Thaum feline viral peritonitis tshwm sim, nws yog ib qho phem tshaj plaws uas tuaj yeem tshwm sim rau tus tswv miv. Tus kab mob tuag no yog tshwm sim los ntawm tus kab mob feline hloov pauv, thiab cov kws kho tsiaj tsis muaj ntau txoj hauv kev los kho nws yav dhau los. Lub discovery ntawmgs -441524 fip uatau hloov qhov xwm txheej tu siab no los ntawm kev cia siab tiag tiag los ntawm kev txwv tsis pub cov kab mob rov ua dua tshiab. Nrhiav seb yuav ua li cas cov nucleoside analog no txwv tus mob coronavirus los ntawm kev ua haujlwm qhia tias yog vim li cas nws tseem ceeb heev hauv kev kho fip tam sim no.Kev sib ntaus ntawm gs-441524 fip thiab feline coronavirus tshwm sim ntawm qib microscopic, qhov twg cov tshuaj nres tus kab mob los ntawm replicating. Cov tshuaj tua kab mob no mus tom qab qhov tseem ceeb uas tus mob coronaviruses yuav tsum muaj sia nyob, txwv kev tawm tsam hauv nws txoj kev. Kev tshawb fawb tom qab qhov kev txiav txim no qhia tau hais tias cov tshuaj tshiab tuaj yeem kho cov mob uas kho tsis tau ua ntej.
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
GS-441524 CAS Nr .: 1191237-69-0
Peb muab gs-441524, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-kev tshawb nrhiav-only/gs-441524-fip.html
Yuav ua li casgs -441524 fip uaInterrupts Feline Coronavirus RNA Synthesis
RNA-Txoj kev sib txuas ntawm RNA Polymerase
Ib qho enzyme tshwj xeeb hu ua RNA-dependent RNA polymerase (RdRp) pab tus kab mob feline tus kab mob luam tawm nws cov khoom siv caj ces. Raws li tus kab mob no luam tawm nws tus kheej, cov enzyme no ua rau cov kab tshiab ntawm RNA uas ua tus qauv rau cov kab mob tshiab. gs-441524 fip nkag mus rau hauv cov hlwb mob thiab hloov mus rau hauv nws daim ntawv nquag triphosphate los ntawm phosphorylation. Lub active molecule no muaj ib tug qauv uas zoo ib yam li adenosine triphosphate, uas yog ib tug ntuj tsim thaiv los ua RNA.
RdRp tsis tuaj yeem paub qhov txawv ntawm gs-441524 fip-hloov thiab tsis tu ncua substrates. Tus kab mob polymerase ua tsis tau ntxiv cov tshuaj molecule es tsis txhob ntawm adenosine thaum ua RNA strands tshiab. Tus kab mob no raug kev txom nyem los ntawm cov tshuaj lom neeg no vim hais tias txawv teb chaws nucleoside tiv thaiv RNA chains los ntawm lengthening.
Xaiv Viral Targeting yam tsis muaj kev puas tsuaj ntawm tus tswv tsev
gs-441524 fip yog qhov zoo heev vim nws tsuas yog xaiv cov khoom tshwj xeeb. Mammals 'polymerase enzymes tsim DNA thiab RNA, tab sis lawv muaj qhov txo qis rau kev hloov pauv nucleoside.
GS-441524 fip tuaj yeem cuam tshuam tus kab mob rov ua dua yam tsis muaj kev txo qis ntawm cellular muaj nuj nqi hauv lub qhov rais kho vim kab mob thiab mammalian polymerases yog lub cev sib txawv. Cov kws tshawb fawb pom tias tus kab mob feline coronavirus RdRp suav nrog gs-441524 fip triphosphate sai thaum lub sij hawm RNA synthesis.Qhov chaw ua haujlwm ntawm cov khoom siv polymer tiv thaiv kev sib txuas ntawm cov enzymes no, tab sis cov kev sib txuas ntawm cov enzymes tau hloov pauv. Qhov kev xaiv no tso cai rau miv tau txais kev kho mob kom noj cov tshuaj zoo, nrog rau cov kev mob tshwm sim uas tswj tau piv rau fip qhov kev tuag.
