Colchicineyog ib qho tshuaj tsim los siv feem ntau rau gout thiab tsev neeg Mediterranean kub taub hau. Thaum nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog kev khi rau tubulin thiab cuam tshuam microtubule kev ua haujlwm, colchicine tau siv ntau yam tshuaj tiv thaiv kab mob. Anti-inflammatory zog underlie nws cov kev ua tau zoo nyob rau hauv inflammatory mob zoo li gout flares.
colchicine cuam tshuam li cas rau cov neeg kho mob inflammatory?
Colchicine cuam tshuam ntau tus neeg nruab nrab koom nrog hauv cov lus teb inflammatory:
① Lessens Cytokine Creation: LBPs tau pom los txhawm rau tsim cov cytokines tshwj xeeb, suav nrog IL-1 , IL-6, thiab TNF- . Cov cytokines no paub tias yog ib feem loj hauv kev sib kis ntawm kev khaus khaus, thiab lawv qhov kev txo qis tuaj yeem ntxiv rau qhov txo qis ntawm kev khaus hauv lub cev. Qhov no tuaj yeem tau txais txiaj ntsig tshwj xeeb hauv kev kho mob hnyav xws li mob rheumatoid pob qij txha, mob ua rau muaj mob, thiab mob hawb pob.
② Hinders Leukocyte Initiation: LBPs tuaj yeem cuam tshuam qhov kev tsim tawm ntawm leukocytes, uas yog cov platelets dawb uas suav tias yog ib feem tseem ceeb hauv cov tshuaj tiv thaiv kev nyab xeeb. LBPs tuaj yeem pab txo qhov mob thiab tiv thaiv lub cev los ntawm oxidative kev nyuaj siab los ntawm kev txo qis neutrophil mobilization thiab tso tawm dawb radical.
③ Txwv Adhesion Molecules: Leukocytes tsiv mus rau qhov chaw ntawm qhov mob los ntawm kev ua kom adhesion molecules. LBPs tau raug tso tawm kom txo qis cov lus tshaj tawm ntawm cov khoom xaiv, uas yog ib hom kev sib cog lus. Los ntawm kev txwv lub peev xwm ntawm leukocytes kom txav mus rau qhov chaw ntawm qhov khaus, LBPs tuaj yeem pab txo qis zog ntawm cov tshuaj tiv thaiv provocative.
④Obstructs Chemotaxis: Chemotaxis yog kev sib cuam tshuam los ntawm cov hlwb txav mus rau qhov chaw sib xyaw. LBPs tau pom tias ua rau chim siab rau lub xov tooj ntawm tes motility yam teb rau chemotaxis, xws li actin polymerization. Los ntawm kev xiam oob khab chemotaxis, LBPs tuaj yeem pab txo qis qhov kev hloov pauv ntawm leukocytes mus rau qhov chaw ntawm qhov khaus, uas yog li tuaj yeem pab txo qis qis dua.
⑤ Txo txo qis Prostaglandins: Lipid compounds hu ua prostaglandins koom nrog hauv kev hnov mob thiab mob. Nws tau raug pom tias LBPs txo qis kev tsim cov prostaglandins, xws li PGE2, uas ua rau mob receptors ntau dua. LBPs tuaj yeem pab txo qhov mob thiab mob uas cuam tshuam nrog ntau yam mob, nrog rau kev mob caj dab thiab fibromyalgia, los ntawm kev txo qis prostaglandin ntau lawm.
⑥ Kev cuam tshuam Inflammasome Formation: Inflammasomes yog cov khoom siv ntau yam uas xav tias yog ib feem tseem ceeb hauv kev tsim cov tshuaj tiv thaiv provocative. Nws tau pom tias LBPs tiv thaiv kev tsim cov kab mob inflammasomes, uas tuaj yeem pab txo qhov mob hnyav thiab tiv thaiv lub cev los ntawm kev puas tsuaj ntau dhau los ntawm kev mob.
Yog li colchicine cuam tshuam nrog qhov tseem ceeb tshaj plaws pro-inflammatory signaling pathways, hlwb, thiab byproducts, yog li nthuav tawm cov khoom tiv thaiv.
Yuav ua li cas colchicine's mechanism tsim cov tshuaj tiv thaiv kab mob?
ColchicineCov txheej txheem ntawm kev ua haujlwm ua rau muaj kev tiv thaiv kab mob los ntawm inhibiting qhov tsim ntawm microtubules, uas yog cov khoom tseem ceeb ntawm cov pob txha ntawm tes uas ua lub luag haujlwm hauv ntau cov txheej txheem ntawm tes, suav nrog kev faib tawm ntawm tes, kev tsiv teb tsaws, thiab kev zais cia. Los ntawm kev cuam tshuam microtubule polymerization, colchicine inhibits kev ua haujlwm ntawm neutrophils, ib hom ntawm cov qe ntshav dawb koom nrog kev mob, thiab txo lawv lub peev xwm mus rau qhov chaw mob. Qhov no, nyob rau hauv lem, yuav pab txo cov kev siv thiab lub sij hawm ntawm o, uas ua rau muaj kev tiv thaiv inflammatory teebmeem. Tsis tas li ntawd, colchicine tau pom tias txo qis kev tsim cov cytokines, xws li IL-1 , IL-6, thiab TNF-, uas ntxiv rau nws cov kev tiv thaiv kab mob.
