Txhawm rau tiv thaiv tus kab mob tshiab, nws tau dhau los ua qhov tseem ceeb dua kom nkag siab tias cov tshuaj tiv thaiv kab mob ua haujlwm li cas ntawm qib molecular.GS-441524 hmoovsawv tawm vim yog txoj kev tshwj xeeb nws ua haujlwm tawm tsam RNA cov kab mob. Nws yog ib qho ntawm cov tshuaj muaj peev xwm uas tau txais kev mloog ntau hauv kev tshawb fawb tshuaj tiv thaiv kab mob. Qhov no nucleoside analogue tau pom lub zog zoo kawg nkaus hauv kev txwv tsis pub rov ua dua ntawm cov kab mob, uas ua rau nws muaj txiaj ntsig zoo hauv kev kawm thiab chaw kho mob.Muaj ntau theem ntawm kev sib cuam tshuam lom neeg uas tshwm sim thaum cov tshuaj no nres tus kab mob ua haujlwm. gs-441524 hmoov ua haujlwm ncaj qha rau hauv cov kab mob sib kis kom tsis txhob muaj tus kab mob rov ua dua tshiab ntawm nws qhov chaw, tsis zoo li lwm txoj hauv kev tiv thaiv kab mob uas tsom rau cov proteins lossis tiv thaiv kab mob. Txoj kev no muaj txiaj ntsig zoo rau kev daws teeb meem kab mob uas lwm txoj hauv kev tsis tuaj yeem daws tau.
Cov kws tshawb fawb thiab cov neeg ua haujlwm tshuaj yeeb tshuaj thoob plaws ntiaj teb tseem tab tom sim xyuas seb cov tshuaj no tuaj yeem ua li cas. Nws ua haujlwm zoo tiv thaiv ntau tus kab mob RNA, xws li feline kis tus kab mob peritonitis thiab lwm yam kab mob loj. Qhov no tau ua rau nws muaj peev xwm tsim cov tshuaj tiv thaiv kab mob tshiab. Cov kws tshawb fawb tuaj yeem txhim kho cov phiaj xwm kho mob thiab ua cov txheej txheem kho mob uas ua haujlwm zoo dua thaum lawv nkag siab txog cov txheej txheem no.
gs-441524 Fip
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-1-001
gs-441524 CAS 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Peb provide gs-441524 fip, thov xar mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-kev tshawb nrhiav-only/gs-441524-fip.html
Yuav Ua Li Cas gs-441524 Powder Block RNA Virus Replication ntawm Cellular Level?
Qhov kev txiav txim ntawm gs-441524 hmoov ntawm qib cellular yog ib qho teeb meem ntawm molecular cuam tshuam nrog cov txheej txheem kab mob. Thaum cov nucleoside variant no nkag mus rau hauv cov hlwb uas muaj kab mob, nws yog phosphorylated thiab hloov mus rau hauv nws daim ntawv active triphosphate. Qhov kev hloov no ua rau cov molecule zoo li lub ntuj nucleotides uas cov kab mob yuav tsum tau luam lawv tus kheej.
Cellular Uptake thiab Activation Process
Nucleoside thauj txheej txheem cia gs-441524 hmoov tau los ntawm cov cell membranes tom qab nws tau muab. Hauv lub cell, cellular kinases pom tias cov molecule muaj cov qauv uas zoo ib yam li cov nucleosides ntuj thiab ntxiv phosphate pawg ib zaug. Nws yog ib qho tseem ceeb heev rau cov txheej txheem no tshwm sim vim hais tias daim ntawv triphosphate yog dab tsi ncaj qha ua haujlwm nrog tus kab mob machinery. Ntau hom cell hloov lub zog ntau dua lossis tsawg dua.
Kev sib tw nrog Natural Nucleotides
Daim ntawv nquag ntawm gs-441524 hmoov sib tw nrog ntuj adenosine triphosphate ntxiv rau tus kab mob RNA chains uas loj hlob. Vim tias lawv muaj cov qauv zoo sib xws, tus kab mob RNA-dependent RNA polymerases tsis tuaj yeem qhia qhov txawv ntawm cov derivative thiab natural nucleotides.
