Cov tswv tsiaj nrhiav kev kho mob feline infectious peritonitis (FIP) zoo.GS-441524 tab, ib qho tshuaj tiv thaiv kab mob tshiab, tau txais kev txaus siab rau cov kws kho tsiaj rau lawv lub peev xwm los tawm tsam cov kab mob. Ntau tus miv uas muaj tus kabmob feline tam sim no tuaj yeem nyob ua tsaug rau qhov nucleoside analogue. To taub tias cov ntsiav tshuaj no ua haujlwm li cas molecularly pab vets thiab cov tswv tsiaj xaiv cov kev kho mob.
Lub 291.27 molecular hnyav ntawm C12H13N5O4 inhibits viral replication. Ntau pawg hydroxyl thiab amino ua haujlwm hauv cov molecule no cuam tshuam nrog cov kab mob enzymes. Txawm hais tias dej solubility (0.5 mg / mL) thiab pH rhiab heev, cov tshuaj formulations tau txhim kho cov ntsiav tshuaj 'kev ua tau zoo. Niaj hnub nimno formulations nce stability thiab bioavailability, pab lub active tshuaj tivthaiv ua hauj lwm.
GS-441524 Tab
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-2-001
GS-441524 CAS Nr .: 1191237-69-0
Chaw tsim tshuaj paus: BLOOM TECH Wuxi Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Kev them nyiaj yug Technology: R&D Dept.-4
Peb muab GS-441524 ntsiav tshuaj, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov khoom lag luam.
Product link:https://www.bloomtechz.com/oem-odm/tablet/gs-441524-tablets.html
Cov khoom siv tshuaj tiv thaiv kab mob no qhia txog cov txheej txheem nyuaj uas cuam tshuam cov kab mob viral nyob rau theem tseem ceeb. Cov ntsiav tshuaj inhibit particle ntau lawm thiab nkag mus rau cov kab mob replication machinery zoo li ntuj nucleosides. Cov phiaj xwm no tiv thaiv cov hlwb noj qab haus huv thaum tswj cov kab mob sib kis hauv cov neeg mob. Cov ntu txuas ntxiv nthuav dav GS-441524 cov teebmeem kev kho mob.
Yuav Ua Li Cas GS-441524 Tablets Inhibit Feline Coronavirus Replication?
GS-441524 ntsiav tshuaj tiv thaiv kab mob thaum lawv cov tshuaj nkag mus rau hauv cov hlwb ntawm nucleoside transporters. Cov proteins no feem ntau thauj DNA thiab RNA cov khoom tsim. Raws li GS-441524 thiab ntuj adenosine muaj cov qauv zoo sib xws, lawv tuaj yeem siv cov kev thauj mus los no. Ib zaug nyob rau hauv lub cell, lub molecule bypasses thawj kauj ruam uas tsis kam mus txawv teb chaws tebchaw.
Cells nqus ntawm passive diffusion thiab nquag thauj. Cov pab pawg hydroxyl ntawm ribose pab thauj cov proteins tsim hydrogen bonds nrog nws, ua rau nws nkag mus rau cov hlwb zoo dua. Qhov no ob -txoj kev uptake lub tswv yim ua kom cov hlwb muaj ntau txawm tias ib txheej txheem puv. Cov pab pawg ua haujlwm hydrophilic ua haujlwm tswj hwm nws lipophilicity, tso cai rau cov ntaub so ntswg txav mus los yam tsis tau nkag mus rau hauv lipid feem.
Viral Polymerase Recognition thiab Binding
RdRp xav tau los ntawm feline coronavirus kom rov ua dua nws cov khoom siv caj ces. Cov enzyme no ntxiv cov nucleoside triphosphates ntuj los tsim RNA strands. GS-441524 zoo li ATP, uas cov kab mob polymerase ib txwm khi rau, thaum ua haujlwm. Cov tshuaj tuaj yeem sib tw nrog cov nucleotides ib txwm muaj rau cov kab mob enzyme khi rau qhov chaw vim nws zoo li txawv molecule.
