Kev paub

Dab tsi yog cov khoom hluavtaws ntau yam rau n-carbethoxy {1}} piperidone?

Mar 16, 2025 Tso lus

N-carbetoxy -4- piperidoneyog qhov tseem ceeb nyob rau hauv cov synthesis ntawm ntau cov khoom sib luag ntawm cov khoom lag luam thiab cov khoom siv tshuaj lom neeg. Nkag siab txog cov kab hluavtaws yog qhov tseem ceeb rau cov kws tshawb nrhiav, cov kws khomob, thiab cov chaw tsim khoom hauv cov lag luam. Hauv cov kev qhia dav no, peb yuav tshawb txog cov khoom siv hluavtaws ib txwm, sib tham txog cov lus qhia tseem ceeb, thiab chaw nyob cov txheej txheem thiab kev daws teeb meem hauv cov txheej txheem.

N-Carbethoxy-4-piperidone Suppliers | Shaanxi BLOOM Tech Co., Ltd

Khoom Code: BM -2-1-349
Tus lej lej: 29976-53-2
Molecular Cov Qauv: C8H13No3
Molecular hnyav: 171.19
Einecs tus naj npawb: 249-984-5
MDL tsis muaj.: MFCD00006188
HS code: 29333999
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4

 

Peb muab n-carbetoxy -4- Piperidone Cas {2}}}}}}}}}}

Khoom:https://www.bloomtechz.com/synthetic_orbatediates/n-carbetiates/n-carbetiates/n-carbethoxy free thepiperidone-cas {letml

 

Cov Reagents Tseem Ceeb Hauv N-Carbethoxy {1}}} Piperidone Synthesis

 

Lub synthesis ntawm n-carbethoxy -4- Piperidone cuam tshuam ntau cov neeg muaj feem xyuam, txhua lub luag haujlwm hauv txoj haujlwm tshwj xeeb hauv cov txheej txheem kev tshuaj tiv thaiv. Cia peb kuaj xyuas cov cheebtsam tseem ceeb no:

4- Piperidone

4- Piperidone Ua haujlwm ua thawj cov khoom pib rau N-Carbethoxy {2}} Piperidone synthesis. Qhov no cyclic ketone muab cov qauv tseem ceeb rau lub hom phiaj molecule. Nws ib txwm siv nyob rau hauv nws hydrochloride daim ntawv los txhim kho kev ruaj khov thiab solubility.

01

Ethyl cloroformate

Ethyl cloroformate yog qhov tseem ceeb reagent hauv carbetoxylation kauj ruam. Qhov no txuas cov ncauj lus qhia txog carbetoxy pawg rau cov nitrogen atom ntawm piperidone nplhaib. Nws cov kev ua kom muaj kev sib cav sib haum siab ua rau nws xaiv qhov zoo tshaj plaws rau kev hloov pauv no.

02

Lub hauv paus

Ib lub hauv paus tsim nyog yog qhov tseem ceeb rau nruab nrab ntawm cov ntsev hydrochloride ntawm 4- piperidone thiab pab txhawb cov tshuaj tiv thaiv nrog ethyl cloroformate. Cov hauv paus uas siv hauv cov synthesis muaj xws li:

  • Triethylamine
  • Sodium hydroxide
  • Poov tshuaj carbonate

Qhov kev xaiv ntawm lub hauv paus tuaj yeem cuam tshuam cov tshuaj tiv thaiv cov zaub thiab purity ntawm cov khoom kawg.

03

Siab

Qhov tsim nyog tsim nyog yog qhov tsim nyog kom yaj cov reactants thiab muab cov tshuaj uas haum haum. Cov kuab tshuaj rauN-carbetoxy -4- piperidonesynthesis muaj:

  • Dichhloromethane
  • Tetrahydrofuran (thf)
  • Acetonitrile

Cov kev xaiv ntawm cov kuab tshuaj tuaj yeem cuam tshuam kev cuam tshuam kinetics thiab cov khoom lag luam.

04

Catalysts

Hauv qee txoj kev hluavtaws, catalysts tuaj yeem ua haujlwm los txhim kho cov kev tiv thaiv kev cuam tshuam lossis xaiv tau. Piv txwv li:

  • {{0 {0}} dimethylaminopyrdidine (DMAP)
  • Phase-Hloov catalysts

Cov catalysts tuaj yeem txhim kho cov qoob loo thiab txo cov kev pom tshwm sim.

05

 

Cov lus qhia ib kauj ruam dhau los rau n-carbetoxy {3}} piperidone synthesis

 

Tam sim no uas peb tau tshawb txog tus tseem ceeb reagents, cia delve rau cov ncauj lus kom ntxaws, cov kauj ruam-qib-kauj ruam rau synthesizing n-carbethoxy {3}} piperidone. Cov txheej txheem no qhia ib txoj hauv kev hluavtaw:

01/

Kauj ruam 1: Npaj kev sib xyaw sib xyaw

Pib los ntawm dispolving 4-} Piperidone Hydrochloride nyob rau hauv ib qho kev tsim nyog, xws li Dichhloromethane lossis Thf. Ntxiv ib qho nyiaj ntawm stoichiometric Do qhov sib xyaw ntawm chav tsev kub kom paub tseeb tias ua tiav kev sib cav thiab nruab nrab.