Rau cov tshuaj ua haujlwm, qhov zoo li molecular no tseem ceeb heev. Thaum cov polymerase ntxiv cov khoom sib xws es tsis txhob ntawm adenosine, cov txheej txheem rov ua dua ua rau muaj teeb meem loj uas txwv tsis pub tus kab mob rov ua tiav.
Kev cuam tshuam nrog Viral Protein Synthesis
Ntxiv nrog rau kev ntxiv nws tus kheej ncaj qha rau tus kab mob RNA, gs-441524 hmoov hloov pauv cov kab mob caj ces li cas yog txhais ua cov protein uas ua ib yam dab tsi. RNA strands los ntawm cov kab mob tuaj yeem cuam tshuam ribosome nyeem ntawv thiab cov tsev protein los ntawm kev hloov nucleotides hauv lawv. Cov txiaj ntsig tseem ceeb yog ua kom muaj zog los ntawm qhov kev cuam tshuam thib ob, ua rau nws nyuaj rau tus kab mob sib kis. Thaum cov kab mob kis tau raug kho nrog cov khoom tsim nyog, lawv ua kom tsawg dua ntawm cov kab mob cov protein uas xav tau los ua cov kab mob tshiab.
RNA Polymerase Targeting Mechanism ntawm gs-441524 Hmoov
Ib qho zoo tshaj plaws txoggs-441524 hmoovyog tias nws tsom rau tus kab mob RNA polymerase tshwj xeeb. RNA-dependent RNA polymerases yog cov enzymes tseem ceeb heev rau cov kab mob vim lawv luam lawv cov khoom siv caj ces. Nyob rau hauv sib piv rau DNA polymerases pom nyob rau hauv tib neeg lub hlwb, cov kab mob enzymes muaj cov yam ntxwv ntawm molecular uas tso cai rau lawv xaiv inhibited.
Binding Affinity rau Viral Polymerase
Daim ntawv triphosphate ntawm gs-441524 hmoov haum zoo heev rau hauv qhov chaw nquag ntawm tus kab mob RNA polymerases, raws li cov qauv kev sim. Nws tuaj yeem cuam tshuam kev nyab xeeb nrog cov tseem ceeb amino acid residues hauv polymerase active domain vim nws cov qauv molecular. Lub enzyme tsis tuaj yeem ua nws txoj haujlwm ib txwm muaj ntawm kev ntxiv cov nucleotides rau kev loj hlob RNA cov hlua vim qhov kev khi no.
Chain Termination Effects
Kev ncua ntawm cov saw hlau txiav yog ib yam uas ua rau gs-441524 hmoov ua haujlwm sib txawv. Thaum qee qhov nucleoside mimics nres RNA synthesis sai li sai tau thaum lawv ntxiv, cov tshuaj no cia ob peb nucleotides ntxiv tom qab nws ntxiv.
Qhov kev ncua ncua sij hawm no tuaj yeem pab cov koom haum tau dhau los ntawm kev kho cov kab ke uas qee tus kab mob RNA muaj. Vim tias RNA cov khoom uas tsim los tsis muaj txiaj ntsig, tus kab mob tsis tuaj yeem ua tiav nws lub voj voog tsim tawm kom zoo.
Kev Xaiv Siab ntawm Viral Mutations
Txoj kev nws ua haujlwm tso cai rau qee yam kev xaiv rau cov zej zog kis. Kev hloov pauv hauv RNA polymerase uas tuaj yeem ua rau nws tiv taus gs-441524 hmoov feem ntau ua rau cov enzyme tsis tshua muaj txiaj ntsig ntawm kev rov ua dua feem ntau. Qhov kev lag luam tawm no ua rau nws nyuaj rau cov kab mob los tiv thaiv thaum tseem tuaj yeem rov ua dua tshiab. Cov kws tshawb fawb uas kawm txog cov kab mob hloov pauv li cas thaum cov tshuaj no muaj nyob rau hauv tau pom tias kev ua siab ntev ua haujlwm qeeb dua li lwm cov tshuaj tiv thaiv kab mob.
Yuav gs-441524 Powder Stop Viral Genome Replication Processes?
Los ntawm ntau qhov kev kuaj sim thiab kev tshawb fawb soj ntsuam, nws tau pom tias gs-441524 hmoov tuaj yeem nres qhov kev rov ua dua ntawm tus kab mob genomes. Qhov sib npaug nucleoside no tau txais nyob rau hauv txoj kev ntawm ob peb kauj ruam hauv viral genome replication voj voog, txwv tsis pub tus kab mob replicating nyob rau hauv txhua txoj kev.
