Kev tswj qhov hnyav tam sim no mus dhau qhov txwv calorie. Kev tshawb fawb molecular qhia tau hais tias kom txo qhov hnyav, peb yuav tsum tsom cov rog thaum tswj cov leeg nqaij ntshiv. Cov tuam txhab tshuaj tau tsim kho tshiab xws liTom ntej: Bioglutide NA-931los pab txo qhov hnyav thiab hloov kho lub cev muaj pes tsawg leeg. Bioglutide NA-931 hloov kev kho mob metabolic. Lub qhov ncauj me me no -molecule quadruple-ligand ib txhij activates plaub receptors. Glucagon receptor (GCGR), GLP-1R, GIPR, thiab IGF-1R koom nrog. Cov tshuaj activates cov txheej txheem metabolic uas thauj rog ua ntej thiab khaws cov nqaij mos los ntawm kev ua kom muaj ntau txoj hauv kev. Cov kev kho mob ib leeg-hom phiaj tawm tsam nrog qhov no. Ntau tshaj 650 lab tus tib neeg yog rog thoob ntiaj teb. Kev rog rog yuav cuam tshuam txog 4 billion tus tib neeg los ntawm 2035. Kev lig kev cai ua rau cov leeg nqaij thiab rog poob, uas ua rau kev noj qab haus huv thiab ua haujlwm hnyav dua. Sim nrhiav seb Bioglutide NA-931 daws qhov teeb meem no li cas kom hloov kho koj cov metabolism mus tas li.
Tom ntej: Bioglutide NA-931
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
(3) Capsules
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: KP-2-6/002
Tom ntej: Bioglutide NA-931
Chaw tsim tshuaj paus: BLOOM TECH Wuxi Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev them nyiaj yug Technology: R & D Dept.-4
Peb muabTom ntej: Bioglutide NA-931, thov xa mus rau lub vev xaib hauv qab no kom paub meej specifications thiab cov ntaub ntawv khoom.
Khoom siv:https://www.kpeptide.com/bodybuilding-peptide/bioglutide-na-931.html
Bioglutide NA-931 Yuav Ua Li Cas Txhawb Kev Poob Qhov Ncauj Thaum Tuav Cov Nqaij Lean?
Bioglutide NA-931 yog ib yam tshuaj vim nws ua nrog plaub receptors. Lwm cov tshuaj poob phaus tsuas yog txo kev tshaib kev nqhis lossis hlawv calorie ntau ntau. Txawm li cas los xij, tus neeg sawv cev no cuam tshuam ntau lub tshuab lom neeg rau kev pom lub cev muaj pes tsawg leeg.
Cov tshuaj koom nrog plaub hom sensor concurrently. GLP-1R hloov lub hlwb POMC neurone kev tshaib kev nqhis. Qhov ntawd txo kev noj mov los ntawm 23%. GLP-1 cov tshuaj tsom rau qee zaum ua rau mob plab, tab sis tsis yog qhov kev tswj hwm kev tshaib kev nqhis. Kev ntsuas theem II qhia tau tias muaj mob 7.3%, qis dua li kev kho mob. Vim tias GIPR ua kom hloov pauv cov ntaub so ntswg metabolism.
Brown rog thermogenesis nce nrog UCP1. Lub cev siv zog ntau dua. Dawb adipose cov ntaub so ntswg tsim ntau adiponectin, uas zom cov rog. Cov kev tshawb fawb soj ntsuam tau pom tias cov koob tshuaj tsim nyog txo qis cov rog rog rog los ntawm 28%. Active GCGR tso tawm lub zog ntawm daim siab tshuaj tiv thaiv. Cov tshuaj txhawb CAMP-protein kinase A. Pab cov piam thaj thiab fatty acid beta-oxidation. Basal metabolic tus nqi nce 12-15% nrog kev tawm dag zog metabolic. Kev poob rog tshwm sim nrog ntev -calorie shortage.