GS-441524's pyrrolotriazine nplhaib qauv pab tiv thaiv kab mob polymerase active site khi. Kev tshawb nrhiav Crystallographic qhia tias qhov no heterocyclic system cuam tshuam nrog kev txuag cov amino acid residues nyob rau hauv lub enzyme lub active cheeb tsam. Cov kev sib cuam tshuam no ruaj khov ntawm cov enzyme-inhibitor complex, tiv thaiv ntuj substrates los ntawm kev koom ua ke. Cov pab pawg nitrile hluav taws xob cuam tshuam nrog qhov zoo ntawm qhov chaw ua haujlwm zoo los txhim kho kev khi.
Ntxiv GS-441524 rau tus kab mob RNA saw txuas txuas txuas txuas ntxiv. Cov molecule no tso cai rau cov nucleotides ntxiv tom qab ntxiv, tsis zoo li cov saw hlau ncaj qha. Cov qauv protein ua ntej ua rau lub luag haujlwm ntawm polymerase, ua rau qhov cuam tshuam qeeb. Tab sis tom qab enzyme-RNA complex cov kev hloov pauv txwv tsis pub nws ntev dua.
Kev ncua ncua sij hawm txo cov kab mob tiv thaiv piv rau kev txiav tawm sai. Polymerase tuaj yeem paub qhov txawv GS-441524 los ntawm lwm cov kev hloov pauv, txawm li cas los xij lawv feem ntau ua rau cov nucleotide ntxiv nyuaj. Qhov no ua rau tus kab mob tsis muaj zog, tiv thaiv kev tiv thaiv. Ntxiv cov tshuaj tso rau ntawm tus kab mob RNA ua kom tag nrho replication stoppage.
Intracellular Activation Pathway ntawm GS-441524 Cov ntsiav tshuaj piav qhia
Phosphorylation los ntawm Cellular Kinases
Tom qab raug coj los ntawm cov hlwb, GS-441524 mus dhau ntawm cov tshuaj tiv thaiv phosphorylation los ua nws daim ntawv active triphosphate. Peb qhov sib txawv kinase enzymes ua haujlwm ua ke los ntxiv ib pab pawg phosphate thaum lub sijhawm ua haujlwm. Adenosine kinase ua kom nrawm rau thawj theem phosphorylation, uas yog qhov qeeb tshaj plaws ntawm cov txheej txheem ua kom muaj zog. Cov enzyme no pom tias GS-441524 muaj cov qauv uas zoo li adenosine thiab hloov mus rau hauv daim ntawv monophosphate.
Nucleoside monophosphate kinases thiab nucleoside diphosphate kinases ua tiav cov kev ua kom muaj zog thiab ua rau cov kauj ruam tom ntej phosphorylation mus sai dua. Cov enzymes no tshwj xeeb tshaj yog rau cov substrates dua li thawj kinase, uas ua rau nws yooj yim dua hloov mus rau daim ntawv triphosphate. Cov kev kho mob dav dav ntawmGS-441524 tabnyob ntawm seb txoj kev ua haujlwm no ua haujlwm zoo npaum li cas, vim tsuas yog daim ntawv triphosphate tuaj yeem tua cov kab mob.
Compartmentalization thiab Metabolic Stability
Lub active triphosphate daim ntawv ntawm GS-441524 tsim nyob rau hauv feem ntau nyob rau hauv lub cytoplasm ntawm cell, uas yog qhov chaw uas cov kab mob replicate. Qhov no compartmentalization tshwm sim vim hais tias cov triphosphate molecule raug them, uas nres passive passive hla daim nyias nyias. Lub active molecule nyob twj ywm hauv cov hlwb, yog li nws tuaj yeem tiv thaiv kab mob txawm tias tom qab cov ntshav plasma poob. Daim ntawv triphosphate muaj ntev intracellular ib nrab-lub neej, feem ntau ntev tshaj 10 teev. Qhov no pab ua kom lub sijhawm noj tshuaj uas ua haujlwm zoo nrog cov ntawv ntsiav tshuaj.