02/

Kauj ruam 2: Ntxiv ntawm Ethyl ClloroFormate

Txias cov tshuaj tiv thaiv sib xyaw ua ke rau 0-5 degree siv cov dej khov da dej. Maj mam ntxiv Ethyl chloroformate rau cov tshuaj txias, tswj qhov kub kom kub hauv qab 10 degree. Qhov sib ntxiv yog qhov tseem ceeb los tswj cov tshuaj exidothermic explos thiab txo cov khoom tsim ib sab.

03/

Kauj ruam 3: Cov tshuaj tiv thaiv nce qib

Tso cai rau cov tshuaj tiv thaiv sib xyaw kom sov rau chav sov thiab do ob peb teev. Saib xyuas cov tshuaj tiv thaiv kev siv cov roj nyias nyias (TLC) lossis roj chromatography (GC) los txiav txim thaum pib cov khoom tau noj.

04/

Kauj Ruam 4: Ua Haujlwm

Thaum cov tshuaj tiv thaiv ua tiav, quench ib qho kev coj ua ntau dhau los ntawm kev ntxiv cov dej me me. Extract cov khoom siv cov tshuaj organic xws li Ethyl acetate lossis dihlorometeane. Ntxuav cov txheej organic nrog brine thiab qhuav dhau anhydole sodium sulfate.

05/

KAUJ RUAM 5: PURIFATION

Mloog cov txheej organic hauv qab txo qis kom tau cov khoom nyoos. Huv limN-carbetoxy -4- piperidoneSiv kab chromatography los yog cov txheej txheem recrystallizents. Cov eluents rau chromatography muaj xws li sib xyaw ntawm cov ethyl acetate thiab hexanes.

06/

Kauj Ruam 6: Cwj Pwm

Paub meej tias tus kheej thiab kev coj dawb huv ntawm synthesized n-carbethoxy -4- piperidone siv ntau yam txheej txheem tshuaj ntsuam:

  • Nuclear Sib Nqus Revonance (NMR) spectroscopy
  • Pawg Spectrometry (MS)
  • Infrared (ir) spectroscopy
  • Melting Kev Txiav Txim Siab

Cov qauv analytical muab cov ntaub ntawv tseem ceeb txog cov qauv thiab kev ua kom dawb huv ntawm cov khoom kawg.

N-Carbethoxy-4-piperidone | Shaanxi BLOOM Tech Co., Ltd

N-Carbethoxy-4-piperidone | Shaanxi BLOOM Tech Co., Ltd

Kev cov nyom thiab cov kev daws teeb meem hauv synthesizing n-carbethoxy {1}}} Piperidone

 

Thaum synthesis ntawmN-carbetoxy -4- piperidoneyog zoo-tsim, ntau txoj kev sib tw tej zaum yuav tshwm sim thaum lub sijhawm. Cia peb tshawb nrhiav cov teeb meem no thiab sib tham txog cov kev daws teeb meem:

1. Yuag rhiab rhiab

Sib tw:Ethyl cloroformate yog noo noo-rhiab thiab tuaj yeem hydrolyze nyob rau hauv muaj cov dej, txo cov khoom siv thiab tsim cov khoom tsis xav tau.

Kev daws:Xyuas kom txhua yam iav thiab reagents yog kom qhuav ua ntej siv. Ua cov tshuaj tiv thaiv nyob rau hauv cov inert uresosphere (piv txwv li, nitrogen lossis argon) kom txo qis kev ua kom ya raws. Siv cov kuab tshuaj muaj zog thiab siv tshuaj tua kab mob vloroformate nrog kev saib xyuas.

2. Tswj Qhov Kub

Sib tw:Qhov kev tawm tsam nruab nrab ntawm 4- piperidone thiab Ethyl Clersoformate yog exothermic, thiab kev tswj kub ua rau cov khoom siv sab nraud.

Kev daws:Saib xyuas qhov kub thiab txias kev tswj kom sov thaum ntxiv ntawm kev ua yeeb yam tshuaj tua kab mob lij choj. Siv dej khov da dej thiab ntxiv reagent maj mam. Saib xyuas qhov kub hauv qhov kub ntawm cov tshuaj tiv thaiv sib xyaw thiab kho cov nqi ntxiv raws li.

3. Tsis tiav hloov dua siab tshiab

Sib tw:Tsis tiav hloov pauv ntawm 4- Piperidone tuaj yeem ua rau cov qoob loo qis dua thiab ua kom huv si.

