Miv thoob plaws lub ntiaj teb no muaj kev cuam tshuam rau cov kab mob hu ua feline infectious peritonitis (FIP), uas yog ib qho nyuaj thiab qee zaum tuag taus. Rau kev kho mob thiab kev tswj hwm, kev txiav txim siab meej yog qhov tseem ceeb heev. Hauv tag nrho - phau ntawv qhia no, peb yuav tshawb txog ntau txoj hauv kev uas tau siv rau hauv tus txheej txheem ntawm kev kuaj mob FIP. Cov txheej txheem no suav nrog kev kuaj ntshav, biomarkers, thiab kev mob tshwm sim. Tsis tas li ntawd, peb yuav tham txog yuav luag tag nrho cov kev xaiv kho mob uas siv tau, xws li covGS-441524 tab, nrog rau kev kho kom zoo ntawm kev kho kom qhuav thiab ntub hom FIP.
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-001
GS-441524 CAS Nr .: 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muabGS-4415 24ntsiav tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/oem-odm/tablet/gs-441524-tablets.html
Kev kuaj ntshav thiab biomarkers rau kev kuaj mob FIP
Kev kuaj mob FIP tuaj yeem nyuaj vim nws qhov kev qhia txog kev kho mob hloov pauv thiab xav tau ib qho kev kuaj pom zoo. Txawm li cas los xij, cov kws kho tsiaj siv kev sib xyaw ua ke ntawm kev kuaj ntshav thiab biomarkers los muab kev pabcuam hauv kev paub txog tus kabmob.
Ua kom tiav ntshav suav (CBC)
Tag Nrho Cov Ntshav Count (CBC) yog ib qho cuab yeej ua piv txwv tseem ceeb siv thaum xav tias FIP. Txawm hais tias nws tsis lees paub qhov mob, nws tuaj yeem taw qhia txog kev hloov pauv kev ntseeg siab nrog FIP. Iron deficiency, los yog txo qis ntawm cov qe ntshav liab, feem ntau saib thiab yuav muaj kev cuam tshuam tsis tu ncua los yog pob txha pob txha zais. Lymphopenia, uas yog ib qho tseem ceeb poob rau hauv lymphocytes, yog lwm qhov kev suav nrog thiab tej zaum yuav ua rau muaj kev tiv thaiv kab mob. Hauv kev sib txawv, neutrophilia-neutrophil suav suav- tau tshwm sim tsis tu ncua thiab tuaj yeem ua rau pom kev ua rau lub cev hnyav lossis kis mob.
Cov kev hloov pauv ntawm hematological no los ntawm cov qauv, thaum pom ua ke nrog cov tsos mob thiab lwm yam kev kuaj pom, ua rau cov ntaub ntawv tsis txaus ntseeg rau FIP. Txawm tias qhov tseeb tias nws tsis yog tshwj xeeb rau FIP, CBC muab kev saib ua ntej ntawm kev tiv thaiv thiab ua rau tus miv, ua qhov sib txawv ntawm seb cov kws kho tsiaj xaiv los txhawb lossis tsom mus rau kev sim ntau dua.
Cov kua qaub organic chemistry profile muab cov kev paub tseem ceeb rau hauv kev ua haujlwm hauv nruab nrog cev thiab kev ua haujlwm ntawm lub cev, uas tsis tu ncua cuam tshuam rau miv nrog FIP. Ib qho kev tshawb pom uas ntseeg tau tshaj plaws yog hyperglobulinemia- nce qib ntawm globulin proteins. Qhov no feem ntau yog vim tsis muaj kev tiv thaiv lub moj khaum actuation. Ntawm qhov tod tes, hypoalbuminemia, lossis qis qe qe dawb, yog ib txwm pom nyob rau hauv cov duab ntawm FIP vim muaj protein ntau hmoov tsis zoo hauv lub cev kab noj hniav. Yog li ntawd, tag nrho cov protein ntau yuav zoo li qub, tab sis kev faib cov protein tsis sib npaug.
Cov kab mob siab siab, xws li ALT (alanine aminotransferase) thiab AST (aspartate aminotransferase), yuav tshwm sim yog tias lub siab suav nrog, uas tsis yog tshwj xeeb hauv FIP. Cov kev tsis txaus ntseeg no, thaum tsis qhia txog lawv qhov kev thov, tsim cov ntaub ntawv biochemical uas txhawb kev kho mob tsis txaus ntseeg ntawm FIP, tshwj xeeb tshaj yog thaum ua ke nrog kev tshawb pom los ntawm CBC thiab kev qhia txog kev kho mob, thiab kev kho mob nrog.GS-441524 tab.
