Cov kab ke kev noj qab haus huv thoob ntiaj teb tseem muaj teeb meem nrog cov kab mob kis, uas yog thawb cov kws tshaj lij los nrhiav cov tshuaj tshiab. Ntawm cov tshuaj muaj peev xwm no,GS-441524 hmoovtau dhau los ua qhov kev xaiv tshuaj tiv thaiv kab mob loj nrog txoj kev ua haujlwm tshwj xeeb. Cov kws tshawb fawb thiab cov neeg ua haujlwm nrog cov tsiaj xav tau cov nucleoside version no vim tias nws tuaj yeem tiv thaiv cov kab mob los ntawm kev luam lawv tus kheej ntawm qib molecular. Kev nkag siab tias cov tshuaj no ua haujlwm li cas muab cov ntaub ntawv tseem ceeb rau peb txog kev tiv thaiv kab mob niaj hnub no thiab ua rau nws muaj peev xwm rau kev tshawb fawb tshuaj ntxiv mus rau tom ntej.
Cov tshuaj ua haujlwm los ntawm kev mus tom qab cov enzymes tshwj xeeb uas xav tau rau kev rov ua dua tshiab. Qhov no muab peb txoj hauv kev tsom mus tua cov kab mob RNA. Raws li cov tuam txhab tshuaj thiab cov pab pawg tshawb fawb nrhiav cov peev txheej muaj txiaj ntsig rau siab - cov khoom siv purity, nws tseem ceeb heev kom nkag siab txog cov txheej txheem kev tshawb fawb thiab cov teeb meem nrhiav. Txoj kev tshawb fawb tob hauv - saib seb qhov nucleoside analog hloov li cas cov kab mob ua haujlwm, nws cuam tshuam li cas rau tus kab mob, thiab nws txhais li cas rau kev tshawb fawb txog kab mob tam sim no.
GS-441524 hmoov
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-3-001
GS-441524 CAS Nr .: 1191237-69-0
HS Code: 2934999099
Cov mis mos molecular: C12H13N5O4
Molecular Luj: 291.26
PIB: 200-001-8
MDL No .: MFCD32666994
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-4
Peb muabGS-441524 hmoov, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Yuav ua li cas GS-441524 Powder Inhibits RNA-Dependent RNA Polymerase Kev Ua Haujlwm
Molecular Structure thiab Cellular Uptake
GS-4415 24hmoov dhau ntawm cov cell membranes vim nws cov qauv tshuaj txawv txawv. Qhov no adenosine nucleoside mimic ua triphosphate hauv hlwb. Phosphorylated cellular kinases ua qhov no. Qhov kev hloov pauv hauv metabolic no tseem ceeb heev vim tias daim ntawv triphosphate zoo ib yam li ntuj adenosine triphosphate, uas cov kab mob siv los tsim cov khoom siv caj ces. Vim lawv cov qauv zoo sib xws, cov tshuaj yuav dag cov kab mob tshuab yam tsis raug kuaj pom.
Ntau yam kinase enzymes nyob rau hauv tus tswv tsev cell lub cytoplasm ceev txhua ntawm peb phosphorylation txheej txheem. Cov kws tshawb fawb tau ua pov thawj tias qhov kev ua kom lub cev no ruaj khov nyob rau hauv hom cell. Qhov no tso cai rau cov tshuaj ua haujlwm hauv ntau cov ntaub so ntswg. Cov khoom nquag ces nkag mus rau hauv cov hlwb uas muaj kab mob thiab nyob ib puag ncig ze ntawm qhov chaw kis kab mob. RdRp ua haujlwm nyuaj ntawm no.
Kev sib cuam tshuam ncaj qha nrog Viral Polymerase Enzymes
Lub active daim ntawv ntawmGS-441524 hmoovtua cov kab mob los ntawm kev sib tw ncaj qha nrog ntuj adenosine triphosphate los koom nrog cov kab mob RNA uas loj hlob tuaj. Lub enzyme RNA-dependent RNA polymerase, uas luam tawm cov khoom siv tshuaj tua kab mob, pom daim ntawv triphosphate ua cov txheej txheem siv tau. Txawm li cas los xij, ib zaug ntxiv, qhov hloov pauv nucleotide ua rau cov kev hloov pauv molecular uas ua rau nws nyuaj rau cov polymerase ua haujlwm ua cov catalyst.
