Thaum koj tus dev khawb lossis zoo li tsis xis nyob, cov kab mob cab yuav raug liam. Cov tsiaj ua khub muaj kev pheej hmoo los ntawm hma, zuam, kab mob plawv, thiab plab hnyuv nematodes. Txhawm rau daws cov teeb meem nyuaj no, niaj hnub kev tshawb fawb kws kho tsiaj tau tsim cov kev kho kom zoo. Cov inventions no suav nrogafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, uas kho cov kab mob sab nrauv thiab sab hauv ib txhij. Kev nkag siab txog qhov no dual - kev tsim cov txheej txheem kev siv tshuab pab cov tswv tsiaj thiab cov kws kho tsiaj xaiv txoj kev tiv thaiv kab mob thiab kev kho kab mob.
Kev tua kab mob yuav siv sij hawm ntau tshaj qhov chaw - theem ua. Cov kev kho mob ib txwm tsom rau cov kab mob sab nraud lossis sab hauv, tsim kom muaj qhov qhib rau rov ua dua lossis hla - kis kab mob. Kev sib xyaw ua ke kho kom zoo dua veterinary parasitology. Cov tshuaj chewable tshiab no cuam tshuam cov kab mob hauv lub paj hlwb kev ua haujlwm ntawm ob lub chaw muag tshuaj, muab kev tiv thaiv dav dav rau tag nrho cov kab mob uas raug cab rau dev.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Peb muab afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/oem-odm/tablet/afoxolaner-thiab-milbemycin-oxime-chewable.html
Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Target txawv Parasites?
Selective Targeting Raws li Parasite Biology
Afoxolaner thiab milbemycin oxime chewable pills ua haujlwm vim lawv siv cov kab mob parasite-tib neeg biochemical txawv. Isoxazoline tshuaj afoxolaner xaiv cuam tshuam rau arthropod paj hlwb. Invertebrates thiab tsiaj txhu muaj qhov chaw receptor sib txawv, uas piav qhia txog qhov kev nyuaj siab no. GABA receptors nyob rau hauv fleas, zuam, thiab mites khi cov tshuaj muaj zog tshaj, whereas tsiaj tiv thaiv los ntawm cov ntshav- hlwb barrier khi tsawg. Milbemycin oxime tua cov kab mob sab hauv nrog rau txoj hauv kev ua ntej. Cov nquag nquag ntawm no macrolides yog A3 thiab A4. Tsuas yog nematodes thiab qee yam lwm yam endoparasites muaj glutamate-gated chloride channels.
Tus tswv tsev tsiaj thiab cov kab mob kis tau cov kab sib txawv. Qhov no yog vim li cas cov combo tua cov kab mob plawv thiab cov kab mob plab zom mov tsis ua mob rau dev lub hlwb. Qhov no ob- cov txheej txheem phiaj xwm npog tag nrho cov tsev neeg cab.
Spectrum of Activity hla cov kab mob parasite
Afoxolaner tua cov neeg laus dev nyob hauv ib teev thiab tiv thaiv lawv rov qab rau ib hlis, raws li kev tshawb fawb soj ntsuam. Tsis tas li ntawd, nws tua cov zuam uas ua rau tus kab mob Lyme thiab lwm yam kab mob vector- kis tau tus kab mob. Ib koob tshuaj ib zaug txo cov ectoparasites ntau dua 95%, raws li kev tshawb fawb hauv teb. Milbemycin oxime ntse tshem tawm cov kab mob sab hauv.
Cov tshuaj tiv thaiv kab mob plawv tsis ua rau cov kab mob laus laus uas tuaj yeem tua lub plawv thiab lub ntsws. Hookworms, roundworms, thiab whipworms tuag ntawm ntau lub hnub nyoog. Qhov no txo cov mob zoonotic thiab plab hnyuv. Cov kev tshawb fawb Pharmacokinetic qhia tau hais tias A4 feem tiv thaiv ntev dua ntawm cov koob tshuaj ntau dua li A3 feem los ntawm kev tswj hwm kev kho mob. Kev kho mob txhua hli pab tswj cov kab mob cab vim lawv qhov kev ua haujlwm ntev.
Physiological Barriers thiab Drug Distribution
To taub cov active compounds 'functions illuminates lwm facet ntawm lawv cov kev ua tau zoo.
Ntau lub cev muaj cov tshuaj, uas tsim nyob rau hauv daim tawv nqaij, qhov twg ectoparasites pub. Cov qauv kev faib tawm no ua kom ntseeg tau tias cov ntshav- pub cov kab mob cab kom txaus kom tuag tes tuag taw thiab tua lawv ua ntej lawv tuaj yeem tsim dua tshiab.