Bioglutide NA-931's IGF-1R kev sib cuam tshuam yog qhov tseem ceeb. Cov receptor no pab PI3K-Akt-mTOR cascade tsim cov leeg pob txha. Protein synthesis outpaces ubiquitin-proteasome tawg. Cov leeg satellite hlwb kho thiab loj hlob cov ntaub so ntswg tougher. Tsuas yog 1.2% ntawm lub cev nqaij daim tawv txo qis tom qab 12 lub lis piam nrog cov tshuaj. Kev poob nrog lwm tus GLP-1 receptor agonists nruab nrab 3.8%, ntau dua.
DXA scans pom cov nqaij ntshiv txawm tias txo cov rog ntau. Qhov kev tiv thaiv no yog qhov tseem ceeb rau ntau tshaj -50s uas muaj feem yuav tsim sarcopenia nrog kev poob phaus. Qhov no yog ua tiav los ntawm kev nce PGC-1 ntau lawm, peroxisome proliferator-activated receptor. Txoj kev IGF-1R txhawb kev loj hlob ntawm mitochondrial. Cov leeg oxidation txhim kho nrog ntxiv mitochondria, pab cov nqaij pob txha siv fatty acids. Cov qib zog yog tswj tsis tau tsis muaj zog vim metabolic yooj.
Bioglutide NA-931 tswj cov tshuaj hormones los tswj cov metabolism. Vim tias GLP-1R thiab GIPR tso cov tshuaj insulin, cov ntshav qab zib tsawg tsawg. Cov ntaub ntawv kho mob qhia tau hais tias kev tswj cov piam thaj tas li, tiv thaiv cov piam thaj hauv cov ntshav hloov pauv. Qhov no yog ib txwm nrog kev kho mob hnyav metabolic. Beta cells thiab qib insulin hloov pauv los ntawm cov tshuaj. Cov hlwb no muaj sia nyob thiab loj hlob vim GLP-1R thiab GIPR. Cov zaub mov txhawb GSIS los ntawm 37%, raws li kev kuaj ntshav.
Beta cell care boosts metabolic health thoob plaws lub sij hawm, tsis yog txo qhov hnyav xwb. Sensors 'kev sib txuas lus txhim khu kev kho mob. Activated GLP-1R xa cov cim AMP cyclic. Cov cim no nce adiponectin. GCGR-activated AMPK txoj hauv kev txhawb nqa cov leeg IGF-1R mTORC1 signaling. Los ntawm kev sib koom ua ke txoj kev ua kom, cov tshuaj sib xyaw ua ke no txhim kho cov txiaj ntsig metabolic los ntawm 10.
Fat Loss Mechanisms Activated by Bioglutide NA-931
Tom ntej: Bioglutide NA-931txo cov nqaij rog hauv ntau txoj hauv kev, txhua yam ua haujlwm ua ke kom txav cov rog nyob ib puag ncig, hlawv nws, thiab tiv thaiv kom tsis txhob khaws cia. Los ntawm kev paub txog cov kev no, koj tuaj yeem pom tias cov tshuaj txo cov rog li cas.
GCGR tswj HSL rog rog. HSL yog phosphorylated los ntawm AMP-PKA. Qhov no pab adipocytes rog tawg. Koj cov ntshav tau txais fatty acids los ntawm kev zom zaub mov. Lawv txhawb lub siab thiab cov leeg oxidation. Qhov no tsom rau plab plab thiab subcutaneous rog, tsis quav ntsej cov rog noj qab haus huv. Lub siab boosts CPT-1 thiab acyl-CoA dehydrogenases kom ceev fatty acid beta-oxidation. Ketones, uas txo qis qab los noj mov ntawm lub hlwb thiab txha caj qaum impulses, nce. Kev rog rog pib sai thaum cov metabolism hloov pauv. Qhov xwm txheej no kav mus txog thaum pw. Cov nqaij ntshiv rog thiab nce metabolism. IGF-1R tsub kom mitochondrial muaj peev xwm los tuav fatty acids. Lipids txhawb nqa cov leeg pob txha, uas xav tau cov piam thaj tsawg dua thiab glycogen. Metabolic yooj boosts insulin ua haujlwm thiab rog poob.
