9-hydroxy-4-androstene-3, 17-dione,(txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/9-hydroxy-4-androstene-3-17-dione-cas-560-62.html) tseem hu ua 4-OHA, muaj cov qauv molecular ntawm C19H26O3 thiab molecular hnyav ntawm 302.41 g / mol. Nws yog ib qho androsterone inducer, ib txwm tshwm sim steroid tshuaj. Qhov tsos yog dawb mus rau lub teeb daj hmoov, nyob rau hauv daim ntawv ntawm cov muaju los yog muaju. Nws yooj yim soluble hauv cov kuab tshuaj organic xws li ethanol, acetone, chloroform, ether thiab benzene, tab sis insoluble hauv dej. Muaj ob lub ntsiab qhov siab tshaj plaws nyob rau hauv cheeb tsam ultraviolet, ib qho ntawm 227 nm thiab lwm qhov ntawm 274 nm. Lub infrared spectrum muaj qhov pom tseeb qhov siab tshaj plaws, feem ntau suav nrog kev co ntawm OH daim ntawv cog lus (3440 cm^-1), kev co ntawm ketone pawg (1732 cm^-1), thiab kev co ntawm propane pawg thiab aromatic hydrocarbon pawg, thiab lwm yam. Nuclear magnetic resonance spectra muaj xws li carbon -13 NMR thiab hydrogen-1 NMR. Nyob rau hauv Hydrogen-1 NMR, nws muaj ob-bonded benzene nplhaib moiety, thiab vim nws txoj hauj lwm, 10 txawv peaks tshwm sim, thaum nyob rau hauv Carbon -13 NMR, 6 peaks tshwm. Nws tuaj yeem hloov mus rau hauv androgens lossis estrogen hauv lub cev, thiab muaj kev cuam tshuam rau kev ua me nyuam thiab cov metabolism. Nws muaj dav daim ntawv thov kev cia siab thiab kev tshawb fawb tus nqi. Cov kws tshawb fawb ntawm Shaanxi Chuzhan Chemical tab tom tshawb nrhiav nws cov qauv molecular, kev ua haujlwm lom neeg thiab cov tshuaj siv tshuaj, thiab xav tias yuav tsim cov tshuaj muaj kev nyab xeeb thiab zoo dua thiab cov khoom noj qab haus huv los pab tib neeg noj qab haus huv thiab lub neej zoo.
1. Androgen:
9-hydroxy-4-androstene-3, 17-dione yog ib qho tseem ceeb androgen precursor. Nws hloov mus rau hauv testosterone, dihydrotestosterone thiab lwm yam txiv neej cov tshuaj hormones los ntawm kev ua haujlwm catalytic ntawm ntau cov enzymes. Cov tshuaj hormones no muaj lub luag haujlwm tseem ceeb hauv lub cev ntawm tus txiv neej thiab poj niam, suav nrog kev tswj hwm kev tsim tawm thiab kev sib deev, txhawb kev loj hlob ntawm cov leeg thiab pob txha ntom ntom, tswj cov lipid metabolism, thiab lwm yam.
2. Physical Enhancer:
Vim nws cov bioactivity zoo ib yam li testosterone, 9-hydroxy-4-androstene-3, 17- dione tau siv dav los ntawm cov neeg ncaws pob thiab cov kws tsim lub cev ua ib qho kev ua tau zoo. Ntau qhov kev tshawb fawb tau pom tias kev ntxiv nrog 9-hydroxy-4-androstene-3, 17-dione tuaj yeem txhim kho cov leeg nqaij, kev ua siab ntev thiab lub cev hnyav, thiab txhawb cov leeg nqaij. Txawm li cas los xij, qhov kev siv no tam sim no txwv los ntawm kev siv tshuaj thiab kev tswj kom tsis txhob muaj kev phom sij rau kev noj qab haus huv.
3. Dehydrogenase inhibitors:
9-hydroxy-4-androstene-3, 17-dione yog ib qho muaj zog dehydrogenase inhibitor. Dehydrogenases yog ib tsev neeg tseem ceeb ntawm cov enzymes koom nrog ntau yam txheej txheem metabolic thiab cov tshuaj tiv thaiv. Inhibition ntawm dehydrogenase kev ua haujlwm tuaj yeem thaiv cov tshuaj hormone synthesis thiab metabolic txoj hauv kev, ua rau muaj ntau yam tshuaj. Piv txwv li, inhibiting estrogen metabolism tuaj yeem txo qhov tshwm sim ntawm poj niam cov kab mob xws li mob qog noj ntshav mis thiab mob qog noj ntshav endometrial; inhibiting testosterone metabolism tuaj yeem kho testosterone tsis muaj peev xwm thiab cuam tshuam txog txiv neej cov teeb meem kev loj hlob.