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajmuaj milbemycin oxime uas yog absorbed zoo; qhov A3 thiab A4 qhov siab tshaj plaws hauv ib mus rau ob teev. Cov tshuaj hauv lub cev ncav cuag cov kab mob sab hauv ntawm cov hlwb. A3 thiab A4 tau txuas ntxiv ib nrab-lub neej-1.6 thiab 3.3 hnub, raws li- khaws cov qib tiv thaiv siab tom qab nqus tau. Qhov tseem ceeb, cov ntshav- lub paj hlwb barrier P-glycoprotein thauj cov tsiaj txhu nquag txwv tsis pub milbemycin oxime nkag mus rau CNS.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets Mechanism: Dual Action Tawm tsam sab nraud thiab sab hauv
Kev cuam tshuam ntawm GABA-Mediated Neurotransmission
Afoxolaner txwv arthropod txav los ntawm kev cuam tshuam nrog neurotransmission. Kab paj hlwb ncua kev xa paj hlwb siv GABA, lawv cov neurotransmitter loj. Nws tswj cov tshuaj chloride thiab lub hlwb teeb liab. Chloride ions nkag mus rau cov neurons thaum GABA hu nws cov receptor. Lub cell membrane ua kom zoo dua thiab tsis txaus siab. Qhov no ua rau cov nqaij ntshiv kom zoo thiab neurones los ntawm kev tua ntau dhau.
Afoxolaner cuam tshuam qhov sib npaug ntawm qhov sib npaug los ntawm kev khi rau GABA-gated chloride channels uas tsis ua haujlwm.
Qhov thaiv inhibits chloride ion passage, tshem tawm lub hlwb - qeeb teeb liab. Cov paj hlwb qhib tsis muaj kev tswj tsis tau qhov system no. Tsis tu ncua lub cev muaj zog neuron firing ua rau contractions thiab spasms nyob rau hauv parasites cov leeg. Hniav thiab zuam tuag los ntawm hyperexcitation vim lawv tsis tuaj yeem noj, tsim tawm, lossis ua haujlwm. Vim tias feem ntau cov tib neeg tuag nyob rau hauv ib teev tom qab raug tshuaj, cov tsiaj muaj mob tau txais txiaj ntsig tam sim ntawd.
Glutamate Channel ua rau hauv Nematodes
Milbemycin oxime tua cov kab mob hauv cov kab mob sib txawv tsis tau zoo. Feem ntau invertebrate neuron thiab nqaij hlwb muaj glutamate-gated chloride channels.
Lawv excite nematode neuromuscular kev sib txuas. Cov kab no tseem raug kaw kom txog thaum glutamate khi qhib rau chloride ions.
Milbemycin oxime's A3 thiab A4 feem tau zoo allosterically modulate glutamate receptors. Nws tso cai rau ntau cov chloride ions nyob rau hauv vim kev khi ua rau cov channel rhiab heev thiab qhib lawv ntev dua. Lub influx nce lub peev xwm ntawm daim nyias nyias, tiv thaiv cov paj hlwb thiab cov leeg nqaij los ntawm kev cuam tshuam rau lub cev. Cov txheej txheem no ua rau cov kab mob ua kom tsis muaj zog, tuag tes tuag taw, thiab tsis tuaj yeem nyob hauv tus tswv tsev cov ntaub so ntswg lossis tiv thaiv kev tiv thaiv kab mob. Ntev hyperpolarization exhausts tus kab mob cov metabolism thiab tshem tawm ntawm lub cev tiv thaiv kab mob. Cov txheej txheem no muaj txiaj ntsig zoo tiv thaiv kab mob plawv thiab kab mob plab hnyuv nematodes ntawm ntau theem.
Pharmacological Synergy thiab Extended Protection
Ib qho kev sib xyaw ua ke ntawm ob txoj hauv kev no tsim kom muaj kev sib koom ua tshuaj ntau dua li txhua feem ib leeg. Afoxolaner rhuav tshem cov kab mob ectoparasites sai, tiv thaiv kev poob ntshav, khaus tawv nqaij, thiab zuam - kis kab mob hauv thawj teev tom qab yug me nyuam. Milbemycin oxime tiv thaiv lub cev tiv thaiv kab mob sab hauv uas yuav tsis pom cov tsos mob kom txog thaum lawv tau ua phem ntau.
Zuag qhia tag nrho, cov tshuaj ua haujlwm zoo dua vim muaj cov yam ntxwv metabolic. Afoxolaner ob-lub lim tiam cov ntaub so ntswg ib nrab- lub neej tswj ectoparasites thoob plaws lub hli. Milbemycin oxime raug tshem tawm hauv ob theem nrog qhov sib txawv A3 thiab A4 ib nrab-lub neej.