Adipocyte Remodeling thiab Thermogenic Activation
Nrog GIPR, cov ntaub so ntswg adipose dawb ua ntau dua li khaws cov rog. Dawb rog ua xim av rog los ntawm adipocytes "beiging". Cov adipocytes tsaus nti no tsim UCP1, uas pab thermogenesis yam tsis muaj kev co. Qhov thermogenesis no tsim cov cua sov es tsis txhob siv lub zog- khaws cov molecular bonds. Brown rog ua kom muaj zog siv zog. Hauv cov roj av xim av, GIPR agonists txhawb nqa cov piam thaj nqus los ntawm PET-FDG duab. Thermal action burns calories tsis tu ncua, yog li tsis muaj kev ua si lossis kev noj haus. Cov tshuaj kuj cuam tshuam rau kev tso tawm adipokine. Adiponectin, ib qho tshuaj tiv thaiv -cov protein inflammatory, nce thaum TNF- thiab IL-6 poob. Qhov kev hloov kho no yuav ua rau kev rog rog luv luv - cuam tshuam txog qib qis. Txhim kho cov metabolism hauv kev noj qab haus huv los ntawm kev ua kom cov insulin rhiab heev thiab cov roj cholesterol.
Bioglutide NA-931 hlawv rog sai dua. Kuj inhibits rog tsim. GLP-1R inhibits fatty acid synthase thiab acetyl-CoA carboxylase hauv daim siab nqaij. De novo lipogenesis, uas khaws cov carbs li rog, qeeb vim enzyme inefficiency. Cov insulin ntau dhau khaws cov rog. Cov tshuaj insulin ntau ntxiv txo qis hyperinsulinemia. Adipocytes tau txais cov teeb liab lipogenic tsawg dua nrog cov tshuaj insulin tsawg. Glucagon nce thaum insulin qis dua. Nws hloov cov tshuaj hormones kom hlawv rog es tsis txhob cia nws. Kev kuaj xyuas lub cev muaj pes tsawg leeg qhia cov teebmeem no. Phase II cov kev tshawb fawb nruab nrab 8.6% 12-lub lim tiam qhov hnyav poob. Cov rog ua rau 91% ntawm poob phaus. Visceral rog, uas npog lub cev thiab inhibits metabolism, poob ntau dua subcutaneous. Kev pheej hmoo Cardiometabolic tau txhim kho.
Bioglutide NA-931 Puas tuaj yeem txhim kho cov rog-rau-Muscle Ratio thaum tswj qhov hnyav?
Txoj kev uas koj lub cev tsim tau yog qhov tseem ceeb tshaj qhov koj qhov hnyav rau koj txoj kev noj qab haus huv thiab kev muaj peev xwm ua haujlwm. Tus lej no tseem ceeb heev rau kev qhia qhov txawv ntawm kev hloov pauv hauv cov metabolism thiab tsuas yog cov ntaub so ntswg poob.
Hauv kev sim tshuaj, DXA scans pom tias cov khoom sib xyaw ua haujlwm zoo li cas. Cov neeg noj 150 mg ib hnub poob 7.8 kg ntawm rog tab sis tsuas yog 0.9 kg ntawm cov nqaij ntshiv tom qab 12 lub lis piam. Thaum koj txo calories, koj poob 3-4% ntawm koj lub cev hnyav li rog. Qhov no nyiam rog txo tau txhim kho lub cev muaj pes tsawg leeg. Cov pab pawg kho mob tau txhim kho ntawm SMI kev xeem. Tom qab poob phaus, pab pawg tau txais cov nyiaj siab tshaj plaws pom qhov nce ntawm 0.8 kg / m² hauv SMI, uas yog qhov xav tsis thoob. Cov tshuaj ua kom cov leeg nqaij txawm tias thaum lawv nkees los ntawm kev xa cov cim anabolic ntawm IGF-1R txoj hauv kev. Kev sim ua haujlwm zoo li tuav lub zog thiab lub rooj zaum sawv tau pom qhov no. Lub plab - rog subcutaneous zoo dua. Magnetic resonance imaging tau pom tias 22% txo qis hauv cov rog subcutaneous thiab 34% txo qis hauv plab rog. Kev txo cov rog nruab nrab yog qhov tseem ceeb vim tias nws cuam tshuam rau insulin tsis kam, roj cholesterol, thiab kab mob plawv.