Qhov sib xyaw ua ke metabolic stability yog ib feem tseem ceeb ntawm nws ua haujlwm zoo li cas. Muaj ntau tshaj li ib pab pawg phosphate feem ntau ua rau ib yam dab tsi ntau dua los ntawm phosphatase. GS-441524 triphosphate, ntawm qhov tod tes, yog resistant rau cov cellular phosphatase vim li cas nws yog tsim. Lub nplhaib pyrrolotriazine ua rau nws nyuaj rau phosphatases kom tau mus rau lub davhlau ya nyob twg phosphate pawg. Qhov no ua rau cov molecule ua haujlwm ntev dua hauv cov kab mob.
Kev Cuam Tshuam -Nyob rau ntawm Antiviral Effects
Kev sib txuas ntawm tus nqi ntawm GS-441524 triphosphate hauv cov hlwb thiab nws lub peev xwm los tua cov kab mob ua raws li kev ua haujlwm zoo. Thaum siv nyob rau hauv kev kho mob theem, cov tshuaj nquag sib tw nrog ntuj ATP rau khi qhov chaw ntawm cov kab mob polymerase. Nrog rau cov nyiaj ntau dua, qhov sib npaug txav ntau dua hauv kev pom zoo ntawm kev koom ua ke inhibitor, uas txwv tsis pub tus kab mob rov ua dua hauv thaj chaw dav dua. Tab sis ntau tus lej yuav ua rau muaj kev cuam tshuam ntawm cellular polymerases uas tsis tau tshwm sim.
Rau kev kho kom ua haujlwm zoo tshaj plaws, tus lej intracellular yuav tsum nyob hauv ib qho kev sib txawv. Cov txheej txheem tsim tawm rau GS-441524 ntsiav tshuaj sim kom ncav cuag tsis tu ncua- xeev cov concentrations uas muaj txiaj ntsig zoo tshaj plaws tiv thaiv kab mob thaum tseem muaj kev nyab xeeb tshaj plaws rau cov hlwb. Hloov kho-tso cov qauv tuaj yeem pab khaws cov qib siab zoo thoob plaws lub sijhawm siv tshuaj, uas tuaj yeem pab tiv thaiv kev hloov pauv ntawm lub ncov mus rau trough uas tuaj yeem ua rau muaj txiaj ntsig ntawm kev kho mob.
GS-441524 Tablets Block Viral RNA Synthesis zoo?
Competitive Inhibition ntawm Natural Substrates
Qhov tshuaj tua kab mob RNA zoo npaum li cas nyob ntawm seb nws tuaj yeem sib tw nrog ntuj adenosine triphosphate. Hauv lub cev noj qab haus huv, tus nqi ntawm ATP hauv cov hlwb feem ntau yog nyob nruab nrab ntawm 1 thiab 10 millimolar, uas ua rau ib puag ncig muaj kev sib tw. GS-441524 triphosphate yuav tsum muaj qhov muaj zog txaus affinity rau tus kab mob RdRp kom ncav cuag cov tshuaj uas muaj peev xwm ua tau zoo hloov lub ntuj substrate uas twb muaj nyob rau hauv loj.
Kinetic tests qhia tias cov tshuaj muaj cov qauv ntawm kev sib tw inhibition thaum nws los txog rau ATP. Yog tias koj saib ntawm qhov inhibition tas li (Ki) tus lej rau GS-441524 triphosphate, lawv qhia tias nws khi zoo dua li cov nucleotides ntuj. Qhov kev sib khi zoo dua yog vim lub nplhaib pyrrolotriazine thiab tus kab mob polymerase active site cuam tshuam nrog ntau txoj hauv kev. Lub qhov rais kho qhov sib xyaw yog pab los ntawm qhov tseeb tias nws tsuas yog tsom cov kab mob polymerases thiab tsis yog cov cellular.
