Feline Infectious Peritonitis yog ib qho kev kuaj mob hnyav nrog ob peb txoj kev kho mob.GS-441524 IB Kev kho mob tau hloov pauv FIP kev tswj hwm los ntawm ncaj qha ntsib tus kab mob rov ua dua tshiab. Qhov no nucleoside analog inhibits viral enzymes, cuam tshuam tus kabmob coronavirus ntau hauv cov hlwb. Los ntawm kev tsom mus rau cov txheej txheem kab mob tshwj xeeb ntawm qib cellular, qhov kev kho no tso cai rau lub cev tiv thaiv kab mob feline kom rov qab tswj tau thiab kis kab mob. Kev nkag siab txog cov txheej txheem molecular no pab cov tswv tsev miv txiav txim siab txog kev noj qab haus huv rau lawv cov tsiaj.
GS-4415 24
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-1-001
GS-441524 CAS Nr .: 1191237-69-0
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Peb muab gs-441524, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-kev tshawb nrhiav-only/gs-441524-fip.html
Yuav ua li cas GS-441524 FIP Mechanistically Blocks Feline Coronavirus RNA Replication Hauv Cells?
GS-441524 fip zoo ib yam li ntuj adenosine nucleosides, ua kom nkag mus los ntawm nucleoside thauj cov proteins nyob rau hauv cell membranes. Nyob rau hauv lub hlwb, sequential phosphorylation hloov nws mus rau active triphosphate daim ntawv. Equilibrative nucleoside transporters pab txhawb cellular uptake, cia cov compound mus cuag cov kab mob replication site. Nws muaj peev xwm nkag mus rau ntau yam ntaub so ntswg, suav nrog cov kev tiv thaiv los ntawm kev tiv thaiv kab mob lom, ua kom cov kev kho mob kom ncav cuag cov kab mob kis thoob plaws hauv lub cev.
Kev cuam tshuam nrog RNA-Dependent RNA Polymerase
Lub hom phiaj tseem ceeb yog tus kab mob RNA- nyob ntawm RNA polymerase, qhov tseem ceeb rau tus kabmob coronavirus. GS-441524 triphosphate yog muab tso rau hauv RNA chains loj hlob es tsis txhob ntawm ntuj adenosine, ua rau cov saw txiav los yog cov kab mob tsis zoo RNA ntau lawm. Molecular sib txawv ntawm tus kab mob thiab tus tswv tsev polymerases conferencing kev xaiv, nrog feline coronavirus RdRp khi cov analog yooj yim dua li mammalian polymerases. Qhov kev xaiv no inhibition maximizes antiviral kev ua si thaum txo tus tswv tsev cell puas.
Kev cuam tshuam ntawm Viral RNA Synthesis Dynamics
Dhau ntawm chain termination,GS-441524 IBtxo cov txheej txheem polymerase, qeeb RNA strand elongation los ntawm steric hindrance. Qhov no txo qis tag nrho cov kab mob genome ntau lawm txawm tias qhov kev txiav tam sim ntawd tsis tshwm sim. Cov compound kuj nce kev hloov pauv thaum lub sij hawm RNA synthesis, ua rau cov kab mob kis tsis zoo. Txo kom muaj nuj nqis thiab qhov zoo ntawm tus kab mob RNA ua rau muaj kev cuam tshuam tus kabmob coronavirus, ua rau lub cev tiv thaiv kab mob feline kom tshem tawm cov kab mob ntxiv.