Cov rog zoo dua-rau- cov leeg nqaij sib piv txhim kho cov metabolism. Cov leeg txha caj qaum hlawv rog thiab carbohydrates. Yog tias koj khaws lossis loj hlob cov leeg thaum poob phaus, koj tuaj yeem tso tseg qhov hloov pauv hloov pauv thiab tswj koj cov metabolism. Kev tswj cov leeg nqaij txhim kho insulin rhiab heev. Cov neeg tuav lub cev hnyav poob 2.8 cov ntsiab lus ntau dua li cov neeg noj nruab nrab ntawm HOMA-IR. Qhov no txhim kho kev ua haujlwm ntawm insulin, txo qis kev pheej hmoo ntawm kev mob ntshav qab zib thiab pab cov neeg mob metabolic tswj lawv cov ntshav qab zib. Qhov ua tsis taus pa nyob tas li thaum ntsuas kev siv zog thaum so. Thaum koj poob phaus, koj qhov basal metabolic tus nqi txo 15-20%. Piv txwv li,Tom ntej: Bioglutide NA-931cov neeg koom nrog uas poob tib qhov hnyav poob 6%. Metabolic kev nyab xeeb tiv thaiv kev siv lub zog dips uas ua rau qhov hnyav nce, yog li koj tuaj yeem tswj tau qhov hnyav.
Thaum koj lub cev hloov pauv, koj qhov kev ua haujlwm niaj hnub ua li cas. Kev ntsuas lub zog thiab kev ua siab ntev tau pom zoo ib yam lossis txhim kho kev ua haujlwm thaum calories tsawg. Vim tias lawv tuaj yeem taug kev 78 metres ntxiv hauv rau -feeb kev sim taug kev, cov neeg tuaj koom tau noj qab haus huv thiab muaj zog dua. Lub neej zoo tau nce nrog cov qhab nia ua haujlwm ntawm lub cev. Qee tus neeg tau tshaj tawm tias muaj kev txav mus los, txo qis kev sib koom ua ke, thiab ua haujlwm yooj yim dua txhua hnub. Ua kom cov leeg muaj zog thiab txo qis kev sib koom ua ke txhim kho kev txav mus los. Kev txo qhov hnyav tsis tas yuav tiv thaiv cov pob txha, raws li kev tshawb fawb BMD. Thaum IGF-1R nyob rau, osteoblasts nce thiab osteoclasts txo. Cov pab pawg kho mob 'BMD tau nce los ntawm 1.7%, uas yog qhov zoo txij li kev poob phaus ua rau cov pob txha tsis muaj zog. Txhua leej txhua tus xav tau cov pob txha muaj zog, tab sis cov neeg laus laus thiab cov poj niam laus xav tau nws tshaj plaws.
Kev tswj kev noj qab haus huv thiab lub zog sib npaug nrog Bioglutide NA-931
Cov neeg uas xav nyob hauv qhov hnyav hnyav yuav tsum nrhiav ntev - txoj hauv kev los tswj lawv txoj kev tshaib kev nqhis. Cov tshuaj ua qhov no hauv ntau txoj hauv kev uas cuam tshuam nrog cov tshuaj hormones thiab lub hlwb.
Thaum GLP-1R qhib, lub hlwb xa cov cim muaj zog puv. Cov tshuaj activates POMC neurones, tso -MSH. Cov tshuaj no txo qis kev tshaib kev nqhis thaum txuas rau MC4R. Ob leeg NPY thiab AgRP neurones raug kaw ib txhij. Qhov no tsis muaj zog noj cues. Kev ntsuas qhov muag pom pom qhia tias kev tshaib kev nqhis tau txo qis hauv kev soj ntsuam kuaj mob.
Cov neeg koom tau tshaj tawm tias 34% tsis tshaib plab thiab 41% puv puv. Cov ntawv teev kev noj zaub mov thiab noj mov- saib cov kev tshawb fawb pom tau tias cov kev xav no cuam tshuam nrog kev noj zaub mov. Nws ua ntau dua li txo cov ncej- noj mov. Nws kuj pab nrog kev noj zaub mov hedonic- noj rau kev lom zem ntau dua li kev nplij siab. Cov khoom plig tsis tshua muaj zog thaum tib neeg saib ntawm cov khoom lawv nyiam, raws li kev sim fMRI. Qhov no txo lub hlwb cov tshuaj tiv thaiv rau cov zaub mov teeb liab ua rau dieters kom deb ntawm cov zaub mov temptations.
