Cov kws tshawb fawb thiab cov neeg ua haujlwm hauv kev lag luam kws tshuaj tuaj yeem ua cov phiaj xwm kho mob zoo dua los ntawm kev nkag siab tias cov tshuaj tiv thaiv kab mob ua haujlwm li cas ntawm qib molecular.GS-441524 hmoovyog ib qho zoo nucleoside analogue uas tsom cov kab mob RNA-nyob ntawm RNA polymerase. Qhov no ua rau nws muaj txiaj ntsig zoo hauv kev tawm tsam cov kab mob RNA sib txawv. Txoj kev sib ntaus cov kab mob no ua haujlwm los ntawm messing cov txheej txheem yooj yim uas cov kab mob siv los luam lawv tus kheej hauv tib neeg lub hlwb.
Cov tshuaj ua haujlwm los ntawm kev siv cov txheej txheem molecular kom zoo li cov nucleotides ntuj thaum tso tseg cov kab mob sib kis tib lub sijhawm. Los ntawm kev ntxiv nws tus kheej mus rau cov saw RNA loj hlob thaum tus kab mob rov ua dua, qhov sib npaug ntawm nucleoside blocks ntxiv ntau lawm ntawm qib molecular. Cov txheej txheem no ua haujlwm tau zoo tshwj xeeb tshaj yog tiv thaiv tus kab mob feline kis kab mob peritonitis, thiab nws tau ntes cov neeg tshawb nrhiav cov pab pawg uas tab tom nrhiav rau cov kab mob RNA zoo sib xws.
Kev txheeb xyuas qhov tseeb tias GS-441524 hmoov nres RNA polymerase yog qhov tseem ceeb heev rau kev nkag siab tias nws tuaj yeem siv rau hauv cov tshuaj li cas. Lub compound yog ib qho kev xaiv zoo rau kev tsim cov tshuaj tiv thaiv kab mob vim tias nws tuaj yeem ua tib zoo tsom cov kab mob enzymes thaum ua rau muaj kev puas tsuaj tsawg rau cov txheej txheem ntawm tes. Cov khoom no nkag mus rau hauv qhov tob tob txog cov tshuaj lom neeg sib cuam tshuam uas tshwm sim thaum cov nucleoside analogue ntsib tus kab mob RNA polymerase.
GS 441524 hmoov CAS 1191237-69-0
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-1-049
GS-441524 CAS Nr .: 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-4
Peb muab GS 441524 Powder, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov ntaub ntawv khoom.
GS-441524 Powder Block RNA-Dependent RNA Polymerase Ua Haujlwm Li Cas?
Thaum GS-441524 hmoov nkag mus rau hauv cov hlwb uas cuam tshuam thiab dhau los ntawm cytoplasmic phosphorylation, nws pib nres tus kab mob. Qhov kev hloov pauv hauv metabolic no hloov cov molecule rau hauv nws daim ntawv nquag triphosphate, uas zoo ib yam li adenosine triphosphate uas tus kab mob polymerases feem ntau siv. Vim tias cov qauv zoo ib yam, qhov hloov pauv nucleotide tuaj yeem dag cov kab mob enzyme ntxiv rau RNA uas tau tsim.
RNA-dependent RNA polymerase yog qhov tseem ceeb ntawm tus kab mob RNA uas theej nws tus kheej. Cov enzyme no nyeem cov kab mob genome code thiab tsim cov RNA tshiab los ntawm kev ntxiv nucleotides ib zaug. Cov polymerase tuaj yeem paub txog qee yam tshuaj lom neeg ntawm nucleotides uas tuaj, xws li cov piam thaj molecule, phosphate pawg, thiab nitrogenous bases. Daim ntawv triphosphate ntawm no antiviral molecule muaj cov qauv tsim nyog kom tau raws li qhov xav tau ntawm cov enzyme, yog li nws tuaj yeem sib tw nrog ntuj substrates rau suav nrog.