Kev Cuam Tshuam -Nyob ntawm Kev Tiv Thaiv Kab Mob
Qhov tseeb theem ntawm gs-441524 fip hauv hlwb yog qhov tseem ceeb rau nws cov txiaj ntsig. Cov koob tshuaj kho mob muab txaus txaus rau daim ntawv triphosphate los tiv thaiv kab mob sib kis, raws li kev tshawb fawb cov ntaub so ntswg. Pharmacokinetics qhia tias gs-441524 fip tau faib tau zoo hauv cov ntaub so ntswg. Kab mob monocytes thiab macrophages yog qhov chaw feline coronavirus feem ntau ua rau muaj mob. Cov lus pom zoo ntawm kev noj tshuaj raws li kev noj tshuaj xav txog kev nyab xeeb ntawm cov tshuaj. Yog tsis muaj kev kho mob, cov kab mob miv tau luam tawm lawv tus kheej, tsim ntau txhiab tus kab mob tshiab txhua hnub.
gs -441524 fip uathiab RNA Chain Termination Mechanisms
Delayed Chain Termination Strategy
Qee cov tshuaj tua kab mob nucleoside analogs nres tus kab mob tam sim ntawd thaum lawv koom nrog cov saw hlau nucleic acid loj hlob, tab sisgs -441524 fip uasiv txoj kev maj mam. Tom qab muab tso ua ke, qhov hloov pauv nucleoside cia RNA ntau lawm mus rau ob peb lub hauv paus ntxiv. Qhov kev ncua ncua sij hawm no txwv tsis pub tus kab mob polymerase los ntawm kev nrhiav qhov yuam kev thiab kho nws los ntawm cov txheej txheem uas kuaj xyuas qhov ua yuam kev.Coronavirus RdRp tuaj yeem tshem tawm cov tsis xav tau nucleotides los ntawm nascent RNA strands '3' xaus raws li exonuclease.
Cov tshuaj cuam tshuam qhov kev hloov kho no los ntawm kev txuas cov saw txuas dhau gs-441524 fip suav nrog. Qhov no tsim cov kab mob RNA molecule uas tsis tuaj yeem tswj tau tus kab mob, txawm tias kev tsim khoom rov pib luv luv tom qab cov tshuaj molecule nkag mus rau hauv cov saw hlau.
Conformational Hloov hauv Polymerase Complex
RdRp qhov chaw nquag hloov pauv me ntsis thaum gs-441524 fip triphosphate ntxiv, raws li kev tshawb fawb txog biology. Cov kev hloov pauv no ua rau nws nyuaj rau lub enzyme los tso nws tus kheej rau lub voj voog catalytic tom ntej.
Thaum cov saw hlau txiav tau ncua qeeb, cov polymerase complex muaj cov txheej txheem tsis zoo thiab tsis tuaj yeem ua kom tiav tag nrho -ntev RNA raws li sai.X-ray crystallography thiab cryo-electron imaging ntawm tus mob coronavirus polymerases txuas rau gs-441524 fip-hloov RNA templates cov enzymes sib cais thiab ab. Cov kev hloov kho molecular no sib sau ua ke thaum lub sijhawm ua ke. Cov khoom tsis tiav RNA tsis muaj cov txheej txheem coding uas xav tau los tsim cov kab mob sib kis los yog ntim cov genome.
Synergistic Effects ntawm Viral RNA Stability
Ntxiv nrog rau kev hloov pauv polymerase, gs-441524 fip hloov pauv tus kab mob RNA stability. Viral ntim yog hindered los ntawm hloov RNA strand theem nrab qauv. gs-441524 fip-muaj RNA tsis tshua nyiam los ntawm cov kab mob genome nucleocapsid proteins, ua rau cov kab mob rov ua dua tshiab txawm tias tsis muaj txiaj ntsig.Cov ntau cov txheej txheem sib txuas los muab cov tshuaj tua kab mob tseem ceeb. Tom qab tau txais cov koob tshuaj zoo ntawm gs-441524 fip, miv cov kab mob hnyav txo qis hauv hnub. Coronavirus RNA nyob rau hauv cov ntshav, effusions, thiab cov ntaub so ntswg txo sai sai hauv chav kuaj thaum cov neeg mob txhim kho.