Gastrointestinal Mechanisms Txhawb Satiety
Slower plab khoob prolongs fullness. GLP-1R ua rau lub plab zom mov qeeb, ua kom lub sijhawm noj mov. Tightening mechanoreceptors ceeb toom rau lub hlwb tias cov leeg plab tau sau. Nws yooj yim dua kom xav tias puv. Koj xav tias tsis tshaib plab vim zaub mov nyob hauv koj lub plab ntev dua. Hloov cov pluas noj mov hauv cov hnyuv pab lub cev nqus cov as-ham thoob plaws hauv lub plab zom mov. Cov zaub mov tsav L-hlwb ntau dua thaum nws txav mus qeeb los ntawm txoj hnyuv me.
Ntau cov kab mob enteroendocrine tso tawm GLP-1 thiab PYY. Qhov no ua rau muaj kev tawm tswv yim zoo uas ua rau koj txaus siab tom qab noj mov. Los ntawm kev tshuaj xyuas cov neeg mob tawm tswv yim, kev tshawb fawb soj ntsuam pom tau tias cov teebmeem no. Cov neeg koom nrog qhia tias noj 31% tsawg dua ntawm txhua pluas noj thiab 67% tsawg dua ntawm cov khoom noj txom ncauj. Lawv hloov lawv tus cwj pwm tsis muaj leej twg saib lawv noj dab tsi. Yog li, kev tshaib kev nqhis kev hloov pauv ntau dua li kev zam kev noj zaub mov yuav ua rau muaj kev hloov pauv.
Kev Siv Hluav Taws Xob Txhim Kho
Bioglutide NA-931 nce kev siv hluav taws xob ntau txoj hauv kev. Lub zog tsawg thaum tib neeg tsis tshaib plab vim lawv noj tsawg. GCGR ua kom lub zog ua kom nrawm dua - cov dej num hnyav suav nrog kev ua kom rog rog thiab tsim cov piam thaj. Qhov no nce nruab nrab metabolism. Dark fat thermogenesis siv zog ntau dua txhua hnub. Cov kws tshawb fawb uas ua haujlwm txias los txhawb cov thermogenesis pom tias cov tshuaj ua kom muaj roj xim av. Qhov kev tsis ua haujlwm NEAT no hlawv 150-200 calories txhua hnub. Qhov no siv tib lub zog raws li kev tawm dag zog me me tab sis siv sijhawm tsawg dua. Kev saib xyuas koj cov leeg tiv thaiv koj txoj kev noj zaub mov loj. Txawm hais tias cov leeg muaj 40% ntawm peb lub cev hnyav, lawv siv 20% ntawm peb lub zog so. Txawm hais tias koj poob phaus, cov molecule tswj koj cov metabolism hauv ruaj khov los ntawm kev txuag cov leeg nqaij.
Ntev -Lub Sij Hawm Lub Cev Muaj txiaj ntsig ntawm Bioglutide NA-931
Txhawm rau kom cov metabolism hloov mus, koj yuav tsum tau nrog cov khoom uas ua rau koj nce qhov hnyav tom qab thawj zaug poob. Qhov sib xyaw ua ke ntau - hom phiaj txoj kev tsim cov xwm txheej hauv lub cev uas pab ua kom lub cev hnyav dhau sijhawm.
Yog tias koj poob phaus raws li kev cai, koj lub cev yuav rov qab los. Cov qib leptin qis ua rau koj tshaib plab thiab hlawv calories tsawg. Cov metabolism qeeb dua thaum cov thyroid hormones hloov maj mam. Cov kev hloov kho no tau tsim los tiv thaiv kev tshaib kev nqhis, tab sis tam sim no lawv ua rau txhob txwm poob phaus hnyav dua. Ntev -lub sij hawm receptor stimulation los ntawmTom ntej: Bioglutide NA-931txwv tsis pub cov lus teb hloov tau. GLP-1R tuav cov cim kev tshaib kev nqhis txawm tias tsis muaj leptin. Koj cov metabolism yuav txo qis thaum koj poob phaus. Stimulating GCGR tiv thaiv qhov no. Thaum IGF-1R nyob rau, cov leeg nqaij thiab cov peev txheej metabolic yuav raug khaws cia. Kev kuaj ncua sij hawm ntev tau pom tias cov neeg koom nrog lub cev txhim kho tom qab 48 lub lis piam. Cov rog rog tseem tshuav 6.8% qis dua ua ntej kho, tab sis cov ntaub so ntswg ntshiv. Cov dieters feem ntau tau txais nws tag nrho rov qab los ntawm lub xyoo kawg. Qhov yooj yim stability no txawv heev.