Incorporation Efficiency thiab Error Catastrophe
GS-441524 triphosphate yog ntxiv los ntawm cov kab mob polymerases nyob rau hauv ntau txoj kev, raws li cov ntsiab lus sib lawv liag ntawm cov saw RNA loj hlob. Qee cov kab ke motifs ua kom muaj txiaj ntsig zoo dua, thaum lwm tus ua rau nws nyuaj rau ntxig. Qhov kev sib koom ua ke raws li kev sib koom ua ke ua rau nws muaj peev xwm ua rau muaj teeb meem rov ua dua nyob rau ntau qhov chaw hauv tus kab mob genome. Thaum muaj ntau yam xwm txheej tshwm sim nyob rau tib lub sijhawm, lawv tuaj yeem ua rau muaj kev puas tsuaj loj uas ua rau tus kab mob ua rau cov menyuam noj qab nyob zoo.
Lub tswv yim ntawm "yuam kev puas tsuaj" yog hais txog cov kev hloov pauv ntau tshaj plaws uas lub zej zog tus kab mob tuaj yeem daws tau thiab tseem nyob zoo. Thaum ntxivGS-441524 tabua rau muaj kev ua yuam kev txaus lossis kev txiav cov saw hlau, tus kab mob mus dhau qhov no, thiab nws cov lej pib poob. Cov txheej txheem no pab piav qhia tias vim li cas cov kab mob kis tau poob sai sai hauv kev kuaj mob ntawm GS-441524 ntsiav tshuaj rau kev kho FIP.
Kev xaiv rau Viral Versus Cellular Polymerases
Ib feem tseem ceeb ntawm kev nyab xeeb tshuaj tiv thaiv kab mob yog qhov zoo npaum li cas cov tshuaj tiv thaiv kab mob polymerases tsis yog cov cellular. DNA polymerases thiab RNA polymerases los ntawm tib neeg thiab miv yog cov qauv sib txawv ntawm cov kab mob enzymes, uas hloov pauv lawv paub cov substrates. GS-441524 triphosphate yog yooj yim dua los ntawm tus kab mob RdRp dua li ntawm cellular polymerases. Qhov no tsim lub qhov rais kho uas tso cai rau cov tshuaj tua kab mob zoo yam tsis muaj kev puas tsuaj ntawm tes ntau dhau.
Qhov kev xaiv no yog ua raws li kev hloov pauv me me hauv cov chaw ua haujlwm polymerase ntawm qib molecular. RdRp hauv cov kab mob hloov mus rau lub sijhawm ua kom rov ua dua sai dua, qee zaum ntawm tus nqi qis dua rau qee qhov substrates. Qhov qis qis ntawm kev ntxub ntxaug no ua rau nws yooj yim dua rau GS-441524 triphosphate kom nkag mus rau cov enzymes virus. Cellular polymerases muaj peev xwm zoo dua los qhia qhov txawv ntawm ntuj thiab tsis yog ntuj nucleotides, uas tiv thaiv cov teebmeem uas yuav tsis tshwm sim.
Molecular Targeting Mechanism Tom qab GS-441524 ntsiav tshuaj
Kev sib xyaw ua ke nrog Viral Enzymes
Peb - qauv qauv ntawm GS-441524 triphosphate haum zoo heev nrog cov qauv ntawm feline coronavirus RdRp. Molecular qauv qhia tau hais tias cov molecule haum zoo kawg nkaus hauv lub enzyme lub chaw ua haujlwm, ua ntau yam kev sib cuam tshuam uas ua rau nws ruaj khov. Qhov ribose siv rau ntawm cov duab zoo ib yam li cov nucleotides ntuj, uas ua kom nws haum rau hauv lub hnab catalytic. Vim tias qhov zoo sib xws ntawm cov molecular no, cov compound tuaj yeem ua raws li kev hloov pauv hauv substrate thiab pib lub voj voog catalytic ntawm RNA ntau lawm.
