Thaum Lub Peb Hlis 6, 2026, Hangzhou Xianweida Biotechnology Co., Ltd. (tom qab no hu ua "Xianweida Biotechnology"), lub tuam txhab biopharmaceutical tshwj xeeb hauv kev tshawb pom thiab kev txhim kho cov kev kho tshiab rau cov kab mob metabolic, tshaj tawm hnub no: lub ntiaj teb thawj cAMP biasedGLP-1receptor agonist enoglutide txhaj (Xianweida) ®) Pom zoo rau kev lag luam los ntawm National Medical Products Administration (NMPA), tsim nyog rau kev tswj kev noj zaub mov thiab ua kom lub cev muaj zog.
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
(3) Capsule
(4) Txhaj tshuaj
(5) Ua kua dej
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Internal Code: BM-3-094
GLP-1 CAS Nr .: 87805-34-3
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muab GLP-1 Txhaj Tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/oem-odm/injection/glp-1-injections.html
Raws li lub sijhawm ntev - tswj qhov hnyav rau cov neeg laus rog / rog rog.
Xianweiying @ yog lub ntiaj teb thawj zaug pom zoo cAMP biased GLP-1 RA cov tshuaj poob phaus, nrog cov txheej txheem tsis ncaj ncees uas pab ua kom poob phaus tau zoo. Qhov nruab nrab qhov hnyav poob ntawm cov neeg Suav nyob rau hauv 48 lub lis piam mus txog 15.4% (tom qab kho cov placebo, 15.1%), thiab 92.8% ntawm cov neeg mob tau txais kev kho mob hnyav hnyav. Qhov no yog ib qho kev ua tiav ntawm kev noj qab haus huv yuag poob hauv Suav teb thiab muab txoj hauv kev tshiab rau kev tshawb fawb, mus sij hawm ntev, thiab noj qab nyob zoo.
Raws li lub ntiaj teb thawj CAMP biased GLP-1 receptor activation mechanism, Xianweiying @ tuaj yeem xaiv qhib cAMP kev taw qhia txoj hauv kev thiab txo qis B-arrestin recruitment, uas txawv txawv ntawm cov tsoos tsis ncaj ncees GLP-1 RA. Cov txheej txheem no ncaj qha coj ob qho txiaj ntsig zoo: ua ntej, qhov hnyav poob yog qhov muaj zog thiab kav ntev, tsis muaj lub sijhawm pom tseeb toj siab thoob plaws hauv cov txheej txheem; Thib ob, thaum txo qhov hnyav, nws synchronously txhim kho cov metabolism thiab txo cov kev pheej hmoo ntawm cov kab mob ntev, ua kom tau raws li cov kev xav tau tseem ceeb ntawm kev noj qab haus huv yuag.
Kangzhe Pharmaceutical tus kheej -tsim INHBE me me nucleic acid tshuaj CMS-D008 tau pom zoo los ntawm NMPA
Tsis ntev los no, Kangzhe Pharmaceutical Holdings Limited ("Kangzhe Pharmaceutical" lossis "Cov Pab Pawg") tshaj tawm tias cov tshuaj tshiab INHBE me nucleic acid tshuaj CMS-D008 txhaj ("CMS-D008") ntawm nws tus kheej tsim los ntawm Pab Pawg tau txais cov tshuaj soj ntsuam kuaj pom zoo rau cov khoom lag luam (National Medical Administration).
NMPA pom zoo ua qhov kev sim tshuaj ntawm CMS-D008 txhaj tshuaj rau rog rog lossis rog rog. CMS-D008 yog ib qho tshuaj subcutaneous siRNA tshuaj uas ua rau lub hom phiaj inhibition ntawm kev qhia ntawm inhibin subunit E (INHBE) noob hauv daim siab, txo qis qib ntawm INHBE encoded protein Activin E (ActinE), yog li txo qis kev ua kom muaj roj metabolism hauv Activin E{5}. Cov kev tshawb fawb ua ntej qhia tias CMS-D008 ua tau zoo thiab tsis tu ncua inhibits INHBE qhia. Hauv cov qauv tsiaj rog rog, qhov hnyav hnyav thiab txo cov rog tau ua tiav yam tsis muaj kev cuam tshuam rau cov leeg, thiab kev nyab xeeb yog qhov zoo; Qhia tau tias muaj kev cia siab zoo rau ntev - lub sij hawm siab - zoo yuag yam tsis poob cov leeg nqaij. Nyob rau yav tom ntej, kev kho mob hnyav / rog, plab rog, thiab cov kab mob metabolic tuaj yeem tsim.
CMS-D008 yuav koom tes nrog tus kheej- tsim tshuaj tshiab CMS-D005, uas tam sim no nyob rau hauv kev kho mob. CMS-D008 precisely inhibits INHBE noob qhia, ua rau poob phaus yam tsis muaj cov leeg; Raws li ib tug dual agonist ntawm GLP-1R/GCGR, CMS{12}}DO05 tuaj yeem txo lub siab rog thaum txo qhov hnyav. Ob leeg ua haujlwm ua ke kom ua tiav cov txiaj ntsig kev poob phaus thiab kev ua haujlwm ntev ntev, sib koom ua ke txhim kho kev tshawb fawb thiab txhim kho lub zog thiab cov khoom sib tw ntawm peb pab pawg hauv kev kho mob rog rog / metabolic. Kev vam khom peb cov peev txheej network paub tab hauv thaj tsam ntawm cov kab mob plawv metabolic, peb ua kom txoj kev loj hlob thiab kev lag luam cov txheej txheem ntawm cov tshuaj thiab muab cov neeg mob nrog ntau yam kev kho mob thiab kho tshiab.