Kev cuam tshuam ntawm qhov zoo -Sense RNA Synthesis
Qhov zoo -sensitive RNA genomes yog siv los ntawm ntau tus kab mob RNA, suav nrog tus mob coronaviruses. Cov genomes no ua raws li cov khoom siv caj ces thiab tus xa xov RNA. Lub gs-441524 hmoov lub hom phiaj tsim cov khoom zoo-sensitive strands los ntawm kev txuas nws tus kheej rau RNA molecules tshiab thaum lawv luam tawm. Ntau qhov chaw raws RNA strand raug cuam tshuam los ntawm cov analogue, uas txwv tsis pub tus kab mob polymerases los ntawm kev luam RNA. Cov kev tshawb fawb siv cov kab lis kev cai kab lis kev cai qhia tau hais tias cov hlwb uas raug tawm tsam thiab kho nrog cov khoom tsim nyog ua rau cov kab mob kis tau tsawg dua li cov hlwb uas tsis kho.
Inhibition of Negative -Sense RNA Intermediate Formation
Txhawm rau luam lawv tus kheej, ntau tus kab mob RNA ua rau tsis zoo -sens RNA intermediates uas tom qab ntawd siv los ua qhov zoo tshiab -sens genomes. Lub gs-441524 hmoov tau txais nyob rau hauv txoj kev ntawm cov txheej txheem no los ntawm kev tso tseg qhov tseeb creation ntawm cov nruab nrab strands. Cov kab mob tsis tuaj yeem luam lawv cov khoom siv caj ces zoo yog tias lawv tsis muaj txiaj ntsig zoo - cov qauv kev nkag siab. Cov ntaub ntawv pov thawj pom tau hais tias cov tshuaj no txo qis cov txiaj ntsig tsis zoo RNA hauv cov hlwb cuam tshuam, txwv tsis pub tus kab mob rov ua dua.
Intracellular Viral Lifecycle Disruption los ntawm gs-441524 Powder
Kev cuam tshuam rau Early Viral Gene Expression
Thaum cov kab mob nkag mus rau hauv cov hlwb thiab tso lawv cov genomes, lawv yuav tsum tau qhib cov genes thaum ntxov uas ua cov proteins kom luam lawv cov genomes. gs-441524 hmoov hloov cov theem pib ntawm cov noob qhia los ntawm kev ua cov kab mob RNA cov ntaub ntawv tsis raug thiab tag nrho. Thaum cov kab mob kis tau raug muab txhais los ntawm cov ntawv sau uas puas lawm, lawv feem ntau tsis ua lawv txoj haujlwm zoo, uas txwv tsis pub kis kab mob. Qhov kev ua thaum ntxov no muaj txiaj ntsig tshwj xeeb vim nws txwv tsis pub tus kab mob sib kis ua ntej nws ua rau muaj kev puas tsuaj ntau rau cov hlwb.
Kev cuam tshuam nrog Viral Assembly Processes
gs-441524 hmoov tuaj yeem hloov pauv hloov pauv li cas cov kab mob sib xyaw ua ke, txawm tias qee qhov kab mob tau ua tiav. Thaum ua txhaum RNA genomes nrog cov analogue ntxiv, lawv koom ua ke ua cov kab mob uas tsis tuaj yeem tua lwm lub hlwb. Cov kws tshawb fawb uas saib cov kab mob uas ua nrog cov tshuaj pom tau tias ntau ntawm lawv muaj cov genomes uas ploj lawm lossis puas, ua rau lawv tsis tuaj yeem pib tawm tsam tshiab. Qhov kev poob qis hauv kev tsim cov kab mob sib kis ua rau nws nyuaj rau cov kab mob kis los ntawm cov ntaub so ntswg.
