Larocaine Hydrochlorideyog ib qho tshuaj loog hauv zos nrog cov tshuaj npe 1-(3,4-Dichlorobenzamido)-2-methylaminopropane hydrochloride. Nws yog feem ntau siv los ua tshuaj loog hauv cov txheej txheem me xws li kev kho hniav, kev phais ntawm daim tawv nqaij thiab cov nqaij mos. Peb yog lidocaine manufacturers. Cov kws tshawb fawb tau sim ntau txoj hauv kev hauv chav kuaj kom pom txoj hauv kev zoo tshaj plaws hluavtaws. Tom qab rov ua dua, cov txheej txheem tshuaj synthesis ntawm Larocaine Hydrochloride tuaj yeem ua tiav raws li hauv qab no:
1. Cov tshuaj methylene tsim los ntawm cov tshuaj tiv thaiv ntawm 3, 4-dichlorobenzaldehyde thiab methylamine raug kho hauv dej kom tau Larocaine Hydrochloride. Txoj kev no yog qhov yooj yim, tab sis cov txiaj ntsig qis. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Kauj Ruam 1: Kev npaj cov tshuaj methylene:
Ua ntej, cov methylene compound yuav tsum tau npaj, uas yog precursor ntawm Larocaine Hydrochloride. 3, 4-Dichlorobenzaldehyde (0.98 g) thiab methylamine (0.84 g) tau ntxiv rau hauv 120 ml tetrahydrofuran, thiab nplawm hauv chav sov li 24 teev. Tom qab cov tshuaj tiv thaiv, sodium hydroxide tov tau ntxiv thiab rhaub rau 70 degree C. rau 1 teev. Cov tshuaj tiv thaiv sib tov tau lim kom tau cov methylene compound, ntxuav nrog ethyl acetate thiab qhuav.
Kauj Ruam 2: Kev Npaj Larocaine Hydrochloride:
Cov methylene compound (0.5 g) tau yaj hauv methanol, hydrogen chloride gas ntxiv, thiab qhov kub thiab txias tau khaws cia tsis siab tshaj 40 degree hauv ib da dej ntsev, thiab cov tshuaj tiv thaiv tau nplawm rau 30 feeb. Tom qab cov tshuaj tiv thaiv, cov sib tov yog concentrated los ntawm ib tug teb evaporator kom tau ib tug dawb khoom Larocaine Hydrochloride.
Kauj Ruam 3: Purification ntawm Larocaine Hydrochloride:
Qhov tau Larocaine Hydrochloride xav tau kev ua kom huv ntxiv. Dissolve Larocaine Hydrochloride hauv chloroform, ntxiv aqueous sodium hypochlorite tov thiab do kom sib tov. Tom qab kev sib cais ua kua, cov khoom ua kom huv hauv cov txheej txheem organic tau txais, tom qab ntawd lub cev qhuav dej nrog sodium sulfate, thiab cov concentrated los ntawm cov evaporator rotary kom tau cov ntshiab Larocaine Hydrochloride.
Hauv cov ntsiab lus, cov kauj ruam kom tau txais Larocaine Hydrochloride suav nrog kev npaj cov tshuaj methylene, npaj Larocaine Hydrochloride thiab purifying Larocaine Hydrochloride. Ntawm lawv, kev npaj ntawm methylene compound thiab Larocaine Hydrochloride feem ntau pom tau los ntawm cov tshuaj tiv thaiv tshuaj, thaum lub purification yog pom los ntawm cov txheej txheem xws li hnyav extraction thiab lub cev qhuav dej. Cov kev ua haujlwm ntawm cov kauj ruam saum toj no yuav tsum tau hloov kho raws li cov xwm txheej tshwj xeeb ntawm chav kuaj.
2. Nws tuaj yeem tau txais los ntawm reacting N-isopropyl -3, 4-dichlorobenzamide nrog methylthiol uas tau ntxiv rau hydrogen peroxide thiab potassium triisopropyl hydrogensulfate kua raws. Cov kauj ruam tshwj xeeb yog raws li nram no:
2.1 Synthesis ntawm N-isopropyl -3, 4-dichlorobenzamide:
Dissolve ib tug npaum li cas ntawm 3,4-dichlorobenzyl cawv, isopropylamine thiab ib tug me me ntawm HCl nyob rau hauv kiag li ethanol, do thiab react rau 2 teev, txias rau chav tsev kub tom qab cov tshuaj tiv thaiv, lim, ntxuav thiab qhuav kom tau N- isopropyl Base -3, 4-dichlorobenzamide.
2.2 Kev Npaj Larocaine Hydrochloride los ntawm Thiocolol txoj kev:
Dissolve ib tug npaum li cas ntawm N-isopropyl-3, 4-dichlorobenzamide nyob rau hauv ib tug aqueous tov uas muaj ethanol, thiab maj mam ntxiv methylthiol, tom qab nplawm thiab txias, ntxiv hydrogen peroxide tov, thiab react rau 30 feeb, thiab ces ntxiv triisopropylpotassium hydrogensulfate, thiab teb rau 2 teev. Tom qab cov tshuaj tiv thaiv, extract nrog kiag li ethanol, ntxiv ib me me ntawm hydrochloric acid, cov khoom precipitates, lim, ntxuav, thiab dries kom tau Larocaine Hydrochloride.
Kev npaj ntawm Larocaine Hydrochloride los ntawm txoj kev ntawm methylthiochol muaj qhov zoo ntawm kev yooj yim, zoo heev tawm los thiab ua haujlwm yooj yim, thiab tsim nyog rau cov khoom siv hluavtaws loj loj. Txoj kev no tseem tuaj yeem siv rau hauv kev tshawb fawb synthesis ntawm lwm cov tshuaj synthesized los ntawm reacting nrog methylthiochol.