Plasma concentrations nyob twj ywm siab txaus los rhuav tshem cov kev txav thiab cov ntaub so ntswg -cov kab mob hauv lub plawv. Lub sijhawm sib txawv no lav kev tiv thaiv txuas ntxiv yam tsis tas yuav tsum tau muab ntxiv tsis tu ncua, ua rau cov tswv tsiaj muaj peev xwm ua raws thiab txo cov tsiaj tsis xis nyob. Kev kho mob txhua hli tswj kom ruaj khov- theem hauv xeev uas tiv thaiv kab mob kom tsis txhob nthuav dav es tsis txhob kho cov kab mob.
Yuav ua li cas Afoxolaner thiab Milbemycin Oxime cuam tshuam Parasite Nervous System Activity
Molecular Binding thiab Channel Modulation
Molecularly, afoxolaner cuam tshuam nrog GABA receptor complex amino acid residues. Cov qauv kev tshawb fawb pom tau hais tias cov molecule inhibits channel pore los ntawm kev haum rau receptor protein transmembrane khi qhov chaw. Kev sib tw inhibitors tsuas yog thaiv GABA qhov chaw sib txuas, qhov kev tawm tsam no tsis sib tw. Txoj kev afoxolaner tau teeb tsa hauv cov channel tsim ib qho chaw tsis muaj zog. Txawm tias thaum synaptic GABA qib hloov pauv, qhov no thaiv cov receptors rau lub sijhawm ntev.
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajmuaj milbemycin oxime uas khi glutamate receptors sib nrug ntawm qhov chaw lees paub.
Lub complex ua kom lub channel qhib, ua kom nws nquag. Cov txheej txheem no piav qhia vim li cas milbemycin oxime txhim kho glutamate es tsis hloov lossis inhibiting nws. Milbemycin oxime nce glutamatergic signaling txawm nyob rau hauv me me vim qhov no allosteric kev sib cuam tshuam. Parasites raug rau nws ua pathologically hyperpolarized.
Selective Toxicity thiab Safety Margins
Vim yog cov kab mob cab thiab tsiaj hloov pauv, afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj hauv dev muaj kev nyab xeeb heev. Mammalian GABA receptors muaj tsawg afoxolaner affinity tshaj kab receptors vim molecular sib txawv.
Afoxolaner tsis tuaj yeem nkag mus rau CNS vim yog cov ntshav - lub hlwb thaiv. Qhov no tiv thaiv ilv neuronal hlwb.
Milbemycin oxime muaj kev tiv thaiv zoo sib xws. Cov tsiaj txhu lub hlwb tsis muaj glutamate-gated chloride channels, lub hom phiaj tseem ceeb ntawm cov tshuaj tiv thaiv kab mob. Milbemycin oxime tsis cuam tshuam nrog mammalian glutamate receptors, uas yog qhov sib txawv. P-glycoprotein transporters ntawm cov ntshav- hlwb barrier tshem tawm miltefosine oxime los ntawm lub hlwb thiab qaum qaum. Lub hlwb tsis tshua muaj siab nyob mus li txawm tias tom qab qib plasma nce mus txog qib kho mob. Cov kev tiv thaiv ntau yam no tso cai rau cov kab mob kom puas tsuaj yam tsis muaj kev phom sij rau dev. MDR1 gene mutations nyob rau hauv collies yuav txo tau P-glycoprotein muaj nuj nqi, ntau npaum yuav tsum tau ua tib zoo kho los ntawm kws kho mob.
Temporal Dynamics ntawm Parasite Elimination
Sab nraud thiab sab hauv kab tua cov sij hawm tom qab kev kho mob sib txawv. Fleas ua hyperactive hauv 4-6 teev tom qab tau txais afoxolaner. Kev txav mus los yam tsis muaj kev tswj hwm, poob kev sib txuas rau tus tswv tsev, thiab tuag tes tuag taw yog qhov cuam tshuam. Qhov no sai inhibits fleas los ntawm reproduces thiab txo allergens, relieving tsis xis nyob.
Kev tshem cov zuam yuav siv sij hawm ntev dua tab sis sib piv. Ticks tuag nyob rau hauv 24-48 teev, nyob ntawm seb hom thiab engorgement. Qhov kev ncua yog vim lawv tsis noj lossis tau txais cov tshuaj xws li hma.
