj ntsig, chlorpromazine yog txuam nrog ntau cov kev mob tshwm sim uas tuaj yeem txwv nws siv hauv qee cov neeg mob. Kev phiv zoo xws li txaus ntshai, kiv taub hau, qhov ncauj qhuav, quav ntsej muag, thiab xiav lub zeem muag. Cov kev phiv loj loj dua suav nrog cov tsos mob sib txawv (EPS), tardive dyskinesia, ortostatic hypotension, thiab agranulocytosis.
EPS yog ib pab pawg txav tsis zoo uas yuav tshwm sim los ntawm cov tshuaj tiv thaiv kab mob antocschotic, suav nrog chlorpromazine. Cov tsos mob no tuaj yeem suav nrog Dystonia, Akathisia, Parkinsonism, thiab Tardive Dyskinesia. Qhov kev pheej hmoo ntawm EPS yog feem ntau siab dua nrog cov antipsychotics zoo li chlorpromazine thiab tuaj yeem raug txo qis thiab tuaj yeem raug txo qis thiab maj mam teev cov tshuaj.
Tardive Dyskinesia yog ib qho kev tsis txaus ntshai txav kev cuam tshuam uas tuaj yeem txhim kho tom qab siv tshuaj tiv thaiv kev tiv thaiv kev siv tshuaj tiv thaiv. Nws yog tus cwj pwm los ntawm kev tsis tuaj yeem, rov ua dua lub ntsej muag ntawm lub ntsej muag, tus nplaig, lossis nqua. Txoj kev pheej hmoo ntawm tardive dyskinesia nce nrog lub sijhawm ntawm kev kho thiab qhov sib xyaw ntawm cov tshuaj. Cov neeg mob nyob rau lub sijhawm ntev chlorpromazine yuav tsum saib xyuas saib xyuas kom pom cov paib ntawm Todive Dyskinesia.
OrthoTatic hypoticty yog qhov poob rau cov ntshav siab uas tshwm sim thaum sawv, ua rau cov tsos mob xws li kiv taub hau, ligrimedness, thiab tsaus muag. Chlorpromazine tuaj yeem ua rau orthostatic hypotension vim nws cov kev cuam tshuam tawm tsam adrengic. Patients on chlorpromazine therapy should be advised to rise slowly from a sitting or lying position to minimize the risk of orthostatic hypotension.
Agranulocytosis yog qhov tsis tshua muaj tab sis muaj feem cuam tshuam txog kev ua kom muaj kev cuam tshuam ntawm Chlorpromazine uas cuam tshuam nrog kev txo qis hauv cov ntshav dawb. Qhov no tuaj yeem ua rau muaj kev pheej hmoo kis tau ntau ntxiv. Cov neeg mob ntawm Chlorpromazine txoj kev pabcuam yuav tsum raug saib xyuas kom pom cov tsos mob kis tus kab mob thiab muaj lawv cov qe ntshav dawb suav mus kuaj tsis tu ncua.
Kev sib cuam tshuam yeeb tshuaj
Chlorpromazine tuaj yeem cuam tshuam nrog ntau yam ntawm lwm cov tshuaj noj, ua rau muaj kev cuam tshuam loj heev. Piv txwv li, nws tuaj yeem muaj zog ua kom muaj kev cuam tshuam ntawm kev haus cawv, barckiturates, thiab lwm yam kev ua haujlwm hauv nruab nrab ntawm kev ntxhov siab. Nws tseem tuaj yeem cuam tshuam nrog tshuaj tua kab mob, ua rau muaj kev pheej hmoo siab ntawm kev mob siab rau orthostatic. Cov neeg mob ntawm chlorpromazine yuav tsum tau qhia kom tsis txhob haus cawv thiab lwm yam kev ua haujlwm hauv nruab nrab thiab qhia lawv cov tshuaj kho mob txog txhua yam tshuaj uas lawv noj.
