Yuav ua li cas Milbemycin Oxime ntsiav tshuaj thaiv Heartworm Larvae ua ntej kom loj hlob

Niaj hnub no, kab mob plawv yog ib qho teeb meem loj tshaj plaws rau peb cov tsiaj hauv tsev. Kab mob plawv yog tshwm sim los ntawm kab mob parasite roundworm, Dirofilaria immitis, uas kis tau los ntawm yoov tshaj cum. Tus kab mob parasitic no yuav maj mam ua rau tus dev lub plawv, lub ntsws, thiab cov hlab ntsha rau lub hlis ua ntej pom cov tsos mob sab nraud. Qhov xov xwm zoo yog tias cov tshuaj kho tsiaj niaj hnub no muaj cov khoom zoo, zoo - kawm teb:milbemycin oxime ntsiav tshuaj.

Cov tshuaj tiv thaiv kab mob hauv qhov ncauj no ua haujlwm los ntawm kev ntes cov kab mob plawv thaum ntxov hauv lawv txoj kev loj hlob, deb ua ntej lawv dhau los ua cov kab mob laus. Kev nkag siab txog qhov tseeb ntawm qhov kev cuam tshuam no tuaj yeem pab cov tswv tsiaj thiab cov kws kho tsiaj hauv kev xaiv zoo dua ntawm kev tiv thaiv kab mob.

Milbemycin Oxime ntsiav tshuaj

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-067
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Mechanism Tom qab Kev Tiv Thaiv

Nws yog tshuaj tua kab mob macrolide. Milbemycin oxime ntsiav tshuaj yog. Lawv tua cov kab mob los ntawm kev sib raug zoo nrog cov kab mob hauv cov hlab ntsha ntawm cov pob txha. Lub active ingredient nyob rau hauv cov ntsiav tshuaj yog absorbed rau hauv tus aub lub cev thiab ua kom puas lub plawv larvae uas nyob rau hauv cov ntaub so ntswg.

Milbemycin oxime ntsiav tshuaj ua haujlwm los ntawm kev khi nkaus xwb rau glutamate-gated chloride channels hauv hlwb (cov ion channel no tsuas muaj nyob rau hauv cov hlab ntsha thiab cov leeg hlwb ntawm cov pob txha pob txha). Qhov kev khi no ua rau cov channel qhib thiab nyob twj ywm hauv qhov txawv txawv, tso cai rau ntau cov chloride ions nkag mus rau hauv lub cell. Qhov no ua rau tsis tu ncua hyperpolarization ntawm cov paj hlwb lossis cov leeg nqaij, uas ua rau tus menyuam tuag tes tuag taw thiab thaum kawg tua nws.

Cov dev thiab miv muaj lawv tus kheej mammalian hauv nruab nrab lub paj hlwb uas tsis muaj cov tib yam ntawm cov channel; Yog li ntawd, cov khoom no tsis tshua muaj kev cuam tshuam rau lawv.

Targeting The Right Life Stage

Kev tiv thaiv kab mob plawv yog nyob ntawm lub sijhawm. Thaum noj ntshav, yoov tshaj cum tso cov kab mob L3 tus menyuam mos (thib peb-stage larvae) rau ntawm daim tawv nqaij ntawm tus dev. Cov larvae molt mus rau L4 thiab tom qab ntawd thaum ntxov L5 theem nyob rau hauv ob peb lub lis piam tom ntej no thaum lawv taug kev los ntawm daim tawv nqaij mus rau kev ncig.Milbemycin oxime ntsiav tshuajTam sim no muaj txiaj ntsig zoo tshaj plaws rau kev tsiv teb tsaws chaw subcutaneous, tshwj xeeb tshaj yog tawm tsam L3 thiab L4 larvae uas tseem nyob sab nraud ntawm cov hlab ntsha.