GS-441524 FIP thiab nws lub luag haujlwm hauv kev cuam tshuam cov kab mob Polymerase kev ua haujlwm ntawm qib Molecular
Lub hauv paus ntawm Polymerase Inhibition
Cov kev tshawb fawb Crystallographic qhia tau hais tias yuav ua li cas nucleoside analogs haum rau cov kab mob coronavirus polymerase cov chaw nquag. GS-441524 triphosphate zoo ib yam li tej yam ntuj tso substrates, tso cai rau polymerase txais thaum tiv thaiv ib txwm catalytic muaj nuj nqi. Hydrogen bonds thiab hydrophobic kev sib cuam tshuam stabilize lub analog nyob rau hauv lub active site. Cov enzyme tsis tuaj yeem ntxiv cov nucleotides tom ntej, uas ua rau cov saw hlau txiav tawm ntxov ntxov lossis tsis ua haujlwm RNA cov khoom, piav qhia txog kev muaj peev xwm tiv thaiv kab mob nrog kev cuam tshuam ntawm cellular tsawg.
Kinetic Parameters ntawm Viral Polymerase Inhibition
Enzyme kinetics qhia kev sib tw inhibition zog, nrog GS-441524 triphosphate sib tw ncaj qha nrog adenosine triphosphate rau kev koom ua ke rau hauv kab mob RNA. Inhibition nyob ntawm qhov piv ntawm inhibitor rau natural substrate concentrations. Kev siv tshuaj kho mob lub hom phiaj kom tswj tau cov kab mob hauv lub cev GS-441524 triphosphate qib nyiam kev koom ua ke analog. Polymerase catalytic kev ua ub no txo qis proportionally nrog nce analog concentration, ua kom pom kev pom kev noj tshuaj uas ua rau kom muaj txiaj ntsig zoo tshaj plaws thaum txo cov kev mob tshwm sim.
Conformational Hloov Induced los ntawm Analog Binding
GS-441524 triphosphate binding induces conformational hloov nyob rau hauv viral polymerase, cuam tshuam tsis tau tsuas yog lub active site tab sis kuj cov cheeb tsam nyob ze koom nrog hauv template khi thiab cov khoom tso tawm. Cov kev tshawb fawb Spectroscopic qhia txog kev hloov pauv cov protein ntau raws li kev sib koom ua ke, qhia txog cov teebmeem dhau ntawm qhov chaw ua haujlwm polymerase. Cov teebmeem allosteric propagates los ntawm cov qauv polymerase, destabilizing tag nrho cov replication complex thiab ua rau tag nrho cov inhibitory potency, ua rau txo tus kab mob loads soj ntsuam.
Vim li cas GS-441524 FIP Targets Intracellular Viral Replication Pathways dua li cov tsos mob sab nraud?
Direct Antiviral Action Versus Symptomatic Management
GS-441524 fip sawv cev rau kev hloov pauv hloov pauv los ntawm kev tsom ncaj qha rau cov kab mob uas ua rau muaj kab mob ntau dua li kev tswj hwm cov tsos mob thib ob. Kev tswj hwm FIP yav dhau los tau tsom mus rau qhov mob, ua kom cov kua dej ntau ntxiv, thiab lub cev tsis ua haujlwm yam tsis muaj kev cuam tshuam cov kab mob sib kis. Cov kab mob no- qhia txoj hauv kev muaj peev xwm kho tau tiag tiag es tsis yog cov tsos mob tshwm sim ib ntus. Txo tus kab mob rov ua dua tso cai rau cov txheej txheem inflammatory kom txo qis, granulomatous lesions kho, thiab effusions los daws los ntawm kev tiv thaiv kab mob sib kis.
Intracellular Accumulation thiab ncua kev ua haujlwm
Phosphorylation trapsGS-441524 IBnyob rau hauv cov kab mob kab mob, tsim ib lub reservoir ntawm active compound. Cov triphosphate uas tau them ntau heev tsis tuaj yeem hla cov cell membranes yooj yim, ua rau cov tshuaj tiv thaiv kab mob ntev ntev ntawm cov koob tshuaj. Intracellular ib nrab-lub neej tseem ceeb tshaj plasma ib nrab-lub neej, tswj cov tshuaj tiv thaiv kab mob txawm tias cov ntshav poob qis. Qhov kev tiv thaiv tsis tu ncua no tiv thaiv kev rov ua dua tshiab thiab txhawb nqa ib zaug -ib hnub lossis ob zaug - cov sijhawm noj txhua hnub. Maj mam txo cov kab mob kis tau yooj yim ua kom lub cev tiv thaiv kab mob tshem tawm ntawm kev kis kab mob.