Vim li cas Viral RNA Polymerase yog Lub Hom Phiaj Tseem Ceeb ntawmgs -441524 fip ua
Lub luag haujlwm tseem ceeb hauv Coronavirus Lifecycle
Rau tus kabmob coronavirus kom rov ua dua, nws yuav tsum muaj RNA polymerase enzyme. Nws yog tsis yooj yim sua kom tus kab mob no ua tau ntau npaum li cas luam ntawm nws tus kheej raws li nws yuav tsum tau nyob twj ywm tsis muaj RdRp kev ua si. Txhawm rau kom cov kab mob kis mus, txhua lub xov tooj ntawm tes yuav tsum tau ua ntau txhiab daim ntawv luam ntawm genome. Qhov no ua rau cov polymerase yog lub hom phiaj tseem ceeb heev rau kev kho mob.Coronaviruses yog ib hom kev zoo - hnov tib yam - tus kab mob RNA uas tsuas yog theej nws tus kheej hauv cytoplasm ntawm lub hom phiaj hlwb.
Txhawm rau ua cov genomic RNA, ua subgenomic messenger RNAs, thiab ua cov genomes tshiab, txoj kev rov ua dua no xav tau cov haujlwm polymerase txhua lub sijhawm.Txhua feem ntawm cov txheej txheem no uas cuam tshuam tsis zoo ua rau tus kab mob muaj zog.Vim tias tus kabmob coronavirus RdRp ua haujlwm zoo li catalyst, nucleoside analog inhibitors zoo ligs -441524 fip uatau yooj yim nres nws. Txhua feeb, cov enzyme ua haujlwm ntau txhiab tus nucleotide suav nrog cov xwm txheej. Thaum txhua lub voj voog, cov tshuaj molecules muaj lub sijhawm los koom nrog cov hlua RNA loj hlob. Thaum muaj cov tshuaj inhibitors muaj txiaj ntsig zoo, cov khoom siv rov ua haujlwm siab ua haujlwm tawm tsam tus kabmob vim tias kev ua haujlwm polymerase ntau dua txhais tau tias kev nqus tshuaj ntau dua.
Kev txuag thoob plaws Coronavirus Variants
RdRp's amino acid sequence thiab peb - qauv qauv zoo ib yam thoob plaws tus mob coronaviruses. Qhov kev txwv caj ces no tshwm sim los ntawm enzyme lub luag haujlwm tseem ceeb thiab muaj peev xwm tswj tau cov kev hloov pauv uas yuav hloov kho nws cov yam ntxwv catalytic. Cov tshuaj tsom mus rau qhov chaw ua haujlwm polymerase tseem ua haujlwm tawm tsam ntau yam kab mob, ua kom muaj txiaj ntsig zoo rau kev kho mob.Kev tshuaj ntsuam genomic ntawm feline coronaviruses los ntawm fip miv pom me ntsis RdRp coding hloov.
Kev hloov pauv uas txo cov txiaj ntsig ntawm gs-441524 fip ua rau cov kab mob sib kis tau nyuaj dua. Yog li, kev kho cov tshuaj tiv thaiv tsis zoo yog qhov tsis tshua muaj tshwm sim hauv kev kho mob. Tus kab mob no tawm tsam kom hla dhau cov polymerase cov cai.
Tsis Muaj Tus Tswv Cell Homologs
Mammalian hlwb khaws cov ntaub ntawv caj ces hauv DNA, lawv tsis muaj RNA -nyob ntawm RNA polymerase. Qhov kev sib txawv tseem ceeb ntawm tus tswv tsev thiab tus kab mob kis tau tus kab mob tso cai rau kev kho lub hom phiaj.
Cov tshuaj uas inhibit tus kab mob RdRp tuaj yeem cuam tshuam nrog kev ua haujlwm ntawm tes, ua rau lawv muaj kev nyab xeeb dua.GS-441524 fip nyiam cov kab mob polymerase tshaj tus tswv tsev enzymes. Vim qhov sib txawv ntawm qhov chaw ua haujlwm tsim thiab kev txheeb xyuas substrate. Cov tsiaj nyeg tsis tshua muaj kev cuam tshuam rau cov kab mob tua cov nucleoside analogues vim tias lawv cov DNA thiab RNA polymerases txawv. Qhov kev sib cais molecular no tso cai rau cov tshuaj tiv thaiv kab mob tshwj xeeb.
