Abstract
Paeoniflorin(PF), ib qho monoterpene glycoside muab tau los ntawm cov hauv paus hniav ntawm Paeonia lactiflora, Paeonia suffruticosa, thiab Paeonia delavayi, tau kawm dav dav rau nws txoj kev kho mob hauv ntau yam kab mob neurological. Qhov kev tshuaj xyuas no yog txhawm rau sau cov kev tshawb fawb tam sim no ntawm PF cov teebmeem neuroprotective thiab cov txheej txheem hauv kev kho cov kab mob neurological xws li Alzheimer's disease, Parkinson's disease, schizophrenia, thiab qaug dab peg. Kev tshuaj xyuas qhia txog PF lub peev xwm los txo oxidative kev nyuaj siab, inhibit neuronal apoptosis, thiab txhawb neurogenesis, yog li muab kev cog lus kho mob rau cov kab mob neurological.
Keywords: paeoniflorin, kab mob neurological, neuroprotective teebmeem, oxidative kev nyuaj siab, neuronal apoptosis
Peb muab Paeoniflorin CAS 23180-57-6, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/paeoniflorin-cas-23180-57-6.html
Taw qhia
Cov kab mob neurological, suav nrog Alzheimer's disease (AD), Parkinson's disease (PD), schizophrenia, thiab qaug dab peg, yog lub nra hnyav thoob ntiaj teb. Cov kab mob no yog tus cwj pwm los ntawm cov txheej txheem pathophysiological uas cuam tshuam nrog oxidative kev nyuaj siab, neuronal apoptosis, thiab o. Tam sim no, muaj cov kev kho mob uas muaj cov tsos mob zoo tab sis tsis hais txog cov txheej txheem kab mob. Yog li ntawd, muaj qhov xav tau ceev ceev rau cov tshuaj kho tshiab uas tuaj yeem tsom rau cov txheej txheem no. Paeoniflorin (PF), ib qho tseem ceeb ntawm cov tshuaj suav tshuaj Peony, tau tshwm sim los ua tus neeg sib tw muaj peev xwm vim nws cov khoom siv tshuaj sib txawv, suav nrog cov teebmeem neuroprotective.
Paeoniflorin thiab nws cov Neuroprotective Mechanisms
Antioxidant thiab Anti-inflammatory teebmeem
Oxidative stress thiab o yog qhov tseem ceeb hauv kev tsim cov kab mob neurological. PF tau pom tias muaj lub zog antioxidant thiab tiv thaiv kab mob. Los ntawm kev nce kev ua haujlwm ntawm superoxide dismutase (SOD), glutathione (GSH), thiab catalase (CAT), PF txo cov qib ntawm malondialdehyde (MDA), ib qho cim ntawm oxidative kev nyuaj siab. Qhov kev ua no pab tiv thaiv cov hlwb neuronal los ntawm kev puas tsuaj oxidative thiab tswj kev ncaj ncees ntawm cov ntaub so ntswg neuronal. Tsis tas li ntawd, PF inhibits kev tsim cov nitric oxide (NO) thiab inducible nitric oxide synthase (iNOS), uas cuam tshuam rau kev puas tsuaj rau neuronal thiab neuroinflammation.
Inhibition ntawm Neuronal Apoptosis
Neuronal apoptosis yog ib qho cim ntawm ntau yam kab mob neurological. PF tau pom tias inhibit neuronal apoptosis los ntawm ntau lub tshuab. Nws upregulates qhov kev qhia ntawm Bcl -2, ib qho anti-apoptotic protein, thaum downregulating kev qhia ntawm Bax, ib tug pro-apoptotic protein. Qhov kev txiav txim no tswj cov mitochondrial membrane muaj peev xwm thiab tiv thaiv kev tso tawm ntawm cytochrome c thiab ua kom cov caspases, cov neeg kho mob tseem ceeb ntawm apoptosis. Tsis tas li ntawd, PF ua rau PI3K / Akt signaling txoj hauv kev, uas ntxiv txhawb kev muaj sia nyob ntawm neuronal los ntawm inhibiting apoptosis.