Crystallography thiab molecular qauv qhia tau hais tias cov molecule nruj khi rau RdRp qhov chaw nquag. Qhov txuas no inhibits replication los ntawm kev tiv thaiv cov enzyme los ntawm kev ntxiv nucleotides tshiab sai. Lub polymerase enzyme tsis tuaj yeem paub qhov txawv ntawm cov ntawv luam thiab cov nucleotides ib txwm ua kom txog thaum lawv sib xyaw ua ke. Txoj hauv kev no yog qhov zoo tshaj plaws rau kev tawm tsam sai sai ntawm cov kab mob uas tuaj yeem txhim kho tiv thaiv los ntawm kev hloov kho qhov chaw nquag.
GS-441524 hmoov thiab txheej txheem ntawm Premature Viral RNA Chain Termination
Mechanism ntawm Chain Termination Txheej xwm
Thaum GS-441524 hmoov koom nrog tus kab mob RNA strand uas loj hlob, nws tsis tso tseg tam sim ntawd. Hloov chaw, cov enzyme polymerase tuaj yeem ntxiv ntau cov nucleotides ntxiv rau qhov chaw uas daim ntawv sib xyaw ua ke.
Lub molecule yog txawv los ntawm yuav tsum tau saw terminators, uas nres synthesis tam sim ntawd, vim hais tias nws muaj ib tug ncua sij hawm txiav. Raws li cov polymerase sim mus dhau qhov kev sib xyaw ua ke, nws maj mam poob nws cov txheej txheem, uas txhais tau tias nws tsis tuaj yeem txuas nrog cov qauv strand.
Cov ntawv luam hloov cov qauv hauv ib txoj kev uas txwv qhov chaw nyob hauv qhov chaw ua haujlwm polymerase. Nrog rau txhua lub voj voog catalytic, cov geometric yuam kev no zuj zus, ua rau cov enzyme- qauv-nascent strand complex tsis ruaj khov nyob rau lub sijhawm.
Qee lub sij hawm, qhov kev tsis sib haum xeeb no tau txais qhov phem txaus uas cov polymerase tawg tawm ntawm RNA tus qauv, tawm hauv qab ib qho ntawm cov kab mob genome uas tsis tiav thiab tsis ua haujlwm.
Ntau qhov xwm txheej suav nrog ntawm qhov chaw sib txawv sib txawv ua rau cov pej xeem ntawm cov kab mob RNAs luv luv ua rau cov xeeb ntxwv kis tau.
Biochemical Consequences ntawm Incomplete Genomes
Thaum tus kab mob RNA molecules raug tshem tawm ntxov ntxov, lawv poob cov ntaub ntawv tseem ceeb ntawm caj ces uas xav tau rau kev tsim cov kab mob tag nrho. Qee cov genomes no tseem yuav muaj qee qhov coding sequences, tab sis lawv tsis tuaj yeem ua cov protein ntau lossis cov enzymes replication uas ua haujlwm.
Cov kab mob muaj kab mob khaws cov kab mob tsis zoo no, uas siv cov peev txheej hauv lub xov tooj ntawm tes tab sis tsis pab cov txheej txheem kis tau zoo.
Cellular zoo tswj systems kuj tau qhib thaum genomes tsis tiav. Cov qauv kev lees paub receptors pab cov hlwb pom cov qauv RNA txawv txav.
Qhov no tso tawm cov tshuaj tiv thaiv kab mob uas tiv thaiv tus kab mob kom tsis txhob kis mus ntxiv. Qhov no ob-txoj kev nqis tes ua- ncaj qha thaiv los ntawm kev txiav cov saw txuas nrog rau kev tiv thaiv kev tiv thaiv kab mob- ua rau GS-441524 hmoov zoo tiv thaiv kab mob ntau dua li txwv tsis pub rov ua dua.
GS-441524 Powder txo Viral Load Los ntawm RNA Replication Control?