Milbemycin oxime yuav tsum khaws cia hauv cov cab- tuav cov ntaub so ntswg kom tshem tawm cov cab sab hauv, uas yuav siv sijhawm. Vim tias hyperpolarization ntws tawm lawv qhov tseem ceeb, cov hnyuv nematodes tuag nyob rau hauv ib hnub. Heartworm larvae muaj zog dua thiab xav tau lub lis piam lossis ntau lub hlis ntawm kev siv tshuaj los ua kom puas. Redosing txhua hli kom ntseeg tau tias cov larvae tau txais tshiab tuaj yeem ncav cuag cov tshuaj kho mob ua ntej ua tus kab mob laus. Qhov no tiv thaiv kab mob patent.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets: Ua ke ob txoj hauv kev rau Kev Tswj Kab Mob
Formulation Design thiab Bioavailability Enhancement
Cov kev tshawb fawb pharmacological tau pom tias cov tshuaj chewable yog txoj hauv kev zoo tshaj plaws los xa cov tshuaj nquag no. Saj enhancers ua rau dev txaus siab noj cov tshuaj ntawm lawv tus kheej, txo cov kev ntxhov siab thiab tsis paub tseeb ntawm kev muab tshuaj. Flavoring thiab shaping nws zoo li kev kho mob tuaj yeem pab dev ntawm txhua hom tsiaj thiab tus kheej txais nws.
Nws ntiav excipients kom yaj thiab nqus cov tshuaj thiab txhim kho tsw. Afoxolaner thiab milbemycin oxime yog lipophilic; lawv yuav tsis yaj zoo hauv dej los yog bioavailable.
Surfactants thiab solubilizing agents nyob rau hauv cov ntsiav tshuaj matrix disperse active tshuaj nyob rau hauv lub digestive system, ua rau kom nqus tau qhov chaw. Kev tshawb fawb Pharmacokinetic qhia 88% bioavailability rau afoxolaner thiab 65-81% rau milbemycin oxime Cheebtsam vim yog kws tshuaj engineering.
Lwm cov kauj ruam tseem ceeb ntawm kev npaj yog particle loj optimization. Micronization accelerates kev puas tsuaj los ntawm kev ua kom cov khoom muaj nyob rau saum npoo thaj tsam ntawm qhov ntim. Dissolving tej yam sai dua speeds nqus thiab noj tshuaj. Daim ntawv qhia sib npaug tam sim - tso tawm thiab ntev - cuam tshuam ntev. Qhov no ua rau qeeb kev nqus tshuaj, tiv thaiv cov concentration ntau dhau uas tsis ua rau lub sijhawm siv tshuaj.
Clinical Efficacy hla ntau yam Parasite Challenges
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj tau raug pom los tua cov kab mob sib kis hauv kev sim teb hauv ntau thaj chaw kub thiab qhov chaw. Cov kev tshawb fawb hauv cov dev mub- cov cheeb tsam uas muaj kev cuam tshuam qhia tau tias kev kho mob ib hlis ib zaug txo cov dev mub ntau dua 98% hauv 12 teev thiab tiv thaiv kab mob tshiab rau 30 hnub. Flea cov lej poob qis heev hauv tsev nrog ntau tus tsiaj tom qab tag nrho cov canines tau muab kev sib xyaw ua ke vim tias cov dev mub tsis tuaj yeem yug me nyuam ntxiv lawm, uas ua rau muaj kev sib kis.Tick tswj kev tshawb fawb tau txais txiaj ntsig ntau hom. Tua dub-legged, American aub, aub xim av, thiab ib leeg hnub qub zuam tam sim ntawd txo cov kab mob sib kis los ntawm ntau, raws li kev tshawb fawb.
Acaricidal kev ua tau zoo yog siab dua 95% hauv 48 teev tom qab kis tau, txwv tsis pub cov kab mob uas xav tau cov zuam kom txuas ntxiv mus. Tus kab mob Lyme thiab lwm tus zuam - kis tau tus kab mob yog teeb meem loj rau pej xeem kev noj qab haus huv hauv cov chaw uas qhov kev cuam tshuam tam sim no tau txais txiaj ntsig.
Kev kho mob plawv txhua hli yog kwv yees li 100% zoo thoob plaws lub caij sib kis. Kev sib xyaw ua ke tua cov ntaub so ntswg-theem larvae ua ntej lawv mus txog lub plawv thiab cov hlab ntsha pulmonary. Txuag lub plawv tiv thaiv cov neeg laus lub plawv. Hom kab nuv ntses, kab kab kab, thiab kab kab kab kab muaj li 95% tsawg dua qe hauv lawv cov quav tom qab tswj tau. Cov kev tshawb pom no ua rau cov qauv tsim ib qho tseem ceeb ntawm cov kws kho tsiaj cov kws kho tsiaj 'tag nrho cov kab mob tswj hwm kab mob.
