Hauv kev sib ntaus sib tua tsis tu ncua tiv thaiv kab mob kis, kev kho tshiab txuas ntxiv tshwm sim. Ib qho kev cog lus zoo li no yog kev txhim khoGS-441524 txhaj tshuaj, ib qho kev sib xyaw ua ke uas tau tshwm sim muaj peev xwm ua rau muaj peev xwm sib ntaus sib tua kab mob sib txawv. Kab lus no dhia mus rau hauv qhov nyuaj ntawm GS-441524, tshawb xyuas nws cov khoom siv tshuaj tiv thaiv kab mob, tiv thaiv kev ua haujlwm, thiab kev siv tshuaj kho mob.
GS-441524 Txhaj tshuaj
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-3-001
GS-441524 CAS Nr .: 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muab GS-441524 Txhaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/oem-odm/injection/gs-441524-injection.html
Dab tsi yog GS-441524 Txhaj thiab Nws Lub Hom Phiaj Antiviral?
GS-441524 yog ib qho nucleoside analog uas tau sau cov kev xav tseem ceeb hauv kev kho tshuaj tiv thaiv kab mob. Cov tshuaj no ua haujlwm ua tus thawj coj rau lub zog zoo ntawm remdesivir, uas paub zoo txog kev tiv thaiv kab mob sedate. Qhov laj thawj tseem ceeb rau kev txhaj tshuaj GS-441524 yog txhawm rau tiv thaiv kab mob sib kis, ua rau nws muaj txiaj ntsig zoo hauv kev tawm tsam ntau yam kab mob kis.
Chemical Structure thiab Properties
GS-441524 muaj ib qho chaw hauv zaj lus qhia ntawm C-nucleosides, uas yog tus cwj pwm los ntawm lawv cov qauv tshuaj lom neeg. Cov qauv no tso cai rau cov khoom sib xyaw ua kom pom cov nucleosides ib txwm muaj, txhawb nws kom cuam tshuam nrog cov kab mob RNA sib xyaw. Lub peev xwm ntawm molecule nkag mus rau hauv cellular films thiab nws cov solidness nyob rau hauv physiological tej yam kev mob pab txhawb rau nws viability raws li ib tug antiviral neeg sawv cev.
Broad -Spectrum Antiviral Activity
Ib lub kaum ntse ntse tshaj plaws ntawm GS-441524 yog nws qhov dav -spectrum antiviral action. Kev Tshawb Fawb tau piav qhia nws qhov kev txaus ntshai tiv thaiv kab mob RNA sib txawv, suav tus kabmob coronaviruses, filoviruses, thiab paramyxoviruses. Qhov kev ua haujlwm dav dav noGS-441524 txhaj tshuajraws li ib qho kev kho mob lwm txoj rau kev sib kis kab mob sib txawv, qee qhov tam sim no xav tau kev kho kom zoo.
Mechanism of Action: Inhibiting Viral RNA Replication
Lub zog ntawm GS-441524 nyob rau hauv nws lub peev xwm los cuam tshuam tus kab mob rov ua dua tshiab ntawm qib atomic. Kev nkag siab txog cov ntsiab lus no yog qhov tseem ceeb rau kev nce nqi ntawm qhov sib xyaw ua ke muaj peev xwm pab tau thiab nws feem hauv cov tswv yim tiv thaiv kab mob.
GS-441524's viability stems los ntawm nws lub peev xwm los sib koom ua ke ncaj nraim mus rau hauv cov kab mob RNA cov kab mob sib kis. Thaum sab hauv lub cell muaj, GS-441524 ntsib phosphorylation, hloov nws mus rau hauv nws dynamic triphosphate zoo. Qhov no dynamic particle sib tw nrog ntau nucleosides, uas yog lub tsev ntawm RNA. Raws li qhov tshwm sim, GS-441524 tau sib sau ua ke rau hauv cov kab mob RNA, uas nws ua raws li cov saw tshem tawm. Qhov kev tsis sib haum xeeb no xaus rau kev pab tus kab mob RNA sib koom ua ke, cia siab tias yuav kis tus kab mob los ntawm kev xyaum thiab kis mus rau hauv qhov muaj. Los ntawm interferometer nrog cov kauj ruam tseem ceeb no hauv kab mob viral lifecycle, GS-441524 tag nrho txwv kev kis tus kab mob, ua rau nws muaj zog tiv thaiv kab mob tshwj xeeb hauv kev kho mob kis kab mob.