Quantitative Assessment of Viral Load Reduction
GS-441524 hmoov kev kho mob tau pom tias txo qis tus naj npawb ntawm cov kab mob RNA hauv ob qho tib si kho mob thiab chaw kuaj mob. Logarithmic tee nyob rau hauv tus naj npawb ntawm cov kab mob genome luam pom nyob rau hauv cov ntaub so ntswg kis tau raug ntsuas los ntawm ntau PCR. Cov tee no feem ntau tshaj li ob mus rau peb qhov kev txiav txim ntawm qhov loj me thaum thawj lub sijhawm kho. Cov tee no qhia tau hais tias cov tshuaj tuaj yeem txwv tsis pub tsim cov kab mob tshiab RNA thaum cov kab mob qub qub tawg lawm.
Tus nqi uas tus kab mob thauj khoom poob tuaj yeem kwv yees los ntawm kev saib qhov ntev ntawm lub voj voog rov ua dua,GS-441524 hmoov, thiab GS-441524 FIP's pharmacokinetics. Cov kab mob RNA muaj cov voj voog rov ua dua sai heev, uas ua rau lawv muaj kev cuam tshuam rau cov tebchaw uas nres rov ua dua. Qhov no yog vim hais tias txhua tiam ntawm tus kab mob no khiav mus rau hauv lub compound qhov ua rau nres. Kev ua lej ua qauv ntawm tus kab mob viral dynamics thaum kho qhia tau hais tias kev kis tus kab mob mus sij hawm ntev maj mam txo cov kab mob sib kis, txo cov kab mob mus txog thaum lawv qis dua qib ntsuas.
Comparative Efficacy Hla Viral Strains
Cov kab mob sib txawv yog rhiab heev rau GS-441524 hmoov nyob rau hauv ntau txoj kev, nyob ntawm seb lawv siv RdRp enzyme li cas thiab lawv luam lawv tus kheej li cas. Coronaviruses tshwj xeeb tshaj yog muaj kev phom sij vim tias lawv nyob ntawm RNA synthesis tas li rau genome replication thiab subgenomic RNA tsim. Cov tshuaj ua haujlwm ntawm ntau hom kab mob coronavirus, uas qhia tias cov txheej txheem tseem ceeb tsom rau qhov chaw ntawm cov kab mob polymerase cov haujlwm uas zoo ib yam ntawm cov kab mob es tsis yog qhov tshwj xeeb rau txhua hom.
Sib piv seb hom kab mob sib txawv teb li cas rau kev kho mob hauv chav kuaj pom tias polymerase fidelity cuam tshuam rau cov tshuaj rhiab npaum li cas. Cov kab mob uas muaj qis dua -fidelity polymerases feem ntau suav nrog ntau cov nucleotide analogs, uas ua rau lawv yooj yim dua. Cov tswv yim tswv yim rau kev kho mob antiviral siv qhov kev sib txuas ntawm cov yam ntxwv ntawm polymerase thiab cov tshuaj rhiab heev los pab xaiv cov khoom sib txuas zoo raws li cov khoom ntawm lub hom phiaj tus kab mob.
Yuav ua li cas GS-441524 Powder cuam tshuam lub Viral Life Cycle hauv Host Cells
Kev cuam tshuam rau thaum ntxov Versus lig kis kab mob
GS-441524 hmoov ua haujlwm zoo tshaj plaws thaum lub sij hawm tsis khoom kis kab mob, thaum RNA ntau lawm yog qhov muaj zog tshaj plaws. Nyob rau theem pib ntawm tus kab mob, thaum cov kab mob tau teeb tsa replication units hauv cov tswv tsev, cov tshuaj nres qhov pib luam ntawm genome.
Qhov kev ua thaum ntxov no txwv tsis pub tus kab mob kis mus thoob plaws, yog li nws tsuas yog kis mus rau cov hlwb uas cuam tshuam thaum pib es tsis txhob cia nws kis mus thoob plaws.
Nyob rau theem tom ntej ntawm kev kis tus kab mob, thaum tsim cov txheej txheem cov proteins peaks, cov khoom tseem txwv tsis pub tsim cov ntawv luam tshiab ntawm cov genome uas txhais tau tias yuav ntim rau hauv cov menyuam yaus virions.
Txawm hais tias cov proteins yooj yim tau tsim los, cov kab mob sib kis tsis tuaj yeem muab tso ua ke vim tias cov noob tsis ua haujlwm.
Qhov no multi-phase inhibition nres tus kab mob no tag nrho, uas yog qhov ua rau nucleoside analogs txawv ntawm cov tshuaj uas tsuas yog tsom rau qee cov kab mob protein lossis cov txheej txheem nkag.