Intracellular Activation Pathways ntawmgs -441524 fip ua
Phosphorylation Requirements for Activity
Thaum gs-441524 fip nkag mus rau hauv cov hlwb, nws yog ib qho tsis muaj nuj nqis nucleoside uas yuav tsum tau phosphorylated ib kauj ruam ntawm ib lub sij hawm los ua ib qho active triphosphate daim ntawv. Hauv kev hloov pauv biochemical no, cellular kinase enzymes tau siv los ua kom muaj cov nucleosides ntuj kom lawv tuaj yeem ntxiv rau nucleic acids. Txoj kev stimulation no ua haujlwm tau zoo npaum li cas cuam tshuam ncaj qha rau cov tshuaj tua kab mob zoo li cas.Muaj cov hlwb tsis tuaj yeem txav mus sai txaus rau phosphorylate gs-441524 fip rau monophosphate.
Adenosine kinase thiab lwm cov cellular kinases ceev cov txheej txheem no, txawm hais tias lawv nyiam ntau yam nucleosides. Kev qhia kinase siab dua lossis kev ua haujlwm nrawm dua cov tshuaj ua haujlwm hauv cov hlwb, uas yuav piav qhia vim li cas qee cov miv hnov mob txawv rau kev kho mob.Nucleoside monophosphate thiab diphosphate kinases muaj ntau yam substrate, ua rau phosphorylation yooj yim dua. Cov kab mob kis tau tsim cov triphosphate variant kom txog thaum nws sib tw nrog endogenous adenosine triphosphate rau cov kab mob polymerase recruitment. Hauv cov hlwb, gs-441524 fip triphosphate muaj ob peb- teev ib nrab-lub neej. Qhov no txhais tau hais tias nws tua cov kab mob ntawm cov tshuaj.
Cellular Uptake thiab Distribution
gs-441524 fip yuav tsum ceev nrooj nkag mus rau cov hlwb thiab mus txog qhov chaw kis kab mob los ua tshuaj. Cov khoom zoo ntawm lub cev thiab tshuaj lom neeg tso cai rau niam txiv nucleoside ntws los ntawm cov phab ntsa ntawm tes yam tsis tau nqus. Txij li thaum nws tsis muaj cov pab pawg phosphate, daim ntawv yog pob tshab dua li muab cov nucleotide derivatives ncaj qha.GS-4415 24fip uatuaj yeem nkag mus rau cov hlwb ntawm nucleoside transporter proteins ntawm sab nrauv, tab sis passive diffusion zoo li txaus rau kev kho mob.
Cov lipophilic, me me -molecule compound tuaj yeem hla daim nyias nyias yam tsis muaj kev thauj mus los tshwj xeeb. Cov yam ntxwv no pab cov protein kom tsis txhob muaj cov qauv kev nthuav qhia uas sib txawv ntawm cov xov tooj ntawm tes thiab lub cev.Biodistribution thwmsim hauv miv pom tau tias gs-441524 fip mus txog thaj chaw muaj kab mob xws li peritoneum, pleura, thiab fip- cov kabmob puas. Cov tshuaj nkag mus rau hauv cov ntshav- cov ntaub so ntswg tiv thaiv kom mus txog qib kho mob hauv feline coronavirus replication sites. Lub peev xwm nthuav dav no piav qhia tias yog vim li cas cov neeg mob effusive thiab non-effusive fip tau pom kev txhim kho kev noj qab haus huv.
Metabolic Stability thiab Duration ntawm kev ua
gs-441524 fip yog tshuaj ruaj khov nyob rau hauv cov tsiaj txhu, ua rau nws ua tshuaj. Lub molecule tsis tawg sai los ntawm cellular nucleases thiab phosphatase, ua rau nws tsis tshua muaj txiaj ntsig. Daim ntawv triphosphate tawg los ntawm dej, txawm hais tias nws khaws cov tshuaj tua kab mob ntev txaus rau kev siv tshuaj kho mob.Raws li kev tshawb fawb pharmacokinetic, miv feem ntau tshem tawm gs-441524 fip kwv yees. Cov kev kho mob tsim kom muaj lub sijhawm zoo tshaj plaws los tswj cov qib tshuaj thiab txo cov tshuaj noj. Yog tias koj haus lossis siv cov tshuaj hauv qab koj cov tawv nqaij, nws yuav nyob hauv koj lub cev thiab tawm tsam tus kabmob coronavirus.