Xaiv Lub Hom Phiaj ntawm Viral RNA Polymerase
Ib qho ntawm cov ntsiab lus tseem ceeb ntawm GS-441524's tivthaiv yog nws cov haujlwm tshwj xeeb ntawm cov kab mob RNA polymerases, cov proteins nco ntsoov ua raws li cov kab mob genome. GS-441524 sib txuas nrog qhov tshwj xeeb siab rau RNA-dependent RNA polymerase (RdRp) protein, uas yog qhov tseem ceeb rau kev rov ua dua ntawm ntau yam kab mob. Qhov no tau tsom mus rau txoj hauv kev tau lees paub tias GS-441524 txwv tsis pub kis tus kabmob kis tsis tau cuam tshuam cov ntaub ntawv xovtooj ntawm tes zoo tib yam hauv qhov muaj. Los ntawm tshwj xeeb thaiv cov kab mob polymerase txav, GS-441524 txo qis qhov phom sij ntawm kev cuam tshuam ntawm lub hom phiaj, uas ua rau nws muaj kev nyab xeeb me ntsis siv hauv cov chaw kho dua tshiab. Qhov siab ntawm kev xaiv no tso cai rau GS-441524 los muab kev ua haujlwm tiv thaiv kab mob uas ua rau txo qis qhov tshwm sim ntawm kev ua phem rau cov hlwb.
Cellular Uptake thiab Targeted Viral Suppression
Kev ua tau zoo ntawmGS-441524 txhaj tshuajfeem ntau nyob ntawm nws lub peev xwm nkag mus rau cov hlwb thiab ncav cuag nws lub hom phiaj qhov chaw. Nkag siab txog cov txheej txheem ntawm cov cellular uptake mechanisms thiab cov khoom sib xyaw ua ke hauv cov ntaub so ntswg uas muaj kab mob yog qhov tseem ceeb rau kev ua kom zoo rau nws daim ntawv thov kho mob.
Cellular Thauj Mechanisms
Lub cellular coj-nce ntawm GS-441524 yog txhawb los ntawm cov nucleoside transporters tshwj xeeb, tshwj xeeb tshaj yog cov equilibrative nucleoside transporter 1 (ENT1). Cov neeg thauj khoom no tso cai rau cov khoom sib xyaw ua kom muaj txiaj ntsig hla cov txheej txheem ntawm tes, lav qhov txaus siab nkag mus rau hauv cov hlwb uas kis kab mob tshwm sim. Thaum sab hauv ntawm tes, GS-441524 muaj kev paub txog phosphorylation kom xaus nws cov duab triphosphate dynamic. Qhov sib xyaw ua ke no sib tw nrog cov nucleosides ntau, koom nrog cov kab mob RNA, ua tiav kev cuam tshuam cov kab mob sib kis. Kev tsom mus rau kev ua haujlwm intracellular tau lees paub tias GS-441524 tuaj yeem cuam tshuam tus kab mob sib kis, thaum txo qis cov txiaj ntsig ntawm cov ntaub ntawv cellular, ua rau nws muaj zog tiv thaiv kab mob.
Cov ntaub so ntswg Distribution thiab Viral Reservoirs
GS-441524 tau piav qhia txog kev nthuav dav ntawm cov ntaub so ntswg, tuaj txog qhov tseem ceeb hauv cov kabmob sib txawv, suav cov khoom siv kis kab mob, xws li daim siab. Qhov kev nthuav dav dav no yog qhov tseem ceeb rau nws lub peev xwm los tsom cov kab mob kis kab mob. Qhov sib xyaw ua ke nyob ze ntawm cov khoom siv kis kab mob ua rau nws ua rau muaj kev cuam tshuam cov kab mob sib kis hauv cov kab mob tsis tu ncua lossis tsis tu ncua, tejzaum nws zam kev kis tus kab mob los ntawm kev rov ua dua. Lub peev xwm los tsom rau cov khw muag khoom kis kab mob no yog qhov txiaj ntsig tseem ceeb ntawm GS-441524, vim nws tso cai rau kev zais cov kab mob ntau dua ntawm cov kab mob hauv nruab nrog cev, thaum kawg ua rau cov txiaj ntsig rov qab zoo dua thiab tshaj tawm txoj hauv kev zoo dua rau kev tswj tus kab mob mus ntev.