Specificity rau Virally Infected Cells
Tag nrho cov hlwb phosphorylate GS-441524 fip, tab sis cov tshuaj tiv thaiv kab mob tshwm sim tsuas yog hauv cov kab mob kis kab mob uas muaj cov hom phiaj polymerase. Cov hlwb noj qab haus huv tsis muaj tus kab mob RdRp, yog li kev sib xyaw ua ke analog tsis cuam tshuam rau lawv txoj haujlwm. Qhov kev xaiv ntuj no piav qhia txog qhov sib xyaw ua ke kom muaj kev nyab xeeb zoo. Cov kab mob kis tau rov ua dua tus mob coronavirus muaj ntau tus kab mob polymerase, tsim kom muaj ib puag ncig biochemical qhov twg GS-441524 triphosphate tuaj yeem cuam tshuam kev rov ua dua tshiab thaum tiv thaiv cov hlwb noj qab haus huv los ntawm kev puas tsuaj yam tsis tsim nyog.
Mechanism of Cellular Uptake thiab Activation of GS-441524 FIP nyob rau hauv cov ntaub so ntswg kab mob
Nucleoside Transporter-Kev nkag nruab nrab
GS-441524 fip nkag mus rau hauv hlwb los ntawm nucleoside transporters ib txwm koom nrog hauv kev thauj mus los ntawm nucleoside. Ob leeg concentrative thiab equilibrative nucleoside transporters pab txhawb cellular uptake. Cov ntaub so ntswg tshwj xeeb thauj cov lus qhia cuam tshuam rau kev faib khoom sib xyaw, nrog ntau dua cov khoom hauv nruab nrog cev nthuav qhia ntau tus neeg thauj khoom. Cov qauv kev faib tawm no ua kom cov tshuaj mus txog qhov chaw kis kab mob thoob plaws ntau lub cev, txhawb nqa nws cov txiaj ntsig tiv thaiv ob daim ntawv ntub thiab qhuav ntawm FIP.
Sequential Phosphorylation Cascade
Intracellular phosphorylation pib los ntawm peb cov kauj ruam ua ntu zus los ntawm cov cellular kinases. Thawj phosphorylation rau monophosphate feem ntau yog tus nqi - txwv, ua raws li sai dua ntxiv ntawm pawg thib ob thiab thib peb phosphate. Kinase enzyme abundance sib txawv ntawm hom cell, cuam tshuam rau kev ua kom muaj zog. Cov cell uas muaj cov metabolism hauv siab yuav ua rau phosphorylate GS-441524 zoo, ua kom muaj txiaj ntsig zoo triphosphate. Qhov kev ua kom sib txawv no cuam tshuam rau cov ntaub so ntswg tshwj xeeb cov tshuaj tiv thaiv kab mob thiab piav qhia txog cov tsos mob sib txawv.
Retention thiab Stability ntawm Activated Metabolite
Daim ntawv tsis zoo triphosphate tsis tuaj yeem cuam tshuam thoob plaws cell membranes, tsim kom muaj ib qho chaw cia khoom intracellular. Txhua molecule inhibits viral polymerase rau lub sijhawm txiav txim siab los ntawm triphosphate stability. Intracellular ib nrab- kev tshawb fawb txog lub neej qhia tau hais tias ntev GS-441524 triphosphate retention, ua rau muaj kev cuam tshuam los tiv thaiv kab mob. Cellular phosphatase tuaj yeem dephosphorylate qhov sib xyaw, nrog rau dephosphorylation tus nqi sib txawv los ntawm hom cell thiab lub xeev metabolic, cuam tshuam rau lub sijhawm tiv thaiv kab mob thiab kev coj noj coj ua kom zoo dua cov tswv yim.