Cov koom haum hydroxyl pawg thiab khaws cia cov khoom seem hauv cov chaw ua haujlwm polymerase tsim hydrogen- cov sib txuas sib txuas uas pab ua kom ruaj khov. Vim tias nws tuaj yeem rub cov electrons tam sim ntawd, cov pab pawg nitrile tau koom nrog kev sib cuam tshuam ntau dua, uas tsim cov khoom siv hluav taws xob zoo. Cov ntsiab lus sib cuam tshuam ntau no ua rau nws tsis tshua pom tias ib qho - cov ntsiab lus hloov pauv hauv cov kab mob polymerase yuav nres tag nrho kev sib txuas. Qhov no pab ua kom cov tshuaj tiv thaiv kab mob ua haujlwm tiv thaiv kev hloov pauv hloov tau.
Conformational hloov thaum khi
GS-441524 triphosphate khi rau kab mob polymerase thiab hloov nws cov qauv me ntsis. Cov kev hloov pauv no cuam tshuam txog qhov ua tau zoo ntawm cov enzymes tawg thiab paub txog cov tebchaw. X-ray crystallography ntawm polymerase-inhibitor complexes qhia tau hais tias lub nplhaib pyrrolotriazine qee zaum hloov cov active residues tseem ceeb. Qhov kev tweak no tso cai rau polymerization tom qab siv cov inhibitor, pab ncua kev txiav cov saw hlau.
Lub enzyme lub peev xwm los txuas mus rau ntuj nucleotides tom qab hloov cov duab kuj raug cuam tshuam. Kev hloov pauv hauv qhov chaw ua haujlwm zoo li qeeb saw txuas ntxiv. Qhov no txo cov kab mob RNA synthesis ua ntej nres. Qhov sib xyaw no lub peev xwm los txuas thiab sib txuas cov kab mob boosts nws antiviral potency.
Resistance Barrier thiab Genetic Limits
GS-441524 ntsiav tshuaj txwv tsis pub muaj kev txhim kho hauv kev kho mob. Cov kev hloov pauv uas cuam tshuam inhibitor khi feem ntau cuam tshuam cov polymerase ntuj substrate paub. Qhov no tiv thaiv cov kab mob kis tau zoo los ntawm kev sib kis thiab muaj nqi zog. Vim nws cov qauv zoo sib xws rau adenosine, kev hloov pauv uas ua rau nws tiv taus qee zaum ua rau nws nyuaj rau cov enzyme kom nqus ATP, ib qho tseem ceeb ntawm ntuj substrate.
GS-441524-cov pab pawg neeg kis tus kab mob genes qhia tau hais tias muaj feem cuam tshuam txog kev hloov pauv feem ntau nyob rau hauv cov chaw ua haujlwm polymerase lossis thaj chaw nucleotide-binding. Txawm li cas los xij, cov kev hloov pauv no feem ntau txo cov kab mob sib kis tsis muaj tus inhibitor. Qhov kev tawm dag zog no txwv cov kev hloov pauv thiab cuam tshuam kev tawm tsam. Kev siv ntau yam tshuaj tiv thaiv kab mob tuaj yeem ua rau muaj kev cuam tshuam ntawm caj ces, ua rau muaj kev tiv thaiv tsis zoo thaum lub sijhawm kho.
Kev Tshawb Fawb Txog Kev Tshawb Fawb Kev Ua Haujlwm hauv GS-441524 Cov ntsiav tshuaj
Pharmacokinetic Properties thiab Tshuaj Txhaum Cai
Txoj kev GS-441524 tau muab faib rau hauv lub cev cuam tshuam zoo npaum li cas nws tua cov kab mob los ntawm kev hloov cov tshuaj ntau npaum li cas thiab nws mus qhov twg hauv lub cev. Thaum twgGS-441524 tabyog noj los ntawm qhov ncauj, lub compound yog absorbed nyob rau hauv lub digestive system. Lub bioavailability ntawm lub compound nyob ntawm seb nws tau ua li cas. Txhim kho cov txheej txheem solubility ua kom nqus tau zoo dua, ua kom cov tshuaj nkag mus rau hauv cov tshuab txaus kom ncav cuag cov nqi kho mob hauv cov ntaub so ntswg.