Kev txo qis hauv Viral Particle tso tawm
Nyob rau theem kawg ntawm tus kab mob lub neej, cov kab mob kis tau tso tawm cov khoom tshiab uas kis tus kab mob. Thaum koj kho cov kab mob nrog gs-441524 hmoov, muaj tsawg dua cov kab mob uas tuaj yeem tso tawm. Cov kev tshawb fawb uas tshawb xyuas cov kab mob hauv kab lis kev cai supernatants pom tias thaum cov cell raug kho nrog cov tshuaj, cov kab mob muaj tsawg dua hauv cov hlwb uas tsis kho. Qhov kev txiav txim no txwv tsis pub kis tus kab mob thiab muab sijhawm rau lub cev tiv thaiv kab mob kom tshem tau cov kab mob ua ntej lawv ua mob ntau ntawm cov ntaub so ntswg.
Nucleotide Metabolism Interactions
Ntau lub cellular enzymes uas feem ntau ua haujlwm nrog ntuj nucleosides yog ib feem ntawm txoj kev phosphorylation uas tig rau gs-441524 hmoov. Cov tshuaj nkag mus rau hauv lub pas dej nucleotide ntawm cov hlwb, qhov twg nws sib tw nrog adenosine cov ntaub ntawv uas twb muaj lawm. Qhov kev sib tw no yog nyob ntawm seb cov ntsiab lus ntawm cov nucleotides piv rau cov neeg tiag tiag thiab cov enzymes ua haujlwm sai npaum li cas. Yog li ntawd, cellular nucleotide metabolism tswj cov tshuaj ua haujlwm zoo npaum li cas, thiab tej yam uas hloov cov pas dej nucleotide tuaj yeem cuam tshuam rau cov tshuaj tiv thaiv kab mob.
Molecular Action Pathways ntawm gs-441524 Hmoov hauv RNA Virus Control
Cov txheej txheem molecular uas uags-441524 hmoovantiviral yog txoj kev nyuaj biochemical uas cov kws tshawb fawb tseem tab tom sim txiav txim siab. Kev txheeb xyuas cov kev no yuav pab ua kom cov phiaj xwm kho mob ua haujlwm zoo dua thiab nrhiav txoj hauv kev los siv kev sib xyaw ua ke.
Antiviral Synergy Mechanisms
gs-441524 hmoov tuaj yeem ua haujlwm zoo dua nrog lwm txoj hauv kev tiv thaiv kab mob, raws li kev tshawb fawb uas tau saib ntawm kev sib xyaw ua ke. Thaum cov tshuaj tiv thaiv kab mob los yog cov tshuaj uas tsom mus rau theem sib txawv ntawm tus kab mob lub neej siv ua ke, tag nrho cov tshuaj tiv thaiv kab mob feem ntau muaj zog dua li cov kev kho mob ntawm tus kheej. Cov txiaj ntsig zoo no yuav yog vim tias cov tshuaj txo qis cov kab mob hauv lub cev txaus rau lwm lub cev kom tshem tau tus kab mob ntxiv.
Kev nkag siab txog qhov kev sib raug zoo no ua haujlwm pab cov kws kho mob tuaj nrog txoj hauv kev zoo tshaj plaws los kho cov kab mob nyuaj.
Viral Enzyme Specificity Factors
Qhov tseeb tias gs-441524 hmoov ua haujlwm zoo dua ntawm cov kab mob polymerases dua li cov enzymes ntawm tes yog vim muaj kev hloov pauv me me ntawm ob hom enzymes. Lub hom phiaj ntawm tus kab mob RNA polymerases hloov zuj zus los ua kom nrawm nrawm dua, txawm tias nws txhais tau tias qee zaum xaiv cov substrate. Vim tias qhov kev lag luam no- tawm hauv kev txhim kho, lawv yuav muaj feem cuam tshuam los ntawm cov tshuaj nucleoside. Cov kev tshawb fawb hauv qhov tob tau pom cov cim khi hauv hnab tshos nyob rau hauv cov kab mob polymerases uas cuam tshuam nrog cov analogue nyob rau hauv ib txoj kev uas txawv ntawm li cas cellular polymerases ua. Qhov no piav qhia tias yog vim li cas lub qhov rais kho tau pom nyob rau hauv cov tsiaj uas tau kho tau zoo heev.