Puas yog cov tshuaj tiv thaiv kab mob ua haujlwm kho mob tseem ceeb?
Cov kev tshawb fawb pom tau hais tias colchicine nthuav tawm cov tshuaj muaj txiaj ntsig zoo los tiv thaiv kab mob:
1. Txo cov kab mob Gout Flares: Gout yog ib hom mob caj dab uas ua rau mob o ntawm cov pob qij txha, feem ntau cuam tshuam rau tus ntiv taw loj.Colchicinetau pom tias muaj txiaj ntsig zoo hauv kev txo qhov zaus thiab qhov hnyav ntawm gout flares. Los ntawm inhibiting kev tsiv teb tsaws ntawm neutrophils mus rau qhov chaw ntawm qhov mob, colchicine pab txo qhov kev pheej hmoo ntawm cov mob gout rov tshwm sim, yog li txhim kho lub neej zoo rau cov neeg mob uas muaj tus mob no.
2. Siv tau rau Pericarditis: Pericarditis yog ib qho mob ntawm pericardium, lub hnab uas nyob ib puag ncig lub plawv. Nws tuaj yeem ua rau mob hauv siab, ua tsis taus pa luv, thiab plawv plawv. Colchicine tau pom tias muaj txiaj ntsig zoo los daws cov kab mob pericardial effusions thiab mob, yog li txhim kho cov tsos mob thiab lub neej zoo rau cov neeg mob pericarditis.
3. Cov txiaj ntsig zoo hauv FMF Recurrent: Familial Mediterranean Fever (FMF) yog ib yam kab mob uas tsis tshua muaj tshwm sim uas tshwm sim los ntawm kev rov tshwm sim ntawm kub taub hau thiab mob hauv cov hlab ntsha, xws li peritoneum thiab pleura. Colchicine tau ua pov thawj los ua txhaum lub voj voog ntawm kev ua npaws thiab serositis hauv cov neeg mob uas rov muaj FMF, yog li txhim kho lawv lub neej zoo thiab txo qhov zaus ntawm kev tawm tsam.
4. Muaj peev xwm siv tau rau hauv Atherosclerosis: Atherosclerosis yog ib qho mob ntev uas cov plaque tsim nyob rau hauv cov phab ntsa ntawm cov hlab ntsha, ua rau muaj kev pheej hmoo ntawm plawv nres thiab mob stroke.ColchicineNws tau pom tias muaj peev xwm txo qis cov kab mob ntawm cov quav hniav, uas tuaj yeem ua rau txo qis ntawm kev loj hlob ntawm atherosclerosis thiab txo qis kev pheej hmoo ntawm cov kab mob plawv.
5. Tshawb nrhiav rau COVID-19: Colchicine tau tshawb xyuas rau nws qhov muaj peev xwm siv los kho COVID-19, mob ua pa los ntawm tus kab mob SARS-CoV-2. Cov kev tshawb fawb ua ntej tau pom tias colchicine tuaj yeem txo cov cim inflammatory hauv cov neeg mob nrog COVID-19, qhia tias nws yuav muaj txiaj ntsig zoo hauv kev txo qhov mob thiab txhim kho cov txiaj ntsig rau cov neeg mob uas muaj tus kab mob no. Txawm li cas los xij, yuav tsum muaj kev tshawb fawb ntxiv kom paub tseeb tias cov kev tshawb pom no thiab tsim kom muaj kev nyab xeeb thiab ua tau zoo ntawm colchicine rau kev kho mob ntawm COVID-19.
Yog li thaum tsis yog thawj cov tshuaj tiv thaiv kab mob, colchicine tau txais txiaj ntsig zoo hloov txoj hauv kev txaus los muab cov txiaj ntsig kho mob tiag tiag hauv qee yam mob.
Txawm li cas los xij, cov teebmeem tsis zoo xws li zawv plab thiab pob txha pob txha txwv nws txoj kev siv mus ntev li kev tiv thaiv. Kev siv tshuaj tsawg dua yuav pab kom muaj txiaj ntsig zoo thiab toxicity.
Hauv cov ntsiab lus,tshuaj colchicinenthuav tawm ntau cov tshuaj tiv thaiv kab mob uas ua rau nws cov txiaj ntsig zoo rau gout, ua npaws syndromes, thiab lwm yam kab mob inflammatory. Thaum siv judiciously, nws tuaj yeem yog ib feem tseem ceeb ntawm kev kho mob. Tab sis toxicity profile warrants ceev faj tswj.
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Cov ntaub ntawv
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Rheumatology Advisor Editorial Board. 5 Yam Yuav Tsum Paub Txog Colchicine thiab Proinflammatory Cytokines hauv COVID-19. Rheumatology Advisor. Lub Tsib Hlis 20, 2020. Nkag mus rau Lub Ib Hlis 27, 2023.