Txoj kev npaj thiab biosynthesis ntawm 5-methoxytryptamine txawv ntawm melatonin li cas?
Melatonin thiab5-Methoxytryptamine(5-MT) yog ob qho kev sib txuas endogenous tau txais los ntawm serotonin uas muaj feem cuam tshuam nrog rau lub sijhawm no muaj cov phiaj xwm tsis txaus ntseeg thiab txoj hauv kev biosynthetic:
Qauv:
5-MT suav nrog methoxy pob khoom ntawm 5 qhov chaw ntawm lub nplhaib indole. Qhov txawv, melatonin muaj methoxy pob khoom ntawm 5 txoj hauj lwm thiab ib qho acetyl sab saw ntawm amine nitrogen.
Biosynthesis:
5-MT yog yooj yim los ntawm serotonin los ntawm enzymatic cycles nrog rau tryptamine 5-hydroxylase thiab hydroxyindole-O-methyltransferase (HIOMT). Pom tseeb, melatonin tau piav qhia los ntawm serotonin los ntawm acetylation catalyzed los ntawm arylalkylamine N-acetyltransferase (AANAT), taug qab los ntawm O-methylation los ntawm HIOMT.
Txawm hais tias ob qhov sib xyaw ua ke sib koom ua ke ib txwm biosynthetic pib los ntawm serotonin, qhov tseem ceeb ntawm qhov tsis sib xws nyob hauv qhov pom ntawm acetyl pawg hauv melatonin, uas ploj lawm hauv 5-MT. Qhov no ntau yam prompts tshwj xeeb pharmacological thaj chaw ntawm ob lub mixs.
Melatonin qhov sib ntxiv ntawm ib qho acetyl sab saw ho hloov nws cov yam ntxwv ua haujlwm, cuam tshuam rau nws cov kev cuam tshuam nrog ntau yam receptors thiab cov txheej txheem physiological, piv rau 5-MT, uas tsuas muaj ib pawg methyl ncaj nraim. Qhov tseem ceeb tshwj xeeb no sawv cev rau qhov sib txawv ntawm qhov cuam tshuam thiab kev tawm dag zog uas tshwm sim los ntawm 5-MT thiab melatonin hauv cov txheej txheem organic.
Dab tsi paub txog 5-methoxytryptamine thiab melatonin kom deb li deb ntawm lawv cov receptor txwv kev cuam tshuam?
Tus thawj receptors faib los ntawm5-Methoxytryptamine(5-MT) thiab melatonin lub hnab ntawv serotonin thiab melatonin receptors, tab sis lawv qhia qhov sib txawv hauv kev nthuav dav thiab tus cwj pwm:
5-MT:
qhia thaj chaw ntawm lub zog rau ib qho sib txawv 5-HT1-, 5-HT2-, 5-HT5-, 5-HT 6-, thiab 5-HT7-receptors.
Nws txawv ntawm melatonin nyob rau hauv uas nws tsis feem ntau khi rau melatonin receptors.
pab tawm ib assortment ntawm serotonin receptor subtypes, qhia ib tug ntau dua polypharmacology.
Melatonin:
Kev sib raug zoo rau melatonin receptors, meej meej MT1, MT2, thiab MT3.
muaj lub zog sub-nanomolar thiab ntau dua proclivity rau melatonin receptors.
Nws tshwj xeeb tshaj yog rau melatonin receptors, uas qhia qhov tsis txaus ntseeg rau serotonin receptors.
Hauv kev nthuav dav, thaum ob qho tib si 5-MT thiab melatonin txuas nrog melatonin receptors, lawv sib piv qhov tseem ceeb hauv lawv cov receptor txwv cov profiles. Melatonin qhia tau hais tias qhov tshwj xeeb thiab lub zog rau melatonin receptors, thaum 5-MT qhia txog kev txav mus los ntawm ntau hom serotonin receptor subtypes txawm tias nws qhov kev sib txuas nrog melatonin receptors. Cov kev tsim nyog hauv receptor proclivity thiab selectivity ntxiv rau qhov sib txawv pharmacological cuam tshuam pom nrog txhua qhov sib xyaw.
