Yog tias koj nyob nrog Irritable Bowel Syndrome (IBS) los yog tsis muaj qhov txhaws, koj yuav tau mloog.linaclotideraws li kev xaiv kev kho mob. Ib yam li txhua yam tshuaj, nws yog ib txwm muaj lus nug txog nws qhov cuam tshuam, suav txog kev txhawj xeeb txog kev quav tshuaj.
Linaclotide tsis muaj cov khoom siv ntxiv. Nws yog ib qho tshuaj tshwj xeeb uas tau teev tseg los saib xyuas qhov tsis txaus ntseeg thiab IBS-C los ntawm kev txhim kho plab hnyuv los ntawm kev ua haujlwm hauv zej zog hauv txoj hnyuv. Ib yam li txhua yam tshuaj, nws yuav tsum tau siv raws li kev pom zoo, thiab txhua qhov kev txhawj xeeb lossis kev cuam tshuam yuav tsum tau tham nrog tus kws kho mob.
Kev Ua Haujlwm: Linaclotide yog guanylate cyclase-C (GC-C) agonist siv los kho cov kab mob tsis tu ncua thiab tsis zoo ntawm lub plab zom mov nrog kev cuam tshuam (IBS-C). Nws ua haujlwm los ntawm kev nthuav tawm cov tshuaj chloride thiab bicarbonate mus rau hauv txoj hnyuv lumen, uas txhim kho cov kua dej thiab lub plab zom mov.
Kev cuam tshuam rau lub cev: Tsis yog txhua yam zoo li cov tshuaj uas muaj peev xwm ntxiv, linaclotide ua haujlwm hauv zos hauv plab hnyuv thiab tsis cuam tshuam rau lub hauv paus kev txhawj xeeb lossis cheeb tsam hauv hlwb ntsig txog kev quav tshuaj.
Linaclotide yog dab tsi thiab nws ua haujlwm li cas?
Linaclotide, muag hauv qab cov npe xws li Linzess thiab Constella, yog cov tshuaj siv los kho Crabby Bowel Disorder with Obstruction (IBS-C) thiab Persistent Idiopathic Stoppage (CIC) hauv cov neeg laus. Nws muaj qhov chaw rau zaj lus qhia ntawm cov tshuaj hu ua guanylate cyclase-C agonists.
Cov tshuaj no ua haujlwm los ntawm kev nthuav tawm cov kua dej hauv koj lub plab thiab ua kom txoj kev loj hlob ntawm cov khoom noj khoom haus thiab kev sib cais los ntawm koj lub plab ntsig txog lub cev. Los ntawm kev ua li ntawd, cov khoom ua rau qhov sib txawv los soothe clogging thiab txo lub plab torment cuam tshuam nrog IBS-C.
Linaclotide tau noj hauv qhov ncauj, ib txwm ib hnub ib hnub ntawm lub plab huv si, ntawm me ntsis 30 feeb qee lub sijhawm tsis ntev los no pib noj hmo ntawm hnub. Nws yog ib qho tseem ceeb uas yuav tau ua tib zoo saib xyuas koj tus kws kho mob cov ntaub ntawv thaum noj cov tshuaj no.
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Hais txog Kev Tiv Thaiv Kev Txhaum Cai: Puas yog Linaclotide Addictive?
Ib qho kev txhawj xeeb tshaj plaws uas tib neeg muaj txog tshuaj yog seb lawv puas tuaj yeem ua rau muaj kev quav yeeb quav tshuaj. Thaum nws los txog rau linaclotide, cov lus teb luv luv yog tsis yog, linaclotide tsis suav tias yog hom tshuaj.
Nov yog vim li cas:
Tsis muaj teebmeem euphoric
Tsis zoo li cov tshuaj uas tuaj yeem ua rau muaj kev quav yeeb quav tshuaj, nws tsis tsim "siab" lossis ib qho kev xav zoo siab uas yuav ua rau muaj kev puas siab puas ntsws.