Kev koom ua ke rau hauv Kev Tiv Thaiv Kev Noj Qab Haus Huv raws tu qauv
Cov kws kho tsiaj tau pom zoo kom afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj rau xyoo -ib puag ncig tswj kab mob. Qhov koob tshuaj ib hlis ib zaug yog qhov yooj yim dua ua raws li txoj hauv kev uas yuav tsum tau siv tshuaj rau txhua tus kab. Kev txo qis kev tiv thaiv kev tiv thaiv kab mob tshwm sim los ntawm cov kev coj ua yooj yim uas cov tswv tsiaj yuav ua raws. Kev mus ntsib kev noj qab haus huv tsis cuam tshuam nrog cov qauv, thiab cov kws kho tsiaj tau sau cov khoom siv txhua xyoo. Nws yog ib qho yooj yim los saib xyuas qhov kev sib koom ua ke txhua hnub rau qhov tsis zoo los yog cov kab mob parasite siab hloov pauv uas yuav xav tau kev hloov kho lub tswv yim. Nyob rau hauv xyoo - ncig thaj chaw flea thiab heartworm, kev kho mob txhua hli yuav tiv thaiv koj.
Kev hloov pauv raws caij nyoog yog xav tau nyob rau hauv huab cua sov vim tias qee cov kab mob tsis tshua muaj zog thaum lub caij ntuj no. Ntau tus kws tshaj lij tam sim no tawm tswv yim ua raws li cov ntsiab cai tib lub xyoo- puag ncig txij li lub caij ntuj no sov dua thiab cov yoov tuaj yeem nyob hauv.
Nrog rau kev tiv thaiv ntxiv, lawv ua haujlwm zoo dua. Tsis tu ncua tu thiab ntxhua khaub ncaws tsiaj yuav txo tau cov qe qe thiab cov larvae uas cov tshuaj tua kab tuaj yeem rhuav tshem. Kev tshuaj xyuas cov quav tsis tu ncua tuaj yeem kuaj pom thiab kho cov kab mob sib kis ua ntej lawv loj. Ua ntej pib kev tiv thaiv kab mob plawv, dev tau sim rau cov kab mob plawv antigen kom txiav txim siab txog cov xwm txheej uas yuav nyuaj rau kev kho mob. Cov tswv yim no ua ke nrog qhov zoo tshaj plaws ntawm cov tshuaj -raws li kev kho mob nrog ib puag ncig thiab kev kuaj kab mob parasite.
Nkag siab Yuav Ua Li Cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Txhawb Kev Tiv Thaiv Tus Tsiaj
Kev cuam tshuam rau Vector-Kev Tiv Thaiv Kab Mob
Afoxolaner thiab milbemycin oxime chewable tshuaj tua kab mob thiab kab mob vectors. Zuam -cov kab mob kis tau, protozoa, thiab kab mob tuaj yeem ua rau dev mob. Afoxolaner tua cov zuam sai, txo lawv lub sijhawm txuas thiab kis kab mob. Ua ntej kis tus zuam lub plab mus rau tib neeg, tus kab mob Lyme spirochetes yuav tsum tau noj 24 mus rau 48 teev. Txawm tias thaum dev hu rau cov zuam kab mob, 24-teev tua tus nqi yuav xaus rau feem ntau cov kab mob. Kev tswj ceev ectoparasitic pab cov kab mob ntawm cov yoov tshaj cum. Fleas xa cov kab mob Bartonella, tapeworms, thiab lwm yam kab mob phem rau dev. Tshem tawm cov yoov tshaj cum ua ntej lawv noj lov cov kab sib kis.
Cov mis no ntev - ua haujlwm ntev ib hlis tiv thaiv cov dev mub los ntawm kev nthuav dav ntawm koob tshuaj, tiv thaiv kev kis mob.
Qhov no kab mob tiv thaiv combo tshuaj ntawmafoxolaner thiab milbemycin oxime chewable ntsiav tshuajtsom rua kev tiv thaiv kab mob plawv. Cov kab mob plawv tuaj yeem cuam tshuam koj lub siab lub sijhawm thiab tuaj yeem tua koj yog tias tsis kho. Cov neeg laus cov kab mob hauv cov hlab ntsha pulmonary thiab lub plawv sab xis ua rau mob, ua kom cov phab ntsa ntawm cov hlab ntsha, thiab txo qis ntawm cov hlab plawv. Milbemycin oxime, ib hlis ib zaug, tiv thaiv kev mob los ntawm kev rhuav tshem cov menyuam yaus theem ua ntej lawv nkag mus rau hauv cov hlab ntsha. Txoj kev tiv thaiv kab mob no muaj kev nyab xeeb dua, pheej yig dua, thiab noj qab haus huv dua li kev kho mob uas twb muaj lawm.