Broad RNA Virus Inhibition Muaj peev xwm ntawmgs -441524 fip ua
Kev Tiv Thaiv Kab Mob Coronaviruses
gs-441524 fip ua haujlwm tawm tsam ntau tshaj li tus kabmob feline xwb; nws kuj ua haujlwm tawm tsam lwm tus neeg mob coronavirus hauv tsev neeg. Kev tshawb fawb hauv chav kuaj pom tias qhov sib xyaw no tuaj yeem nres ntau hom kab mob coronavirus, uas qhia tau tias RdRp lub hom phiaj feem ntau ruaj khov. Cov peev txheej dav dav no tau ua rau muaj kev txaus siab rau kev siv tau rau tib neeg thiab tsiaj noj qab haus huv. Cov kws tshawb fawb tau tshawb xyuas seb cov khoom gs-441524 fip puas tuaj yeem kho tib neeg cov kab mob thaum muaj tus kabmob coronavirus tam sim no.
Cov kab mob coronavirus sib txawv muaj cov qauv zoo sib xws; cov tshuaj uas tiv thaiv miv yuav ua haujlwm tawm tsam lwm yam tsiaj. Remdesivir, prodrug ntawm gs-441524 fip's metabolite, tau tso cai los kho tib neeg tus mob coronaviruses, ua pov thawj lub hom phiaj thiab cov txheej txheem ua haujlwm Coronaviruses qhia cov ntaub ntawv caj ces; kev kho mob yuav tsom mus rau ntau hom. Cov tshuaj xws li gs-441524 fip uas lub hom phiaj ntawm cov yam ntxwv polymerase yog qhov pib zoo rau kev kho kab mob tshiab. Kev kho tus kab mob peritonitis hauv miv qhia tias nucleoside analogues tuaj yeem kho tus mob coronavirus.
Muaj peev xwm tawm tsam lwm tus kab mob RNA
Los ntawm inhibiting RNA polymerase kev ua haujlwm nrog nucleoside analogues, gs-441524 fip ua haujlwm rau ntau tus kab mob RNA, tsis yog tus kabmob coronavirus xwb. Lub tswv yim no rhuav tshem ntau tus kab mob tsev neeg txoj kev theej tus kheej. Cov kws tshawb fawb hauv chav kuaj tau tshawb xyuas seb gs-441524 fip tuaj yeem tiv thaiv cov kab mob flaviviruses, paramyxoviruses, thiab lwm yam kab mob RNA.GS-441524 fip tsis tuaj yeem tawm tsam tag nrho cov kab mob RNA vim nws tsuas yog ua rau xaiv hom polymerase.
Kev txiav txim siab tiv thaiv thiab Ntev -Tsev Kawm Ntawv
Tag nrho cov kev kho tshuaj tiv thaiv kab mob yuav tsim tshuaj - cov kab mob resistant. Kev hloov pauv ntawm RdRp noob yuav ua rau gs-441524 fip nyuaj rau khi lossis nqus, ua rau kev kho mob tsis zoo. Peb tau kho ntau pua tus miv nrog fip hauv tsev kho mob thiab paub tias kev tiv thaiv tsis tshua muaj tshwm sim ntawm qhov kev noj kom raug.GS-441524 fip yuav muaj kev cuam tshuam caj ces siab rau kev ua siab ntev. Kev hloov pauv uas txo cov kev siv tshuaj cuam tshuam cuam tshuam kev ua haujlwm ntawm polymerase, ua rau cov nqi qoj ib ce uas tiv thaiv kev hloov pauv ntawm kev nthuav tawm.
Coronavirus polymerases 'siab replication fidelity txo tus kab mob reproduction mutations, tiv thaiv tsis kam.Kev kam rau siab yuav tsum tau soj ntsuam raws li gs-441524 fip kev siv nce. Kawm txog cov kab mob sib cais los ntawm kev kho tsis tau zoo tuaj yeem nthuav tawm cov kev hloov pauv noob uas txo cov tshuaj tiv thaiv. Qhov kev pom no yuav pab nrog kev hloov kho ntau npaum li cas thiab kev xaiv kev kho mob ua ke kom tswj tau qhov kev kho mob zoo. Raws li peb paub, cov sij hawm kho mob thiab ntau npaum li cas yuav tshem tawm cov kab mob uas tsis tsim cov neeg tiv taus.
Xaus
Ntse tshuaj tua kab mob zoo ligs -441524 fip uainhibit tus kabmob coronavirus los ntawm cov txheej txheem molecular. Los ntawm kev siv tus kab mob feline tus kabmob RNA polymerase qhov yuav tsum tau ua, qhov nucleoside analogue no tiv thaiv nws qhov kev loj hlob. Cov tshuaj nyiam nyiam lub hom phiaj ntawm cov kab mob enzymes, ua haujlwm hauv lub cev, thiab siv cov hlua txuas txuas ntxiv, ua rau nws muaj zog fip kho rau miv.