Dab tsi yog qhov cuam tshuam rau kev siv hluav taws xob thiab kev siv ntawm 5-methoxytryptamine piv rau melatonin?
Melatonin thiab5-Methoxytryptamine(5-MT) muaj cov tshuaj pharmacological tshwj xeeb vim qhov sib txawv ntawm kev txwv receptor:
Melatonin:
Feem ntau saib xyuas so, circadian rhythms, thiab mus zaum raws li kev txhawb nqa ntawm tes.
Paub txog nws txoj hauv kev nkag mus rau circadian rhythms thiab nce qib pib thiab kho.
Melatonin cov khoom muaj kev cuam tshuam ntau dhau los ntawm nws qhov kev sib koom siab thiab kev xaiv rau melatonin receptors, tshwj xeeb tshaj yog MT1 thiab MT2.
Feem ntau muaj yam tsis muaj daim ntawv sau tshuaj raws li kev ua kom muaj kev ntxhov siab thiab rau kev saib xyuas lub dav hlau slack vim nws lub peev xwm los tswj kev so ntawm lub voj voog.
5-MT:
Qhia txog ntau yam tshuaj kho mob ntau dua vim nws kev koom tes nrog serotonin thiab melatonin receptors.
Daim iav serotonin cov dej num, ua rau mob nyem, vasoconstrictive, thiab tiv thaiv lub nra hnyav txawm tias cov dej num zoo li melatonin.
vim nws cov khoom siv tshuaj sib xyaw ua ke, siv sim los kawm serotonin thiab melatonin receptor subtypes.
Kev tshawb fawb txog kev siv tshuaj kho mob xws li pw tsaug zog tsis zoo, tsim txom cov thawj coj, thiab kev kho mob sab saud.
Kev sib piv:
Thaum 5-MT muab ob peb lub chaw muag tshuaj rau melatonin, nws qhov kev txiav txim ntau dua, tshwj xeeb tshaj yog los ntawm serotonin receptor agonism, lees paub nws. 5-MT, piv rau melatonin, muaj cov tshuaj tua kab mob thiab tshuaj tiv thaiv kev ntxhov siab ntxiv rau nws cov khoom siv pw tsaug zog. Hauv kev sib piv rau 5-MT, uas tseem yog qhov tseem ceeb ntawm kev tshawb fawb kev sim ntau dua li kev siv tshuaj kho mob, melatonin muaj lub luag haujlwm tsim tau zoo raws li kev pab pw tsaug zog. Feem ntau, cov neeg tsis paub txog tshuaj kho tus kheej ntawm 5-MT thiab melatonin los ntawm lawv cov koom haum sib txawv ntawm cov neeg txais kev sib txawv thiab cov txiaj ntsig tshwm sim rau ntau lub cev muaj zog.
Dab tsi yog qee cov ntsiab lus tseem ceeb ntawm kev sib piv ntawm 5-methoxytryptamine thiab melatonin?
Hauv daim ntawv qhia,5-Methoxytryptamine(5-MT) thiab melatonin, thaum sib koom ob peb lub ntsiab lus pib, qhia txog kev sib txawv ntawm cov tshuaj muaj txiaj ntsig thoob plaws qhov kev xav sib txawv:
Qauv:
5-MT muaj ib qho 5-methoxyindole pawg, thaum melatonin sib sau ua ke nrog N-acetyl sab saw. Qhov kev hloov pauv tseem ceeb no ntxiv rau lawv cov kev ua haujlwm pharmacological sib txawv.
Kev khi:
5-MT qhia tau hais tias nyiam rau ob qho tib si serotonin thiab melatonin receptors, txawm hais tias melatonin cuam tshuam rau melatonin receptors. Qhov kev sib txawv no hauv receptor explicitness underlies lawv assorted physiological cuam tshuam.