Txhawb Kev Ua Haujlwm Zoo ntawm Lub Neej
Kev tswj cov kab mob parasite txhim kho tus khub tsiaj noj qab haus huv thiab kev ua neej ntev. Flea-cov dev dawb muaj kev pab tam sim ntawd los ntawm flea spit allergen- ua kom khaus khaus. Cov tawv nqaij zoo, thiab cov plaub hau rov qab thaum khawb thiab tus kheej - txo qis. Txij li qhov mob tsis tu ncua lossis kev chim siab cuam tshuam rau koj tus cwj pwm, pw tsaug zog, thiab cuam tshuam nrog tib neeg thiab tsiaj, qhov zoo ntawm lub hlwb yog qhov tseem ceeb.Internal parasite tshem tawm cov teeb meem digestive uas txo qis kev noj qab haus huv thiab tseem ceeb. Hookworm-cov dev uas muaj kab mob no qaug zog thiab tsis muaj zog vim ntshav ntshav. Kab mob kab mob kab mob ua rau kev nqus zaub mov nyuaj, yog li cov tib neeg uas noj cov calories txaus ua rog.
Cov kab mob colitis ntev nrog cov hnoos qeev - los yog ntshav raws plab yuav tshwm sim los ntawm cov kab mob npaws. Tom qab tshem tawm cov kab mob no, lub plab zom mov tuaj yeem kho thiab noj cov zaub mov zoo li qub. Kev txav mus los pab dev kom muaj zog, tswj qhov hnyav, thiab tsim kom muaj zog.
Ua kom tsis txhob muaj kab mob parasite muab cov tswv tsiaj rau kev nplij siab, uas feem ntau tsis saib xyuas. Paub tias lawv cov tsiaj muaj kev nyab xeeb los ntawm txhua tus kab mob uas muaj kab mob ua rau cov tswv xav zoo dua thiab txhim kho tsiaj - tib neeg txuas. Cov tswv tsev muaj kev ntseeg siab cia lawv cov dev ua si nrog lwm cov tsiaj, txaus siab rau sab nraum zoov, thiab txhim kho lawv lub neej thaum lawv tso siab rau lawv cov phiaj xwm tiv thaiv. Kev ntseeg siab txhim kho kev sib raug zoo thiab kev zoo siab rau tsiaj.
Kev txiav txim siab nyiaj txiag hauv Parasite Management
Cov tshuaj tiv thaiv raug nqi ntau dua, tab sis lawv txuag nyiaj piv rau kev kho cov kab mob cab. Kev kho mob dev plawv yog kim thiab yuav ua rau thromboembolism thiab anaphylaxis. Lub hli - kev kho mob ntev yuav txwv tsis pub txav mus los, ntau mus ntsib kws kho tsiaj, thiab kev soj ntsuam tas li. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj ib hlis ib zaug pab tiv thaiv cov neeg laus mob plawv hauv cov tsiaj thiab txuag nyiaj rau kev kho mob. Fleas xav tau kev kho mob tshwj xeeb rau ib puag ncig, dev xav tau mus ntsib kws kho mob ntau zaus rau cov kab mob ntawm daim tawv nqaij, thiab khawb cov khoom puas.
Kev kho kab tsuag tej zaum yuav xav tau yog tias dev mub nyob txhua qhov chaw hauv koj lub tsev, nrog rau cov ntaub pua plag, rooj zaum, thiab lwm yam khoom. Kev txwv tsis pub dev mub yug me nyuam txhua hli ua ntej cov pej xeem loj hlob tuaj pab tiv thaiv cov kev siv nyiaj nce ntxiv.
Cov kws kho tsiaj yuav tsum ua cov tshuaj ntsuam xyuas, deworm, thiab kho cov teeb meem thib ob los kho cov kab mob cab sab hauv, uas yog kim. Ntau tus kab mob roundworms tuaj yeem ua rau mob plab hnyuv uas xav tau kev phais hauv cov menyuam yaus. Hookworm anemia yuav tsum tau pub ntshav rau hauv qhov mob hnyav. Whipworm colitis yuav tsum tau ntev -lub sij hawm los tiv thaiv- noj tshuaj thiab cov khoom noj tshwj xeeb. Kev tshem tawm cov kab mob tsis tu ncua tiv thaiv cov teeb meem no, uas muaj txiaj ntsig nyiaj txiag thiab kev noj qab haus huv.