Kev nkag siab txog cov txheej txheem no pab koj tso siab rau cov ntaub ntawv tshawb fawb txhawb nqa gs-441524 fip therapy. Txij li cov tshuaj siv lub hom phiaj tiv thaiv kab mob kis tau zoo, nws yuav muaj txiaj ntsig zoo tiv thaiv tus kabmob coronaviruses thiab txo qhov kev pheej hmoo ntawm kev tiv thaiv. Pharmacological zog ua kom cov tshuaj tiv thaiv kab mob tuaj yeem nkag mus rau cov ntaub so ntswg thiab khaws cov qib siab, ua rau muaj kev xav tsis thoob hauv kev kho mob.
Cov ntsiab lus tseem ceeb los ntawm gs-441524 fip yuav tsav cov tswv yim tiv thaiv kab mob yav tom ntej raws li kev tshawb fawb ntxiv los txhim kho txoj hauv kev kho thiab tshawb xyuas cov tshuaj zoo sib xws. Mechanism-based tshuaj tshawb fawb tau ua kom kho tau los ntawm tus kab mob tuag taus. Nws kuj txhawb kev cia siab rau lwm yam kab mob loj ntawm tib neeg thiab tsiaj txhu.
FAQ
1. Ua dab tsigs -441524 fip uaPuas muaj txiaj ntsig tiv thaiv tus kabmob feline tshwj xeeb?
Vim tias nws yog lub hom phiaj zoo rau feline coronavirus's RNA-dependent RNA polymerase enzyme, gs-441524 fip tua nws. Tus kab mob polymerase ntxiv cov molecule rau RNA tsim vim nws cov qauv zoo li ntuj adenosine. Nws txawv txaus los tiv thaiv chains los ntawm expanding ib txwm. Daim ntawv triphosphate nquag ntawm gs-441524 fip cuam tshuam rau feline coronavirus polymerase tab sis tsis yog tib neeg cellular polymerases. Cov koob tshuaj kho mob tuaj yeem txwv cov kab mob sib ntxiv yam tsis muaj kev cuam tshuam feline cell muaj nuj nqi vim qhov kev xaiv no. Lub qhov rais kho tau zoo ua rau kev kho mob ua tau zoo thiab ua kom muaj kev nyab xeeb.
2. Ntev npaum li casgs -441524 fip uanyob twj ywm hauv cov kab mob uas muaj kab mob?
gs-441524 fip tseem muaj tshuaj tiv thaiv kab mob rau qee lub sijhawm tom qab nkag mus rau hauv feline hlwb thiab raug phosphorylated rau nws daim ntawv active triphosphate. gs-441524 fip triphosphate muaj ib nrab ntawm lub neej ntawm 4-8 teev, nyob ntawm kev ua haujlwm ntawm tes thiab phosphatase. Qhov kev ua ntev ntev no pab koj nthuav tawm ntau npaum li cas thaum tswj kev tiv thaiv kab mob siab rau kev nthuav dav tus kabmob coronavirus. Cov molecule yog metabolically ruaj khov, yog li cellular enzymes tsis tuaj yeem zom nws sai. Nrog rau kev noj ntau dua, cov ntaub ntawv phosphorylated mus txog qib tseem ceeb ntawm kev kho mob. Nws cov tshuaj lom neeg tso cai rau nws muab ib zaug lossis ob zaug hauv ib hnub, raws li feem ntau cov kev kho fip ua. Qhov no tiv thaiv kab mob RNA ntau lawm thaum kho.