Yuav ua li cas GS-441524 FIP cuam tshuam nrog Viral Genome Copy los txwv kev kis kab mob?
Ua ntej lub sij hawm saws tes Termination Mechanisms
Thaum tus kab mob RNA polymerase ntxiv GS-441524 triphosphate rau ib qho RNA strand uas loj hlob, cov hloov nucleoside tsis muaj cov tshuaj uas xav tau los ntxiv nucleotides ntxiv. Muaj 3'-hydroxyl pawg ntawm cov nucleotides ntuj uas ua rau cov phosphodiester daim ntawv cog lus uas txuas ib nucleotide mus rau tom ntej hauv RNA saw. Vim hais tias cov analog tau hloov nws cov qauv, qhov txuas tseem ceeb no tsis tuaj yeem tsim, uas nres cov txheej txheem synthesis thaum ntxov. Vim tias cov txheej txheem no, cov khoom tsis tiav RNA uas tau tsim tsis tuaj yeem ua haujlwm raws li kab mob genomes lossis tus xa xov RNAs.
Raws li tus kab mob polymerase sim thiab ua tsis tau ntau dhau los ua kom tag nrho - ntev RNA, cov khoom luv RNA no tsim nyob rau hauv cov kab mob uas muaj kab mob.Tej zaum yuav muaj kev tiv thaiv kab mob hauv cov hlwb uas tuaj yeem pom cov nucleic acids txawv txav thaum muaj ntau RNA molecules tawg nyob ib ncig ntawm. Qee qhov kev tshawb fawb qhia tau hais tias tus kab mob RNAs uas tsis ua haujlwm zoo tuaj yeem ua rau muaj kev cuam tshuam interferon, uas tuaj yeem ua rau cov tshuaj tiv thaiv kab mob ncaj qha ntawm polymerase inhibition tseem muaj zog. Kev tshem tawm cov saw muaj ntau yam cuam tshuam uas ua rau sab hauv cov hlwb tsis zoo rau tus kab mob rov ua dua tshiab, mus dhau qhov tsuas yog txo qis kev tsim cov genome.
Mutagenic Effects rau Viral Populations
Txawm hais tias ntxiv GS-441524 triphosphate tsis nres RNA ntau lawm tam sim ntawd, qhov tseeb tias nws yog nyob rau hauv cov kab mob kis tau ua rau nws muaj peev xwm ua rau muaj qhov tsis zoo tshwm sim thaum lub sijhawm rov ua dua tom qab. Nws yog qhov ua tau tias lub hauv paus hloov pauv yuav tsis sib haum nrog cov nucleotides uas muaj qhov sib ntxiv, uas tuaj yeem ua yuam kev thaum RNA siv los ua tus qauv rau kev sib txuas tshiab. Cov nyhuv no hloov cov noob kom muaj ntau qhov yuam kev thaum cov kab mob luam lawv tus kheej. Qhov no ua rau cov kab mob tawg uas tsis tuaj yeem ua rau muaj mob.
Kev sib xyaw ua ke ntawm kev puas tsuaj los ntawm ntau qhov sib txuas ua ke ua rau tus kab mob tsis haum rau lub sijhawm.Lub tswv yim ntawm "kev tuag mutagenesis" piav qhia tias cov zej zog tus kab mob no ploj mus li cas thaum muaj kev hloov pauv ntau dhau. Zoo li txhua tus kab mob RNA, tus mob coronaviruses tuaj yeem tswj tau qee yam ntawm cov noob caj noob ces. Tab sis ib zaug qhov kev hloov pauv mus dhau ib qho taw qhia, tus kab mob tsis tuaj yeem txuas ntxiv kev hloov pauv tsis zoo.GS-441524 IBtej zaum yuav nce tus nqi ntawm tus kab mob hloov pauv siab tshaj qhov tseem ceeb no, tshwj xeeb tshaj yog tias nws tau khaws cia ntawm qib kho mob thoob plaws hauv chav kho mob. Kev thaiv ncaj qha ntawm RNA synthesis ua haujlwm nrog cov caj ces degradation ntawm cov neeg kis kab mob txhawm rau txhawm rau txhawm rau tshem tawm cov kab mob.