Cov kev tshawb fawb ntawm nws qhov kev faib tawm qhia tias GS-441524 yooj yim nkag mus rau cov ntaub so ntswg uas cuam tshuam los ntawm feline coronavirus. Cov ntaub so ntswg muaj xws li cov nyob ib ncig ntawm lub peritoneum, lub siab, thiab lub hauv paus paj hlwb. Cov molecule no tuaj yeem tau txais mus rau qhov chaw uas cov kab mob nquag rov ua dua vim tias nws muaj cov hneev taw zoo. Tus nqi ntawm kev sib kis feem ntau mus dhau tag nrho cov dej hauv lub cev, uas qhia tau tias muaj ntau cov ntaub so ntswg faib. Qhov kev sib kis thoob plaws no, nrog rau qhov sib xyaw ua ke muaj peev xwm qhib thiab nyob hauv cov hlwb, pab nws muaj kev tiv thaiv kab mob ntev ntev.
Sijhawm -Kev txo qis ntawm Viral Load Reduction
Kev kuaj mob ntawm kev kho tus kab mob peritonitis hauv miv nrog GS-441524 qhia tias cov kab mob kis tau txo qis hauv txoj kev kwv yees dhau sijhawm. Hauv thawj lub lim tiam ntawm kev kho mob, cov kab mob RNA txo qis sai, uas qhia tau hais tias cov tshuaj no zoo heev ntawm kev txwv tsis pub kis kab mob. Cov tshuaj tiv thaiv thaum ntxov no txuas nrog kev hloov kho kho mob, txij li cov kab mob kis qis qis qis qis dua cov lus teb inflammatory thiab cov tsos mob uas mus nrog lawv. Ntev npaum li kev kho mob txuas ntxiv mus, tus kab mob no tseem tswj tau.
Qhov no txwv tsis pub rov ua dua tshiab uas tuaj yeem tshwm sim yog tias kev kho mob raug tso tseg sai dhau. Yuav tua tus kab mob sai npaum li cas yog nyob ntawm ob qho tib si cov tshuaj pharmacological zoo thiab cov tshuaj tiv thaiv kab mob ntawm tus tswv tsev. Los ntawm kev txo tus naj npawb ntawm cov kab mob hauv qab theem uas tiv thaiv kab mob tsis tuaj yeem ua rau lawv, GS-441524 muab lub zog tiv thaiv kab mob rau lub sijhawm los tsim cov tshuaj tiv thaiv kab mob zoo. Cov kev ua tau zoo siab pom nyob rau hauv kev siv tswv yim yog ib feem ntawm txoj kev uas pharmacological thiab immunological txheej txheem ua hauj lwm ua ke.
Kev sib raug zoo ntawm qhov tshwm sim thiab cov txiaj ntsig kho mob
GS-441524's pharmacokinetic-pharmacodynamic kev sib cuam tshuam qhia tau tias kev siv tshuaj cuam tshuam rau kev kho mob. Qhov siab dua trough concentrations yuav tsum inhibit cov kab mob thiab txhim kho cov txiaj ntsig kho mob. Kev sib cuag ntau dua tsis pab ntawm qee qhov chaw vim qhov kev sib txuas muaj qhov cuam tshuam rau lub qab nthab. Raws li qhov kev txiav txim siab no, cov kev kho mob zoo tshaj plaws sib npaug nrog cov txiaj ntsig tsis zoo. Cov ntsiav tshuaj ntawm GS-441524 muab cov koob tshuaj kom raug thiab cov tshuaj pharmacokinetics zoo ib yam. Cov formulations tam sim no tau sau txog kev nqus thiab kev faib khoom zoo, yog li cov kws kho tsiaj tuaj yeem ua tiav qhov zoo tshaj plaws ntawm qhov raug. Clinical teb thiab viral load xyuas pab optimize txhua tus neeg mob txoj kev kho. Cov txheej txheem pov thawj-raws li kev siv tshuaj boosts kev vam meej thaum txo qis kev siv tshuaj tsis tsim nyog.