Ib feem tseem ceeb ntawm cov txheej txheem yog qhov kev sib tw thaiv kev sib tw. Lub polymerase khi qhov chaw hloov mus rau hauv kev sib ntaus sib tua thaum lub sij hawm nquag kis kab mob, qhov twg cov nucleotides ntuj thiab cov ntawv hloov pauv sib ntaus sib tua. Tus nqi ntawm GS-441524 hmoov piv rau cov pas dej nucleotide hauv cov hlwb ncaj qha cuam tshuam rau cov analogues ntau npaum li cas. Cov polymerase feem ntau yuav xaiv cov nucleotide hloov kho dua nws cov qauv qub thaum cov concentration siab dua.
Thaum xaiv thawj kauj ruam, kev tshawb fawb tau pom tias cov enzyme tsis tuaj yeem qhia qhov txawv ntawm qhov hloov pauv nucleotide thiab ib txwm adenosine triphosphate. Cov tshuaj muaj peev xwm mus ncig ntawm cov polymerase cov kev tswj xyuas zoo vim tias nws zoo li cov molecule sib txawv. Cov enzyme ces ua kom cov phosphodiester daim ntawv cog lus uas txuas cov nucleotide hloov mus rau cov saw RNA loj hlob. Qhov no teeb tsa theem rau replication tsis ua hauj lwm yam tsis tau paub txog nws.
Cov kev hloov pauv molecular nyob rau hauv cov nucleoside counterpart, tshwj xeeb tshaj yog kev hloov ntawm 1'-cyano pawg ntawm ribose qab zib, ua rau me me hloov nyob rau hauv cov duab uas ua ib qho tseem ceeb tsuas yog tom qab lawv ntxiv. Cov kev hloov no tsis tso tseg kev tsim daim ntawv cog lus tam sim ntawd; Hloov chaw, lawv ua rau cov qauv txwv uas tshwm sim tom qab puag ncig ntawm elongation. Nucleoside analogues txawv ntawm lwm hom tshuaj tiv thaiv kab mob uas txwv cov enzymes los ntawm kev ua haujlwm ncaj qha los ntawm lawv qhov chaw nquag. Lawv ua qhov no los ntawm kev ncua kev cuam tshuam.
GS-441524 Powder and Termination of Viral RNA Chain Elongation Process
Ua keGS-441524 hmoovnrog tus kab mob tshiab RNA strands ua rau cov saw hlau txiav, uas yog qhov kawg tshwm sim. Cov polymerase sim ua kom txuas ntxiv mus los ntawm kev ntxiv cov nucleotide tom ntej tom qab hloov nucleotide koom nrog cov saw loj loj. Daim ntawv hloov pauv cov qauv hauv ib txoj hauv kev uas txwv tsis pub cov geometry ntawm lub enzyme lub chaw ua haujlwm, ua rau nws tsis tuaj yeem ua rau cov nucleotide tom ntej nkag mus zoo.
Thaum lub sij hawm ua RNA, 3'- pawg hydroxyl ntawm ntuj ribose qab zib ua qhov txuas rau nucleotide tom ntej. Rau txhua lub voj voog elongation, qhov txuas tshiab phosphodiester yog tsim los ntawm 3'-hydroxyl pawg thiab triphosphate ntawm cov nucleotide tom ntej. Vim hais tias cov tshuaj tiv thaiv kab mob no tau hloov pauv, cov pab pawg ua haujlwm tsis tau npaj rau tib txoj kev. Qhov no ua rau nws lub cev tsis tuaj yeem ua rau cov polymerase kom ceev cov txheej txheem tsim cov ntawv cog lus tom ntej.
