Tianeptine sulfate, ib tug subordinate ntawm stimulant tianeptine, tau raug kev sib tham ntau li ntawm lig. Raws li cov kws tshawb fawb txuas ntxiv tshawb xyuas nws cov cuab yeej ntawm kev ua ub no, ib qho kev nug tshwm sim: nws puas txuas nrog narcotic receptors? Hauv tsab xov xwm no, peb yuav dhia tob rau hauv kev nkag siab tsis tu ncua ntawm nws qhov tshwm sim rau lub siab, nws muaj peev xwm koom tes nrog cov tshuaj receptors, thiab yuav ua li cas qhov no cuam tshuam rau nws txoj kev siv thiab kev ruaj ntseg profile.
Peb muab tianeptine sulfate, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Taw qhia ntawm Tianeptine Sulfate
Ua ntej peb hais txog thawj qhov kev nug, nws yog ib qho tseem ceeb kom nkag siab tias nws yog dab tsi thiab txoj hauv kev uas nws txawv ntawm nws cov poj koob yawm txwv, tianeptine sodium. Nws yog ib hom kev hloov pauv ntawm tianeptine, npaj kom muaj kev txhim kho bioavailability thiab txuas ntxiv ib nrab-lub neej. Thaum xub thawj tsim los ua ib qho stimulant, tianeptine tau siv nyob rau hauv qee lub teb chaws los kho cov teeb meem tseem ceeb thiab tsis yooj yim.
Nws cov qauv tshuaj yog zoo li tianeptine sodium, txawm li cas los xij rau qee qhov sib txawv tseem ceeb. Cov qauv sulfate yog ruaj khov thiab raug lees txais los muab kev xa khoom zoo dua hauv lub cev. Qhov no tau ua raws nws qhov kev txiav txim siab nto moo ntawm cov neeg tab tom nrhiav qhov ua tau zoo ntawm tianeptine nrog cov teebmeem thib ob thiab txo qis ntawm kev siv tsis raug.
Opioid Receptor Nqe Lus Nug: Kev Tshawb Fawb Hais Li Cas?
Tam sim no, cia peb hais lo lus nug hauv nruab nrab: puas yogtianeptine sulfatentaus opioid receptors? Cov lus teb tsis yog ncaj nraim thiab yuav tsum muaj kev nkag siab zoo ntawm kev tshawb fawb tam sim no.
Cov kev tshawb fawb pib ntawm tianeptine (niam txiv compound) qhia tias nws feem ntau ua haujlwm los ntawm kev hloov kho cov kab mob glutamatergic thiab cuam tshuam rau neuroplasticity.Txawm li cas los xij, tom qab kev tshawb nrhiav tau nthuav tawm qhov muaj peev xwm txuas nrog lub moj khaum narcotic, tshwj xeeb tshaj yog cov mu-narcotic receptors.
Kev tshuaj xyuas muab faib rau xyoo 2014 hauv Kev Txhais Lus Psychiatry pom tias tianeptine yog ib qho agonist tag nrho ntawm mu-narcotic receptor, nrog lub zog zoo li morphine. Qhov kev tshwm sim no tau ua rau muaj kev txaus siab rau tianeptine lub peev xwm narcotic xws li cuam tshuam thiab ua rau muaj teeb meem txog nws txoj kev ua phem rau.
Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias feem ntau ntawm cov kev ntsuam xyuas no tau coj los ntawm tianeptine sodium, tsis yog nws. Thaum ob qhov sib xyaw ua ke sib piv, lawv cov tshuaj pharmacokinetics thiab tejzaum lawv cov tshuaj pharmacodynamics tuaj yeem sib txawv.
Flow pov thawj qhia tias nws, zoo ib yam li nws tus khub sodium, tej zaum yuav muaj kev sib txuas lus nrog narcotic receptors, tab sis cov degree thiab lub ntsiab lus ntawm lub koom haum no tseem yog cov kev tshawb fawb txuas ntxiv. Kev xa khoom qeeb dua thiab kev tsim kho bioavailability ntxiv ntawm nws yuav ua tau kho nws cov kev sib koom ua ke nrog cov tshuaj receptors sib piv nrog tianeptine sodium.
Qhov cuam tshuam rau kev siv thiab kev nyab xeeb: Cov neeg siv yuav tsum paub dab tsi
Muab qhov muaj peev xwm cuam tshuam nrog opioid receptors, qhov no txhais li cas rau cov uas xav txog lossis tam sim no sivtianeptine sulfate?