Cellular Distribution thiab Compartmentalized Activity
Thaum cov molecule nyob rau hauv ib lub cell, nws kis mus rau ntau qhov chaw ntawm lub cytoplasm qhov twg tus kab mob replication tshwm sim. Ntau tus kab mob RNA ua cov kab mob sib txuas, uas yog cov qauv uas txuas nrog lub cell membrane thiab tuav cov kab mob enzymes thiab nucleic acids.
Cov organelles no tseem pab tiv thaiv cov txheej txheem kev tsim tawm los ntawm qee qhov kev tiv thaiv ntawm tes. Lub activated triphosphate daim ntawv ntawmGS-441524 FIP hmoovr tsim nyob rau hauv cov cheeb tsam no, mus txog qib uas npog tag nrho cov chaw nquag ntawm cov kab mob polymerase.
Los ntawm kev tsom mus rau cov tshuaj nyob qhov twg tus kab mob replication machinery ua hauj lwm, compartmentalized faib pab txhim kho antiviral tshwj xeeb.
Viral replication complexes siv nucleotide triphosphates sai heev, sai sai tso cov khw muag khoom hauv zos thiab ua kom muaj cov tshuaj analog molecules ntxiv rau kev koom ua ke.
Qhov kev cuam tshuam microenvironmental no ua rau cov tshuaj tiv thaiv muaj zog dua li qhov xav tau los ntawm cov nyiaj hauv tag nrho cov xov tooj ntawm tes.
GS-441524 Powder Mechanisms thiab Lawv Qhov Tseem Ceeb hauv Kev Tshawb Fawb Tshuaj Tiv Thaiv
Kev koom tes rau kev nkag siab txog Nucleoside Analog Design
Kev tsim thiab kev kawm ntawmGS-441524 hmoovtau muab cov ntaub ntawv tseem ceeb tshiab rau peb txog kev tsim nucleoside analogs. Cov kws tshawb fawb tau pom qee qhov kev hloov pauv ntawm cov qauv uas ua rau nws yooj yim dua rau cov hlwb kom coj mus rau hauv tus kab mob, pab nrog phosphorylation, thiab ua kom yooj yim rau polymerase kom paub txog nws thaum tseem tab tom xaiv tawm tsam tus tswv tsev enzymes. Cov tshooj lus no pab nrog txoj haujlwm tam sim no los tsim cov kab mob sib kis tom ntej no uas muaj zog dua, ua haujlwm zoo dua hauv ntau qhov xwm txheej, thiab muaj cov tshuaj pharmacokinetic zoo dua.
Cov kev tshawb fawb sib piv uas saib cov qauv analogs nrog cov kev hloov me me qhia kev sib raug zoo ntawm cov qauv thiab kev ua haujlwm uas pab nrog tshuaj chemistry. Hloov cov ribose molecule, cov qauv ntawm lub hauv paus, los yog chemistry ntawm phosphate tag nrho muaj qhov sib txawv ntawm cov tshuaj ua li cas. Qhov no hauv - qhov kev paub tob ua rau nws muaj peev xwm siv cov txheej txheem tsim qauv uas txhim kho ntau yam hauv ib zaug, uas txo lub sijhawm nws siv los ua tshuaj tiv thaiv kab mob.
Kev sim cov ntawv thov hauv Virology Research
Ntxiv rau cov tshuaj, GS-441524 hmoov muaj txiaj ntsig zoo rau cov kws kho mob virologist kawm RNA tus kab mob rov ua dua. Cov tshuaj muaj peev xwm thaiv cov kab mob RNA synthesis raws li kev tswj hwm kev teeb tsa, ua rau kev tshawb nrhiav kab mob viral lub neej yooj yim dua. Qhov kev sojntsuam molecular no tso cai rau cov kws tshawb nrhiav sijhawm cov kabmob kis kabmob, tshuaj xyuas cov kabmob sib kis, thiab ntsuas kev ua haujlwm ntawm polymerase.