Xaus
Muaj ntau txoj kev uasgs-441524 hmoovnres qhov kev rov ua dua ntawm cov kab mob RNA qhia tau hais tias cov tshuaj muaj txiaj ntsig zoo li cas hauv kev kho mob antiviral. Qhov nucleoside analogue no muaj cov tshuaj tua kab mob dav dav vim nws tsom cov kab mob RNA polymerases, nres genome replication, thiab cuam tshuam nrog ntau cov kauj ruam ntawm cov kab mob viral lifecycle. Cov kev sib cuam tshuam ntawm cov kab mob enzymes, cellular metabolism, thiab cov khoom sib xyaw ua ke cov yam ntxwv tshwj xeeb tuaj yeem pom hauv cov txheej txheem molecular uas ua rau nws ua haujlwm.
Raws li cov kws tshawb fawb kawm paub ntxiv txog yuav ua li cas gs-441524 hmoov ua haujlwm, lawv tuaj yeem siv nws hauv ntau qhov chaw kho mob thiab kev kawm. Cov tshuaj no zoo heev ntawm kev tawm tsam cov kab mob RNA sib txawv, thiab nws kuj muaj kev nyab xeeb siv rau tsiaj. Qhov no ua rau nws yog ib qho tseem ceeb rau kev tswj cov kab mob viral. Kev tshawb fawb ntxiv tau ua tiav txhawm rau txhawm rau nrhiav txoj hauv kev zoo tshaj plaws, kev kho mob ua ke, thiab txoj hauv kev siv cov tshuaj zoo no tawm tsam cov kab mob tshiab. Qhov no yuav tsis muaj kev poob siab ua rau nws muaj txiaj ntsig ntau dua.
Kev xaiv lub siab nws tso rau ntawm tus kab mob evolution, ncua sij hawm saw hlau txiav mechanism, thiab kev cuam tshuam ntawm ntau theem ntawm lub neej voj voog tag nrho ua hauj lwm ua ke kom cov tshuaj tua kab mob ua haujlwm ntev. Vim tias cov khoom zoo no, gs-441524 hmoov yog ib tus neeg sib tw zoo rau kev tshawb fawb ntxiv thiab kev loj hlob hauv thaj tsam ntawm cov tshuaj tiv thaiv kab mob.
FAQ
1. gs-441524 hmoov ua haujlwm li cas tiv thaiv ntau tus kab mob RNA?
gs-441524 hmoov muaj ntau yam teebmeem vim nws lub hom phiaj RNA-dependent RNA polymerase, ib qho enzyme uas muaj nyob hauv ntau tsev neeg RNA tus kab mob. Cov tshuaj muaj peev xwm txwv tsis pub muaj ntau hom kab mob vim tias cov polymerase no xav tau rau cov kab mob sib kis thiab cov kab mob sib faib cov qauv. Cov qauv nucleoside analogue cia cov kab mob sib txawv ntawm cov polymerases ntes thiab ntxig rau nws, txwv tsis pub cov saw thiab rov ua dua txawm tias hom kab mob twg nws yog.
2. Dab tsi yog qhov txawv ntawm gs-441524 hmoov los ntawm lwm cov nucleoside analogs?
gs-441524 hmoov yog txawv ntawm cov saw terminators ceev ceev vim nws muaj cov txheej txheem ncua sij hawm ncua. Qhov kev ncua sij hawm no tso cai rau ob peb nucleotides ntxiv tom qab suav nrog, uas tuaj yeem pab cov khoom sib txuas tau dhau los ntawm tus kab mob kho cov kab ke. Txoj kev phosphorylation tshwj xeeb thiab daim ntawv triphosphate lub peev xwm los txuas rau cov kab mob polymerase kuj txawv ntawm lwm cov analogues. Qhov no pab piav qhia vim li cas nws ua haujlwm tau zoo thiab tsuas yog tsom cov kab mob enzymes thiab tsis yog cellular polymerases.
3. Puas tuaj yeem tiv thaiv kab mob rau gs-441524 hmoov tsim tau yooj yim?
Nws zoo li tsis kam mus rau gs-441524 hmoov ua kom qeeb qeeb dua li lwm cov tshuaj tiv thaiv kab mob. Kev hloov pauv ntawm tus kab mob RNA polymerase uas ua rau nws tiv taus feem ntau ua rau cov enzyme tsis zoo ntawm kev rov ua dua tshiab, uas ua rau kev noj qab haus huv ntawm cov kab mob uas tiv taus. Vim tias cov kab mob yuav tsum xaiv ntawm kev tiv thaiv thiab muaj peev xwm rov ua dua, nws nyuaj rau lawv kom nyob twj ywm thiab muaj peev xwm kis tau. Vim tias cov khoom muaj feem cuam tshuam ntau tshaj ib theem ntawm cov kab mob viral lifecycle, nws nyuaj rau cov kab mob ua kom tiv taus tag nrho tshaj li ib hom tshuaj tiv thaiv kab mob.