Kev tshawb fawb tam sim no thiab yav tom ntej cov lus qhia
Txawm tias muaj kev txhim kho cov tshuaj tua kab mob tshiab ntawm cov tshuaj tiv thaiv tshiab nrog cov khoom siv txhim kho cov txiaj ntsig, cenporpromazine tseem yuav yog cov kev tshawb fawb hauv ntau cov ntsiab lus. Kev tshawb fawb txuas ntxiv yog tsom rau kev nkag siab txog cov txheej txheem uas ua raws li nws cov kev cuam tshuam thiab kev tshawb nrhiav nws cov peev txheej hauv cov chaw kho tshiab.
Pharmacogenomics
Pharthacogenomics yog kev kawm txog kev hloov caj ces cuam tshuam li cas rau ib tus neeg cov lus teb rau cov tshuaj. Kev tshawb fawb hauv thaj chaw no tau txheeb xyuas ntau txoj kev sib txawv ntawm cov kev sib txawv ntawm cov neeg cov lus teb rau Chlorpromazine. Piv txwv li, kev hloov pauv hauv Dopamine D2 Receptor Gene tau pom tias cuam tshuam rau kev ua tau zoo thiab sab ntawv Profile ntawm chlorpromazine. Kev tshawb fawb yav tom ntej hauv tshuaj yuav pab txheeb xyuas cov neeg mob uas feem ntau yuav tau txais txiaj ntsig los ntawm CLORPromazine kev kho thiab cov neeg uas muaj kev pheej hmoo ntawm kev tsis zoo.
Rov qab ua rau mob qog noj mis
Cov kev tshawb fawb tsis ntev los no tau hais tias Chlorpromazine tej zaum yuav muaj peev xwm ua tus kab mob kev tiv thaiv mob cancer. Cov kev tshawb fawb tau pom tias Chlorpromazine tuaj yeem cuam tshuam tau ntau yam kev loj hlob ntawm ntau yam kabmob ntawm tes thiab indophet autophagy thiab kev ua haujlwm ntawm lub voj voog. Txawm li cas los xij, cov txheej txheem uas cuam tshuam cov teebmeem no tsis nkag siab, xav tau kev nkag siab ntxiv, xav tau kev txiav txim siab ntxiv los txiav txim siab txog cancerpromazine hauv kev kho mob cancer.
Kev Kho Mob
Kev kho kom haum, muaj feem xyuam nrog kev siv ntau yam tshuaj nrog cov txheej txheem sib txawv ntawm kev nqis tes ua, yog qhov kev tawm tsam ntawm kev kho mob hlwb. Kev tshawb fawb tab tom tshawb nrhiav cov txiaj ntsig zoo ntawm kev sib txuas nrog kev sib xyaw nrog lwm cov tshuaj, xws li cov tshuaj tiv thaiv kev siv tshuaj tua kab mob, txhawm rau txhim kho cov txiaj ntsig kev kho mob thiab txo cov kev mob tshwm sim.
Tag
Chlorpromazine hydrochloride tau ua lub luag haujlwm tseem ceeb nyob rau hauv keeb kwm ntawm kev tiv thaiv kev yog ib qho kev kho mob tseem ceeb rau kev kho mob hlwb. Nws cov spectrum dav ntawm kev kho thiab tsim qauv kev nyab xeeb kom nws muaj cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob hlwb. Txawm li cas los xij, nws siv yuav tsum ua tib zoo sib piv tiv thaiv nws cov kev mob tshwm sim, tshwj xeeb hauv cov neeg mob uas muaj kev pheej hmoo ntawm kev cuam tshuam loj.
Kev tshawb fawb txuas ntxiv hauv chaw muag tshuaj hauv kev kho mob qog noj mis, thiab kev sib xyaw ua ke yuav ua rau cov kev kho mob tshiab thiab txhim kho cov txiaj ntsig kev kho mob rau cov neeg mob hlwb. Raws li peb kev nkag siab txog cov txheej txheem nyob rau hauv kev tsis sib haum xeeb kev tsis sib haum xeeb txuas ntxiv mus ntxiv, nrog Chlorpromazine tseem tshuav ib qho tseem ceeb hauv lub toj roob hauv pes no?