Tsis zoo siv
Silibinin, ib qho ntuj flavonoid tau los ntawm mis thistle, tau tau txais kev mloog tseem ceeb nyob rau xyoo tas los vim muaj ntau hom Pharmacological. Cov lus tshawb nrhiav no yog kev tshuaj xyuas cov ntawv thov kev sib raug zoo, tsom mus rau nws cov kab mob los tiv thaiv kab mob, tiv thaiv cov teebmeem, thiab kev tawm tsam kev tiv thaiv kab mob, thiab kev tawm tsam zoo nkauj. Los ntawm kev txheeb xyuas kev txheeb xyuas ntau ntawm cov kev tshawb fawb tsis ntev los no, qhov kev tshuaj xyuas no ua rau eliminin muaj peev xwm ntawm silibinin hauv ntau yam kab mob thiab cov kab mob.
Peb muab silibinin hmoov cas 22888-70-6}}}}}}, Thov saib mus rau lub vev xaib hauv qab no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Lub hauv paus rau phau ntawv
Silibinin, tseem hu ua Silymarin Dihydrogen citrate, yog qhov feem ntau biologically acative tivthaiv ntawm slymarin, uas tau muab rho tawm los ntawm cov kua mis thistle cog (Silybum Marianum). Silibinin tau siv rau kev kho mob ntawm cov kab mob siab, suav nrog kab mob siab thiab mob siab thiab mob siab ua kom muaj zog. Txawm li cas los xij, cov kev tshawb fawb tsis ntev los no tau pom tias muaj kev saib xyuas dav dav uas cuam tshuam nrog silibinin, suav nrog cov tshuaj tiv thaiv mob cancer, thiab tiv thaiv oxidative, thiab anti-oxidative. Qhov kev tshuaj xyuas no yuav qhia txog cov ntawv thov kev kho mob ntawm Silibinin hauv ntau qhov chaw kho mob.
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Los tiv thaiv kev cuam tshuam cancer
Silibinin tau qhia cov ntsiab lus muaj txiaj ntsig hauv kev kho mob ntawm ntau hom mob qog noj ntshav, suav nrog lub mis, prostate, tawv nqaij, zais zis. Nws cov tshuaj tua kab mob tawm tsam koom nrog kev tiv thaiv cov kws tshuaj ntsuam xyuas ntawm tes, Angiogenesis, thiab Metastasis, thiab kev ua yeeb yam hauv lub voj voog.
Firstly, silibinin cov khoom pov thawj muaj peev xwm tiv thaiv kev tawm tsam, uas txhais tau nws tuaj yeem cuam tshuam txoj kev tswj tsis tau cov kabmob kheesxaws tsis raug mob. Qhov no yog qhov tseem ceeb npaum li cov neeg muaj peev xwm sai yog qhov ua rau mob cancer. Los ntawm kev ua kom qeeb lossis nres lub faib ntawm cov qog nqaij hlav cancer, silibinin pab kom txwv txoj kev kis tau thiab muaj kev loj hlob.
Thib ob, silibinin lub hom phiaj Angiogenesis, txheej txheem los ntawm qhov twg cov ntshav tshiab cov ntshav ua rau cov qog noj ntshav ntxiv. Los ntawm inhibiting angiogenesis, silibinin txiav tawm cov ntshav muab rau cov qog thiab cov kua txiv thiab oxygen nws yuav tsum muaj sia nyob thiab loj hlob.
Ntxiv mus, silibinin tau pom tias yuav ua rau muaj kev cuam tshuam, muaj peev xwm ntawm cov qog nqaij hlav cancer kom kis mus rau lwm qhov ntawm lub cev. Qhov no yog ua tiav los ntawm kev cuam tshuam cov phiajcim txoj hauv kev uas cov kabmob kheesxaws siv los txeeb cov ntaub so ntswg nyob puag ncig thiab tsiv mus nyob deb.
Ntxiv nrog rau cov txheej txheem no, silibinin tseem ua rau apoptosis, ib tug programmed cell tuag tus txheej txheem uas tshem tawm cov hlwb puas lossis tsis xav tau. Los ntawm kev ua kom muaj ntxhiab tsw qaboptosis hauv cov qog nqaij hlav cancer, silibinin pab txo kom cov tawv nqaij yuag thiab ua kom qeeb qeeb zuj zus.
Tsis tas li ntawd, Silibinin tuaj yeem ua rau lub voj voog ntawm tes, lub ntsiab lus nws nres nws cov kabmob kheesxaws ntawm qhov tshwj xeeb hauv lawv txoj kev loj hlob thiab kev sib yuav. Qhov no tiv thaiv lawv los ntawm ua kom tiav lub voj voog thiab faib rau hauv cov hlwb tshiab, yog tsis muaj kev txwv lawv lub peev xwm los tso cai thiab tsim cov qog.
Ntau cov kev tshawb fawb tau tshawb xyuas qhov ua tau zoo ntawm silibinin hauv Cancer mis. Hauv cov kev tshawb fawb vitro thiab tsiaj txhu muaj pom tias silibinin tuaj yeem cuam tshuam cov kab mob cancer ntawm downregulating ntawm lub ntsej muag thiab cov qog ua siab dawb. Tsis tas li ntawd, Silibinin tau pom tias muaj tshuaj kho mob tso pa, xws li Paclitaxel thiab Cisplatin, hauv kev txhim kho cov nyhuv kho mob kheesxaws mis.
Silibinin kuj tau pom muaj peev xwm ua tau kev kho mob kheesxaws mob prostate. Nws tau pom tias inhibit txoj kev loj hlob thiab kev nce qib ntawm prostate cancer hlwb los ntawm kev ua kom muaj kev ua kom lub androgen receptor thiab erbb2 / her2 signaling txoj kev. Tsis tas li ntawd, silibinin tuaj yeem txo cov prostate-tshwj xeeb antigen (PSA) qib, uas yog biomarker rau prostate rau prostate rau prostate.