Ntxiv rau kev tiv thaiv tus kab mob rov ua dua tshiab, GS-441524 ntsiav tshuaj txhawb nqa lub cev tiv thaiv kab mob. FIP protein uas txhawb kev mob txo qis nrog cov kab mob suav. Qhov no txo qhov mob, uas pab lub cev tiv thaiv kab mob hloov pauv los ntawm kev puas tsuaj rau cov lus teb rau cov tshuaj tiv thaiv kab mob.
Cov kev tshawb fawb siv GS-441524 tau pom tias cov cim qhia txog kev tiv thaiv kab mob uas tsis zoo li qub qub. Kev kho kom zoo ua kom cov lymphocyte suav, uas feem ntau txo qis thaum lub sijhawm ua haujlwm FIP. Antibody teb hloov los ntawm kev txhim kho antibody-dependant mus rau kev tiv thaiv. Cov kev hloov pauv ntawm lub cev tiv thaiv kab mob no ua rau ncua kev kho mob thiab txo qhov yuav tshwm sim dua vim tus kab mob no raug txwv.
Xaus
Txoj kev ntawdGS-441524 tabKev sib ntaus cov kab mob cuam tshuam nrog ntau theem ntawm tshuaj lom neeg thiab kev sib cuag ntawm tes. Txhua kauj ruam, los ntawm qhov sib xyaw ua ntej nkag mus rau hauv cov hlwb los ntawm nucleoside transporters mus rau nws qhov kawg koom nrog cov kab mob RNA chains, ua rau nws zoo dua li tshuaj. Lub molecule tus qauv tso cai rau nws siv lub tshuab luam ntawv tus kab mob thaum muaj kev xaiv txaus los ua kom cov tswv tsev tsis muaj tshuaj lom heev.
Kev nkag siab txog cov txheej txheem no yuav pab tau zoo rau kev txhim kho cov phiaj xwm kho mob thiab tsim cov tshuaj tiv thaiv kab mob tshiab. Thaum koj sib tov kev sib tw inhibition ntawm tus kab mob polymerase nrog ncua kev kaw cov saw thiab kev tiv thaiv siab, koj tau txais cov ntaub ntawv kho mob zoo. Qhov tseeb tias qhov no nucleoside analog txoj kev ua haujlwm los kho cov kab mob peritonitis hauv miv pom tias cov tswv yim tsim tom qab lawv yog suab.
Kev kawm ntxiv rau hauv cov molecular thiab pharmacological nta ntawm GS-441524 yuav tsum qhia cov ntsiab lus ntxiv txog yuav ua li cas nws tua cov kab mob. Cov kev nkag siab no tuaj yeem pab ua cov ntawv hloov pauv uas txhim kho kev nqus, ruaj khov, thiab ua raws li tus neeg mob. Lub hauv paus kev tshawb fawb rau cov ntsiav tshuaj no qhia tau hais tias kev nkag siab tob npaum li cas ntawm cov khoom ua haujlwm tuaj yeem ua rau muaj txiaj ntsig zoo rau kev kho mob uas tsis tuaj yeem kho ua ntej.