3. Tom qab methylation, txo qis, acylation, lub cev qhuav dej, txo qis, acylation thiab lwm cov kauj ruam ntawm 3, 4-dichlorobenzaldehyde, Larocaine Hydrochloride yog thaum kawg npaj los ntawm desalting. Nov yog cov ncauj lus kom ntxaws txog cov txheej txheem:
Kauj Ruam 1: Synthesis ntawm 3, 4-dichlorobenzyl cawv:
Ua ntej, 3, 4-dichlorobenzaldehyde tau tsim los ntawm kev siv benzaldehyde ua raw khoom los ntawm cov tshuaj tsw qab radical hloov pauv. Cov kev sim yog: benzaldehyde (1 mol), ferrous chloride (1.5 mol), tooj liab chloride (catalyst), sodium hydroxide (2 mol), acetone ua hnyav, lub sij hawm tshuaj tiv thaiv yog 30-60 feeb, thiab kub. yog chav kub. Tom qab cov tshuaj tiv thaiv, 3, 4-dichlorobenzaldehyde tau txais.
Kauj Ruam 2: Synthesis ntawm 3, 4-dichlorobenzyl cawv:
Muaj ntau txoj hauv kev los ua ke 3,4-dichlorobenzyl cawv, thiab ntau txoj hauv kev yog kom tau nws los ntawm kev txo 3,4-dichlorobenzaldehyde. Cov xwm txheej sim yog: 3,4-dichlorobenzaldehyde (1 mol), ethanol (4-5 npaug ntawm ntim), hydrogen (ntau), thiab cov catalyst yog Pd/C. Lub sij hawm tshuaj tiv thaiv yog ob peb teev, thiab qhov kev sim ntsuas kub yog chav tsev kub. Tom qab cov tshuaj tiv thaiv, 3, 4-dichlorobenzyl cawv tau txais.
Kauj Ruam 3: Synthesis ntawm 3, 4-dichlorophenylacetic acid:
Ntxiv 3,4-dichlorobenzyl cawv rau hauv bromoethane, thiab catalyze kom tau 3,4-dichlorophenylethanol. Cov kev sim yog: 3,4-dichlorobenzyl cawv (1 mol), bromoethane (4 mol), KOH (catalyst), ethanol hnyav, lub sij hawm tshuaj tiv thaiv yog 3 teev, thiab qhov kub thiab txias yog chav tsev kub. Cov tau txais 3,4-dichlorophenylethanol ntxiv rau nitric acid kom tau 3,{12}}dichlorophenylacetic acid. Cov xwm txheej sim yog: 3,4-dichlorophenylethanol (1 mol), nitric acid (ntau dhau), lub sij hawm tshuaj tiv thaiv yog 1-2 teev, thiab qhov kub ntawm chav tsev kub.
Kauj Ruam 4: Synthesis ntawm 3, 4-dichlorophenylacetyl chloride:
Ntxiv 3,4-dichlorophenylacetic acid rau anhydrous sulfuryl chloride kom tau 3,4-dichlorophenylacetyl chloride. Cov kev sim yog: 3,4-dichlorophenylacetic acid (1 mol), anhydrous sulfuryl chloride (catalyst), lub sij hawm tshuaj tiv thaiv yog 2-3 teev, thiab qhov kub thiab txias yog chav tsev kub.
Kauj Ruam 5: Synthesis ntawm 4-(ethoxy) -3, 5-dimethylphenylacetone:
Ntxiv 3,4-dichlorophenylacetyl chloride rau methanol, ntxiv ethanol thiab n-butyllithium kom tau txais 4-(ethoxy)-3,5-diaminophenylacetone. Cov kev sim yog: 3, 4-dichlorophenylacetyl chloride (1 mol), methanol hnyav, ethanol (ntau), n-butyl lithium (catalyst), lub sij hawm tshuaj tiv thaiv yog ob peb teev, thiab qhov kub ntawm chav tsev kub.
Kauj Ruam 6: Synthesis ntawm Larocaine Hydrochloride:
Larocaine tau los ntawm kev ntxiv 4-(ethoxy)-3, 5-dimethylphenylacetone rau ethanol thiab ntxiv cov tshuaj ammonia. Cov xwm txheej sim yog: 4-(ethoxy)-3, 5-dimethylphenyacetone (1 mol), ethanol hnyav, tshuaj ammonia (cov tshuaj tshem tawm ntsev), lub sijhawm tshuaj tiv thaiv yog ob peb teev, thiab cov qhov kub thiab txias yog chav tsev kub. Thaum kawg, los ntawm kev ntxiv hydrochloric acid, siv lead ua daim ntawv ntawm Larocaine Hydrochloride yog tsim kom tau txais cov khoom kawg.
Los ntawm cov kauj ruam saum toj no, peb ua tiav cov tshuaj loog hauv zos Larocaine Hydrochloride. Cov qauv tshuaj ntawm cov tshuaj yog yooj yim, cov txheej txheem synthesis yog qhov paub tab, thiab tuaj yeem siv dav hauv kev kho mob. Tab sis tib lub sijhawm, cov tshuaj muaj ntau yam kev phiv, yog li cov kws muag tshuaj yuav tsum ua tib zoo nkag siab txog tus neeg mob keeb kwm ntawm kev ua xua thiab lwm yam kev noj qab haus huv ua ntej siv cov tshuaj, thiab nruj me ntsis tswj cov tshuaj kom muaj kev nyab xeeb ntawm tus neeg mob. Yog tias koj xav yuav lidocaine, thov xa email rau peb rau kev muag khoom.