Albumin-rau-Globulin (A:G) Ratio
Cov albumin-rau-globulin (A:G) feem yog ib qho kev txhawb nqa cov tsos mob hauv kev ntsuam xyuas cov miv xav tias muaj FIP. Nws yog xam los ntawm kev faib cov ntshav qe dawb concentration los ntawm globulin concentration. Hauv cov miv suab, qhov kev faib ua feem ntawm thiab loj ntawm 0.8 txog 2.0. Ua li ntawd, nyob rau hauv miv nrog FIP, qhov kev faib ua feem poob qis hauv qab 0.8, thiab nyob rau hauv ntau qhov xwm txheej, nws tuaj yeem poob hauv qab 0.5.
Qhov no yog vim lub synchronous diminish nyob rau hauv qe dawb thiab increment nyob rau hauv globulin theem, xav txog cov tshuaj tiv thaiv tiag tiag thiab txawv txawv protein yam yam ntxwv ntawm tus mob. A moo A:G kev faib ua feem tsis yog cov neeg tseem ceeb rau FIP, tab sis thaum ua ke nrog lwm qhov chaw tshawb fawb tshawb pom -xws li hyperglobulinemia, hypoalbuminemia, thiab cov tsos mob zoo ib yam - nws tau los ua tus taw qhia muaj zog. Cov kws kho tsiaj tsis tu ncua siv qhov kev faib ua feem no ua ib feem ntawm cov tsos mob kom cais FIP los ntawm lwm yam mob hnyav lossis tsis tuaj yeem tiv taus.
Qhov kev sim Rivalta yog ib qho yooj yim, tus nqi - siv cov tsos mob zoo siv los ntsuas qhov emissions hauv qhov xav tias muaj qhov ntub dej (tsis muaj kev txwv) FIP. Thaum tus miv nthuav tawm nrog lub plab lossis cov kua hauv lub plab, qhov kev sim ntawm cov kua no tuaj yeem sim siv lub tswv yim Rivalta. Hauv qhov kev sim no, me ntsis poob ntawm cov pa tawm yog ntxiv rau lub raj uas muaj cov dej ua kom zoo thiab cov kua qaub corrosive. Yog hais tias qhov poob tuav nws cov duab los yog dab dej maj mam mus rau ko taw zoo li jellyfish, qhov tshwm sim yog suav tias yog qhov zoo- qhia txog cov protein ntau thiab cov khoom ntawm tes. Qhov tshwm sim no yog qhov chaw rau exudates pom hauv FIP.
Thaum qhov kev ntsuam xyuas tsis yog 100% tshwj xeeb, qhov kev ntsuam xyuas Rivalta zoo, tshwj xeeb tshaj yog thaum ua ke nrog lwm qhov chaw tshawb fawb anomalies thiab cov tsos mob, qhov tseem ceeb nce qhov tshwm sim ntawm FIP. Nws yog ib qho tseem ceeb tshwj xeeb tshaj yog nyob rau hauv cov chaw uas tau txais mus rau qhov kev ntsuam xyuas ntau dua yog txwv lossis tseem tos.
Cov kev kho mob dab tsi tom qab kuaj mob?
Thaum FIP raug tshuaj xyuas, cov kev xaiv kho mob tau nce qib tseem ceeb hauv lub sijhawm ntev. Qhov tseeb tiag, FIP tau suav tias yog qhov tuag taus, cov tshuaj tiv thaiv kab mob tsis tau siv tau pom tias muaj txiaj ntsig zoo.
Kev kho mob antiviral
Kev kho mob zoo tshaj plaws rau FIP tam sim no suav nrog kev siv tshuaj tiv thaiv kab mob. GS-441524, ib qho yooj yim nucleoside, tau tshwm sim los ua ib qho kev xav tsis thoob hauv kev kho ob qho tib si ntub dej thiab qhuav ntawm FIP.