FAQ
1. Dab tsi ua rau GS-441524 tiv thaiv feline coronavirus piv rau lwm cov tshuaj tiv thaiv kab mob?
2. Nws siv sijhawm ntev npaum li cas rau cov ntsiav tshuaj GS-441524 los qhia txog kev txhim kho kev kho mob hauv miv?
3. Vim li cas thiaj tsim nyog tsim nyog tseem ceeb rau GS-441524 ntsiav tshuaj muaj txiaj ntsig?
Koom tes nrog BLOOM TECH raws li Koj Trusted GS-441524 Tablets Supplier
Nws yog ib qho tseem ceeb heev uas yuav tau ua hauj lwm nrog tus kws tshaj lijGS-441524 tabtus neeg muag khoom thaum tab tom nrhiav rau siab -cov tshuaj intermediates zoo thiab cov khoom xyaw nquag. BLOOM TECH tau ua haujlwm nyob rau hauv cov organic synthesis thiab tshuaj intermediate manufacturing rau ntau tshaj 12 xyoo thiab muaj 100,000 square meters ntawm GMP- tau ntawv pov thawj qhov chaw tsim khoom. Triple-qib xeem yog ib feem ntawm peb txoj kev ua pov thawj zoo. Nws ua kom paub tseeb tias txhua pawg ua tau raws li lub ntiaj teb cov qauv tsim los ntawm US -FDA, EU-GMP, thiab PMDA.
Peb paub tias nws tseem ceeb npaum li cas rau kev siv tshuaj kom muaj purity, stability, thiab cov ntaub ntawv. Peb tau cog lus rau kev sib raug zoo ntev - lub sij hawm luv luv - lub sij hawm deals, uas qhia tau hais tias nyob rau hauv peb lub peev xwm los ua customized synthesis thiab peb tus nqi tsim nyog. Txawm hais tias koj xav tau cov nyiaj me me rau kev kawm lossis ntau ntau rau kev tsim khoom, peb cov saw hlau tsim khoom thiab cov hlau lead raug raug-sijhawm kwv yees yuav ua kom koj cov haujlwm ua haujlwm tau zoo. 24 cov koom haum tshuaj thiab tshawb fawb thoob ntiaj teb ua haujlwm nrog BLOOM TECH. Qhov no qhia tau hais tias peb muaj kev ntseeg siab thiab txawj ntse npaum li cas hauv peb txoj haujlwm. Hu rau peb pab neeg tam sim ntawd ntawmSales@bloomtechz.comtham txog koj cov kev xav tau tshwj xeeb thiab nrhiav seb peb cov kev txawj ntse tuaj yeem pab koj ua tiav hauv kev tsim cov khoom siv tshuaj tshiab.
Cov ntaub ntawv
1. Murphy BG, Perron M, Murakami E, et al. Lub nucleoside analog GS-441524 muaj zog inhibits feline infectious peritonitis tus kab mob nyob rau hauv cov ntaub so ntswg kab lis kev cai thiab kev sim kuaj kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
2. Pedersen NC, Perron M, Bannasch M, et al. Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline kis kab mob peritonitis. Phau ntawv Journal of Feline Medicine and Surgery. 2019;21(4):271-281.
3. Dickinson PJ, Bannasch M, Thomasy SM, et al. Kev kho tshuaj tua kab mob siv cov adenosine nucleoside analogue GS-441524 hauv cov miv uas tau kuaj pom tus kab mob neurological feline kis kab mob peritonitis. Phau ntawv Journal of Veterinary Internal Medicine. 2020;34(4):1587-1593.
4. Kankanamalage ACG, Kim Y, Damalanka VC, et al. Tus qauv-qhia kev tsim cov muaj zog thiab permeable inhibitors ntawm MERS coronavirus 3CL protease uas siv cov piperidine moiety raws li cov qauv tsim tshiab. European Journal of Medicinal Chemistry. 2018; 150:334-346.
5. Simons FA, Vennema H, Rofina JE, et al. Ib mRNA PCR rau kev kuaj mob feline infectious peritonitis. Phau ntawv Journal of Virological Methods. 2005;124(1-2):111-116.
6. Warren TK, Jordan R, Lo MK, et al. Kev kho tau zoo ntawm lub me me molecule GS-5734 tiv thaiv tus kab mob Ebola hauv rhesus liab. Xwm . 2016;531(7594):381-385.