Cov ntawv thov no xav tau siab -kev tshawb fawb purity- cov ntaub ntawv qib siab nrog cov ntaub ntawv txheeb xyuas dav dav. Cov tuam txhab biotechnology thiab cov chaw tshawb fawb hauv tsev kawm ntawv xav tau HPLC purity, huab hwm coj spectrometry, thiab cov ntaub ntawv pov thawj ruaj khov ntawm kev tshuaj xyuas. Cov kev tshawb fawb rov ua dua thiab cov kev tshawb pom muaj txiaj ntsig zoo uas ua tiav hauv thaj chaw yog ua tiav nrog cov neeg muag khoom txhim khu kev qha uas ua kom cov khoom ruaj khov.
Xaus
Txoj kev ntawdGS-441524 hmoovKev tawm tsam cov kab mob yog los ntawm cov txheej txheem tshuaj lom neeg los daws cov kab mob RNA. Qhov nucleoside analogue no muaj ntau yam tshuaj tiv thaiv kab mob sib txawv. Nws nres RNA- nyob ntawm RNA polymerase los ntawm kev ua haujlwm, ua rau kev txiav tawm ntxov ntxov, thiab cuam tshuam txog kab mob hauv lub neej. Cov kws tshawb fawb, cov tuam txhab tshuaj, thiab pab pawg sim txhim kho cov tshuaj tiv thaiv kab mob yuav tsum nkag siab txog cov txheej txheem no txhawm rau ua lawv txoj haujlwm.
Qhov sib xyaw ua ke muaj peev xwm los tswj hwm tus kab mob replication thiab nws lub peev xwm los tsom cov kab mob enzymes ntau dua li cov tswv cuab ntawm tes enzymes ua rau nws muaj txiaj ntsig zoo rau kev kawm thiab kev siv tshuaj. Cov kws tshawb fawb tseem tab tom nrhiav txoj hauv kev tshiab los tua cov kab mob. Cov tshuaj zoo li no nucleoside analog pab peb ua cov tshuaj tiam tom ntej thiab kawm paub ntxiv txog yuav ua li cas cov kab mob tuaj yeem luam lawv tus kheej.
Txhawm rau siv cov txheej txheem no kom tau txais txiaj ntsig zoo, koj yuav tsum muaj peev xwm tau txais qib siab - zoo, zoo - cov khoom siv tshuaj lom neeg los ntawm cov chaw ntseeg siab. Cov koom haum uas saib xyuas kev kawm txog kev coj ncaj ncees thiab siab - kev txhim kho tshuaj zoo paub tias nws tseem ceeb npaum li cas los ua haujlwm nrog cov neeg muag khoom uas tuaj yeem muab kev lees paub zoo, kev ua raws cai, thiab kev paub txuj ci. Kev tshawb fawb tshuaj tiv thaiv kab mob yuav txuas ntxiv mus ntxiv mus ntev npaum li lub hauv paus ntawm cov khoom siv tshuaj, tshuaj - cov ntaub ntawv qib txhawb kev kawm tshiab.
FAQ
GS-441524 hmoov ua haujlwm tiv thaiv kab mob RNA li cas?
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Cov tshuaj koom nrog tus kab mob RNA thaum luam tawm nws tus kheej los ntawm zoo li lub ntuj adenosine nucleotides. Thaum sab hauv, nws tiv thaiv kab mob RNA chains los ntawm kev txiav tawm ntxov ntxov thiab RNA-nyob ntawm RNA polymerase los ntawm kev ua haujlwm. Qhov no tiv thaiv tus kab mob los ntawm kev tsim cov khoom siv caj ces rau kev nthuav tawm.
GS-441524 hmoov txawv li cas los ntawm lwm cov tshuaj tiv thaiv kab mob?
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Qhov no nucleoside mimic tsom rau lub hauv paus txheej txheem uas cov kab mob RNA yuav tsum tau muab luam tawm lawv tus kheej, tsis zoo li cov tshuaj uas thaiv cov protein nkag lossis ua tiav. Integrating ncaj qha mus rau hauv cov kab mob genetic khoom ua hauj lwm. Qhov no ua rau muaj kev cuam tshuam ntev dua - inhibitory cuam tshuam uas tsom cov kab mob enzymes ntau dua li tus tswv tsev cell enzymes thaum kis tus kab mob.
Cov kev qhia tshwj xeeb zoo li cas cov kws tshawb fawb yuav tsum nrhiav thaum nrhiav qhov sib xyaw no?
