Tsis zoo siv
Dermorphin, yog ib qho tshwm sim heptapeptide cais tawm ntawm cov tawv nqaij amphibians, tau raug txheeb xyuas tias yog muaj zog thiab xaiv cov neeg Agonist ntawm lub μ-opioid receptor (mor). Qhov kev ua tau zoo no zoo kawg tau ua tau zoo nyob rau hauv inhibiting neurochath qhov mob, ib hom mob mob feem ntau tiv taus cov analceuralics. Tsab ntawv no rov tshawb nrhiav cov kev tshawb fawb tshiab tshaj plaws hais txog nws cov khoom siv tshuaj tiv thaiv kev ua si, tsom mus rau cov kev ua si ntawm neurropathic, tsom mus rau nws cov ntawv thov kev ua tau zoo, thiab cov peev xwm kho mob. Txoj kev tshuaj xyuas tseem tau tham txog kev coj zoo thiab kev nyab xeeb cuam tshuam nrog dermorphin siv.
Khoom Code: BM -2-4-003
Lub npe: dermorphin acetate
CAS TSIS MUAJ.: 77614-16-5
Molecular Cov Qauv: C40h50N8O10
MW: 802.87
Eineecs tsis muaj.: 202-853-6
Enterprise standard: HPLC>99.5%, LC-MS
HS code: Xav paub meej
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUM TECH YINCHUAAN HOOB
Kev Pab Technology: R & Dept. {-3
Peb muab dermorphin cas 77614-16-5}}, Thov saib mus rau lub vev xaib hauv qab no rau cov ncauj lus kom ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomteechz.com/synthetic addhermorphin-cas edmin- -HTML
Lo lus tseem ceeb: Dermorphin, μ-Opioid receptor (mor), mob neuropathic, analgesics, cov chaw muag tshuaj
Lub hauv paus rau phau ntawv
Kev mob neuropathic, tus cwj pwm los ntawm kev mob siab, hyperalgesia, thiab tag nrho cov kev puas tsuaj lossis tsis sib xws ntawm Somatosensory cov paj hlwb. Nws yog ib qho kev sib cav sib ceg thiab txo qis kev cuam tshuam uas cov neeg mob lub neej zoo. Kev ua yeeb yam ib txwm muaj, xws li cov tshuaj tsis yog-steroidal los tiv thaiv (NSAIDS) thiab opioids, feem ntau muab kev mob siab rau neuropathic mob. Yog li ntawd, muaj kev nias xav tau rau cov kev kho tshiab uas muaj kev ua tau zoo thiab tsawg dua kev phiv. Dermorphin, nrog nws lub horstelity thiab xaiv rau cov mor, tau tawm los ua ib tug neeg sib cav sib ceg rau neuropathic qhov kev tswj hwm mob hlwb.
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Pharmacological yam ntxwv ntawm dermorphin
Dermorphin, nrog cov qauv tshuaj ntawm Tyr- {d-ala}-}-tyr-ser-s-nh2), yog ib lub ntuj heptapeptide nrhiav tau hauv daim tawv nqaij ntawm phyllomedusa frogs. Nws muaj cov qauv tshuaj tshwj xeeb uas tau lees paub txog kev sib raug zoo thiab xaiv tau rau Mor, deb tshaj plaws rau Δ-opioid receptor. Qhov tshwj xeeb no ua rau dermorphin ib qho kev tshawb fawb hauv neurohmacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacic thiab cov neeg tuaj yeem kho cov neeg sawv cev rau qhov mob.
Cov chaw muag tshuaj ua rau dermorphin yog feem ntau ua ntej los ntawm nws kev sib cuam tshuam tshwj xeeb nrog MU-Opioid receptor (mor). Thaum dermorphin khi thiab ua kom zoo mor, nws ua kom cov kev tso tawm ntawm endogenous opioids, zoo li endorphins zoo, uas paub rau lawv qhov mob-hloov kho cov khoom. Tsis tas li ntawd, dermorphin muaj cov muaj peev xwm los hla cov ntshav-lub hlwb barrier (BBB). Qhov muaj peev xwm no tso cai rau nws ua rau nws muaj kev cuam tshuam thoob plaws hauv nruab nrab ntawm cov leeg hlwb, yog li pab txhawb rau nws cov kev ua kom muaj txiaj ntsig zoo, uas yog cov khoom siv dav dav.