Kev ntsuam xyuas biochemical tau pom tias kev txiav cov saw hlau tsis tas yuav tshwm sim tam sim ntawd tom qab kev tso tshuaj analogue. Qee cov polymerases tuaj yeem ntxiv ib lossis ob qho ntxiv nucleotides dhau los ntawm qhov chaw suav ua ntej lawv tsis ua haujlwm tag nrho. Qhov kev ncua ncua sij hawm no tshwm sim vim hais tias cov enzyme yog cov qauv hloov tau yooj yim thiab tuaj yeem tswj cov kev hloov me me hauv RNA-enzyme complex. Nws nyob ntawm tus kab mob polymerase thiab cov kab ke ib puag ncig ib puag ncig ntawm qhov chaw koom ua ke kom paub meej qhov twg cov txheej txheem xaus.
RNA chains uas tau txiav tawm nyob twj ywm txuas nrog cov enzyme polymerase ib ntus ua ntej tawg. Cov khoom lag luam RNA tsis tiav thiab cov enzyme polymerase tseem ceeb tau muab tshem tawm los ntawm qhov kev sib koom ua ke ntev ntev no, tshem tawm lawv los ntawm lub pas dej ua ke ntawm kev ua haujlwm replication machinery.Tus kab mob lub peev xwm los ua cov ntawv luam tshiab caj ces maj mam txo qis raws li nres complexes tsim, ua rau poob loj hauv kev tsim cov kab mob sib kis.
Kev ntsuas ntawm RNA synthesis nyob rau hauv lub xub ntiag ntawm GS-441524 hmoov qhia tau hais tias qhov nruab nrab ntev ntawm cov tshiab synthesized kab mob RNA strands tau luv luv thaum lub concentration nce. Qee cov ntawv sau tag nrho tseem ua rau me me, tab sis ntau ntawm lawv raug txiav sai sai.
Raws li cov concentrations nce, lub caij nyoog ntawm analogue inclusion thaum lub sij hawm muab elongation voj voog kuj nce. Qhov no ua rau qhov nruab nrab cov ntawv sau ntev dua qis dua thiab nres tus kab mob replication ntau dua.
Qhov tseeb tias cov saw hlau xaus tsis tuaj yeem thim rov qab ua rau cov txheej txheem no muaj txiaj ntsig zoo. Covalent suav nrog cov hloov kho nucleotide ua rau lub sijhawm ntev, tsis zoo li rov qab enzyme inhibitors uas tuaj yeem sib cais thiab cia cov enzyme pib ua haujlwm dua. Lub cell mob tsis tuaj yeem kho tau yooj yim lossis tshem tawm qhov sib npaug ntawm cov saw hlau uas tau tas lawm. Qhov no ua rau cov tshuaj tiv thaiv kab mob mus rau tag nrho ib nrab - lub neej ntawm cov khoom sib txuas hauv lub cell.
Yuav ua li cas tshwm sim thaum Polymerase Binding Inhibition los ntawm GS-441524 Hmoov?
Thawj qhov kev sib cuag ntawm tus kab mob RNA polymerase thiab triphosphate daim ntawv ntawm nucleoside analogue no tshwm sim nyob rau hauv nucleotide-binding hnab tshos ntawm enzyme. Qhov chaw tshwj xeeb no hauv qhov chaw ua haujlwm polymerase tau hloov zuj zus kom paub txog thiab txuas cov nucleoside triphosphates tshwj xeeb. Muaj ntau cov amino acid residues nyob rau hauv hnab tshos. Lawv cuam tshuam nrog ribose qab zib, tsim hydrogen bonds nrog lub hauv paus, thiab ua electrostatic tiv tauj nrog cov pab pawg tsis zoo triphosphate.
Thaum cov nucleotide hloov pauv tau nkag mus rau hauv lub hnab ntawv khi no, cov khoom siv polymerase kev lees paub cuam tshuam nrog cov yam ntxwv ntawm cov ntawv luam. Nyob rau hauv tib txoj kev uas ntuj adenosine triphosphate ua, adenine puag ib feem ua hydrogen bonds nrog amino acids uas yog complementary. Qhov triphosphate reacts nrog cov khoom seem zoo, feem ntau magnesium ions npaj los ntawm aspartate residues, uas ua rau cov tshuaj tiv thaiv yooj yim dua. Cov kev sib cuam tshuam zoo sib xws no pab piav qhia vim li cas cov enzyme tsis tuaj yeem qhia qhov sib txawv ntawm cov qauv thiab cov txheej txheem ntuj thaum nws thawj khi lawv.
