Fipronil Spot-Ntawm cov khoom xyaw nquag: Fipronil muab cov txiaj ntsig zoo li cas

Thaum koj tus tsiaj tuaj txog hauv tsev khawb relentlessly, tus neeg ua txhaum yuav luag ib txwm hma los yog zuam. Cov tswv tsiaj thoob ntiaj teb ntseegfipronil chaw -raukev kho mob los daws qhov teeb meem no sai thiab ntseeg tau. Tab sis dab tsi ua rau fipronil ua haujlwm tau zoo? Kev nkag siab txog kev tshawb fawb tom qab cov khoom xyaw nquag no pab koj xaiv cov kev xaiv ntse dua rau koj tus tsiaj noj qab haus huv - thiab pab cov kws tshaj lij los muab cov khoom tsim nyog rau lawv txoj kev lag luam.

Fipronil Spot-Nyob

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
PE / Al foil hnab / ntawv lub thawv rau Pure hmoov
(2) Spot-On
qw :0.5ml
dog: 0.67ml: 2-10kg / 1.34ml: 10-20kg / 2.68ml: 20-40kg / 4.02ml: 40-60kg
(3) Kev daws teeb meem
(4) Poob
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Khoom siv: BM-9-018
Fipronil CAS 120068-37-3
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-3

Kev Tshawb Fawb Tom Qab Cov Khoom Siv Muaj Zog

Fipronil (CAS 120068-37-3) yog ib yam tshuaj uas muaj nyob hauv tsev neeg phenylpyrazole thiab tua ntau yam kab. Nws tau tsim los tsom rau lub paj hlwb ntawm kab thiab kab laug sab, thiab thaum siv kom zoo, nws tsis muaj qhov cuam tshuam zoo rau tib neeg. Vim hais tias ntawm nws cov molecules li cas, nws muaj peev xwm heev khi rau paj receptors ntawm kab. Qhov no yog vim li cas nws yog siv los ua lub hauv paus rau niaj hnub tshuaj tua kab mob parasiticides.

Veterinary noj qab haus huv cov neeg saib xyuas thiab tswj lub cev xws li US EPA tau lees paub tias fipronil yog ib qho chaw nyab xeeb rau kev tswj ectoparasites hauv cov tsiaj.Nws nyob ruaj khov hauv qhov kub thiab txias,

uas ua rau nws muaj cov khoom xyaw zoo rau kev ua cov khoom siv tawv nqaij.

Vim li cas Spot-Ntawm Kev xa khoom ua haujlwm

Nrog rau txoj kev no, cov kua dej ntshiab yog muab tso ncaj qha rau ntawm tus tsiaj daim tawv nqaij, feem ntau nyob rau sab nraub qaum ntawm caj dab, qhov twg nws tsis tuaj yeem licked yooj yim. Cov khoom xyaw nquag kis thoob plaws hauv lub cev los ntawm cov qog sebaceous tom qab siv. Qhov no ua rau cov kws tshawb fawb hu ua lub dermal reservoir tsis tu ncua.

Txoj kev ntawm daim ntawv thov phiaj no ua rau thaj tsam loj tshaj plaws thaum txo qhov raug rau tag nrho lub cev. Cov kev tshawb fawb txog kev nqus ntawm daim tawv nqaij qhia tau tias qhov chaw fipronil - ntawm kev kho mob siv fipronil lub ntuj lipophilic zoo los khi nrog cov roj ntawm daim tawv nqaij.

Qhov no ua rau cov khoom xyaw ua haujlwm rau lub lis piam tom qab siv ib zaug xwb.

Yuav ua li cas Parasites ntsib lub Active Compound

Ticks thiab fleas tsis tas yuav tom tus tsiaj rau fipronil ua haujlwm. Cov tshuaj tiv thaiv pib sai li sai tau thaum cov tawv nqaij kho tau kov. Thaum ib tug yoov los yog zuam los rau hauv kev sib cuag nrog plaub los yog daim tawv nqaij uas tau kho nrog fipronil, cov tshuaj raug coj mus rau hauv lub cuticle thiab mus rau parasite lub hlwb.

Txoj kev tua ntawm kev sib cuag no yog ib feem ntawm yog vim li casfipronil chaw -rauCov khoom lag luam nrov heev rau kev kho ectoparasites. Veterinary parasitology cov ntaub ntawv tsis tu ncua qhia tias dev mub raug tua ntawm tus nqi ntawm 98% lossis siab dua hauv 24 teev ntawm kev kho mob,

thiab zuam raug khaws cia rau ntau tshaj 30 hnub.

Spectrum ntawm Parasite Control

Fipronil zoo tiv thaiv ntau yam kab mob. Nws tuaj yeem tshem tawm cov neeg laus dev mub, flea larvae, flea qe, nab, thiab ntau ntau hom zuam. Qhov kev tiv thaiv dav dav no txhais tau hais tias cov tswv tsiaj thiab cov kws kho tsiaj tuaj yeem siv ib yam khoom los daws ntau yam kab mob.