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Tsis muaj cov tsos mob tshem tawm
Thaum koj tsis noj linaclotide, koj tsis muaj cov tsos mob tshem tawm, uas yog ib qho ntawm cov tshuaj tiv thaiv.
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Tsis muaj tus cwj pwm nrhiav tshuaj
Cov neeg mob noj nws tsis pom tus cwj pwm nrhiav tshuaj los yog xav tau kev noj tshuaj, uas yog cov cim ntawm kev quav tshuaj.
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Mechanism ntawm kev ua
Linaclotide ua haujlwm hauv zos hauv cov hnyuv thiab muaj qhov nqus tsawg heev rau hauv cov hlab ntsha, txo qhov muaj peev xwm ntawm cov kab mob uas tuaj yeem ua rau muaj kev quav tshuaj.
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Thaumlinaclotidetsis yog hom tshuaj, nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias koj lub cev tuaj yeem ua rau nws cov teebmeem dhau sijhawm. Qhov no tsis tau txhais hais tias koj nyob nraum addicted; es, nws txhais tau hais tias cov tshuaj ua hauj lwm raws li npaj los tswj koj digestive system.
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Nkag siab txog cov teebmeem tshwm sim thiab kev siv sijhawm ntev ntawm Linaclotide
Txawm hais tias linaclotide tsis yog tshuaj lom, nws yog ib qho tseem ceeb kom paub txog nws cov kev mob tshwm sim thiab cov kev xav rau kev siv mus sij hawm ntev:
Cov teebmeem tshwm sim
Qhov feem ntau tshwm sim ntawm linaclotide yog raws plab, uas feem ntau tshwm sim nyob rau hauv thawj ob lub lis piam ntawm kev kho mob. Lwm yam kev mob tshwm sim muaj xws li:
- Mob plab
- plab hnyuv
- Roj
- Mob taub hau
- Ntshai
Yog tias koj ntsib kev mob tshwm sim hnyav lossis tsis tu ncua, nws yog ib qho tseem ceeb uas yuav tau sab laj nrog koj tus kws kho mob.
Kev txiav txim siab siv lub sijhawm ntev
Txawm hais tias linaclotide tsis yog hom kab mob, muaj qee yam los xav txog kev siv mus ntev:
Kev ua tau zoo ntawm lub sijhawm
Qee tus neeg mob yuav pom tias qhov ua tau zoo ntawm linaclotide txo qis thaum lub sijhawm. Qhov no tsis yog vim kev quav tshuaj tab sis yuav cuam tshuam nrog kev hloov pauv hauv koj lub cev cov lus teb rau cov tshuaj.
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Kev saib xyuas tsis tu ncua
Koj tus kws kho mob yuav xav saib xyuas koj qhov kev nce qib thiab kho koj txoj kev npaj kho mob raws li xav tau.
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Cov yam ntxwv ua neej nyob
Linaclotide ua haujlwm tau zoo tshaj plaws thaum ua ke nrog kev hloov pauv kev noj haus thiab kev hloov pauv kev ua neej los tswj IBS-C lossis CIC.
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Kev txiav tawm
Yog tias koj txiav txim siab tsis txhob noj nws, nws yog qhov zoo tshaj kom ua raws li koj tus kws kho mob cov lus qhia. Thaum tsis muaj cov tsos mob tshem tawm, koj cov tsos mob qub tuaj yeem rov qab los.
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Nws yog ib qho tsim nyog sau cia tias linaclotide feem ntau suav hais tias muaj kev nyab xeeb rau kev siv mus ntev rau cov neeg laus thaum noj raws li kws kho mob tau sau tseg. Txawm li cas los xij, ib yam li txhua yam tshuaj, nws yog ib qho tseem ceeb uas yuav tsum tau kuaj xyuas tsis tu ncua nrog koj tus kws kho mob kom ntseeg tau tias nws tseem ua tau zoo rau koj.