Qhov tseem ceeb ntawm qhov sib txawv molecular tshwm sim los ntawm 1'-cyano hloov pauv tsis muaj qhov cuam tshuam loj rau thawj qhov kev sib raug zoo. Cov kev tshawb fawb crystallographic ntawm cov nucleoside analogues zoo sib xws tau khi rau cov kab mob polymerases qhia tias qhov chaw nquag ntawm cov enzyme tuaj yeem haum rau cov qauv qab zib hloov pauv yam tsis muaj kev hloov pauv loj hauv cov duab thaum lub sij hawm khi. Qhov no yog vim li casGS-441524 hmoovtuaj yeem sib tw nrog ntuj nucleotides txawm tias nws cov qauv tau hloov pauv.
Tom qab txuas, cov polymerase hloov cov duab los muab cov nucleotide txuas rau hauv qhov chaw zoo rau kev ua kom. Thaum lub enzyme kaw nyob ib ncig ntawm lub substrate, nws kab cov active residues zoo kawg nkaus kom ib tug phosphodiester daim ntawv cog lus. Cov khoom hloov pauv ntawm GS-441524 hmoov tsis txhob tso tseg qhov kev hloov ntawm cov qauv tsim nyog thaum lub sijhawm hloov pauv, yog li lub voj voog catalytic tuaj yeem txuas ntxiv mus. Lub enzyme tau ua tiav cov txheej txheem hloov pauv nucleotidyl, uas ntxiv cov ntawv theej rau RNA saw.
Cov teeb meem pib tshwm nyob rau hauv lub voj voog txuas ntxiv. Thaum cov nucleotide ntxiv lawm, cov polymerase yuav tsum txav mus raws tus qauv, tshem tawm ntawm qhov chaw nquag thiab muab tso rau hauv qhov chaw uas cov nucleotide ntxiv tuaj yeem koom nrog. Daim ntawv hloov pauv cov qauv hauv ib txoj hauv kev uas ua rau muaj kev sib cav tsis zoo lossis kev sib cuam tshuam tsis zoo thaum lub sijhawm hloov pauv lossis thaum sim koom nrog cov nucleotide tom ntej, uas nres cov txheej txheem elongation hauv nws cov lem.
GS-441524 Hmoov Lub luag hauj lwm hauv Halting Viral Genome Replication ntawm Qib Enzymatic
Kev rov ua dua ntawm cov kab mob kis kab mob yog nyob ntawm RNA- nyob ntawm RNA polymerase molecules ua haujlwm ua ke nrog cov qauv qauv hauv txoj hauv kev. Txhawm rau ua kom cov kab mob ua haujlwm, txhua tus processor yuav tsum ua kom tiav -ntev genomic lossis antigenomic RNA. GS-441524 hmoov tau txais txoj hauv kev ntawm cov txheej txheem tseem ceeb no thiab ua rau cov khoom tsis tiav RNA uas tsis tuaj yeem ua lawv cov haujlwm lom neeg.
Cov teebmeem ntawm cov enzymes mus dhau tsuas yog rhuav cov saw hlau. Thaum cov pab pawg polymerase tau daig, lawv tuaj yeem thaiv kev nkag mus rau cov qauv, uas txwv tsis pub lwm cov polymerase molecules los ntawm kev pib synthesis ntawm tib qhov chaw template. Qhov kev cuam tshuam no ua rau txhua qhov kev sib koom ua ke muaj zog dua vim tias ib qho kev sib koom ua ke uas tau tawg tuaj yeem nres ntau qhov kev hloov pauv pib tshwm sim. Qhov sib xyaw ua ke ua rau qeeb zuj zus ntawm cov kab mob RNA los ntawm qhov loj heev.