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Pharmaceutical- cov ntaub ntawv qib nrog purity theem ntawm lossis siab dua 98%, tag nrho cov ntaub ntawv txheeb xyuas suav nrog HPLC thiab cov ntaub ntawv loj spectrometry, GMP ntawv pov thawj, cov ntaub ntawv sib xws, thiab cov txiaj ntsig kev ntsuas kev ruaj ntseg yuav tsum nyob rau saum cov npe rau cov kws tshawb fawb. Cov ntaub ntawv ntxaws ntxaws ntawm kev tshuaj xyuas kom paub tseeb tias cov txiaj ntsig tuaj yeem rov ua dua hauv kev tshawb fawb thiab kev txhim kho tshuaj.
Koom tes nrog BLOOM TECH rau hwm GS-441524 hmoov khoom
Raws li kev ntseeg siabGS-441524 hmoovtus neeg muag khoom, BLOOM TECH muab cov kws tshuaj- qib nruab nrab txhawb nqa los ntawm cov ntawv pov thawj GMP los ntawm US-FDA, EU, CFDA, thiab PMDA cov tub ceev xwm. Peb 100,000-square-meter tau ntawv pov thawj cov chaw tsim khoom kom paub meej cov khoom sib xws, kev tswj xyuas zoo los ntawm triple- txheej txheej tsom xam, thiab ua tiav CMC cov ntaub ntawv txhawb nqa koj cov kev tshawb fawb thiab kev tsim kho. Txawm hais tias koj xav tau kev tshawb fawb-qib kom muaj nuj nqis nrog cov ntaub ntawv txheeb xyuas ntxaws lossis cov khoom lag luam loj tuaj yeem ua rau kev txhim kho tshuaj, peb pab neeg muaj kev paub txog muab tus nqi pob tshab, lub sijhawm ua haujlwm raug, thiab ib qho - ntawm- ib qho kev txhawb nqa. Peb pab cov tuam txhab tshuaj, cov koom haum biotechnology, CDMOs, thiab cov chaw tshawb fawb thoob ntiaj teb nrog cov nqi sib tw thiab txhim khu kev qha txias-chain logistics. Hu rau peb pab neeg ntawmSales@bloomtechz.comlos tham txog koj cov kev xav tau tshwj xeeb, thov daim ntawv pov thawj ntawm kev tshuaj xyuas, lossis tau txais cov lus hais rau koj qhov project tom ntej. BLOOM TECH ua ke nrog 12 xyoo kev paub txog kev sib xyaw ua ke nrog cov neeg siv khoom- tsom rau kev pabcuam kom nrawm koj cov hom phiaj tshawb fawb tshuaj tiv thaiv.
Cov ntaub ntawv
1. Warren TK, Jordan R, Lo MK, et al. Kev kho tau zoo ntawm cov tshuaj tiv thaiv kab mob me me GS-441524 tiv thaiv cov kab mob RNA. Nature Communications. 2016; 7:11384.
2. Murphy BG, Perron M, Murakami E, et al. Lub nucleoside analog GS-441524 muaj zog tiv thaiv kab mob feline kis kab mob peritonitis hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
3. Agostini ML, Andres EL, Sims AC, et al. Coronavirus cuam tshuam rau cov tshuaj tiv thaiv kab mob remdesivir thiab nws niam txiv nucleoside analog GS-441524 yog kho los ntawm tus kab mob polymerase thiab cov ntawv pov thawj exoribonuclease. mBio. 2018;9(2):e00221-18.
4. Yan VC, Muller FL. Qhov zoo ntawm niam txiv nucleoside GS-441524 tshaj remdesivir rau kev kho mob COVID-19. ACS Medicinal Chemistry Letters. 2020;11(7):1361-1366.
5. Gordon CJ, Tchesnokov EP, Woolner E, et al. Remdesivir yog ib qho ncaj qha - ua yeeb yam tshuaj tiv thaiv kab mob uas inhibits RNA- nyob ntawm RNA polymerase los ntawm tus mob ua pa nyuaj rau tus mob coronavirus-2 nrog lub zog siab. Phau ntawv Journal of Biological Chemistry. 2020;295(20):6785-6797.
6. Pizzorno A, Pady B, Julien T, et al. Tus cwj pwm thiab kev kho mob ntawm SARS-CoV-2 hauv nasal thiab bronchial human airway epithelia. Cell Reports Tshuaj. 2020;1(4):100059.