Txo cov kab mob kis kab mob
Thaum cov saw txiav txiav thiab mutagenesis ua haujlwm ua ke, lawv txo qis tus nqi ntawm cov kab mob sib kis uas cov hlwb ua. Nrog rau txhua lub voj voog rov ua dua, tus naj npawb ntawm cov kab mob uas tuaj yeem tua ntau lub hlwb poob, ua rau cov saw hlau hloov mus rau hauv lub cev. Tus miv lub cev tiv thaiv kab mob tuaj yeem tiv thaiv tus kab mob zoo dua vim tias tus kab mob tsis ua ntau npaum li ntawd. Cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv kab mob ntawm tes uas yav dhau los dhau los ntawm tus nqi ntawm cov kab mob tau tsim tam sim no tuaj yeem ua tiav thiab tshem tawm cov kab mob uas tseem nyob ib puag ncig.
Tus nqi uas tus kab mob kis tau poob thaum kho nrog GS-441524 fip qhia tias cov tshuaj cuam tshuam li cas rau kev rov ua dua ntawm tus kab mob. Feem ntau, kev ntsuas tus kab mob RNA hauv cov ntshav lossis effusions qhia tias qib qis qis dua nyob rau hauv cov hnub mus rau lub lis piam kho. Tus nqi ntawm kev txo qis yog nyob ntawm tej yam xws li thawj kis kab mob, koob tshuaj, thiab tus neeg tus kheej pharmacokinetics. Feem ntau, kev kho mob rov qab tshwm sim tib lub sijhawm thaum tus kab mob kis mus. Ua npaws ploj mus thiab kev tshaib kev nqhis nce mus ua ntej qhov ntsuas qhov ntsuas thiab cov txiaj ntsig kev ntsuas rov qab mus rau qhov qub. Qhov tseeb tias kev tiv thaiv kab mob thiab kev kho mob tshwm sim nyob rau lub sijhawm sib txawv txhawb txoj kev coj tus kab mob.
Xaus
Cov txheej txheem molecular tom qabGS-441524 IBTxoj kev kho yog ib qho piv txwv ntawm yuav ua li cas cov tshuaj tiv thaiv kab mob tuaj yeem siv rau hauv cov tshuaj tsiaj. Cov tshuaj no xaiv txwv tsis pub kis tus kabmob coronavirus thaum tawm hauv cov txheej txheem cellular ib leeg. Nws ua qhov no los ntawm kev ua kom zoo dua ntawm cov kev tsis haum xeeb hauv tus kabmob coronavirus replication machinery. Los ntawm kev ncaj qha polymerase inhibition, chain termination, thiab mutagenesis, nws txoj kev tsim cov nyom rau cov kab mob sib kis uas nyuaj rau cov kab mob mus ncig. Paub txog cov tswv yim kev tshawb fawb no ua rau cov tswv miv nkag siab zoo dua vim li cas cov phiaj xwm kho mob ua haujlwm thiab nws tseem ceeb npaum li cas los ua raws li lawv.
Targeted atomic tshuaj hloov FIP los ntawm kev tuag mus rau qhov tsim nyog, tshaj tawm kev ntseeg tsim nyog rau kev rov zoo. Nkag siab txog cov kab mob- qhia kev kho mob ua kom muaj kev kho mob. Cov lus nug txuas ntxiv txog yuav ua tiav cov txiaj ntsig. GS-441524 fip txoj kev yeej qhia txog cov tshuaj atomic complex ua haujlwm hauv cov tsiaj, qhib qhov kev xav tau rau cov kab mob uas tsis tuaj yeem kho tau thiab cov tshuaj kho tsiaj raws li kev tshawb fawb.