Xaus
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajQhia tau li cas niaj hnub no veterinary pharmacology daws teeb meem parasitological nrog cov txheej txheem nyuaj. Cov tshuaj ua ke no tsom mus rau glutamate channel kev ua haujlwm hauv cov cab thiab GABA-kev sib haum xeeb neurotransmission hauv arthropods los tiv thaiv cov kab mob sab nraud thiab sab hauv. Qhov no yog ua tiav nrog ib qho kev noj txhua hli. Cov kev xaiv toxicity profiles tshem tawm cov kab mob thaum tiv thaiv tsiaj. Pharmacokinetic optimization ua rau lub sijhawm ntev - ua haujlwm tau zoo thaum lub sijhawm txhaj tshuaj, tiv thaiv kev kis kab mob thiab kab tsuag rov qab los.
Cov ntaub ntawv pov thawj-raws li kev saib xyuas tsiaj txhu hais txog cov tshuaj tiv thaiv uas tiv thaiv kev mob ua ntej cov tsos mob tshwm sim. Txhua hli dual- cov qauv kev ua haujlwm tiv thaiv kab mob ntawm cov kab tsuag, zuam - kab mob, kab mob plawv, thiab kab mob plab hnyuv nematodiasis. Kev nkag siab tias cov tshuaj no ua haujlwm li cas txhawb cov tswv tsiaj thiab cov kws kho tsiaj kom txiav txim siab zoo tshaj plaws rau cov tsiaj, txo cov kab mob sib kis, thiab txhim kho kev sib raug zoo los ntawm kev noj qab haus huv nyob rau ntau xyoo.
FAQ
1. Cov tshuaj afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj pib ua haujlwm sai npaum li cas?
Tsis pub dhau 4 mus rau 6 teev tom qab tau thov, afoxolaner pib tua hma, thiab feem ntau lawv tuag ua ntej lawv tuaj yeem tso qe. Peak plasma concentrations tshwm sim ob mus rau plaub teev tom qab kev tswj hwm, sai sai mus txog qib kho mob hauv cov dermis, uas yog qhov chaw noj fleas. Cov ntaub so ntswg ntev dua ib nrab- lub neej ntawm li ob lub lis piam ua kom cov txiaj ntsig zoo siab thoob plaws lub hli noj. Qhov no ua rau cov fleas rov qab los, txawm tias cov fleas tshiab kov tus dev kho. Qhov kev ua no uas pib sai sai thiab kav ntev, nres lub voj voog lub neej los ntawm kev tua cov neeg laus ua ntej lawv tuaj yeem muaj menyuam. Qhov no txo qis cov dev mub hauv tsev kho mob dhau sijhawm.
2. Cov ntsiav tshuaj no puas tuaj yeem tiv thaiv txhua hom kab mob hauv cov dev?
Milbemycin oxime nres cov kab mob plawv los ntawm kev tua cov ntaub so ntswg -theem larvae ua ntej lawv nkag mus rau lub plawv thiab cov hlab ntsha. Cov kab mob gastrointestinal nematodes xws li hookworms, roundworms, thiab whipworms, kuj raug kho thiab tswj los ntawm kev sib tov. Tab sis cov khoom tsis kho tapeworms; cov no yuav tsum tau kho nyias nrog cov tshuaj uas muaj praziquantel. Tsis tas li ntawd, kev kho mob sib txawv yog xav tau rau cov kab mob protozoal xws li Giardia thiab Coccidia. Cov kws kho tsiaj yuav tsum saib xyuas txhua tus tsiaj cov kab mob uas muaj kab mob parasite thiab qhia tag nrho cov phiaj xwm tswj hwm uas yuav suav nrog cov tshuaj ntxiv kom paub tseeb tias txhua yam raug them.
3. Puas muaj ib hom tsiaj - tshwj xeeb kev txhawj xeeb txog kev nyab xeeb nrog afoxolaner thiab milbemycin oxime?
P-glycoprotein transporters txwv tsis pub cov tshuaj nkag mus rau hauv lub hauv nruab nrab lub paj hlwb, yog li feem ntau hom dev muaj peev xwm tswj tau qhov sib tov zoo. Collie yug me nyuam thiab lwm yam herding dev nrog MDR1 noob kev hloov pauv muaj P-glycoproteins uas tsis ua haujlwm zoo, uas tuaj yeem txhais tau tias lawv tuaj yeem tswj tau ntau dua ntawm milbemycin oxime hauv lawv lub hlwb. Cov khoom tseem raug tso cai rau cov tsiaj no ntawm cov koob tshuaj ib txwm, tab sis cov kws kho tsiaj tuaj yeem hais qhia txog kev kuaj caj ces rau MDR1 kev hloov pauv thiab kev saib xyuas ze rau thawj zaug. Cov dev uas muaj hnub nyoog qis dua 8 lub lis piam los yog tsawg dua 2 kilograms yuav tsum tsis txhob tau txais cov tshuaj kom txog thaum lawv tau txais kev loj hlob zoo. Raws li kev saib xyuas ntawm tus kws kho tsiaj, cov dev cev xeeb tub thiab cov neeg laus tuaj yeem siv cov khoom, tab sis tsis muaj ntau cov ntaub ntawv hais txog nws txoj kev nyab xeeb rau cov pab pawg no.
