Kev tshawb fawb soj ntsuam ntawm Oxacillin Sodium

Oxacillin Sodium hmoov, tseem hu ua cryptocillin, yog ib qho tshuaj tua kab mob isoxazolyl penicillin semi-synthetic. Nws cov qauv tshuaj yog C19H18N3NaO5S, nrog rau qhov hnyav molecular ntawm 423.42. Cov tshuaj no feem ntau yog siv los kho cov kab mob uas tshwm sim los ntawm Staphylococcus aureus thiab Staphylococcus epidermidis uas tiv taus penicillin G, nrog rau cov kab mob hauv lub cev, tawv nqaij, thiab cov nqaij mos. Txawm li cas los xij, nws feem ntau tsis haum rau cov kab mob hauv nruab nrab paj hlwb. Txoj kev tshawb fawb soj ntsuam no yog txhawm rau tshawb nrhiav kev ua tau zoo thiab kev nyab xeeb ntawm Oxacillin Sodium hauv ntau qhov chaw kho mob.

Keeb Kwm thiab Kev Taw Qhia

Oxacillin Sodium yog cov hmoov dawb lossis crystalline hmoov uas tsis muaj ntxhiab lossis tsw ntxhiab me ntsis. Nws yog soluble heev hauv dej tab sis tsuas yog me ntsis soluble hauv acetone los yog butanone. Raws li ib tug -lactam tshuaj tua kab mob thiab penicillin derivative, Oxacillin Sodium yog tshwj xeeb tshaj yog zoo tiv thaiv penicillinase-producing Staphylococcus aureus. Nws ua haujlwm los ntawm inhibiting cov synthesis ntawm cov kab mob ntawm cov phab ntsa ntawm tes, yog li ua rau cov kab mob bactericidal.

Cov lus qhia rau Oxacillin Sodium suav nrog kev kho mob ntawm penicillinase-ua rau Staphylococcus aureus kab mob, xws li sepsis, endocarditis, mob ntsws, thiab kab mob ntawm daim tawv nqaij thiab cov nqaij mos. Nws tuaj yeem siv tau rau hauv cov kab mob sib xyaw ua ke los ntawm Streptococcus pyogenes lossis Streptococcus pneumoniae nrog penicillin-resistant Staphylococcus aureus.

Phau ntawv txheeb xyuas

Cov kev tshawb fawb yav dhau los tau tshawb xyuas kev siv Oxacillin Sodium hauv ntau qhov chaw kho mob. Piv txwv li, ib txoj kev tshawb fawb tshawb fawb txog kev txiav txim siab ntawm butyl acetate residue hauv Oxacillin Sodium siv headspace gas chromatography. Lwm txoj kev tshawb fawb siv qhov sib txawv thermal tsom xam los txiav txim qhov thermal degradation kinetic tsis ntawm cov khoom Oxacillin Sodium. Cov kev tshawb fawb no muab lub hauv paus rau kev nkag siab txog physicochemical zog thiab kev ruaj ntseg ntawm Oxacillin Sodium.

Kawm Tsim thiab Cov Txheej Txheem

Qhov kev tshawb fawb soj ntsuam no tau ua los ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm Oxacillin Sodium hauv kev kho mob Staphylococcus scalded skin syndrome (SSSS). SSSS yog ib qho kab mob ntawm daim tawv nqaij hnyav tshwm sim los ntawm Staphylococcus aureus, uas tshwm sim los ntawm kev nthuav dav liab, tev, thiab hlwv ntawm daim tawv nqaij. Txoj kev tshawb no tau ua nyob rau ntawm Zhumadian Central Tsev Kho Mob txij lub Peb Hlis 2016 txog Lub Peb Hlis 2017.

Tag nrho ntawm 125 tus menyuam yaus nrog SSSS tau tso npe rau hauv txoj kev tshawb no thiab muab faib ua pawg tswj hwm (62 tus neeg mob) thiab pab pawg kho mob (63 tus neeg mob). Pab pawg tswj hwm tau txais kev txhaj tshuaj (IV) Oxacillin Sodium rau kev txhaj tshuaj ntawm koob tshuaj 12.5 mg / kg ntxiv rau ib qho me me ntawm cov dej tsis muaj menyuam rau kev txhaj tshuaj, peb zaug ib hnub. Cov pab pawg kho mob tau txais kev txhaj tshuaj ntawm Xiyanping txhaj tshuaj intramuscular (IM) ntxiv rau kev kho mob Oxacillin Sodium, ntawm ib koob ntawm 10 mg / kg ntxiv rau me me ntawm cov dej tsis muaj menyuam rau kev txhaj tshuaj, ob zaug ib hnub. Ob pab pawg tau kho ob lub lis piam.

Qhov txiaj ntsig tseem ceeb ntawm kev ntsuas yog qhov ua tau zoo ntawm kev kho mob, ntsuas los ntawm kev sib piv kev txhim kho ntawm cov ntsuas ntsuas, cov ntshav dawb suav, thiab interleukin -6 (IL-6) qib ua ntej thiab tom qab kho. Cov txiaj ntsig thib ob ntsuas suav nrog lub sijhawm tshuaj tiv thaiv kab mob, Nikolsky lub sijhawm hloov pauv tsis zoo, lub sijhawm ziab ntawm thaj chaw liab qab, thiab lub sijhawm herpes regression.