Fipronil yog qhov muaj txiaj ntsig zoo vim tias nws rhuav tshem lub neej voj voog, uas yog qhov tseem ceeb heev. Re- Tus kab mob kis tau poob ntau thaum cov larvae raug tua ua ntej lawv ua neeg laus. Qhov no yog qhov zoo dua uas cov kev kho mob ib txwm tsis muab ib txwm muaj.

GABA Receptor Blocking Mechanism

Nyob rau hauv lub paj hlwb ntawm kab, fipronil blocks chloride raws uas tswj los ntawm gamma -aminobutyric acid (GABA). Hauv kab mob hlwb, GABA yog lub ntsiab lus neurotransmitter uas nres cov teeb liab. Fipronil thaiv cov tshuaj chloride ions los ntawm kev nkag mus rau cov paj hlwb thaum nws khi rau chloride channel receptor. Qhov no cuam tshuam qhov sib npaug ntawm cov paj hlwb excitation thiab inhibition.

Qhov no ua rau cov hlab ntsha tawg tsis muaj kev tswj hwm, uas ua rau lub hom phiaj parasite overexcited, tuag tes tuag taw, thiab thaum kawg tua nws. Txoj kev ua haujlwm no tau kawm txog ntau yam kab, uas yog vim li cas fipronil ua haujlwm sai heev ntawm daim tawv nqaij, txawm tias qhov qis qis.

Selectivity ntawm Kab thiab Mammals

Qhov tseeb tias fipronil tsuas yog khi rau kab mob GABA receptors thiab tsis rau tsiaj receptors piav qhia vim li cas nws thiaj li muaj kev nyab xeeb rau miv thiab dev. Fipronil muaj qhov sib txawv qis dua rau cov tsiaj txhu GABA receptors vim tias lawv qhov kev sib txuas ntawm qhov chaw sib txawv.

Ntawm cov koob tshuaj ntau heev, qhov sib txawv ntawm kev sib khi no tsis ploj mus, uas yog vim li cas kev noj tshuaj pes tsawg raws li hom thiab lub cev hnyav ntawm tus tsiaj tseem tseem ceeb heev. Bloomtechz covfipronil chaw -rauformulations yog ua tib zoo calibrated: 0.5 mL rau miv thiab kawm tiav cov nqi ntawm 0.67 mL mus rau 4.02 mL rau dev nyob rau hauv plaub pawg, yog li ntawd lawv yog kho kom raug tsis ntau dhau.

Solvent Systems thiab Skin Penetration

Lub cev hnyav lub cev muaj feem cuam tshuam loj npaum li cas fipronil ua haujlwm zoo hauv qhov chaw- ntawm cov khoom. Raws li kev txhawb nqa nkag, isopropanol thiab cov roj ntxhia hauv lub teeb pom kev zoo pab cov active molecule tau los ntawm keratin txheej ntawm stratum corneum thiab nyob rau hauv cov qog sebaceous.

Txoj kev miv 'thiab dev' tawv nqaij ua haujlwm txawv heev. Muaj 50-80 cov hauv paus plaub hau ib cm² ntawm cov tawv nqaij miv piv rau 30-50 follicles ib cm² ntawm cov tawv nqaij dev, thiab miv tsim ntau sebum ib cheeb tsam txhua hnub. Cov kev hloov pauv no muaj qhov cuam tshuam ncaj qha rau qhov kev sib kis ntawm fipronil tom qab siv.

Cov kev tshawb fawb pom tau tias 0.5 mL daim ntawv thov ntawm cov tshuaj tuaj yeem ncav cuag li 0.12 mg / cm² ntawm daim tawv nqaij ntawm tus miv caj dab, tab sis tsuas yog 0.08 mg / cm² ntawm daim tawv nqaij ntawm tus dev nraub qaum.

Duration ntawm kev ua tau zoo thiab ruaj khov

Vim tias fipronil yog lipophilic, nws khi nruj rau cov roj ntawm daim tawv nqaij thiab tso tawm maj mam dhau sijhawm es tsis txhob ntxuav tawm sai. Ib rau -hli kev ntsuas kev ruaj ntseg ntawm 40℃thiab 75% txheeb ze av noo qhia qhov nruab nrab txhua xyoo degradation tus nqi ntawm 2% lossis tsawg dua, uas txhais tau hais tias cov khoom tsim tau zoo tuaj yeem khaws cia rau peb xyoos.

Qhov nruab nrab, 30 hnub tom qab siv lub qhov dej -ua fipronil chaw- ntawm cov khoom,

miv tseem muaj txog 60% ntawm cov concentration uas nyob rau ntawm lawv daim tawv nqaij thaum pib, thaum dev tsuas muaj li 40%. Qhov sib txawv no piav qhia vim li cas kev kho mob rau miv zoo li ua haujlwm ntev me ntsis.