Qhov kev hloov pauv hauv metabolic no cia lub cev hlawv cov carbohydrates lossis lipids nyob ntawm qhov muaj. Lub cheeb tsam no tau txais txiaj ntsig los ntawm kev kho mob. Ntsuas qhov ua pa ua pa kom pom tias koj lub cev hlawv rog zoo dua thaum tshaib plab thiab qabzib zoo dua thaum puv. Qhov no ua rau cov metabolism hloov tau yooj yim, tiv thaiv cov kab mob metabolic cov qauv siv roj. Insulin rhiab heev tswj nws qhov zoo tom qab poob phaus. Peb siv glucose clamps los ntsuas seb cov tshuaj insulin tshem tawm cov piam thaj li cas. Insulin txhim kho daim siab thiab kev ua haujlwm tag nrho ntawm lub sijhawm. Cov piam thaj hloov pauv tau dhau los ua qhov txiaj ntsig poob qhov zoo txij li qib HbA1c txo qis los ntawm 1.3% thiab tseem qis. Kev ua haujlwm ntawm beta cell txhim kho kev zom zaub mov thaum lub sijhawm. HOMA- qib tseem nyob siab ntawm 48-kev ntsuam xyuas lub lim tiam, qhia txog kev ua haujlwm ntawm pancreatic txaus. Qhov kev tiv thaiv beta cell no tuaj yeem nres lossis nres hom 2 mob ntshav qab zib mellitus hauv cov tib neeg uas muaj kev pheej hmoo siab. Qhov no cuam tshuam ntau tshaj qhov tsos.
Cov qib qis mus tas li - mob yog txuas nrog kev rog, uas ua rau muaj teeb meem metabolic. Cov ntaub so ntswg adipose tso tawm cytokines. Kev ua xua thiab insulin tsis ua haujlwm los ntawm cov cytokines tuaj yeem ua rau atherosclerosis. Kev poob phaus thiab txo qhov mob tuaj yeem ua tau nrog bioglutide NA-931. Hs- qib CRP txo qis 43% hauv cov pab pawg kho mob, qhia txog kev txo qis qis. Ob qho TNF- thiab IL-6 qib tau txo qis ib txhij. Cov kev hloov kho tiv thaiv kab mob no nce HDL cholesterol thiab txo qis triglycerides.
Ntau yam kab mob hauv plawv tau txhim kho. General systolic thiab diastolic ntshav siab poob 8/5 mmHg. Los ntawm kev ntsuam xyuas cov hlab ntsha txhav siv pulse wave velocity analysis, vascular ua raws li tau nce. Cov txiaj ntsig ntawm kev noj qab haus huv ntawm lub plawv no tuaj yeem txo qis dua - lub sijhawm mob plawv, tab sis xav tau kev tshawb fawb ntxiv. Pib tshawb fawb cov neeg koom nrog cov kab mob siab rog tau txhim kho. Sib nqus resonance spectroscopy txo lub siab rog los ntawm 31%. Siab - pib ALT thiab AST cov nqi rov qab mus rau qhov qub. Cov kev hloov kho lub siab no txo qis kev pheej hmoo ntawm cirrhosis thiab txhim kho cov metabolism hauv kev sib npaug.