Kev siv tshuab ntawm kev ua nyob rau hauv inhibiting neuropathic mob
Cov txheej txheem nyob rau hauv dermorphin qhov kev txwv tsis pub muaj kev cuam tshuam ntawm neuropathic mob yog qhov nyuaj thiab encompass thiab encomprass ob qho tib si hauv nruab nrab thiab peripheral. Nyob rau hauv lub hauv paus qib, dermorphin cov hom phiaj mors nyob rau hauv cov chaw tseem ceeb xws li lub correms thiab tus txha caj qaum. Ntawm no, nws modulates kev sib kis nociceptive thiab kev txhim kho kev nqis siab los ntawm txoj hauv kev. Los ntawm kev ua kom cov txiv mors, dermorphin suppresses tso tawm ntawm neurotransmitters zoo li grama-utter acid (gaba) thiab enka) thiab enka) thiab enkey
Nyob rau hauv lub peripheral lub hlwb, dermorphin cov kev sib txuas lus ncaj qha nrog cov mors tam sim no ntawm thawj tus tub rog thiab tus kabmob tiv thaiv kab mob. Cov kev sib cuam tshuam no ua rau muaj kev puas tsuaj thiab cov neeg tsis muaj txiaj ntsig zoo, uas yog qhov tseem ceeb ntawm kev txhim kho thiab kev kho mob ntawm neuropathic mob. Ib qho ntxiv, Dermorphin tau pom lub peev xwm los tswj cov neurophlasticity nyob rau hauv tus txha caj qaum thiab lub hlwb. Qhov kev hloov pauv no tshwj xeeb tshaj yog tias nws pab thim rov qab cov maladaptive uas cuam tshuam nrog kev mob neurochicic, yog li pab txhawb kev kho cov kev ua haujlwm piv txwv thiab ua mob.
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Kev ua tau zoo nyob rau hauv chaw kuaj mob thiab kev kawm ua ntej
Kev tshawb fawb ua qauv tsiaj ntawm cov qauv ntawm cov neeg neuropathic tau ua raws li kev coj ua tsis zoo, xws li cov neeg kho txhua yam thiab cov cua nab thiab thermal hyperalesia. Tshwj xeeb, kev tswj hwm kev tswj hwm dermorphin hauv nas raug rau kev lom zem sciatic sciatic motion-force kev mob tau pom ib qho kev ua kom muaj txiaj ntsig. Cov kev tshawb pom zoo rau tib neeg, ua dermal daim ntawv thov ntawm Dermorphin tau tshaj tawm los muab kev pab los ntawm neuropathic mob hauv cov tib neeg nrog peripheral neuropathy. Cov kev soj ntsuam no zoo tshaj plaws thiab kev tshawb nrhiav tau pom zoo Dermorphin lub peev xwm los ua tus sawv cev ntawm kev tswj hwm neuropathic mob.
Cov kev tshawb fawb soj ntsuam tau txhawb cov dermorphin muaj peev xwm ua ib qho kev ua kom muaj mob hauv kev tswj hwm thiab mob qog nqaij hlav cancer. Qhov tshwj xeeb, dermorphin tau nthuav tawm cov khoom plig ntau dua li morphine, ua rau pom zoo sab txiaj ntsig kev ua tau zoo sab. Txawm li cas los xij, nws yog tsim nyog sau cia tias kev siv tshuaj kho mob dermorphin hauv kev mob neuropathic tseem nyob hauv nws tus menyuam mos. Yog li ntawd, cov kev tshawb fawb ntxiv yog xav tau los txiav txim siab cov kev pom zoo ntawm kev ua haujlwm zoo, cov ntaub ntawv kev nyab xeeb, thiab kev ua tau zoo ntev. Cov kev tshawb fawb txuas ntxiv no yog qhov tseem ceeb rau kev kho kom tau txais daim ntawv thov kev nyab xeeb thiab ua kom muaj kev nyab xeeb thiab siv tau zoo hauv kev tswj hwm neuropathic mob thiab lwm yam mob.