Kev txhawb nqa ntawm Neurogenesis
Neurogenesis, txheej txheem ntawm tsim cov neurons tshiab, yog qhov tseem ceeb rau kev kho lub hlwb thiab rov qab los ntawm cov kab mob neurological. PF tau pom tias txhawb nqa neurogenesis los ntawm kev ua kom loj hlob thiab sib txawv ntawm cov hlwb neural progenitor. Cov nyhuv no yog kho los ntawm kev ua kom lub ERK signaling pathway, uas yog paub los txhawb neuronal proliferation thiab sib txawv.
Paeoniflorin hauv kev kho mob tshwj xeeb ntawm cov kab mob paj hlwb
Alzheimer's Disease
AD yog ib qho kab mob neurodegenerative uas tshwm sim los ntawm kev paub txog kev poob qis thiab sib sau ntawm amyloid beta (A) plaques hauv lub hlwb. PF tau pom tias txo qis A-induced neurotoxicity los ntawm inhibiting oxidative kev nyuaj siab thiab neuronal apoptosis. Hauv cov qauv tsiaj ntawm AD, PF kev kho mob tau txhim kho kev txawj ntse thiab txo cov qib ntawm oxidative kev ntxhov siab. Cov kev tshawb pom no qhia tias PF tuaj yeem yog tus kws kho mob muaj txiaj ntsig zoo rau AD.
Tus kab mob Parkinson
PD yog ib qho mob neurodegenerative mob ntev uas tshwm sim los ntawm kev poob ntawm dopaminergic neurons hauv substantia nigra. PF tau pom tias tiv thaiv dopaminergic neurons los ntawm oxidative kev nyuaj siab thiab apoptosis. Cov kev tshawb fawb tsiaj tau pom tias kev kho PF txo qis cov cim oxidative kev ntxhov siab thiab tiv thaiv kev poob ntawm dopaminergic neurons hauv nas qauv ntawm PD. Cov kev tshawb pom no qhia tias PF tuaj yeem muaj peev xwm kho tau hauv kev kho PD.
Schizophrenia
Schizophrenia yog ib qho kev puas siab puas ntsws loj uas tshwm sim los ntawm cov tsos mob xws li hnov lus, delusions, thiab kev xav tsis zoo. Qhov tseeb ua rau tus mob schizophrenia tsis paub, tab sis oxidative kev nyuaj siab thiab o yog xav ua lub luag haujlwm. PF tau pom tias muaj cov teebmeem neuroprotective hauv tsiaj qauv ntawm tus mob schizophrenia. Kev kho nrog PF txhim kho cov tsos mob ntawm tus cwj pwm thiab txo cov cim kev ntxhov siab oxidative hauv cov qauv no. Cov kev tshawb pom no qhia tias PF yuav yog ib qho kev pab kho mob rau tus mob schizophrenia.
Epilepsy
Epilepsy yog ib yam kab mob neurological uas tshwm sim los ntawm kev qaug dab peg. PF tau pom tias muaj cov tshuaj tiv thaiv kab mob hauv cov tsiaj ua qauv ntawm kev qaug dab peg. Kev kho mob nrog PF txo qhov zaus thiab lub sijhawm ntawm qaug dab peg thiab txhim kho neuronal ciaj sia nyob rau hauv cov qauv no. Cov kev tshawb pom no qhia tias PF tuaj yeem yog tus kws kho mob muaj txiaj ntsig zoo rau kev qaug dab peg.