Cov kab ke tswj kev ua haujlwm zoo ntawm tes tuaj yeem pom RNA-cov protein complexes uas tsis ua haujlwm zoo, uas yog tsim los ntawm polymerases uas tau tso tseg. Cov kev saib xyuas no tuaj yeem tsom rau cov khoom lag luam RNA tsis tiav rau kev puas tsuaj, uas ntxiv txo cov kab mob RNA molecules uas yuav ua haujlwm. Kev sib xyaw ntawm kev sib xyaw ua ke tsawg dua thiab kev puas tsuaj ntau ntxiv muaj qhov cuam tshuam zoo rau kev loj hlob ntawm tus kab mob genomes.
Raws li lawv cov polymerase ua haujlwm li cas, cov kab mob RNA sib txawv txawv ntawm qhov sib txawv nucleoside no. Cov ntawv luam yuav raug ntxiv tsawg dua los ntawm cov enzymes nrog kev ncaj ncees siab dua thiab kev xaiv cov substrate nruj dua, thaum cov polymerases nrog qis fidelity tau yooj yim lees txais cov hloov pauv nucleotide. Qhov ntau ntawm cov tshuaj tiv thaiv kab mob pom nyob rau hauv ntau hom kab mob yog vim ib feem ntawm cov kev hloov pauv hauv enzyme selectivity.
Txoj kev uas polymerase blockage hloov lub sijhawm cuam tshuam rau tus neeg mob zoo npaum li cas.
Kev sib koom ua ke sai thiab kev txiav tawm ua rau cov kab mob RNA txo qis sai, uas tuaj yeem txwv tsis pub cov neeg mob pib yog tias kev kho mob pib ntxov. Kev kho mob qeeb cia cov neeg kis kab mob loj hlob ua ntej kev tiv thaiv yuav siv tau, yog li cov tshuaj yuav tsum tau nthuav tawm rau lub sijhawm ntev kom txo cov kab mob mus rau theem uas lub cev tiv thaiv kab mob tuaj yeem tshem tawm ntawm lawv.
Nws yog qhov ua tau rau GS-441524 hmoov ua haujlwm zoo dua nrog lwm cov txheej txheem tshuaj tua kab mob thaum siv ua ke. Cov tshuaj sib xyaw ua ke uas lub hom phiaj sib txawv ntawm tus kab mob lub neej ua haujlwm nrog cov txheej txheem polymerase inhibition kom tsis txhob muaj kev hloov pauv thiab ua rau nws tsis tshua muaj kev tiv thaiv. Cov kev sib xyaw ua ke no zoo li txoj hauv kev zoo los ua kom cov kev kho mob ua haujlwm zoo dua.
Kauj Ruam -los ntawm -Keeb Molecular Disruption ntawm RNA Polymerase Ua los ntawm GS-441524 Hmoov
Cov txheej txheem tshuaj lom neeg pib nrog qhov nucleoside analogue raug coj los ntawm cov hlwb. Kev thauj cov proteins ua kom yooj yim rau cov tshuaj nkag los ntawm cov phab ntsa ntawm tes thiab mus rau hauv cytoplasm, uas yog qhov chaw uas cov kab mob rov ua dua. Intracellular kinases pom cov molecule thiab pib cov txheej txheem phosphorylation uas hloov nws mus rau hauv daim ntawv active triphosphate. Ua ntej mus rau lub xeev triphosphate, cov txheej txheem tshuaj lom neeg no feem ntau mus dhau ntawm theem monophosphate thiab diphosphate.