Potency:
Melatonin nthuav tawm ntau dua kev hlub, tshwj xeeb tshaj yog nyob rau hauv melatonin receptor locales, sib piv nrog 5-MT. Qhov tsis sib xws hauv lub zog no cuam tshuam qhov loj ntawm lawv cov kev ua haujlwm pharmacological.
Cov teebmeem:
5-MT siv cov kev cuam tshuam uas luam tawm ob qho tib si serotonin thiab melatonin kev ua ub no, ntxiv rau ntau qhov kev cuam tshuam ntawm lub cev. Piv txwv li, melatonin tseem ceeb tswj qhov so ntawm lub voj voog, qhia txog nws cov lus qhia hauv circadian suab paj nruag.
Siv:
5-MT yog qhov tseem ceeb ua cov cuab yeej sim thiab cov tshuaj muaj peev xwm, siv rau hauv kev tshawb fawb. Hloov pauv, melatonin feem ntau muaj yam tsis muaj ntawv sau tshuaj los ua kom muaj kev ntxhov siab vim tias nws tau tso tawm qhov muaj txiaj ntsig hauv kev nce qib pib thiab coj tus qauv so.
Biosynthesis:
Txawm hais tias ob qhov sib xyaw pib los ntawm serotonin, lawv txoj hauv kev biosynthetic suav nrog kev npog tsis tau tshwj xeeb enzymatic cycles. Qhov tsis sib xws hauv biosynthesis ntxiv rau lawv ib yam ntawm cov khoom siv tshuaj thiab cov khoom siv tshuaj.
Txhua yam nyob rau hauv tag nrho, thaum5-Methoxytryptaminethiab melatonin qhia cov ntsiab lus pib ntuj, lawv hais txog cov ntsiab lus tsis muaj tseeb raws li lawv cov qauv tsim, receptor txwv tsis pub muaj zog, muaj zog, cuam tshuam rau lub cev, siv, thiab txoj hauv kev biosynthetic. Kev nkag siab txog cov kev sib txawv no yog qhov tseem ceeb rau kev piav qhia lawv txoj haujlwm cais hauv cov lus qhia txog lub cev thiab kev siv kho mob. 5-MT tsis tuaj yeem tsuas yog suav tias yog ib hom kev xaiv ntawm melatonin vim nws cov yam ntxwv tshwj xeeb ntawm cov tshuaj thiab cov txiaj ntsig zoo.
Cov ntaub ntawv
1. Dubocovich, ML, Delagrange, P., Krause, DN, Sugden, D., Cardinali, DP, & Olcese, J. (2010). International Union ntawm Basic thiab Clinical Pharmacology. LXXV. Nomenclature, kev faib tawm, thiab chaw muag tshuaj ntawm G protein-coupled melatonin receptors. Pharmacological xyuas, 62(3), 343–380.
2. Kennaway DJ (2020). Melatonin khi qhov chaw. Phau ntawv Journal of pineal research, 68(1), e12609.
3. Legros, C., Lancien, F., Dupont, C., Sauerwein, H., Brucker-Davis, F., Lerrant, Y., Ciret, P., & Simoncini, T. (2018). Melatonin: Pharmacology, Functions thiab Kho Cov txiaj ntsig. Tam sim no cov tshuaj chemistry, 25(3), 312–322.
4. Hardeland R. (2005). Antioxidative tiv thaiv los ntawm melatonin: ntau yam ntawm cov txheej txheem los ntawm radical detoxification rau radical zam. Endocrine, 27(2), 119–130.
5. Silman, RE, Leone, RM, Hooper, RJ, Preece, NE, Soper, CR (1979) Melatonin, 5-methoxytryptamine thiab 5-methoxytryptophol: synthesis, identification and quantitation in human pineal gland. Phau ntawv Journal of Neural Transmission, 45, 313-326.