FAQ
1. Dab tsi ua rau GS-441524 fip txawv ntawm kev kho FIP ib txwm?
GS-441524 fip yog tshwj xeeb muaj ntau haiv neeg los ntawm lwm cov tswv yim txij li nws lub hom phiaj ntawm cov cuab yeej siv kev kis kab mob siv los ua kom lawv tus kheej sib npaug tshwj xeeb ntawm kev ncaj ncees kho cov lus qhia. Yav dhau los, khaus khaus thiab sab cuam tshuam tau tswj nrog corticosteroids thiab kev saib xyuas zoo. Qhov no tau muab kev txo qis me ntsis yam tsis tau kho tus mob nws tus kheej. Qhov nucleoside analog no nres cov kab mob RNA polymerase uas ua rau tus kabmob coronavirus, uas txwv tsis pub tus kabmob kis ntawm nws qhov chaw. Qhov no npaj tau tso cai rau kev tshem tawm cov kab mob tiag tiag ntawm cov kev mob tshwm sim tsis zoo, uas hloov FIP los ntawm tus kab mob uas txaus ntshai rau ib qho uas tuaj yeem kho tau thiab muaj qhov muaj sia nyob siab.
2. Ntev npaum li cas GS-441524 fip kev kho mob feem ntau txuas ntxiv ua ntej miv pom kev txhim kho?
Feem ntau cov miv uas tau txais cov txiaj ntsig zoo ntawm GS-441524 fip tshwm sim ntau qhov kev kho mob hloov hauv qhov pib nrog lub lim tiam ntawm kev kho mob. Hauv 24 mus rau 48 teev, kub taub hau feem ntau tsis tuaj thiab miv pib noj ntau dua. Nyob rau ob peb lub lis piam tom ntej no, cov txiaj ntsig ntawm kev kuaj ntshav zoo li qe qe dawb thiab cov cim ua rau khaus pib rov qab mus rau qhov qub. Nyob ntawm seb tus mob hnyav npaum li cas thiab tus neeg mob tau zoo npaum li cas, kev kho mob tag nrho tuaj yeem zaum kawg txog 12 lub lis piam. Qhov ntev ntawm kev kho mob yog nyob ntawm seb muaj kab mob ntau npaum li cas. Kev kho mob pib mus txog thaum tsis tuaj yeem pom tus kab mob RNA thiab tseem tsis tuaj yeem nyob tom qab lub sijhawm. Backslide yuav tshwm sim ntau dua yog tias koj nres kev kho mob ua ntej ntev, uas yog vim li cas nws yuav tsum tau qhwv cov kev kho mob tiag tiag tom qab cov tsos mob ploj mus.
3. Puas yog GS-441524 fip ua haujlwm rau ob daim ntawv ntub thiab qhuav ntawm FIP?
GS-441524 fip ua haujlwm tawm tsam ob qho tib si tsis tau khaws cia (dawb) thiab tsis muaj dej (qhuav) hom FIP, txawm tias qhov tseeb tias tus nqi teb yuav txawv rau txhua hom. Txij li thaum lub compound tuaj yeem nkag mus rau hauv cov ntaub so ntswg dav, nws ua rau tsis muaj kev ntseeg siab tias nws nkag mus rau places qhov chaw uas kis tau tus kab mob reproduce, txawm zoo li cas ntawm kev txom nyem yog raug kho. Raws li cov hluav taws xob tsis tuaj yeem thiab cov cim ua kom hnyav zuj zus mus, damp FIP feem ntau tshwm sim sai dua kev kho mob. Nrog FIP qhuav, uas ua rau granulomatous qog nyob rau hauv ntau yam kabmob, nws yuav siv sij hawm ntev rau kev kho mob hloov mus rau tag nrho. Neurological thiab qhov muag suav nrog, uas tam sim no thiab tom qab ntawd xav tias muaj ntau hom FIP qhuav, tuaj yeem kho tau, txawm tias lawv yuav xav tau kev kho mob ntev dua thiab saib xyuas qee yam teeb meem tib lub sijhawm.