Raws li qee qhov tseem ceeb, nws yog qhov tseem ceeb kom nkag siab tias nws tsis tau pom zoo los ntawm FDA rau kev siv tshuaj kho mob hauv Asmeskas. Nws txoj cai raug cai hloov pauv hauv ntau lub tebchaws, thiab hauv qee qhov chaw, nws tau tso cai rau cov tshuaj kws tshaj lij.
Lub peev xwm opioid receptor kev ua haujlwm ntawm nws nce ntau qhov kev txiav txim siab tseem ceeb:
Muaj peev xwm ua phem rau:
Zoo li lwm yam tshuaj uas cuam tshuam nrog opioid receptors, nws yuav muaj peev xwm tsim txom. Cov neeg siv yuav tsum paub txog qhov kev pheej hmoo no thiab siv lub luag haujlwm yog tias txhua.
Tolerance thiab Dependence:
Kev siv nws li niaj zaus tuaj yeem ua rau muaj kev cia siab thiab kev vam khom, zoo ib yam li lwm cov opioid receptor agonists. Qhov no qhia txog qhov tseem ceeb ntawm kev ceev faj, saib xyuas kev siv nyob rau hauv kev taw qhia kev tshaj lij.
Kev sib tham:
Lub peev xwm ua haujlwm opioid ntawm nws txhais tau tias nws tuaj yeem cuam tshuam nrog lwm yam tshuaj lossis tshuaj uas cuam tshuam rau opioid system. Cov neeg siv yuav tsum tau ceev faj thiab sab laj nrog tus kws kho mob ua ntej muab nws nrog lwm cov tshuaj.
Kev rho tawm:
Qee cov neeg siv tau tshaj tawm cov tsos mob tshem tawm thaum txiav kev siv tianeptine, uas tuaj yeem cuam tshuam nrog nws txoj haujlwm opioid receptor. Tapering tawm cov tshuaj nyob rau hauv kev saib xyuas kev kho mob tej zaum yuav tsim nyog rau cov neeg siv ntev.
Nws yog ib qho tseem ceeb uas tsis hais txog cov kev txhawj xeeb no, ntau tus neeg siv khoom qhia txog cov txiaj ntsig zoo los ntawmtianeptine sulfate, tshwj xeeb tshaj yog nyob rau hauv kev saib xyuas cov kev mob tshwm sim ntawm despondency thiab uneasiness. Txawm li cas los xij, cov lus ceeb toom no yuav tsum tau pom nyob ib puag ncig yam tsis muaj qhov loj, tswj kev kho mob ua ntej.
Qhov kev tso tawm qeeb qeeb ntawm nws piv rau tianeptine sodium tuaj yeem txo qee qhov kev pheej hmoo cuam tshuam nrog kev ua kom sai opioid receptor activation. Txawm li cas los xij, qhov kev xav no xav tau kev tshawb fawb ntxiv kom paub meej.
Xaus
Hauv kev xaus, thaum cov pov thawj tam sim no qhia tias nws, zoo li tianeptine sodium, tuaj yeem cuam tshuam nrog opioid receptors, tag nrho thiab cuam tshuam ntawm qhov kev cuam tshuam no tseem tsis tau nkag siab tag nrho. Cov khoom tshwj xeeb ntawm nws, suav nrog nws txoj kev txhim kho bioavailability thiab kev tso tawm qeeb qeeb, tuaj yeem cuam tshuam nws cov kev cuam tshuam nrog opioid receptors hauv txoj kev uas tseem tab tom tshawb nrhiav.
Raws li kev tshawb fawb txuas ntxiv, nws yog ib qho tseem ceeb rau cov neeg siv muaj peev xwm mus cuag nws nrog ceev faj. Nws cov txiaj ntsig muaj peev xwm yuav tsum tau ntsuas ua tib zoo tiv thaiv cov kev pheej hmoo, suav nrog kev muaj peev xwm ntawm kev vam khom thiab kev tsim txom. Raws li ib txwm muaj, txhua yam kev siv cov tshuaj no yuav tsum tau tham nrog tus kws kho mob uas tuaj yeem muab cov lus qhia tus kheej raws li tus neeg mob kev noj qab haus huv thiab kev xav tau.
Zaj dab neeg ntawmtianeptine sulfatethiab nws txoj kev sib raug zoo nrog opioid receptors tseem nthuav tawm. Raws li peb tos kom muaj kev tshawb fawb ntau dua, nws ua haujlwm ceeb toom txog qhov nyuaj ntawm cov tshuaj psychoactive thiab qhov tseem ceeb ntawm kev tshawb fawb txuas ntxiv kom nkag siab txog lawv cov teebmeem ntawm tib neeg lub hlwb thiab lub cev.
Cov ntaub ntawv
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