Clinical Implications thiab Cov Lus Qhia Yav Tom Ntej
Cov teebmeem neuroprotective ntawm PF hauv cov tsiaj qauv ntawm cov kab mob neurological qhia nws lub peev xwm ua tus neeg sawv cev kho mob rau tib neeg. Txawm li cas los xij, kev sim tshuaj kho mob yuav tsum tau ua kom paub tseeb tias qhov ua tau zoo thiab kev nyab xeeb ntawm PF hauv tib neeg. Tsis tas li ntawd, cov txheej txheem tseeb ntawm PF's neuroprotective teebmeem yuav tsum tau piav qhia kom zoo rau nws txoj kev siv tshuaj kho mob. Kev tshawb fawb yav tom ntej yuav tsum tsom mus rau kev txheeb xyuas lub hom phiaj thiab kev qhia txog txoj hauv kev koom nrog PF cov teebmeem neuroprotective thiab tshawb nrhiav nws lub peev xwm ua ke nrog kev kho mob nrog cov tshuaj uas twb muaj lawm.
PF tau pom cov teebmeem neuroprotective hauv cov qauv tsiaj, tshwj xeeb hauv Parkinson's disease (PD). PD, ib qho nyuaj neurodegenerative tsis meej, yog tus cwj pwm los ntawm kev poob ntawm dopaminergic neurons nyob rau hauv substantia nigra pars compacta. Kev kho tshuaj kho mob tam sim no rau PD, xws li levodopa thiab dopamine agonists, tuaj yeem txo cov tsos mob tab sis tsis txwv kev kis kab mob. PF, los ntawm nws cov txheej txheem tiv thaiv neuroprotective, tuaj yeem muab lwm txoj hauv kev los yog kev kho mob ntxiv. Network pharmacology thiab molecular docking kev tshawb fawb tau txheeb xyuas lub hom phiaj muaj peev xwm ntawm PF hauv PD, paving txoj hauv kev rau kev tshawb fawb ntxiv thiab kev sim tshuaj.
Ntxiv nrog rau PD, PF kuj tseem muaj peev xwm kho tau hauv lwm cov kab mob paj hlwb, xws li Alzheimer's kab mob, mob stroke, thiab txha caj qaum. Cov kab mob no qhia txog cov yam ntxwv pathological, suav nrog neuronal degeneration thiab o. PF's anti-inflammatory thiab neuroprotective zog tuaj yeem siv los txo cov txheej txheem no thiab txhawb kev rov qab los ntawm neuronal.
Cov kev taw qhia yav tom ntej ntawm PF kev tshawb fawb nyob rau hauv cov kab mob neurological yog nyob rau hauv elucidating nws cov txheej txheem ntawm kev ua, ua pov thawj nws cov kev ua tau zoo thiab kev nyab xeeb hauv kev sim tshuaj, thiab tshawb nrhiav kev sib xyaw ua ke nrog lwm cov tshuaj. Los ntawm kev nkag siab yuav ua li cas PF cuam tshuam nrog neuronal pathways thiab modulates o, cov kws tshawb fawb tuaj yeem txhim kho nws txoj kev siv thiab tsim kho tshiab rau cov kab mob neurological. Tsis tas li ntawd, kev txhais cov kev tshawb pom no rau hauv kev kho mob yuav ua rau muaj txiaj ntsig zoo ntawm lub neej zoo rau cov neeg mob uas muaj qhov tsis zoo no.
Xaus
Paeoniflorin, ib qho tseem ceeb ntawm cov tshuaj suav tshuaj Peony, tau pom tias muaj txiaj ntsig zoo rau kev tiv thaiv kab mob hauv cov tsiaj qauv ntawm cov kab mob neurological. Los ntawm kev txo oxidative kev nyuaj siab, inhibiting neuronal apoptosis, thiab txhawb neurogenesis, PF yuav muab ib tug tshiab kho kev xaiv rau kev kho mob ntawm neurological kab mob xws li Alzheimer's kab mob, Parkinson's kab mob, schizophrenia, thiab qaug dab peg. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom paub meej tias nws qhov ua tau zoo thiab kev nyab xeeb hauv tib neeg thiab kom paub meej cov txheej txheem tseeb ntawm nws cov teebmeem neuroprotective.