4. Antiestrogens:
9-hydroxy-4-androstene-3, 17-dione tuaj yeem siv los ua tshuaj tiv thaiv estrogen hauv kev kho mob qog noj ntshav. Cov tshuaj estrogen yog ib qho tseem ceeb ua rau mob qog noj ntshav, nrog rau mob qog noj ntshav mis, qog noj ntshav zes qe menyuam, mob qog nqaij hlav endometrial thiab lwm yam. Los ntawm inhibiting cov synthesis thiab metabolism ntawm estrogen, nws cov nyhuv ntawm cov cellular theem yuav txo tau, yog li tswj txoj kev loj hlob ntawm cancer. 9-hydroxy-4-androstene-3, 17-dione tau pom tias muaj kev ua haujlwm zoo los tiv thaiv estrogen thiab tau siv los kho ntau hom qog nqaij hlav estrogen-dependent.
5. Kev noj qab haus huv kev yug me nyuam:
9-hydroxy-4-androstene-3, 17-dione kuj tau siv dav hauv cov tshuaj kho mob qog noj ntshav. Nws tuaj yeem txhim kho kev noj qab haus huv ntawm cov txiv neej thiab poj niam los ntawm kev txhawb nqa testosterone synthesis, txo cov metabolism hauv testosterone, thiab txhim kho lwm yam kev ua me nyuam. Piv txwv li, 9-hydroxy-4-androstene-3, 17-dione tau xav tias yuav ua kom cov phev suav thiab zoo, txhim kho kev ua haujlwm ntawm erectile, thiab txo qis kev coj khaub ncaws, thiab lwm yam teeb meem.
6. Khoom noj khoom haus additives:
9-hydroxy-4-androstene-3, 17-dione kuj tseem siv tau los ua zaub mov ntxiv. Vim nws muaj ntau yam kev ua ub no thiab kev noj zaub mov zoo, nrog rau kev txhawb nqa cov protein synthesis, tswj cov pob txha ceev, tswj cov lipid metabolism, thiab lwm yam, nws feem ntau ntxiv rau cov khoom noj khoom haus, zaub mov noj, dej haus, thiab lwm yam. noj qab nyob zoo.
7. Lwm lub hom phiaj:
Ntxiv rau cov kev siv saum toj no, 9-hydroxy-4-androstene-3, 17-dione kuj tseem muaj qee qhov kev siv tau. Piv txwv li, nws tau txiav txim siab tias nws tuaj yeem siv los kho cov kab mob ntev xws li mob caj dab, ntshav qab zib, thiab kab mob plawv; Nws tseem tuaj yeem siv los ua tus neeg sawv cev tiv thaiv kev ntxhov siab, antioxidant, thiab immunomodulator, thiab lwm yam, txhawm rau txhim kho lub cev tiv thaiv kab mob thiab muaj peev xwm tiv thaiv.
8. Anti-inflammatory thiab anti-allergic: 9-hydroxy-4-androstene-3,17-dione tej zaum yuav muaj cov tshuaj tiv thaiv kab mob thiab tiv thaiv kev ua xua. Nws hloov kho lub cev tiv thaiv kab mob thiab cov kev taw qhia ntawm tes, txo cov lus teb inflammatory thiab cov tsos mob tsis haum. Yog li ntawd, nws muaj peev xwm siv tau rau hauv kev kho mob ntawm cov kab mob inflammatory thiab tsis haum rau cov kab mob xws li mob hawb pob, ua xua rhinitis, thiab daim tawv nqaij o.
9. Anti-tumor: Qee cov kev tshawb fawb tau pom tias 9-hydroxy-4-androstene-3,17-dione yuav muaj kev cuam tshuam rau qee cov qog. Nws tuaj yeem cuam tshuam nrog kev loj hlob thiab kev cuam tshuam ntawm cov qog hlwb, ua rau apoptosis, thiab inhibit qog angiogenesis. Txawm hais tias qhov kev tshawb fawb cuam tshuam tseem nyob hauv nws cov me nyuam mos, qhov sib xyaw no yuav tsum dhau los ua ib hom tshuaj tiv thaiv qog noj ntshav tshiab lossis tshuaj kho mob ntxiv.
10. Kev tiv thaiv kab mob plawv: 9-hydroxy-4-androstene-3, 17-dione tej zaum yuav muaj kev tiv thaiv kab mob plawv. Nws tuaj yeem tswj cov ntshav lipid metabolism, txhim kho cov txheej txheem ntawm arteriosclerosis, thiab txo cov kev pheej hmoo ntawm cov kab mob plawv. Kev tshawb fawb ntxiv tuaj yeem tshawb nrhiav nws cov peev txheej hauv kev tiv thaiv kab mob plawv thiab kev kho mob.
Nws yuav tsum raug sau tseg tias txawm hais tias 9-hydroxy-4-androstene-3, 17-dione muaj ntau yam kev ua ub no thiab muaj peev xwm siv tau, nws txoj kev nyab xeeb thiab cov kev mob tshwm sim tseem xav tau ntxiv. kev tshawb fawb thiab kev ntsuam xyuas. Thaum siv los yog tsim cov khoom muaj feem xyuam, lawv yuav tsum tau siv nruj me ntsis raws li cov cai thiab cov kev cai, thiab ua raws li cov kws kho mob lossis cov kws tshaj lij cov lus qhia.