Kev ruaj ntseg Profile
Cov teebmeem
Feem ntau cov kev mob tshwm sim ntawm linaclotide muaj xws li raws plab, mob plab, thiab tsam plab. Cov no muaj feem xyuam rau cov tshuaj muaj feem cuam tshuam rau lub plab zom mov thiab kev ua haujlwm ntawm plab hnyuv.
Kev Siv Lub Sij Hawm Ntev
Kev siv lub sij hawm ntev ntawmlinaclotideyuav tsum tau saib xyuas los ntawm tus kws kho mob, feem ntau los xyuas kom meej tias nws tseem ua tau zoo thiab tswj xyuas cov kev mob tshwm sim, tsis yog kev txhawj xeeb txog kev quav tshuaj.
Xaus
Hauv kev xaus, linaclotide tsis yog hom kab mob thiab tuaj yeem yog qhov kev kho mob tseem ceeb rau cov uas tawm tsam nrog IBS-C lossis CIC. Nws cov txheej txheem tshwj xeeb ntawm kev ua, uas tsom mus rau lub plab zom mov, ua rau nws muaj kev xaiv zoo yam tsis muaj kev pheej hmoo ntawm kev quav tshuaj feem ntau cuam tshuam nrog lwm hom tshuaj.
Txawm li cas los xij, nws tseem ceeb heev kom nco ntsoov tias txhua tus neeg sib txawv, thiab qhov ua haujlwm rau ib tus neeg yuav tsis ua haujlwm rau lwm tus. Yog tias koj tab tom txiav txim siab linaclotide ua kev kho mob, lossis yog tias koj muaj kev txhawj xeeb txog koj cov tshuaj tam sim no, nws yog qhov zoo tshaj plaws los sab laj nrog koj tus kws kho mob. Lawv tuaj yeem muab cov lus qhia tus kheej raws li koj qhov kev xav tau kev noj qab haus huv tshwj xeeb thiab keeb kwm kho mob.
Kev ua neej nyob nrog IBS-C lossis CIC tuaj yeem nyuaj, tab sis nrog kev kho thiab tswj kom zoo, suav nrog cov tshuaj xws lilinaclotide, ntau tus neeg pom muaj txiaj ntsig zoo los ntawm lawv cov tsos mob. Los ntawm kev nkag siab txog qhov tseeb ntawm linaclotide, suav nrog nws qhov tsis muaj qhov tsis zoo, koj tuaj yeem txiav txim siab paub txog koj txoj kev noj qab haus huv thiab ua haujlwm rau kev noj qab haus huv zoo dua.
Cov ntaub ntawv
US Food and Drug Administration. (2012). Cov ntsiab lus tseem ceeb ntawm kev sau tshuaj: Linzess (linaclotide). Tau txais los ntawm https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202811lbl.pdf
Chey, WD, Lembo, AJ, & Lavins, BJ (2012). Linaclotide rau kev chim siab plob tsis so tswj nrog cem quav: ib 26-lub lim tiam, randomized, ob-dig muag, placebo-tswj sim los ntsuas kev ua tau zoo thiab kev nyab xeeb. American Journal of Gastroenterology, 107(11), 1702-1712.
Lacy, BE, Levenick, JM, & Crowell, M. (2012). Kev cem quav ntev: kev kuaj mob tshiab thiab kev kho mob. Kev kho mob ua ntej hauv Gastroenterology, 5(4), 233-247.
Rao, SS, & Rattanakovit, K. (2012). Kev kuaj mob thiab kev tswj cov cem quav ntev hauv cov neeg laus. Nature Reviews Gastroenterology & Hepatology, 9(5), 259-270.
Quigley, EM, & Tack, J. (2011). Neurogastroenterology: Linaclotide rau cem quav-predominant IBS-txoj kev tshiab. Nature Reviews Gastroenterology & Hepatology, 8(11), 612-613.