Cov pov thawj kho mob rau kev ua tau zoo tiv thaiv kab mob tshwj xeeb
Lub peev xwm kho dua tshiab ntawm GS-441524 tau pom nyob rau hauv ob peb qhov kev soj ntsuam thiab kev txiav txim siab ua ntej, nthuav tawm nws txoj kev muaj peev xwm tiv thaiv kev kis kab mob. Cov kev tshawb pom no muab cov ntaub ntawv tseem ceeb ntawm kev paub rau hauv qhov sib xyaw ua haujlwm tiag tiag hauv ntiaj teb thiab nws cov peev xwm cuam tshuam rau kev tswj hwm tus kab mob.
Kev ua tau zoo hauv kev kis tus kabmob Coronavirus
GS-441524 tau pom tias muaj kev vam meej hauv kev kho tus mob coronavirus, suav cov uas tshwm sim los ntawm SARS-CoV-2. Nyob rau hauv vitro xav txog tau qhia txog nws lub peev xwm los txwv tsis pub kis tus kab mob, thaum cov qauv tsim tau pom cov kab mob tsawg zuj zus thiab tau txav mus rau tom qab kev kho mob tau noj tom qab kev kho mob nrog GS-441524 lossis nws cov prodrug, remdesivir.
Daim ntawv thov hauv Feline Infectious Peritonitis
Ib qho kev yeej zoo tshaj plaws ntawm GS-441524 tau nyob rau hauv kev kho mob ntawm miv irresistible peritonitis (FIP), uas twb muaj tus kab mob tuag rau miv los ntawm tus mob coronavirus. Kev sim tshuaj kho mob tau tshwm sim tshwj xeeb ntawm kev rov zoo nyob hauv cov miv uas kho nrog GS-441524, hloov qhov kev kwv yees rau qhov kev puas tsuaj ib zaug.
Kev nyab xeeb, kev xav txog kev noj tshuaj, thiab cov txiaj ntsig kho mob
Raws li nrog rau txhua qhov kev kho mob, kev ruaj ntseg profile thiab kev noj tshuaj zoo tshaj plaws ntawm GS-441524 yog qhov kev xav hauv paus hauv nws daim ntawv thov kho mob. Kev nkag siab txog cov ces kaum no yog qhov yooj yim rau kev ua kom muaj txiaj ntsig zoo tshaj plaws thaum txo qis kev pheej hmoo.
Kev nyab xeeb Profile thiab cov teebmeem tsis zoo
Kev tshawb fawb txog kev kho mob thiab kev kho mob muaj, los ntawm thiab loj, tau qhia txog kev nyab xeeb zoo rau GS-441524. Ua li ntawd, zoo li txhua yam tshuaj, qee qhov kev cuam tshuam tsis zoo tau piav qhia. Cov no tuaj yeem suav nrog cov kev cuam tshuam me me ntawm txoj hnyuv, qhov tshwm sim ntawm lub cev nce siab hauv daim siab cov protein, thiab hauv cov xwm txheej tsis tshua muaj, cov lus teb ntau dua. Kev kuaj xyuas thiab kev ruaj ntseg mus sij hawm ntev txiav txim siab txuas ntxiv mus ua kom peb txoj kev nkag siab ntawm qhov sib txuas ntawm qhov kev ruaj ntseg profile.
Dosing Strategies and Treatment Duration
Kev noj tshuaj zoo tshaj plaws rau GS-441524 tuaj yeem hloov pauv nyob ntawm tus kab mob kis tshwj xeeb tau kho thiab tus neeg nkag siab qhov hloov pauv. Cov rooj sib tham tam sim no feem ntau suav nrog kev ntsuas kev ntsuas tom qab los ntawm kev noj cov tshuaj noj, nrog rau cov nqe lus kho mob txuas ntxiv los ntawm ob peb hnub mus rau lub lis piam. Kev nce qib nug txog cov ntsiab lus txhawm rau txhim kho cov kev siv tshuaj no kom ua kom muaj txiaj ntsig zoo tshaj plaws, thaum txo cov peev xwm rau qhov tsis zoo.
Xaus
GS-441524 txhaj tshuaj sawv cev rau kev nce qib tseem ceeb hauv kev kho tshuaj tiv thaiv kab mob, muab los ntawmGS-441524 txhaj tshuajtus neeg muag khoom, muab cov cuab yeej muaj zog hauv kev sib ntaus sib tua tiv thaiv kab mob sib txawv. Nws qhov dav -spectrum kev nqis tes ua, ua ke nrog nws ib qho ntawm cov cuab yeej ua haujlwm, tso nws ua cov peev txheej muaj txiaj ntsig hauv khw muag riam phom rov qab tiv thaiv kab mob. Raws li kev tshawb nrhiav tau ua tiav, tag nrho lub peev xwm ntawm GS-441524 hauv kev tiv thaiv kab mob kis tau zoo yuav raug piav qhia ua ntej, tej zaum yuav qhib txoj kev niaj hnub rau kev kho mob thiab tswj kev kis kab mob.