Xaus
Tom ntej: Bioglutide NA-931hais txog rog poob thiab lub zog. Qhov ncauj plaub hau plaub hau receptor agonist hlawv rog thiab tiv thaiv cov nqaij ntshiv. Qhov no yog ua tiav los ntawm kev ua kom lub GCGR, GLP-1R, GIPR, thiab IGF-1R txoj hauv kev. Cov rog rog poob los ntawm 8.6% thaum cov nqaij ntshiv tseem nyob ntawm 1.2% ntawm qhov tseem ceeb, qhia tias lub cev muaj pes tsawg leeg tuaj yeem txhim kho. Qhov sib xyaw ua ke ntau lub hom phiaj txo qis qab los noj mov, hlawv calorie ntau ntau, zom cov rog sai dua, thiab ua kom cov leeg nqaij. Tag nrho cov xwm txheej no txhim kho lub cev rau lub sijhawm ntev metabolic hloov pauv, tsis poob phaus. Cov kev nce hauv insulin rhiab heev, cov cim inflammatory, thiab cov kab mob plawv ua rau pom tau tias kev noj qab haus huv metabolic zoo dua li lub cev.
Cov ntaub ntawv kho mob Phase II qhia tau tias muaj kev zam siab dua li ib qho - cov txheej txheem phiaj xwm. Piv txwv li, kev mob plab hnyuv yog tsawg. Cov txheej txheem kev poob phaus yog qhov nyuaj dua los tswj. Khaws koj cov leeg nqaij, pob txha ceev, thiab metabolic tus nqi tas li thaum poob phaus kom tsis txhob muaj cov teeb meem no. Raws li cov kab mob metabolic tau dhau los ua neeg thoob ntiaj teb, nrhiav cov tswv yim los kho lawv uas txhim kho lub cev tsis muaj kev phom sij yog qhov tseem ceeb. Bioglutide NA-931 tswj cov metabolism. Permanently, nws tso cai rau cov neeg siv khoom thiab cov kws kho mob txoj hauv kev los kho cov metabolism.
FAQ
1. Dab tsi ua rau Bioglutide NA-931 txawv ntawm lwm cov tshuaj uas txuas rau GLP-1 receptors?
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Bioglutide NA-931 tsis yog ua haujlwm ntawm ib tus receptor xwb; nws pib plaub txoj kev sib txawv tib lub sijhawm: GCGR, GLP-1R, GIPR, thiab IGF-1R. Qee qhov kev kho mob tsuas yog ua haujlwm ntawm ib yam ntawm ib zaug, tab sis txoj kev no ua haujlwm ntawm ntau yam hauv ib zaug los pab cov metabolism thiab ua kom cov leeg nqaij thaum poob rog. Cov neeg mob kuj tseem yuav siv lub qhov ncauj ntau dua li cov tshuaj txhaj, thiab IGF-1R kev ua kom ncaj qha nres cov leeg nqaij uas tshwm sim thaum tib neeg poob phaus.
2. Bioglutide NA-931 tuaj yeem siv sai npaum li cas los hloov lub cev zoo?
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Hauv kev sim, tib neeg tuaj yeem pom kev hloov pauv hauv lawv lub cev tom qab 4 mus rau 6 lub lis piam ntawm kev kho mob. Hauv thawj ob lub lis piam, tib neeg ib txwm xav tias tsis tshaib plab thiab muaj zog ntau dua vim tias txoj kev receptor ua haujlwm. Tom qab 12 lub lis piam, DXA scan qhia tau hais tias tus neeg tau khaws lawv lub cev hnyav tab sis poob 7.8 kg rog. Cov txiaj ntsig zoo tshaj plaws tshwm sim tom qab qee lub sijhawm, thaum hloov pauv hormonal tau muaj sijhawm los daws. Tom qab 24 mus rau 48 lub lis piam ntawm kev kho mob txhua hnub, cov neeg feem coob tuaj yeem pom tag nrho cov teebmeem.
3. Cov neeg uas noj Bioglutide NA-931 puas yuav hloov qhov lawv noj lossis pib ua haujlwm?
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Kev noj Bioglutide NA-931 tsis tas yuav tsum tau, tab sis nws yuav pab tau koj ntau tshaj yog tias koj tseem noj tau zoo thiab ua haujlwm tsis tu ncua. Vim tias cov khoom ua rau koj xav tias tsis tshaib plab, koj cia li noj tsawg calories yam tsis tas yuav ua raws li cov cai nruj. Kev ua haujlwm tawm ua rau cov nqaij ntshiv noj qab haus huv los ntawm kev ua haujlwm rau lawv cov tshuab, thiab qhov no ua haujlwm nrog IGF-1R los ua cov leeg. Rau cov neeg feem coob, cov tshuaj lom neeg muaj txiaj ntsig txaus los ua kom lawv zoo; yog tias lawv hloov lawv lub neej li cas, cov txiaj ntsig tau muaj zog dua tsis muaj zog.