Ib zaug -ib - hli koob tshuaj txhais tau hais tias txhua tus kab mob uas tsim los ntawm yoov tshaj cum nyob rau hauv 30 hnub dhau los yuav raug tshem tawm ua ntej lawv loj hlob mus rau cov neeg laus kab mob phem.Qhov qhov rais tiv thaiv no tau ua pov thawj zoo hauv cov ntaub ntawv kws kho tsiaj uas tshuaj xyuas los ntawm lwm tus kws kho tsiaj thiab yog lub hauv paus rau txhua yam kev tiv thaiv kab mob plawv.

Nkag siab txog Larval Life Cycle

Lub neej voj voog ntawm Dirofilaria immitis yog qhov nyuaj, nrog ntau theem, thiab muaj cov yoov tshaj cum thiab dev ua tswv. Hauv yoov tshaj cum, tus kab mob kis tau los ntawm L1 mus rau L3, theem kis. Lub sijhawm no, hauv tus dev, L3 larvae molt ob zaug ntxiv. Cov txheej txheem no yuav siv sijhawm li 50 mus rau 70 hnub, tom qab ntawd lawv dhau los ua cov neeg laus thiab nkag mus rau hauv cov hlab ntsws pulmonary.

Cov neeg laus lub plawv tuaj yeem nyob hauv cov hlab ntsha pulmonary thiab sab xis ntawm lub plawv ntawm tus dev rau 5 txog 7 xyoo. Lawv tsim microfilariae, uas rov- nkag mus rau hauv cov hlab ntsha thiab nkag mus rau yoov tshaj cum.

Cov tshuaj Milbemycin oxime zoo dua li cov tshuaj tiv thaiv kab mob, txij li thaum lawv tua cov larvae ua ntej lawv dhau los ua neeg laus, uas yog qhov tsis zoo tshaj plaws ntawm kev sib kis.

Vim Li Cas Larval Stage Matters for Treatment Strategy

Cov tshuaj Milbemycin oxime zoo tshaj plaws tiv thaiv Dirofilaria immitis larvae nyob rau theem L3 thiab L4. Cov kws tshawb fawb tau pom tias qhov koob tshuaj ntawm qhov ncauj ntawm cov tshuaj ib hlis ib zaug yog ntau dua 99% kev tua cov larvae thaum lub qhov rais tsis muaj zog. Thaum cov larvae tau dhau los ntawm theem L5 thaum ntxov thiab nyob rau hauv kev ncig, kev tiv thaiv macrolides tsis ua tiav ntawm kev tua lawv. Thiab tseem muaj lwm qhov laj thawj yog vim li cas tsis tu ncua, kev tiv thaiv tsis muaj kev cuam tshuam yog qhov zoo dua li kev kho reactive.

Cov channel no ua dab tsi hauv Parasites

Cov no yog ligand-gated ion channels hu ua glutamate-gated chloride channels (GluCls). Lawv muaj nyob rau hauv peripheral thiab central paj hlwb ntawm nematodes thiab arthropods. Hauv Dirofilaria immitis larvae, cov kab no tswj cov kab mob neuromuscular, uas txhais tau hais tias lawv tswj cov leeg nqaij sib cog lus thiab txav mus ua ke. Thaum cov ntsiav tshuaj milbemycin oxime khi rau cov kab no, lawv kaw lawv hauv lub xeev qhib raws li qhov zoo allosteric modulator. Qhov no pib ib txoj hlua ntawm cov xwm txheej uas txwv cov larvae txav thiab tua lawv.

Yuav ua li cas Channel Selectivity tiv thaiv Mammalian tswv

Qhov tseeb tiasmilbemycin oxime ntsiav tshuajyog channel- xaiv yog ib feem ntawm vim li cas lawv thiaj li muaj kev nyab xeeb rau cov tsiaj.

Lub paj hlwb ntawm cov tsiaj nyeg siv glutamate receptors thiab GABA-gated chloride channels uas txawv ntawm lub cev ntawm GluCl subunits uas worms lub hom phiaj. Qhov sib txawv ntawm cov qauv no txhais tau hais tias cov tshuaj muaj zog antiparasitic tsis cuam tshuam li cas dev thiab miv lub hlwb ua haujlwm. Qhov no yog ib yam uas tau ua pov thawj los ntawm ntau xyoo ntawm kev tshawb fawb tshuaj.

