Tetracaine hydrochlorideyog ib qho compound thiab qhov hnyav molecular ntawm 264.36326. Nws yog cov hmoov dawb, yooj yim soluble hauv dej thiab soluble hauv ethanol.
Lub sijhawm dhau los peb tau tham txog kev npaj cov tshuaj nruab nrab 1, N, N-dimethylethanolamine hydrochloride, lub sijhawm no, peb yuav txuas ntxiv kev npaj ntawm nruab nrab 2 hauv kev npaj ntawm tetracaine hydrochloride.
(1) Nyhav 165g ntawm benzocaine, ntxiv rau lub raj mis, hnyav 139g ntawm bromobutane thiab ncuav rau hauv lub raj mis, thiab thaum kawg ntxiv 58g ntawm sodium carbonate rau lub raj mis.
(2) Nruab ib lub ntsuas kub 0200 degree, agitator, thiab lub siab tsis tu ncua kev poob qis. Ib qho reflux condenser yog ntxiv rau sab saum toj ntawm lub siab tsis tu ncua tso tawm funnel, thiab cua sov tau qhib. Thaum qhov kub ntawm sab hauv mus txog 80 degree, lub nplawm yog qhib, cua sov txuas ntxiv, thiab qhov kub tau tso cai kom nce siab tshaj 90 degree.
(3) Incubate cov tshuaj tiv thaiv ntawm 9095 degree rau plaub teev, 95115 degree rau plaub teev, thiab thaum kawg tshwm sim ntawm 115120 degree rau 23 teev, thiab xa rov qab bromobutane rau cov tshuaj tiv thaiv nyob rau hauv lub sij hawm thaum lub sij hawm cov tshuaj tiv thaiv.
(4) Tom qab cov tshuaj tiv thaiv ua tiav, hloov cov cuab yeej reflux mus rau lub tshuab nqus tsev desolventizing kom tshem tawm cov bromobutane ntxiv hauv lub kaw lus hauv qab txo qis. Distilled.
(5) Qhov hnyav 160g dej thiab hloov mus rau qhov tsis tu ncua ntawm cov dej ntws tawm, maj mam ntxiv nws dropwise rau cov tshuaj tiv thaiv ntxiv, tswj qhov kub ntawm 65 thiab 75 degree, do rau 20 feeb, sawv ntsug rau 20 feeb, thiab siv. ib tug cais funnel. Lub qis aqueous sodium carbonate theem tau sib cais, thiab cov theem sab sauv ntawm cov organic tau pauv mus rau cov tshuaj tiv thaiv lub khob.
(6) Pickling thawj zaug: hnyav 120g dej thiab 5g ntawm hydrochloric acid, hloov lawv mus rau ib tug peb-caj dab, tig rau lub cua sov, ua kom lub sab hauv kub ntawm txog 7080 degree, do rau 10 feeb , ntsuas pH tus nqi ntawm 23, thiab sawv ntsug rau 30 feeb, cov theem qis ntawm cov organic tau sau rau hauv lub beaker, thiab tom qab ntawd cov kua qaub sab saud tau sib cais.
(7) Pickling zaum ob: hloov cov organic theem mus rau cov tshuaj tiv thaiv, ntxiv 120g dej, 3g ntawm hydrochloric acid, kub mus txog 70-80 degree, do rau 10 feeb, sawv ntsug rau 30 feeb, tso tawm qis dua. organic theem, hnyav, qhov nruab nrab loj yog nyob nruab nrab ntawm 180200g.
(8) Raws li qhov sib piv loj ntawm ethanol: organic theem=0.7: 1, ntxiv 120140g ethanol, ntxiv tag nrho cov ntaub ntawv rau hauv 1L cov tshuaj tiv thaiv, tig rau cua sov kom yaj, yaj tag ntawm 60 degree , ces txias kom qis dua 10 degree, nqus pom, lim Lub ncuav mog qab zib yog rinsed ib zaug nrog txias ethanol. Kev ziab thiab hnyav, cov kauj ruam no tuaj yeem tau txais 120125g ntawm nruab nrab II (cov ntsiab lus roj theem ntau dua 95 feem pua)
Kev npaj ntawm qhov nruab nrab 2 yog dhau lawm, thiab peb tuaj yeem tham txog cov txheej txheem kev npaj ntawm nruab nrab 3 thiab kev npaj zaum kawg thiab kev ua kom huv ntawm qhov kawg ntawm tetracaine hydrochloride nrog rau cov txheej txheem tom ntej.