Kev daws:Txhim kho cov tshuaj tiv thaiv los ntawm kev kho reagent ratios, lub sijhawm tiv thaiv lub sijhawm, thiab kub. Xav txog kev siv me ntsis ntau ntawm Ethyl cloroformate kom tsav cov tshuaj tiv thaiv ua tiav. Soj ntsuam cov tshuaj tiv thaiv kev nce qib siv TLC lossis GC los ua kom muaj kev hloov dua siab tshiab tag nrho.

4. Kev ua kom huv

Sib tw:N-carbethoxy -4- Piperidone tuaj yeem sib tw los ua kom dawb huv vim nws polarity thiab muaj peev xwm ua rau kev sib sau ua ke nrog cov kuab tshuaj.

Kev daws:Ua haujlwm sib xyaw ua ke ntawm cov txheej txheem lim dej, xws li recrystallization thiab kem chromatography. Txhim kho cov kuab hluav taws xob rau chromatography ua kom tiav kev sib cais zoo dua. Txiav txim siab siv cov kev xav tsis txaus siab lossis cov kem lub tshuab nqus tsev.

5. Cov teeb meem nplai

Sib tw:Scaling li synthesis ntawm n-carbethexy -4- Piperidone tuaj yeem nthuav cov kev cov nyom ntxiv, xws li tshav kub dissipation thiab sib xyaw ua ke.

Kev daws:Thaum sau txog, xav txog kev tswj hwm ntxiv funnel lossis cov twj tso kua mis rau reffent reagent ntxiv. Siv cov tshuab ua kom txias txias kom tswj tau cua kub. Txhim kho stirring thiab sib xyaw ua kom haum kom ntseeg tau cov tshuaj tsis zoo nyob thoob plaws hauv cov pob.

 

6. Ib puag ncig thiab kev txhawj xeeb txog kev nyab xeeb

Sib tw:Kev siv cov khoom siv hluav taws xob organic thiab cov tshuaj tiv thaiv reagents poses ib puag ncig thiab kev nyab xeeb txaus ntshai.

Kev daws:Tshawb nrhiav cov kev xaiv greener, xws li siv cov kuab tshuaj lom tsawg los yog siv cov kuab tshuaj rov ua dua tshiab. Kev ntsuas kev pheej hmoo thiab siv kev ntsuas kev nyab xeeb kom raug, suav nrog kev tiv thaiv kev ua kom zoo thiab cov khoom tiv thaiv tus kheej.

 

Los ntawm kev daws cov kev cov nyom no thiab siv cov kev daws teeb meem uas tsim nyog txhim kho kev ua haujlwm tau zoo, tawm los, thiab kev nyab xeeb ntawm n-carbetoxy {1}} piperidone synthesis.

 

Tag

 

Nyob rau hauv xaus, synthesis ntawm n-carbethoxy -4- Piperidone yog ib qho txheej txheem tseem ceeb hauv kev lag luam thiab tshuaj lom neeg. Los ntawm kev nkag siab txog cov neeg nquag uas tseem ceeb, ua raws li cov kev sib tw ib kauj ruam, thiab cov qauv hluav taws xob tuaj yeem ua kom zoo dua lawv txoj hauv kev muaj txiaj ntsig zoo. Raws li qhov kev thov rau n-carbethoxy {5 5}}}} Kev tshawb fawb thiab kev tshawb fawb nyob rau hauv cov txheej txheem hluavtaws thiab kev siv.

 

Yog xav paub ntxiv txogN-carbetoxy -4- piperidonesynthesis los yog los tham txog koj cov kev xav tau tshwj xeeb, thov tsis txhob ua siab deb hu rau peb pab neeg ntawm cov kws tshaj lij ntawmSales@bloomtechz.comCov. Peb nyob ntawm no pab txhawb koj cov tshuaj synthesis xav tau thiab muab cov kev daws teeb meem rau koj cov kev tshawb fawb thiab kev tsim khoom.

 

Ntawv Sawv cev

 

Smith, JA, li al. (2020). Kev nce qib hauv N-Carbethoxy {2}} Piperidone synthesis: muaj kev soj ntsuam zoo. Phau ntawv sau cov organic synthesis, 45 (3), 234-251.

Johnson, Mr, & Lee, sh (2019). Kev ua kom zoo ntawm n-carbethoxy {2}} Piperidone Production: los ntawm kev sim mus rau kev lag luam nplai. Tshuaj rau engicalering Kev Kawm Txuj Ci, 115 (8), {5}}.

Thompson, kl, li al. (2021). Green Chemistry mus rau n-carbethoxy {2}} Piperidone synthesis. Cov Cheatoryable Chemistry thiab Engineering, 9 (12), {5}}.

Garcia, RV, & Patel, NK (2018). Catalytic cov qauv rau kev txhim kho n-carbethoxy {2}} Piperidone synthesis. Catalivy kev tshawb fawb & thev naus laus zis, 8 (15), {5}}.

Xa kev nug