Thaum twgGS-441524 hmoovtau hloov mus rau hauv nws daim ntawv triphosphate, nws sib tov nrog ntuj nucleoside triphosphates hauv nucleotide pas dej ntawm cov hlwb. Qhov concentration mus txog yog nyob ntawm tus nqi muab, lub hlwb zoo npaum li cas rau hauv, thiab sai npaum li cas phosphorylation thiab dephosphorylation tshwm sim. Kev tswj hwm tus nqi ntawm cov tshuaj intracellular triphosphate thoob plaws lub sijhawm muab tshuaj ua kom cov tshuaj tiv thaiv kab mob siab rau cov kab mob uas tau luam tawm nws tus kheej tsis tu ncua.
Qhov kev xaiv tseem ceeb tshaj plaws yog qhov kev xaiv polymerase. Ob qho tib si ntuj ATP thiab tweaked counterpart tuaj yeem siv los ua cov substrates thaum cov kab mob polymerase active site yog khoob thiab npaj txhij mus noj cov nucleotide tom ntej. Los ntawm luv luv - nyob rau hauv kev sib cuam tshuam, cov polymerase lub hnab ris khi khi rau cov nucleotides muaj. Qhov hloov pauv nucleotide ua tau raws li qhov kev xaiv enzyme vim nws cov qauv zoo ib yam li ATP ib txwm muaj.
Thaum cov polymerase txiav txim siab ntxiv cov nucleotide xaiv, cov txheej txheem catalytic pib. Lub enzyme tso catalytic residues thiab hlau cofactors nyob rau hauv ib txoj kev uas ua rau nws yooj yim dua rau 3'-hydroxyl pawg ntawm cov saw loj hlob los tua cov -phosphate ntawm nucleoside triphosphate uas yog los rau hauv. Cov phosphodiester txuas yog tsim nyob rau hauv cov txheej txheem no, uas kuj tso tawm pyrophosphate. Txawm hais tias cov qauv hloov pauv, cov tshuaj hloov pauv mus los ntawm qhov zoo, txuas cov ntawv theej rau tus tshiab RNA strand.
Kev hloov pauv tuaj tom qab suav nrog vim tias cov polymerase yuav tsum tau txav mus raws tus qauv los ntawm ib qho nucleotide kom muaj kev loj hlob mus. Coordinated structural hloov nyob rau hauv lub enzyme ua rau no mechanical zog. Cov kev hloov pauv no txav cov nucleotide tshiab tshiab los ntawm qhov chaw koom ua ke mus rau qhov chaw ntws. Cov qauv hloov pauv ntawm cov ntawv luam ntxiv ua rau muaj kev hloov pauv me me hauv cov duab ntawm RNA nraub qaum uas ntxiv rau kev ntxhov siab thaum lub sijhawm hloov pauv.
Thaum cov polymerase sim koom nrog cov nucleotide tom ntej uas tuaj, theem kawg tshwm sim. Cov hmoov ntxiv GS-441524 hloov pauv cov duab ntawm cov khoom, uas nres lub substrate binding qhov chaw los ntawm kev sib raug zoo nrog cov nucleotides uas tuaj txog. Vim tias txoj kev teeb tsa, cov enzyme yuav sim ntau dua tab sis tsis txuas thiab nqus cov nucleotide tom ntej. Lub complex nws thiaj li nres txav thiab nres ua RNA, uas yog qhov kawg ntawm RNA synthesis tshwm sim.
Xaus
Txoj kev ntawdGS-441524 hmoovtxwv tsis pub tus kab mob RNA polymerase ua haujlwm yog ib qho piv txwv zoo nkauj ntawm cov qauv -raws li kev tsim tshuaj tiv thaiv kab mob. Qhov no nucleoside analogue nres qhov kev rov ua dua ntawm cov kab mob genomes ntawm ntau qib, suav nrog los ntawm kev coj ua qauv molecular, kev sib tw suav nrog, thiab ncua kev sib txuas txuas ntxiv. Nucleoside analogues tau raug pov thawj tias yog cov tshuaj tiv thaiv kab mob zoo vim tias lawv tuaj yeem xaiv hom kab mob polymerases thaum tseem muaj kev nyab xeeb.