Dosing Protocols thiab Frequency

Muab cov tshuaj milbemycin oxime ib hlis ib zaug los tiv thaiv kab mob plawv. Cov tshuaj yog tsim nyob rau hauv ntau npaum li cas nyob ntawm seb lub cev hnyav. Cov ntsiav tshuaj muaj nyob rau hauv ntau lub zog rau cov dev ntawm ntau qhov sib txawv: 2.3 mg, 5.75 mg, 11.5 mg, thiab 23.0 mg. Qhov kev kawm tiav qib txhais tau hais tias txhua tus dev tau txais koob tshuaj kho mob, siab txaus los tua cov larvae tsis yooj yim tab sis zoo hauv qhov kev nyab xeeb.

Veterinary cov qauv thoob ntiaj teb, suav nrog American Heartworm Society, pom zoo cov dev nyob rau hauv cov chaw uas muaj kab mob plawv muaj kev tiv thaiv txhua xyoo- puag ncig. Xyoo- kev tswj hwm ib puag ncig yog qhov tseem ceeb tshwj xeeb vim tias thaum lub caij ntuj sov dhau los, yoov tshaj cum tseem tuaj yeem ua haujlwm hauv ntau thaj tsam.

Dav -Spectrum plab hnyuv kab mob ua haujlwm

Milbemycin oxime tshuaj tsis tsuas yog tiv thaiv kab mob plawv, tab sis kuj tshem tawm cov kab mob nematode hauv cov hnyuv. Cov tshuaj no tua cov kab nuv ntses (Ancylostoma caninum), roundworms (Toxocara canis), thiab whipworms (Trichuris vulpis). Cov ntsiav tshuaj yog ib qho zoo tib yam - koob tshuaj los tswj cov kab mob sib kis, uas yog ib qho txiaj ntsig tseem ceeb rau cov tswv tsiaj uas yuav tsum tau tiv thaiv kab mob siab txhua xyoo txij li nws daws ob yam.

Kev pheej hmoo ntawm cov koob tshuaj uas ploj lawm

Yog tias koj tsis nco txawm tias ib qho kev noj txhua hli, koj qhib lub qhov hauv qhov kev tiv thaiv uas cov qe tsim nyob rau lub sijhawm ntawd yuav plam los ntawm L3 / L4 qhov rais uas lawv muaj kev cuam tshuam. Thaum lub sij hawm tus larvae nyob rau hauv lig L5 los yog cov tub ntxhais hluas cov laus theem, kev tiv thaiv macrolides yuav tsis muaj peev xwm tua lawv tsis tu ncua, thiab tus dev yuav xav tau kev kho mob hnyav dua. Tib txoj hauv kev los xyuas kom meej tias lub qhov rais tiv thaiv tau qhib thaum lub caij yoov tshaj cum kis tau tus mob yog siv tshuaj ntau zaus thiab tsis cuam tshuam.

Cov pej xeem-Txoj kev pab cuam ntawm kev tiv thaiv thoob plaws

Thaum muaj ntau tus dev hauv ib cheeb tsam muaj kev tiv thaiv kab mob plawv tsis tu ncua,

Kev txo qis ntawm cov microfilariae nyob rau hauv cov pej xeem tau txo qis. Kev txo qis microfilarial load hauv tus dev ua rau tsawg dua rau yoov tshaj cum kom kis tau thiab kis kab mob larvae. Ib qho ntawm cov laj thawj kev noj qab haus huv zoo tshaj plaws rau kev siv cov ntsiav tshuaj milbemycin oxime nyob rau hauv cov cheeb tsam uas muaj tus kab mob yog qhov cuam tshuam rau tag nrho cov pej xeem. Cov tshuaj no zoo rau txhua tus dev, txawm tias lawv cov tswv tsis ntseeg tias lawv nyob hauv qhov chaw muaj kev pheej hmoo siab heev.