3. Puas muaj tus mob coronavirus tuaj yeem tiv tausgs -441524 fip uathaum kho?
Feline coronavirus tuaj yeem tiv taus gs-441524 fip, txawm tias nws tsis tshua muaj. Feem ntau cov tshuaj tsis muaj txiaj ntsig hloov pauv tshwm sim hauv RNA polymerase qhov chaw nquag. Cov kev hloov kho no txo cov enzyme catalysis. Hom kev tiv thaiv yuav tsum tau them nqi zog kom muaj sia nyob thiab kis tau. Qhov tseem ceeb khaws cia ntawm cov qauv polymerase ntawm cov kab mob coronavirus qhia tias tus kab mob no tau tawm tsam los teb rau kev tiv thaiv modifications. Cov koob tshuaj zoo ntawm gs-441524 fip rau lub sijhawm raug siv los kho ntau tus neeg mob fip hauv tsev kho mob nrog cov txiaj ntsig zoo thiab tsis muaj kev tawm tsam ntau. Kev noj tshuaj kom raug kom muaj cov tshuaj txaus hauv lub cev txo qis kev xaiv siab rau cov ntaub ntawv tiv thaiv. Kev kho mob ntev dua li kev kho mob kom tshem tawm cov kab mob ua ntej kev tiv thaiv.
Koom tes nrog BLOOM TECH - Koj Trustedgs -441524 fip uaTus neeg muab khoom
Puas yog koj tab tom nrhiav kev ntseeg siabgs -441524 fip uaqhov twg koj tuaj yeem tso siab rau koj txoj kev kawm, tshuaj, lossis kev faib khoom? BLOOM TECH yog koj tus khub txhim khu kev qha thaum nws los txog rau tshuaj -qib gs-441524 fip uas yog ntshiab heev, los nrog tag nrho cov ntaub ntawv txheeb xyuas, thiab ib txwm ua raws li cov cai. Peb GMP-cov chaw tsim khoom tau lees paub, uas tau raug kuaj xyuas los ntawm US-FDA, EU cov neeg ua haujlwm, thiab CFDA, xyuas kom txhua pawg ua tau raws li cov qauv nruj tshaj plaws thoob ntiaj teb. Peb tau ua cov organic tebchaw thiab cov tshuaj intermediates rau ntau tshaj 12 xyoo, yog li peb tuaj yeem muab cov lag luam muag tshuaj, cov chaw tshawb fawb, CDMOs, thiab cov neeg muag khoom paub txog kev paub- yuav ua li cas, cov saw hlau ruaj khov, thiab cov nqi qis uas lawv xav tau. Peb pab neeg txawj ntse muaj ib tug - nres kev pab cuam nrog meej tus nqi thiab ib tug ntau yam ntawm kev txiav txim qhov ntau thiab tsawg, los ntawm me me - cov kev tshawb fawb nyob rau hauv lub lab mus rau loj-scale ntau lawm. Hu rau peb cov kws tshaj lij kev cog lus ntawmSales@bloomtechz.comtam sim ntawd los tham txog koj gs-441524 fip xav tau thiab nrhiav seb BLOOM TECH qhov kev mob siab rau qhov zoo thiab tsom rau cov neeg siv khoom txaus siab tuaj yeem pab koj ua tiav.
Cov ntaub ntawv
1. Murphy BG et al. "Lub nucleoside analog gs-441524 muaj zog tiv thaiv feline kis kab mob peritonitis tus mob coronavirus hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb fawb txog kab mob miv." Veterinary Microbiology, 2018; 219:226–233.
2. Pedersen NC, et al. "Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog gs-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline kis kab mob peritonitis." Phau ntawv Journal of Feline Tshuaj thiab Kev phais, 2019; 21(4): 271-281.
3. Dickinson PJ, et al. "Kev kho tshuaj tua kab mob siv cov adenosine nucleoside analogue gs-441524 hauv cov miv uas tau kuaj pom cov kab mob neurological feline kis kab mob peritonitis." Phau ntawv Journal of Veterinary Internal Medicine, 2020; 34(4): 1587-1593.
4. Yan VC, et al. "Cov qauv hauv paus rau GTP kev paub los ntawm triphosphohydrolase NSP15 thiab RdRp hauv tus mob coronavirus RNA ua thiab rov ua dua." Protein Science, 2021; 30(1): 76-85 : kuv.
5. Gordon CJ, et al. "Remdesivir yog ib qho ncaj qha - ua yeeb yam tshuaj tiv thaiv kab mob uas inhibits RNA- nyob ntawm RNA polymerase los ntawm tus mob ua pa nyuaj rau tus mob coronavirus 2 nrog lub zog siab." Phau ntawv Journal of Biological Chemistry, 2020; 295(20): 6785-6797.
6. Kabinger F, et al. "Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis thiab nws siv hauv kev kho tus kab mob feline coronavirus analogues." Nature Structural & Molecular Biology, 2021; 28(9): 740-746.