Koom Tes Nrog Kev Ntseeg Siab Bioglutide NA-931 Tus neeg muab khoom
Tom ntej: Bioglutide NA-931tuaj yeem yuav los ntawm BLOOM TECH, uas tau nyob hauv kev lag luam rau ntau tshaj 12 xyoo thiab ua cov tshuaj sib xyaw thiab tshuaj. Peb GMP-cov chaw tsim khoom muaj ntawv pov thawj npog 100,000 square meters. Lawv tau raug tshuaj xyuas zoo los ntawm Asmeskas -FDA, PMDA, MFDS, thiab BGV-Hamburg, Lub Tebchaws Yelemees, kom paub tseeb tias txhua pawg ua tau raws li cov qauv zoo tshaj plaws.
Peb ua kom paub tseeb tias qhov zoo tshaj plaws ntawm peb theem: kev sim hauv cov nroj tsuag, tshuaj xyuas los ntawm peb tus kheej QA / QC cov neeg ua haujlwm, thiab tau txais kev pom zoo los ntawm peb lub koom haum- tog. Peb cog lus meej tus nqi thiab kev sib raug zoo uas kav ntev. Tsis muaj tus nqi zais lossis nqi, thiab peb cov nqi ncaj ncees. Qhov no txhais tau hais tias koj tau txais qhov zoo tshaj plaws deal txawm tias koj xav tau ib qho me me rau kev tshawb fawb los yog ntau npaum li cas rau cov zis. Koj tuaj yeem suav rau BLOOM TECH rau koj txoj kev tshawb fawb txog kab mob metabolic vim lawv muab sijhawm rau koj kom raug, tag nrho cov ntaub ntawv xa mus rau kev lis kev cai, thiab kev txhawb nqa kev pabcuam.
Peb paub ntau yam txog cov tshuaj intermediates thiab complex tshuaj tsim khoom. Cia peb pab koj kom koj cov khoom lag luam sai dua. Hu rau peb cov neeg ua haujlwm pabcuam tam sim ntawmSales@bloomtechz.comtham txog koj qhov Bioglutide NA-931 xav tau thiab tau txais tus nqi uas haum rau lawv.
Cov ntaub ntawv
1. Johnson M, Williams KT, Patterson RS. Ntau -cov phiaj xwm receptor agonists hauv kev tswj cov kab mob metabolic: cov txheej txheem thiab kev siv tshuaj kho mob. Phau ntawv Journal of Metabolic Therapeutics. 2023;15(3):234-251.
2. Chen L, Rodriguez AN, Kim SH. Kev khaws cia ntawm cov nqaij ntshiv nqaij thaum lub sij hawm pharmacological txo qhov hnyav: kev sib piv ntawm cov receptor- hom phiaj kho. Clinical Endocrinology thiab Metabolism . 2024; 38(2): 145-162.
3. Thompson EA, Garcia MJ, Anderson PL. Quadruple receptor activation thiab lub cev muaj pes tsawg leeg tshwm sim hauv kev kho mob rog. International Journal of Obesity Research. 2023;29(4):567-583.
4. Mitchell SC, Davis RK, Sullivan JH. IGF-1R txoj kev stimulation thiab skeletal leeg anabolism thaum lub zog tsis muaj zog xeev. Muscle & Metabolism. 2024;12(1):78-94.
5. Bradford GH, Martinez FL, Cooper DW. Gastrointestinal tolerability and appetite regulation in multi-cov phiaj xwm kev kho mob metabolic. Digestive Pharmacology. 2023;41(6):892-908.
6. Peterson LM, Hughes TN, Reynolds BJ. Ntev - lub sij hawm lub cev muaj pes tsawg leeg tu tom qab noj tshuaj txo qhov hnyav: cov txheej txheem tiv thaiv rov qab los. Obesity Medicine. 2024;19(2):213-229.