milbemycin oxime ntsiav tshuajyog scientific proven los tiv thaiv heartworm larvae los ntawm kev loj hlob mus rau cov neeg laus kab mob phem. Cov tshuaj tsom mus rau glutamate-gated chloride channels, uas tsuas yog muaj nyob hauv cov tsiaj lub paj hlwb. Qhov no ua rau cov tshuaj tsis zoo rau cov tsiaj txhu thiab tso cai rau nws tua cov larvae tshwj xeeb. Muab nws ib hlis ib zaug txwv lub qhov rais ntawm lub sijhawm Dirofilaria immitis yuav tsum tau kis. Qhov no tiv thaiv tsiaj txhu thiab tiv thaiv kab mob kis mus rau lwm yam tsiaj hauv zej zog. Cov ntsiav tshuaj yooj yim no, thaum koj nkag siab tias nws ua haujlwm li cas, dhau los ua cov cuab yeej tseem ceeb rau cov tswv tsiaj, kws kho mob, thiab cov uas muab cov khoom noj rau tsiaj.

Bloomtechz muab thaum qhov ua tau zoo tas li thiab ua raws li cov cai tseem ceeb. Bloomtechz yog tus paub tseebmilbemycin oxime ntsiav tshuajtus neeg muag khoom thiab muaj GMP- cov chaw tsim khoom tau lees paub los ntawm US FDA, EU, Nyiv, thiab CFDA. Lawv muag cov tshuaj -qib milbemycin oxime li ntshiab API hmoov thiab tiav cov ntsiav tshuaj cov ntaub ntawv rau miv thiab dev. Txhua batch mus txog peb theem ntawm kev tswj kom zoo: kev ntsuam xyuas hauv lub Hoobkas, kev tshuaj xyuas los ntawm peb tus kheej QA / QC department, thiab kev tshuaj xyuas los ntawm peb lub koom haum - tog. Qhov no ua kom cov khoom koj tau txais raws li EP thiab USP cov qauv. Bloomtechz yog tus khub zoo rau koj qhov kev tsim lossis kev lag luam xa tawm. Lawv muaj ntau tshaj 12 xyoo ntawm kev paub hauv cov organic synthesis thiab qhov tseeb, ruaj khov - cov phiaj xwm nqi paj.

EmailSales@bloomtechz.comtam sim ntawd tham txog specs, customization xaiv, lossis OEM / ODM deals.

1. American Heartworm Society. (2020). Cov Lus Qhia Txog Canine tam sim no rau Kev Tiv Thaiv, Kev kuaj mob, thiab kev tswj hwm ntawm Heartworm (Dirofilaria immitis) Kab mob hauv dev. American Heartworm Society.

2. Geary, TG, & Thompson, DP (2001). Caenorhabditis elegans: Yuav ua li cas zoo tus qauv rau veterinary parasites? Veterinary Parasitology, 101(3–4), 371–386.

3. Bowman, DD, & Atkins, CE (2009). Heartworm biology, kho, thiab tswj. Veterinary Clinics of North America: Small Animal Practice, 39(6), 1127–1158.

4. Prichard, RK, & Roulet, A. (2007). ABC transporters thiab -tubulin nyob rau hauv macrocyclic lactone tsis kam: Kev cia siab rau cov cim kev loj hlob. Parasitology, 134(8), 1123–1132.

5. Wolstenholme, AJ, Fairweather, I., Prichard, R., von Samson-Himmelstjerna, G., & Sangster, NC (2004). Tshuaj tiv thaiv nyob rau hauv veterinary helminths. Trends in Parasitology, 20(10), 469–476.

6. Lok, JB, & Ribeiro, JMC (2004). Biology ntawm Dirofilaria immitis: Los ntawm microfilaria mus rau kab mob larva. Hauv Dirofilariasis hauv tib neeg thiab tsiaj txhu: Kev Tshawb Fawb thiab Kev Tswj Xyuas Kev Kho Mob. International Society of Dirofilariasis.