Txhawb nqa
Ntxiv nrog rau kev kho mob antiviral xws liGS-441524 tab, kev saib xyuas muaj zog yog qhov tseem ceeb rau kev saib xyuas FIP:
1. Kev kho kua dej: Kev kho kua dej yog qhov tseem ceeb rau kev khaws cov dej hauv cov miv uas raug FIP. Qhov kev kho mob no ua rau muaj qhov sib txawv hauv kev kho qhov tsis zoo ntawm cov electrolyte uas tuaj yeem tshwm sim vim muaj tus kab mob thiab lav tias tus miv nyob ruaj khov. Kev ywg dej raws cai yog qhov tseem ceeb rau kev noj qab nyob zoo -, tshwj xeeb tshaj yog thaum tus miv yuav ntsib kev noj zaub mov tsis zoo thiab kev noj dej.
2. Zoo Zoo Rov Qab: Muab siab - zoo, kev noj haus zoo yog qhov tseem ceeb rau kev txhawb nqa kev noj zaub mov hauv miv nrog FIP. Miv yuav txo qis kev koom tes hauv kev ntshaw lossis kev mob nkeeg vim muaj kev mob nkeeg, yog li kev tshaj tawm kev koom nrog thiab kev noj zaub mov zoo tuaj yeem muab kev pabcuam los ua kom lawv zoo thiab txhawb kev rov zoo. Kev tawm tswv yim txog kev noj zaub mov yog lub kaum sab xis ntawm txhua yam - kev saib xyuas nyob rau hauv kev kho mob.
3. Kev Tsim Txom Txom Nyem: Kev tswj hwm kev tsim txom yuav tsum tau ua kom tau txais txiaj ntsig kom tau txais txiaj ntsig zoo ntawm tus miv thiab txhim kho lawv lub neej zoo. Miv nrog FIP tuaj yeem ntsib kev ntxhov siab vim muaj kev phiv sib txawv, thiab kev mob siab rau qhov kev tsim txom los ntawm kev daws teeb meem los yog kev kho mob yog qhov yooj yim. Ua kom tus miv xis nyob tso cai rau txoj hauv kev zoo dua nrog kev kho mob thiab txav mus rau pem hauv ntej lawv txoj kev noj qab haus huv -.
Immunomodulatory tshuaj
Qee tus kws kho tsiaj tuaj yeem sau cov tshuaj immunomodulatory los muab kev pabcuam los tswj cov lus teb nyab xeeb:
Prednisolone: Ib qho corticosteroid uas tuaj yeem muab kev pab txo qis qhov mob.
Intergalactic: Tej zaum yuav muab kev pabcuam los txhawb lub hauv paus kev nyab xeeb los tiv thaiv tus kabmob.
Qhov sib txawv ntawm kev kho kom qhuav thiab ntub FIP nrog GS-441524
Txoj kev kho mob rau qhuav thiab ntub FIP siv GS-441524 ntsiav tshuaj tuaj yeem sib txawv ntawm ntau yam:
Dosage thiab Duration
Wet FIP:
Feem ntau xav tau koob tshuaj qis dua (4-6 mg / kg ib hnub)
Lub sijhawm kho feem ntau yog 12 lub lis piam
Qhuav FIP:
Tej zaum yuav xav tau koob tshuaj ntau dua (5-8 mg / kg ib hnub)
Lub sijhawm kho mob tuaj yeem ntev dua 12 lub lis piam hauv qee kis
Teb Sijhawm
Cov miv tau kuaj pom tias damp Cat Irresistible Peritonitis (FIP) tsis tu ncua qhia txog cov tshuaj tiv thaiv sai rau kev kho mob nrogGS-441524 tab. Hauv cov xwm txheej no, effusions- cov kua hauv cov kab noj hniav hauv lub cev- feem ntau pib daws hauv qhov ncaj ncees 1 txog 2 lub lis piam ntawm kev pib kho. Ntawm qhov tod tes, miv nrog FIP qhuav tuaj yeem siv sijhawm ntev dua los qhia cov cim ntawm kev txhim kho, nrog rau cov ntaub ntawv kho mob tuaj yeem tuav ob peb lub lis piam mus rau hauv chav kho mob. Qhov kev sib txawv ntawm lub sijhawm tshuaj tiv thaiv no qhia txog qhov hloov pauv tau li cas tus kab mob no cuam tshuam rau cov qauv sib txawv.