Koom tes nrog BLOOM TECH rau hwm gs-441524 Powder Supply
BLOOM TECH yog ib tus neeg koom tes txhim khu kev qha rau kev nrhiav siab - zoogs-441524 hmoovcov neeg muab khoom. Peb muaj ntau tshaj 12 xyoo ntawm kev paub nyob rau hauv tshuaj chemistry thiab kws tshuaj intermediates. Peb cov chaw tsim khoom yog GMP- ntawv pov thawj thiab ua tau raws li cov qauv ntawm Teb Chaws Asmeskas -FDA, EU, Nyiv, thiab Tuam Tshoj. Qhov no ua kom paub tseeb tias qhov ua tau zoo ntawm koj cov kev tshawb fawb thiab kev txhim kho yog ib txwm zoo ib yam thiab lawv ua raws li cov cai. Peb muab peb npaug - txheej txheej pov thawj zoo los ntawm kev sim cog, peb tus kheej QA / QC department, thiab pom zoo thib peb- pov thawj rau 24 lub tuam txhab tshuaj txawv teb chaws thiab R&D cov koom haum.
BLOOM TECH muaj tus nqi tsim nyog, cov nyiaj tau los meej meej, thiab lub sijhawm tos kom raug uas tuaj yeem taug qab los ntawm peb lub platform ERP tag nrho. Vim tias peb xav tsim kom muaj kev sib raug zoo nrog koj ntev -, peb muab koj txoj kev vam meej ua ntej los ntawm kev muab cov khoom lag luam txhim khu kev qha, cov ntaub ntawv tag nrho rau kev lis kev cai, thiab kev txhawb nqa sai. Txawm hais tias koj xav tau me me rau hauv chav kuaj lossis ntau ntawm lawv, peb cov kev pabcuam sib xyaw ua ke thiab kev sau cov tshuaj lom neeg loj tuaj yeem pab koj ncav cuag koj cov hom phiaj tshawb fawb tshuaj tiv thaiv.
Hu rau peb pab neeg ntawmSales@bloomtechz.comtam sim ntawd los tham txog koj cov gs-441524 hmoov xav tau thiab nrhiav seb BLOOM TECH qhov kev tsom mus rau qhov zoo tuaj yeem ua kom koj txoj kev kawm sai sai thaum txiav nqi.
Cov ntaub ntawv
1. Warren TK, Jordan R, Lo MK, et al. Kev kho tau zoo ntawm lub me me molecule gs-5734 tiv thaiv tus kab mob Ebola hauv rhesus liab. Xwm . 2016;531(7594):381-385.
2. Murphy BG, Perron M, Murakami E, et al. Lub nucleoside analog gs-441524 tiv thaiv feline kis kab mob peritonitis tus kab mob hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
3. Sheahan TP, Sims AC, Graham RL, et al. Dav -spectrum antiviral gs-5734 inhibits ob qho tib si kis mob thiab zoonotic coronaviruses. Science Translational Medicine. 2017;9(396): eaal3653.
4. Lo MK, Jordan R, Arvey A, et al. gs-5734 thiab nws niam txiv nucleoside analog inhibit Filo-, Pneumo-, thiab Paramyxoviruses. Kev Tshaj Tawm Txog Kev Tshawb Fawb. 2017; 7:43395.
5. Siegel D, Hui HC, Doerffler E, et al. Kev tshawb nrhiav thiab kev sib txuas ntawm phosphoramidate prodrug ntawm pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (gs-5734) rau kev kho mob Ebola thiab cov kab mob tshwm sim. Phau ntawv Journal of Medicinal Chemistry. 2017;60(5):1648-1661.
6. Pedersen NC, Perron M, Bannasch M, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog gs-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline kis kab mob peritonitis. Phau ntawv Journal of Feline Medicine and Surgery. 2019;21(4):271-281.