Cov txiaj ntsig

Tom qab ob lub lis piam ntawm kev kho mob, kev soj ntsuam kev ua tau zoo hauv pawg tswj hwm yog 82.26%, thaum nyob hauv pab pawg kho mob, nws yog 95.24%. Qhov sib txawv ntawm ob pawg yog qhov tseem ceeb (P < 0.05).

Lub sijhawm antipyretic, Nikolsky lub sijhawm hloov pauv tsis zoo, lub sijhawm ziab ntawm thaj chaw liab qab, thiab lub sijhawm herpes regression hauv pab pawg kho mob tau luv dua li cov hauv pawg tswj hwm. Qhov sib txawv ntawm ob pawg kuj tseem ceeb heev (P < 0.05).

Ua ntej kev kho mob, cov ntshav dawb suav thiab IL {{0}} qib hauv ob pawg tau nce siab. Tom qab kev kho mob, cov qe ntshav dawb suav thiab IL-6 qib hauv ob pawg tau txo qis, nrog rau qhov sib txawv tseem ceeb hauv tib pab pawg (P < 0.05). Tsis tas li ntawd, cov ntshav dawb suav thiab IL-6 qib hauv pab pawg kho mob tom qab kho tau qis dua li cov hauv pawg tswj hwm, nrog rau qhov sib txawv tseem ceeb ntawm ob pawg (P <0.05).

Kev sib tham

Cov txiaj ntsig ntawm txoj kev tshawb fawb no qhia tau hais tias kev sib xyaw ntawm Xiyanping Txhaj Tshuaj thiab Oxacillin Sodium ua haujlwm zoo thiab nyab xeeb hauv kev kho SSSS. Kev kho mob ntawm pab pawg kho mob tau nce siab dua li ntawm pawg tswj hwm, qhia tias qhov sib ntxiv ntawm Xiyanping Txhaj Tshuaj txhim kho cov txiaj ntsig kho ntawm Oxacillin Sodium.

Lub sij hawm antipyretic luv luv, Nikolsky lub cim tsis zoo hloov lub sij hawm, qhuav lub sij hawm ntawm qhov chaw liab qab, thiab herpes regression lub sij hawm nyob rau hauv cov kev kho mob pab pawg neeg qhia hais tias qhov kev kho mob sib xyaw ua ke yuav ua tau sai dua kho cov tsos mob thiab txhawb rov qab.

Qhov tseem ceeb txo qis hauv cov ntshav dawb suav thiab IL-6 qib tom qab kev kho mob ntxiv tau lees paub cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm qhov kev sib xyaw ua ke no. Cov qib qis ntawm cov cim inflammatory no nyob rau hauv pab pawg kho mob piv rau pawg tswj xyuas qhia tau hais tias muaj kev tawm tsam ntau dua.

Kev xav txog kev nyab xeeb

Oxacillin Sodium tuaj yeem ua rau muaj kev tsis haum tshuaj, nrog rau kev poob siab anaphylactic. Yog li ntawd, kev kuaj kev tsis haum tshuaj yuav tsum tau ua ua ntej kev tswj hwm. Cov kab mob hauv plab xws li xeev siab, ntuav, mob plab, raws plab, thiab anorexia kuj tuaj yeem tshwm sim, tshwj xeeb tshaj yog thaum noj qhov ncauj. Lwm yam kev phiv tshwm sim muaj xws li venous o, neurological cov tshuaj tiv thaiv (xws li convulsions, spasms, tsis meej pem, thiab mob taub hau) ntawm koob tshuaj ntau, thiab ib tug nyiam los ntshav rau cov tib neeg. Qee cov neeg mob kuj tseem muaj cov enzymes siab siab, uas feem ntau rov qab mus rau qhov qub tom qab txiav cov tshuaj.

Xaus

Hauv kev xaus, qhov kev tshawb fawb soj ntsuam no qhia tau hais tias kev sib xyaw ntawm Xiyanping Txhaj Tshuaj thiab Oxacillin Sodium ua haujlwm zoo thiab nyab xeeb hauv kev kho mob ntawm Staphylococcus scalded tawv nqaij syndrome. Kev sib xyaw ua ke kho tau zoo txhim kho cov tsos mob, txo cov cim inflammatory, thiab txhawb kev rov zoo sai. Txawm li cas los xij, vim muaj peev xwm ua rau muaj kev tsis haum tshuaj thiab lwm yam kev phiv, kev saib xyuas kom zoo thiab kev tswj xyuas tsim nyog yuav tsum tau ua thaum kho.

Cov kev tshawb fawb yav tom ntej yuav tsum tau tshawb xyuas ntxiv txog qhov ua tau zoo thiab kev nyab xeeb ntawm qhov kev sib xyaw ua ke no hauv cov neeg mob loj dua thiab hauv cov chaw kho mob sib txawv. Tsis tas li ntawd, kev tshawb fawb txog pharmacokinetic thiab pharmacodynamic cov khoom ntawm Oxacillin Sodium ua ke nrog lwm cov tshuaj yuav muab kev nkag siab rau kev kho kom zoo dua qub thiab txhim kho cov txiaj ntsig ntawm tus neeg mob.

Hauv cov ntsiab lus, Oxacillin Sodium yog ib qho tshuaj tua kab mob tseem ceeb hauv kev kho cov kab mob Staphylococcus aureus, tshwj xeeb tshaj yog cov tshuaj tiv thaiv penicillin G. Nrog rau kev saib xyuas thiab kev tswj xyuas kom tsim nyog, nws tuaj yeem siv tau zoo thiab zoo los txhim kho cov txiaj ntsig ntawm tus neeg mob.