Kev soj ntsuam thiab kev hloov kho
Rau kev tswj hwm kev siv tau, kev kuaj xyuas yog qhov tseem ceeb los ntawm kev kho mob. Nyob rau hauv cov ntaub ntawv ntawm damp FIP, veterinarians nquag siv ultrasounds los ntsuam xyuas qhov kev txiav txim ntawm emissions thiab lav tias qhov kev kho mob yog nce raws li kev cia siab. Hauv qhov sib piv, rau cov miv uas muaj FIP qhuav, kev ua haujlwm ntawm cov ntshav thiab ua tib zoo kuaj xyuas lub cev yog qhov tseem ceeb hauv kev ntsuam xyuas cov tshuaj tiv thaiv. Cov kev ntsuam xyuas no muab kev pab rau cov kws kho tsiaj kom hloov pauv qhov tseem ceeb rau kev kho mob thiab lav qhov txiaj ntsig zoo tshaj plaws rau tus miv noj qab haus huv.
Neurological kev koom tes
Cov miv uas pom cov tsos mob ntawm lub paj hlwb, uas yog qhov tseem ceeb tshaj plaws nyob rau hauv cov xwm txheej ntawm FIP qhuav, yuav xav tau kev ntsuas siab dua ntawm GS-441524-rau kev piav qhia, 10-15 mg / kg ib hnub twg. Qhov kev ntsuas nthuav dav no yog qhov tseem ceeb los lav qhov txaus siab nkag mus ntawm cov ntshav-hlwb lub hlwb, tso cai rau cov kws kho mob kom ua tiav cov cheeb tsam cuam tshuam hauv lub hauv paus kev txhawj xeeb. Kev soj ntsuam kaw thiab kev hloov pauv raws li tus miv tus mob yog qhov tseem ceeb hauv cov xwm txheej no txhawm rau ua kom muaj kev kho mob zoo tshaj plaws thiab daws txhua qhov teeb meem cuam tshuam txog kev cuam tshuam ntawm neurological.
Tau txais kev kuaj pom tseeb & Kawm Txog BLOOM TECH GS-441524
Hauv kev xaus, kev txiav txim siab thiab kev kho mob ntawm FIP tau ua qhov tseem ceeb tshaj plaws nyob rau lub sijhawm ntev dhau los. Cov tsos mob ntawm kev kho mob antiviral, tshwj xeeb tshaj yogGS 441524 tabkev muag khoom, tau hloov dab tsi yog ib qho kev txiav txim siab tuag rau hauv ib qho kev kho mob rau ntau tus miv. Txawm li cas los xij, kev txiav txim siab ntxov thiab kev kho mob raug cai yog qhov tseem ceeb rau cov txiaj ntsig zoo tshaj plaws.
Yog tias koj nyob hauv kev lag luam kws tshuaj thiab xav paub ntau ntxiv txog cov tshuaj tshwj xeeb xws li GS-441524 rau kev tshawb nrhiav lossis tsim lub hom phiaj, BLOOM TECH nyob ntawm no los muab kev pab. Nrog rau peb lub xeev- ntawm--GMP-cov ntawv pov thawj GMP- cov chaw ua haujlwm tau ntawv pov thawj thiab cov txuj ci hauv cov lus teb tshuaj sib txawv thiab cov tswv yim decontamination, peb tuaj yeem ua tau raws li koj xav tau rau cov khoom siv tshuaj zoo. Yog xav paub ntxiv txog peb cov khoom thiab yuav ua li cas peb tuaj yeem rov qab koj cov kev xav tau tshuaj, yog tias nws tsis muaj teeb meem ntau, tiv tauj peb ntawmSales@bloomtechz.com. Peb pab pawg tau npaj los pab koj nrog ntev - cov ntawv cog lus ntev thiab lav cov khoom siv tau zoo rau koj cov phiaj xwm kev txhim kho tshuaj.
Cov ntaub ntawv
1. Pedersen, NC (2019). "Feline Infectious Peritonitis: Kev kuaj mob thiab kev kho mob." Phau ntawv Journal of Feline Medicine and Surgery.
2. Addie, DD (2020). "Tam sim no Kev Pom Zoo ntawm Feline Infectious Peritonitis." Veterinary Clinics ntawm North America: Me Tsiaj Xyaum.
3. Murphy, BG, et al. (2018). "Lub nucleoside analog GS-441524 muaj zog inhibits feline infectious peritonitis (FIP) tus kab mob hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv." Veterinary Microbiology.
4. Kipar, A., & Meli, ML (2014). "Feline Infectious Peritonitis: Puas yog Enigma?" Veterinary Pathology.