Los ntawm kev nkag siab txog cov yam ntxwv ntawm cov molecular no, peb tuaj yeem ua kom cov phiaj xwm kho mob zoo dua thiab tsim cov khoom sib txuas ntxiv tom ntej nrog cov txiaj ntsig zoo dua. Cov teebmeem uas tso siab rau kev ua kom pom tseeb, kev teeb tsa ntawm qhov kev txiav txim, thiab lub sijhawm ntws mus rau txhua qhov tam sim no muaj peev xwm los txhim kho kev kho mob. Kev kawm ntxiv txog yuav ua li cas polymerase thiab inhibitors ua haujlwm ua ke yuav tsum ua rau cov tshuaj zoo dua uas muaj txiaj ntsig zoo dua rau ntau yam kab mob thiab tsis tshua muaj kev tiv thaiv.
Txoj kev no ua haujlwm zoo tiv thaiv cov kab mob RNA, uas qhia tau hais tias nws tseem ceeb npaum li cas rau lub hom phiaj tseem ceeb ntawm cov kab mob enzymes. Raws li cov kab mob tshiab tawm, cov cai uas tau teev tseg los ntawm kev kawm cov khoom xws li GS-441524 hmoov yuav pab tib neeg ua sai sai. Kev tshawb fawb tshuaj tiv thaiv kab mob zoo tshaj plaws niaj hnub no los ntawm kev sib koom ua ke ntawm kev paub tob txog kev ua haujlwm li cas nrog kev siv tshuaj hauv ntiaj teb tiag.
FAQ
1. Dab tsi ua rau GS-441524 hmoov zoo tiv thaiv kab mob RNA?
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Vim tias cov khoom sib xyaw ua ke zoo ib yam li ntuj adenosine, nws tuaj yeem ntxiv rau cov kab mob RNA chains thaum lawv luam lawv tus kheej. Ib zaug ntxiv, cov qauv hloov pauv nres cov saw txuas ntev dua, uas nres cov kab mob genome los ntawm kev tsim. Txoj kev no tsom rau tus kab mob RNA- nyob ntawm RNA polymerase enzymes thiab tsis muaj kev cuam tshuam ntau rau cov tswv tsev cell polymerase enzymes. Qhov no ua rau cov tshuaj tiv thaiv kab mob xaiv tau.
2. Nws siv sijhawm ntev npaum li cas rau GS-441524 hmoov txhawm rau txhawm rau txhawm rau kis tus kabmob?
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Thaum cov molecule hits rau theem sab hauv cov hlwb thiab yog phosphorylated rau nws active triphosphate daim ntawv, nws pib thaiv lub teeb liab. Qhov no biochemical stimulation feem ntau tshwm sim ob peb teev tom qab muab tshuaj. Tom qab tau ntxiv rau cov kab mob RNA tshiab, cov txheej txheem kev txiav tawm cov kab mob qeeb zuj zus ntawm cov kab mob RNA ntau lawm nyob rau ob peb teev tom ntej mus rau hnub, raws li kev pib kis kab mob thiab tshuaj kho.
3. Cov kab mob polymerases puas tuaj yeem tiv taus GS-441524 hmoov?
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Nws tseem muaj peev xwm tsim kom muaj kev tiv thaiv los ntawm kev hloov qhov chaw ntawm tus kab mob RNA polymerase nyob rau hauv txoj kev uas ua rau nws nyuaj rau cov analogues los yog ua kom yooj yim qhia qhov sib txawv ntawm cov nucleotides ib txwm thiab cov analogue hloov. Vim hais tias cov compound thiab ntuj substrates yog ze heev structurally, cov kev hloov kuj tsis tshwm sim ntau zaus. Lawv kuj ua rau nws nyuaj rau cov enzyme kom koom nrog ntuj nucleotides ua tiav. Kev sib xyaw ua ke thiab txoj hauv kev zoo rau kev txhaj tshuaj tuaj yeem pab tiv thaiv kev txhim kho.