Koom Tes Nrog BLOOM TECH: Koj Trusted GS-441524 fip Supplier rau Veterinary Applications
BLOOM TECH sawv ua tus thawj cojGS-441524 IBtus neeg muag khoom nrog ntau tshaj 12 xyoos ntawm kev txawj ntse hauv cov tshuaj intermediates thiab organic synthesis. Peb GMP-cov chaw tsim khoom tau lees paub, hla 100,000 square metres thiab tau lees paub los ntawm US-FDA, EU, JP, thiab CFDA cov tub ceev xwm, xyuas kom cov kws kho mob- qib zoo uas ua tau raws li cov qauv thoob ntiaj teb. Raws li cov neeg tsim khoom tsim nyog rau 24 lub koom haum kws tshuaj thiab kev tshawb fawb thoob ntiaj teb, peb muab kev lees paub zoo los ntawm triple-theem kev soj ntsuam raws tu qauv: Hoobkas kuaj, QA / QC department kuaj xyuas, thiab thib peb- ntawv pov thawj los ntawm cov koom haum tso cai.
Peb qhov kev cog lus rau kev sib koom tes ntev -lub sij hawm sib koom tes txhais tau tias tus nqi pob tshab nrog cov nyiaj tau los ruaj khov, cov sij hawm ua cov khoom raug taug qab los ntawm peb lub ERP platform, thiab ua tiav cov ntaub ntawv rau kev lis kev cai tsis sib haum xeeb. Txawm hais tias koj sawv cev rau cov tuam txhab tshuaj, cov chaw tshawb fawb, lossis cov kws kho tsiaj cov khoom lag luam nrhiav kev nkag mus rau siab -purity GS-441524 fip, BLOOM TECH muab qhov zoo, sib xws, thiab kev tswj xyuas raws li koj cov kev xav tau. Hu rau peb pab neeg ntawmSales@bloomtechz.comlos tham txog koj cov kev xav tau tshwj xeeb thiab nrhiav seb peb cov kev txawj ntse thiab kev tsim khoom muaj peev xwm tuaj yeem pab txhawb koj cov tswv yim kws kho tsiaj.
Cov ntaub ntawv
1. Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho cov miv nrog ib txwm tshwm sim feline infectious peritonitis. Phau ntawv Journal of Feline Medicine and Surgery. 2019;21(4):271-281.
2. Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. Cov nucleoside analog GS-441524 muaj zog tiv thaiv kab mob feline infectious peritonitis (FIP) hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
3. Dickinson PJ, Bannasch M, Thomasy SM, Murthy VD, Vernau KM, Liepnieks M, Montgomery E, Knickelbein KE, Murphy B, Pedersen NC. Kev kho tshuaj tua kab mob siv cov adenosine nucleoside analogue GS-441524 hauv cov miv uas tau kuaj pom tus kab mob neurological feline kis kab mob peritonitis. Phau ntawv Journal of Veterinary Internal Medicine. 2020;34(4):1587-1593.
4. Krentz D, Zenger K, Alberer M, Felten S, Bergmann M, Dorsch R, Matiasek K, Walter B, Fischer A, Hofmann-Lehmann R, Kolberg L, Meli ML, Spiri AM, Hartmann K. {Kho miv uas muaj kab mob feline nrog ntau yam kab mob periton} GS-4415 24. Tus kab mob . 2021; 13(11): 2228.
5. Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E., Truyk. Feline infectious peritonitis: ABCD cov lus qhia txog kev tiv thaiv thiab kev tswj xyuas. Phau ntawv Journal of Feline Medicine and Surgery. 2009;11(7):594-604.
6. Jones S, Novicoff W, Nadeau J, Evans S. Unlicensed GS-441524-Zoo li tshuaj tua kab mob tuaj yeem ua tau zoo rau kev kho mob hauv tsev ntawm feline infectious peritonitis. Tsiaj. 2021;11(8):2257.