Silibinin muaj kev tiv thaiv cov teebmeem tiv thaiv photocarcinogenesis, uas yog kev txhim kho ntawm daim tawv nqaij yog vim raug rau ultraviolet (UV) hluav taws xob. Cov kev tshawb fawb tau pom tias silibinin tuaj yeem inhibit txoj kev loj hlob thiab kev ua tiav ntawm cov protein ntawm lub voj voog los ntawm kev txhim kho cov protein ntau (maps), thiab akt signing
Silibinin tau pom tias inhibit txoj kev loj hlob ntawm cov neeg liam ntawm cov qog nqaij hlav hauv cov gene ntawm lub koob ciaj sia muaj sia, uas cuam tshuam nrog cell muaj sia nyob thiab proliferation. Qhov no qhia tau tias silibinin tej zaum yuav muaj peev xwm ua tus neeg saib xyuas tshuaj chemical rau cov zais cancer.
Kev noj haus silibinin tau pom tias nyob rau hauv inhibit txoj kev loj hlob thiab kev loj hlob ntawm thawj lub qog hauv nas. Cov nyhuv no yog kho kom haum los ntawm kev txwv ntawm ERK-nyob hauv C-Jun / AP} induction ntawm mmp {}}, uas yog koom nrog hauv kev ntxaij qog thiab metastasis.
Anti-inflammatory teebmeem
Silibinin tseem tau pom los ntawm cov neeg tawm tsam kev cuam tshuam hauv ntau yam kab mob thiab cov xwm txheej. Nws cov tshuaj tua hluav taws xob tiv thaiv kev tsim cov canniakines,} (tna} (tnf-), thiab muaj kev tiv thaiv kev ua haujlwm ntawm kev ua haujlwm ntawm kev ua haujlwm no Factor-κb (NF-κB) thiab Maps.
Rheumatoid Mob
Silibinin tau pom muaj peev xwm nyob rau hauv kev kho mob rheumatoid mob caj dab (RA) los ntawm inhibiting canning cytokines thiab txo cov o mob thiab kev rhuav tshem.
Inflammatory bowel kab mob
Silibinin tau pom tias ameliorate offel kab mob (IBD) hauv cov qauv tsiaj los ntawm kev ua haujlwm ntawm NF-κb thiab maps thiab maps cannines.
Kev tiv thaiv oxidative
Silibinin muaj cov khoom siv hauv qab-oxidative thaj chaw, uas ua rau nws muaj txiaj ntsig zoo rau kev kho mob ntawm oxidation cov kab mob. Nws cov txheej txheem oxidation cuam tshuam nrog cov kab mob oxygen
Mob siab Kab Mob
Silibinin tau siv tas li rau kev kho kab mob ntsws, suav nrog kab mob siab thiab mob siab. Nws cov teebmeem hepatoproprotective yog cov kev kho kom haum los ntawm nws cov khoom tiv thaiv oxidative, uas tiv thaiv hepatocytes los ntawm oxidative kev puas tsuaj.
Kab mob plawv
Silibinin tau qhia cov kab mob plawv thiab kho cov kab mob plawv los ntawm kev tiv thaiv oxiding oxidingosclerosis thiab vascular dysfunction.
Lwm cov ntawv thov kho mob
Dhau li nws cov tshuaj tiv thaiv mob cancer, anti-inflampatory, thiab anti-oxidative, silibinin kuj tau qhia muaj peev xwm ua rau kev kho mob ntawm lwm cov kab mob thiab cov xwm txheej.
Ntshav qab zib
Silibinin tau pom tias txhawm rau txhim kho cov insabolism thiab cov roj ntsha me me hauv cov tsiaj muaj mob ntshav qab zib, tawm tswv yim nws lub peev xwm los kho tus kab mob no.
Chra Mob Mob Mob Mob Mob Mob
Silibinin tau qhia cov teebmeem tiv thaiv kev raug mob raum hauv cov qauv tsiaj ntawm cov kab mob raum, uas yog kho kom haum rau nws cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv.
Kev neuroprotection
Silibinin tau pom cov teebmeem ntawm cov tsiaj ntawm cov kab mob nurodegenerative cov kab mob thiab tus kab mob Parketon, los ntawm kev cuam tshuam oxidating oxidative kev ntxhov siab thiab mob.
Tag
Hauv kev xaus, silibinin tau qhia txog cov kab mob thiab cov kab mob plawv, ntshav qab zib, mob raum, thiab neurodegenerative kab mob. Nws cov tshuaj tua kab mob tawm tsam koom nrog kev tiv thaiv cov kws tshuaj ntsuam xyuas ntawm tes, Angiogenesis, thiab Metastasis, thiab kev ua yeeb yam hauv lub voj voog. Nws cov khoom siv tawm tsam thiab tiv thaiv oxidative cov khoom ua rau nws muaj txiaj ntsig zoo hauv kev kho mob ntawm oxidation-offource. Cov kev tshawb fawb ntxiv yog xav tau rau elucategs ntawm kev ua ntawm silibinin thiab los tsim cov tswv yim zoo siv rau nws daim ntawv thov kho mob.
Yav tom ntej ntawm silibinin hauv kev kho mob tshuaj zoo li muaj kev cia siab, nrog cov ntawv thov yuav muaj kab mob ntau. Raws li kev tshawb fawb txuas ntxiv mus qhia cov haujlwm tshiab uas cuam tshuam nrog lub ntuj flavonoid, siliinin yuav dhau los ua kev kho mob ntawm ntau yam kev kho mob.