Cov Ntawv Thov Kev Kho Mob Muaj Peev Xwm
Dermorphin lub Portical cov khoom siv thiab ua pov thawj ua tau txiaj ntsig nyob rau hauv inhibiting neurochic mob tso nws raws li kev cog lus siv kho rau ntau qhov kev thov kho mob. Nws lub peev xwm tau tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj kev txom nyem los ntawm kev mob neuropathic uas tsis tau teb rau cov analgesics. Tsis tas li ntawd, dermorphin muaj peev xwm hla cov ntshav-lub hlwb) thiab muaj kev kho mob rau pob txha caj qaum lossis mob ntsws. Raws li kev tshawb fawb tau zuj zus, dermorphin yuav tawm los ua piv txwv ntxiv ntxiv rau kev tswj hwm neuropathic mob thiab txhim kho cov neeg mob lub neej zoo.
Tsis tas li ntawd, Dermorphin tus neeg nyob hauv kev ua pa loj heev thiab cov neeg muaj kev nyab xeeb rau nws cov neeg laus xws li cov neeg ua haujlwm tsis txaus ntseeg uas muaj kev cuam tshuam ntau rau kev cuam tshuam zoo. Txawm li cas los xij, cov kev sim hauv chaw kho mob tseem ceeb kom paub meej tias cov txiaj ntsig zoo no thiab tsim Dermorphin qhov chaw hauv kev kho mob algorithm rau kev mob neuropathic. Cov kev sim siab no yuav yog qhov tseem ceeb rau kev kho kom tau siv dermorphin siv kev nyab xeeb, kom tsim kev nyab xeeb, thiab tsim nws tus neeg mob ntau yam kev mob hlwb.
Kev coj ncaj ncees thiab kev saib xyuas kev nyab xeeb
Txawm hais tias nws muaj kev kub ntxhov rau lub peev xwm, kev siv dermorphin tsis yog tsis muaj kev txhawj xeeb thiab kev nyab xeeb kev nyab xeeb. Zoo li lwm cov opioids, dermorphin muaj peev xwm ua rau kev tsim txom thiab kev quav yeeb. Nws lub peev xwm los tsim cov txiaj ntsig zoo thiab lwm yam cuam tshuam cov txiaj ntsig tau txais txiaj ntsig kev pheej hmoo ntawm kev pheej hmoo ntawm kev siv tsis raws cai thiab vam khom. Yog li ntawd, kev tswj hwm nruj thiab cov cai tswj tau tsim nyog yuav tsum ua rau dermorphin kev nyab xeeb thiab kev siv hauv kev coj ua.
Tsis tas li ntawd, tej peev xwm rau kev tsis zoo, xws li xeev siab, ntuav, thiab yuav tsum ua kom zoo saib xyuas cov neeg mob tau txais cov neeg mob dermorphin. Kev siv ncua ntev kuj tseem yuav cuam tshuam nrog kev txhim kho kev ua siab ntev thiab tshem tawm cov tsos mob, xav tau kev saib xyuas zoo thiab tshuaj xyuas.
Tag
Dermorphin, ib qho tshwm sim Heptapeptide Mor agonist cais tawm ntawm amphibian qhov mob ntawm cov nehogeensy ua rau muaj kev cuam tshuam zoo nkauj hauv kev kawm thiab kev tshawb nrhiav kev tshawb fawb. Nws cov khoom lag luam tshwj xeeb, suav nrog kev xaiv siab thiab muaj peev xwm hla tus BBB, ua rau nws cov kev ua kom dav dav. Cov ntawv thov kho mob muaj xws li cov kev kho mob ntawm kev ua kom mob neuropathic thiab mob nruab nrab ntawm cov mob neuropathic. Txawm li cas los xij, kev siv dermorphin yog nrog kev sib raug zoo thiab kev saib xyuas kev nyab xeeb, suav nrog kev pheej hmoo ntawm kev tsim txom thiab kev quav phom, thiab kev cuam tshuam tsis zoo. Yuav tsum muaj cov kev tshawb fawb ntxiv los tsim kom muaj kev nyab xeeb dosing, qhov kev nyab xeeb ntawm dermorphin rau hauv kev kho mob kev kho mob rau neuropathic qhov kev tswj hwm mob neuropathic.