Koom tes nrog BLOOM TECH raws li koj qhov kev ntseeg siab Afoxolaner thiab Milbemycin Oxime Chewable Tablets Supplier
Thaum koj xav tau kev ntseeg siabafoxolaner thiab milbemycin oxime chewable ntsiav tshuajtus neeg muag khoom, BLOOM TECH tau npaj txhij los txhawb koj cov kws kho tsiaj cov cai uas muaj pov thawj zoo thiab kev pabcuam dav dav. Peb GMP-cov chaw muaj ntawv pov thawj raws li US FDA, EU, thiab cov qauv kev tswj hwm thoob ntiaj teb, kom ntseeg tau tias txhua pawg muab kev ua kom huv thiab muaj zog. Nrog rau ntau tshaj 12 xyoo ntawm cov organic synthesis kev txawj ntse thiab kev tsim nyog raws li cov neeg muag khoom rau 24 lub tuam txhab tshuaj loj thoob ntiaj teb, peb nkag siab txog qhov tseem ceeb ntawm kev lees paub zoo hauv kev kho tsiaj kho tsiaj.
Peb triple -txheej txheej tswj kev ua haujlwm zoo- Hoobkas kuaj, sab hauv QA / QC department pov thawj, thiab thib peb- ntawv pov thawj tog- lav cov khoom uas ua tau raws li cov lus qhia nruj. BLOOM TECH muaj cov qauv sib tw nqi nrog cov nyiaj tau los pob tshab, hloov kho cov kev xaiv hloov pauv nrog rau OEM / ODM cov kev pabcuam, thiab cov sijhawm ua haujlwm raug coj los tswj los ntawm peb cov kev sib koom ua ke ERP platform.
Txawm hais tias koj xav tau API- cov ntaub ntawv qib, cov ntsiav tshuaj tiav hauv cov qauv tshwj xeeb, lossis cov qauv kev cai rau kev tshawb fawb daim ntawv thov, peb pab neeg ua haujlwm muab cov kws tshaj lij kev taw qhia thoob plaws hauv cov txheej txheem yuav khoom. Hu rau peb pab neeg muag khoom ntawmSales@bloomtechz.comlos tham txog yuav ua li cas BLOOM TECH tuaj yeem dhau los ua koj tus khub nyiam rau siab - zoo afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj thiab lwm cov kws kho tsiaj cov tshuaj intermediates.
Cov ntaub ntawv
1. Shoop WL, Hartline EJ, Gould BR, et al. Kev tshawb nrhiav thiab hom kev ua ntawm afoxolaner, ib qho tshiab isoxazoline parasiticide rau dev. Veterinary Parasitology. 2014;201(3-4):179-189.
2. Prichard RK, Geary TG. Kev pom ntawm kev siv hluav taws xob ntawm moxidectin rau kev tswj cov kab mob parasitic nematodes nyob rau hauv lub ntsej muag ntawm kev txhim kho anthelmintic tsis kam. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv . 2019; 10:69-83.
3. Bowman DD, Little SE, Lorentzen L, et al. Kev nthuav dav thiab thaj chaw faib khoom ntawm Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, thiab Anaplasma phagocytophilum hauv cov dev hauv Tebchaws Meskas: cov txiaj ntsig ntawm chaw kho mob hauv tebchaws -raws li kev soj ntsuam serologic. Veterinary Parasitology. 2009;160(1-2):138-148.
4. Dryden MW, Payne PA, Smith V, et al. Kev ua tau zoo ntawm selamectin, spinosad, thiab spinosad ntxiv rau milbemycin oxime tawm tsam KS1 Ctenocephalides felis flea strain infesting dev. Parasites & Vectors. 2013; 6:80.
5. Jacobs DE, Arakawa A, Courtney CH, et al. World Association for the Advancement of Veterinary Parasitology (WAVP) cov lus qhia rau kev soj ntsuam kev ua tau zoo ntawm anthelmintics rau dev thiab miv. Veterinary Parasitology. 1994;52(3-4):179-202.
6. Beugnet F, Halos L, Larsen D, et al. Kev ua tau zoo ntawm qhov ncauj afoxolaner rau kev kho mob ntawm canine generalized demodicosis. Parasite. 2016; 23:14.