Cov ntaub ntawv pov thawj khiav hla kev lag luam

Raws li ntawm nruab nrab-1990s, fipronil tau muag hauv cov khoom lag luam dermal. Nws tseem yog qhov kev kho mob ectoparasite nrov tshaj plaws nyob rau hauv lub ntiaj teb ua lag luam, uas ua rau li 35% ntawm tag nrho cov muag khoom ntawm parasite tswj cov tsiaj. Nws yog tus qauv active ingredient nyob rau hauv cov pab pawg neeg no vim hais tias nws ua hauj lwm tib yam nyob rau hauv tag nrho cov cheeb tsam, nrog rau tag nrho cov hom tsiaj, thiab nrog rau tag nrho cov theem ntawm infestation.

Kev tswj hwm kev pom zoo los ntawm ntau qhov chaw, xws li FDA, EU, thiab lwm yam, qhia tias cov ntaub ntawv kev nyab xeeb thiab kev ua tau zoo npaum li cas tau sau tseg ntau xyoo ntawm kev siv.

Manufacturing Integrity thiab Quality Assurance

Qhov zoo ntawm qhov chaw fipronil- ntawm cov khoom yog nyob ntawm ob qho tib si cov khoom xyaw ntshiab yog li cas (feem ntau tsawg kawg yog 95% purity) thiab cov khoom tsim tau zoo npaum li cas. Cov khoom kawg qhov kev ua tau zoo yog kuaj xyuas los ntawm siab - nrawm nqus emulsification ntawm qhov ntsuas kub (40-50 degree), ceev faj HPLC-raws li kev txheeb xyuas cov ntsiab lus, thiab ib puag ncig GMP nruj heev.

Zoo siab, tswj qhov kub ntawm 20 txog 25 degree, thiab cov av noo ntawm 40 mus rau 60% yog txhua yam uas cov chaw tsim khoom yuav tsum muaj kom ua tau raws li cov qauv ntsuas microbiological (tag nrho cov colony suav tsawg dua lossis sib npaug li 100 CFU / g).

Rau ib yam khoom uas yuav muab tso rau ntawm daim tawv nqaij ntawm ib tug tsiaj nyob, cov kev tswj ntau lawm yuav tsum tau ua raws li.

Fipronil tseem yog cov khoom muaj txiaj ntsig zoo tshaj plaws hauv cov khoom tiv thaiv kab mob sab nraud vim tias nws ua haujlwm tau zoo ntawm qib molecular - thaiv cov kab mob GABA receptors, kis los ntawm sebaceous raws, thiab nyob rau ntawm daim tawv nqaij ntawm lub lis piam. Kev kawm txog kev tshawb fawb no tsis yog rau tsev kawm ntawv xwb; nws pab koj txiav txim siab zoo dua txog qhov twg yuav tau txais koj cov ntaub ntawv, yuav muab lawv li cas, thiab yuav ua li cas los nrog cov khoom tshiab. Bloomtechz muaj kev tsim kev ntseeg siab thiab kev ua haujlwm tob kom ua tau raws li cov kev xav tau ntawm cov lag luam thiab cov kws tshawb fawb nrhiav kev ntseeg siab, GMP- ntawv pov thawj qhov chaw siab - zoofipronil chaw -raucov qauv.

Bloomtechz tau ua lub chaw tsim khoom cog lus thiabfipronil chaw -rautus neeg muag khoom txij li xyoo 2008. Lawv muaj ntau tshaj 12 xyoo ntawm kev paub hauv cov organic chemistry thiab 100,000 m² GMP- cov nroj tsuag muaj ntawv pov thawj uas tau pom zoo los ntawm US FDA, EU GMP, Nyiv, thiab CFDA. Txhua batch mus txog peb theem ntawm kev tswj kom zoo: kev sim hauv cov nroj tsuag, tshuaj xyuas los ntawm peb tus kheej QA / QC department, thiab tshuaj xyuas los ntawm peb lub koom haum thib peb-. Qhov no ua kom koj tau txais raws nraim li daim ntawv cog lus hais tias koj yuav tau txais. Peb cov qauv nyiaj tau los yog qhov tseeb (10% mus rau 30% cov npoo ruaj khov), peb qhov system ERP khaws cov ntaub ntawv raug ntawm peb lub sijhawm ua haujlwm, thiab peb cov ntaub ntawv xa khoom yog tsim los ua kom yooj yim rau kev lis kev cai kom tshem peb cov khoom. Koj tuaj yeem tau txais kev pab los ntawm peb pab pawg R & D nrog rau ib feem ntawm cov txheej txheem tsim khoom, los ntawm kev ntsuas ntsuas mus rau tag nrho cov ntim lag luam. Lawv tuaj yeem muab API ntau, npaj tau-- muag chaw- ntawm hom, lossis OEM / ODM kev hloov kho. Hu rau peb tam sim ntawd kom paub seb yog vim li cas 24 lub tuam txhab loj thoob ntiaj teb tso siab rau Bloomtechz ua lawv cov chaw muab tshuaj lom neeg.

Tiv tauj peb:Sales@bloomtechz.com.

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