Koom tes nrog BLOOM TECH: Koj Trusted GS-441524 Powder Supplier
BLOOM TECH yog lub tuam txhab muaj kev vam meej uas tuaj yeem muab rau kojGS-441524 hmoov. Lawv muaj ntau tshaj li 12 xyoo ntawm kev paub nyob rau hauv tshuaj chemistry thiab kws tshuaj intermediates. Peb 100,000-square-}meter GMP- tau ntawv pov thawj cov chaw tsim khoom, uas tau lees paub los ntawm US-FDA, EU-GMP, thiab CFDA, xyuas kom txhua pawg ua tau raws li cov qauv zoo tshaj plaws. Peb qhov kev mob siab rau kev ua tau zoo yog pom los ntawm qhov tseeb tias peb ua haujlwm nrog 24 lub tuam txhab tshuaj loj txawv teb chaws thiab R & D cov koom haum. Peb cov txheej txheem kev tswj hwm peb txheej ua kom paub tseeb tias txhua qhov kev xa khoom ua tau raws li qhov yuav tsum tau ua, thiab peb yuav muab cov nyiaj rov qab rau koj rau txhua yam khoom uas tsis ua. Peb muaj cov nqi meej nrog cov nyiaj tau los ntawm cov nyiaj tau los, cov sij hawm ua cov hmoov txhuas raug saib xyuas los ntawm peb lub ERP platform, thiab tag nrho cov ntaub ntawv koj xav tau kom tshem tawm kev lis kev cai yooj yim. Txawm hais tias koj xav tau me me rau kev kawm lossis ntau ntawm lawv rau kev tsim khoom, peb pab pawg kws tshaj lij tuaj yeem pab koj nrhiav kev daws teeb meem uas haum rau koj cov kev xav tau. Hu rau peb pab neeg muag khoom paub txog ntawmSales@bloomtechz.comtham txog koj GS-441524 hmoov xav tau thiab nrhiav seb peb tsom ntsoov rau qhov zoo thiab tus nqi qis tuaj yeem pab koj ncav cuag koj cov kev tshawb fawb tshuaj tiv thaiv thiab kev loj hlob.
Cov ntaub ntawv
1. Warren TK, Jordan R, Lo MK, et al. Kev kho tau zoo ntawm cov me me molecule GS-441524 tiv thaiv tus kab mob Ebola hauv rhesus liab. Xwm . 2016;531(7594):381-385.
2. Murphy BG, Perron M, Murakami E, et al. Lub nucleoside analog GS-441524 muaj zog inhibits feline infectious peritonitis tus kab mob nyob rau hauv cov ntaub so ntswg kab lis kev cai thiab kev sim kuaj kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
3. Siegel D, Hui HC, Doerffler E, et al. Kev tshawb nrhiav thiab kev sib txuas ntawm phosphoramidate prodrug ntawm pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-441524) rau kev kho mob Ebola thiab cov kab mob tshwm sim. Phau ntawv Journal of Medicinal Chemistry. 2017;60(5):1648-1661.
4. Yan VC, Muller FL. Qhov zoo ntawm niam txiv nucleoside GS-441524 tshaj remdesivir rau kev kho mob COVID-19. ACS Medicinal Chemistry Letters. 2020;11(7):1361-1366.
5. Gordon CJ, Tchesnokov EP, Woolner E, et al. Remdesivir yog ib qho ncaj qha - ua cov tshuaj tiv thaiv kab mob uas inhibits RNA - nyob ntawm RNA polymerase los ntawm tus mob ua pa nyuaj ua rau tus mob coronavirus 2 nrog lub zog siab. Phau ntawv Journal of Biological Chemistry. 2020;295(20):6785-6797.
6. Pedersen NC, Perron M, Bannasch M, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline kis kab mob peritonitis. Phau ntawv Journal of Feline Medicine and Surgery. 2019;21(4):271-281.