FAQ
1. Yam kab mob dab tsi tuaj yeem kho tau GS-441524?
GS-441524 tau tshwm sim muaj peev xwm tiv thaiv ntau yam kab mob RNA, suav cov kab mob coronaviruses (xws li SARS-CoV-2), filoviruses, thiab paramyxoviruses. Nws tau zoo tshwj xeeb hauv kev kho miv 'irresistible peritonitis hauv miv.
2. GS-441524 txawv ntawm lwm cov tshuaj tiv thaiv kab mob li cas?
GS-441524 yog tshwj xeeb hauv nws cov ntsiab lus ntawm kev ua haujlwm raws li nucleoside analog uas tshwj xeeb yog tsom rau tus kab mob RNA replication. Nws qhov kev ua haujlwm dav dav thiab muaj peev xwm nkag mus rau cov ntaub so ntswg sib txawv ua rau nws hloov pauv tus neeg siv tshuaj tua kab mob piv rau cov kev kho mob ntau dua.
3. Puas muaj tej yam kev mob tshwm sim ntawm GS-441524 txhaj?
Thaum GS-441524 los ntawm thiab loj muaj qhov kev ruaj ntseg zoo, ob peb cov ncauj lus kom ntxaws txog kev cuam tshuam nrog kev ua rau lub plab zom mov maj mam thiab lub cev nce hauv daim siab cov protein. Raws li nrog rau txhua yam tshuaj, tib neeg cov tshuaj tiv thaiv tuaj yeem hloov pauv, thiab kev soj ntsuam tas li yog qhov tseem ceeb thaum kho.
Tshawb nrhiav lub zog ntawm GS-441524 Txhaj nrog BLOOM TECH
Raws li tus thawj cojGS-441524 txhaj tshuajtus neeg muag khoom, BLOOM TECH tau cog lus tias yuav muab siab - cov kev npaj tshuaj tua kab mob zoo kom tau raws li koj qhov kev nug txog thiab kev kho mob xav tau. Peb lub xeev - ntawm--art GMP- cov chaw ua haujlwm tau lees paub tau lees paub qhov tsim txiaj ntsig zoo- qib GS-441524 txhaj tshuaj, txhawb nqa los ntawm kev tswj xyuas kom zoo. Nrog ntau tshaj kaum xyoo ntawm kev ntsib nyob rau hauv natural union thiab ib tug cog lus pab pawg neeg ntawm cov kws tshwj xeeb, peb muab unparalleled bolster thiab customization xaiv rau koj antiviral ventures. Muaj kev paub txog BLOOM TECH qhov sib txawv hauv kev sib ntaus sib tua kab mob - tiv tauj peb hnub no ntawmSales@bloomtechz.comkom paub ntau ntxiv txog peb GS-441524 txhaj tshuaj thiab lwm yam tshuaj tua kab mob.
Cov ntaub ntawv
1. Murphy, BG, et al. (2022). "GS-441524 rau Kev Kho Mob Feline Infectious Peritonitis: Kev Ua Tau Zoo thiab Kev Nyab Xeeb." Phau ntawv Journal of Feline Medicine and Surgery, 24(1), 22-30.
2. Wang, Y., et al. (2021). "Remdesivir and GS-441524 Exhibit Potent Antiviral Activity Against SARS-CoV-2 in vitro." Antiviral Research, 185, 104960.
3. Agostini, ML, et al. (2020). "Me-Molecule Antiviral -d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance." Phau ntawv Journal of Virology, 94(16), e01348-20.
4. Pedersen, NC, et al. (2019). "Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline kis kab mob peritonitis." Phau ntawv Journal of Feline Medicine and Surgery, 21(4), 271-281.
5. Gordon, CJ, et al. (2020). "Remdesivir yog ib qho ncaj qha - ua yeeb yam tshuaj tiv thaiv kab mob uas cuam tshuam RNA- nyob ntawm RNA polymerase los ntawm tus mob ua pa nyuaj rau tus mob coronavirus 2 nrog lub zog siab." Phau ntawv Journal of Biological Chemistry, 295(20), 6785-6797.
6. Sheahan, TP, et al. (2020). "Ib qhov ncauj bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 nyob rau hauv tib neeg txoj hlab ntsws epithelial cell kab lis kev cai thiab ntau tus kab mob coronaviruses hauv nas." Science Translational Medicine, 12(541), ebb5883.