18 -Glycyrrhetinic AcidNws yog ib qho ntuj glucocorticoid receptor agonist, uas tuaj yeem khi rau intracellular glucocorticoid receptors thiab ua raws li cov teebmeem ntawm endogenous glucocorticoids, yog li ua rau muaj kev tiv thaiv kev tiv thaiv thiab kev tiv thaiv kab mob. Tsis tas li ntawd, 18 -Glycyrrhetinic Acid tuaj yeem siv nws cov tshuaj tiv thaiv kab mob los ntawm ntau txoj hauv kev, suav nrog inhibiting tus kab mob ntxeem tau, rov ua dua, hloov pauv thiab tso tawm.
18 -Glycyrrhetinic Acid (18 -glycyrrhizic acid) muaj ntau yam kev ua haujlwm lom neeg thiab tshuaj. Hauv qab no yog cov ncauj lus kom ntxaws txog nws cov kev siv tseem ceeb:
1. Cov tshuaj tiv thaiv kab mob: 18 -Glycyrrhetinic Acid yog cov tshuaj tiv thaiv kab mob dav dav uas tuaj yeem tiv thaiv ntau yam kab mob (xws li kab mob siab B, kab mob tib neeg tiv thaiv kab mob, kab mob khaub thuas, thiab lwm yam). Cov kev tshawb fawb tau pom tias 18 -Glycyrrhetinic Acid tuaj yeem cuam tshuam cov txheej txheem ntawm tus kab mob ntxeem tau, rov ua dua, hloov pauv thiab tso tawm, yog li siv nws cov tshuaj tiv thaiv kab mob.
2. Cov nyhuv Antioxidant: 18 -Glycyrrhetinic Acid muaj cov nyhuv antioxidative pom tseeb, uas tuaj yeem tshem tawm cov dawb radicals thiab txo cov oxidative puas tsuaj, yog li tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Cov kev tshawb fawb tau pom tias 18 -Glycyrrhetinic Acid tuaj yeem txo cov cim oxidative kev ntxhov siab (xws li MDA, ROS, thiab lwm yam), ua rau muaj kev ua haujlwm ntawm cov enzymes antioxidant (xws li SOD, CAT, thiab lwm yam), yog li ua rau nws cov nyhuv antioxidant.
3. Anti-inflammatory effect: 18 -Glycyrrhetinic Acid muaj cov nyhuv anti-inflammatory pom tseeb, uas tuaj yeem cuam tshuam kev tsim cov inflammatory mediators thiab tshwm sim ntawm inflammatory teb, yog li txo cov tsos mob inflammatory. Cov kev tshawb fawb tau pom tias 18 -Glycyrrhetinic Acid tuaj yeem cuam tshuam kev tsim tawm ntawm ntau yam inflammatory mediators (xws li IL-1 , TNF- , thiab lwm yam), txo cov inflammatory cell infiltration thiab cov ntaub so ntswg puas, yog li exerting nws anti-inflammatory nyhuv.
4. Cov nyhuv los tiv thaiv qog: 18 -Glycyrrhetinic Acid muaj qhov pom tseeb los tiv thaiv qog noj ntshav, uas tuaj yeem cuam tshuam kev loj hlob, kev loj hlob thiab cuam tshuam ntawm cov qog hlwb, yog li siv cov nyhuv tiv thaiv qog. Cov kev tshawb fawb tau pom tias 18 -Glycyrrhetinic Acid tuaj yeem cuam tshuam qhov kev loj hlob thiab kev loj hlob ntawm ntau lub qog hlwb (xws li mob qog noj ntshav mis, mob ntsws cancer, mob qog noj ntshav, thiab lwm yam), ua rau cov qog cell apoptosis thiab cell voj voog raug ntes, yog li ua rau nws cov tshuaj tiv thaiv. - qog nyhuv.
5. Hepatoprotective nyhuv: Txhawm rau txo lub siab cell puas, txo alanine transferase (AST) thiab pyruvate transferase hauv daim siab, inhibit oxidative stress thiab inflammatory teb ntawm daim siab hlwb, thiab txo lub siab puas thiab fibrosis. Nws yog dav siv nyob rau hauv kev kho mob daim siab kab mob thiab daim siab tiv thaiv cov khoom.
6. Cov nyhuv hypoglycemic: 18 -Glycyrrhetinic Acid tuaj yeem txhawb kev tsim cov tshuaj insulin thiab cov ntaub so ntswg rhiab heev rau insulin, yog li txo cov ntshav qab zib. Nws yog dav siv hauv kev kho mob ntshav qab zib thiab khoom noj qab haus huv.
7. Cov ntshav lipid-txo cov nyhuv: 18 -Glycyrrhetinic Acid tuaj yeem txo cov roj cholesterol tag nrho, triacylglycerol thiab cov roj lipoprotein tsawg ntom ntom, yog li txo qhov kev pheej hmoo ntawm cov kab mob plawv. Nws yog dav siv hauv kev kho mob hyperlipidemia thiab khoom noj qab haus huv.
8. Cov nyhuv tshuaj pleev ib ce: 18 -Glycyrrhetinic Acid tuaj yeem txhawb kev sib txuas ntawm collagen thiab rov tsim dua tshiab ntawm daim tawv nqaij, thiab muaj lub luag haujlwm ntawm daim tawv nqaij moisturizing, whitening thiab anti-aging. Nws yog dav siv hauv tshuaj pleev ib ce thiab cov khoom tu tawv nqaij.
18 -Glycyrrhetinic Acid (18 -glycyrrhetinic acid) yog ib qho triterpene compound nrog ntau yam tshuaj ua haujlwm, uas tuaj yeem tau txais los ntawm licorice extract lossis tshuaj synthesis. Cov hauv qab no yog qee qhov kev paub txog hluavtaws ntawm 18 -glycyrrhizic acid: Nws tuaj yeem ua kom huv ntawm licorice extract. Cov hauv qab no yog cov txheej txheem yooj yim rau kev rho tawm 18 -Glycyrrhetinic Acid los ntawm licorice extract:
(1) Kev npaj ntawm licorice extract: lub hauv paus qhuav hmoov ntawm licorice yog tov nrog ib tug tsim nyog tus nqi ntawm cov dej, thiab kev khiav hauj lwm xws li rov qab soaking, pom, concentration thiab ziab yog ua los npaj licorice extract.
(2) Pretreatment: Ntxiv licorice extract rau ethanol lossis acetone, thiab tshem tawm impurities thiab tshuaj soluble hauv ethanol lossis acetone los ntawm cua sov thiab nplawm.
(3) Kev sib cais thiab kev ua kom huv: ntxiv cov kua txiv hmab txiv ntoo ua ntej tso rau hauv cov kua-kua dispenser, thiab ntxiv qhov tsim nyog ntawm cov kuab tshuaj organic (xws li n-hexane lossis ether) rau kev sib cais thiab purification. Cov txheej txheem organic tau sib cais, thiab cov kuab tshuaj organic tau raug tshem tawm kom tau txais cov khoom ua ntej purified ntawm 18 -Glycyrrhetinic Acid.
(4) Crystallization: Dissolve cov khoom ua ntej purified hauv ethanol los yog acetone, thiab recrystallize kom tau cov khoom crystallized ntawm 18 -Glycyrrhetinic Acid.
(5) Kev tshawb nrhiav khoom ntiag tug: Siv cov txheej txheem spectroscopic (xws li huab hwm coj spectrometry thiab infrared spectroscopy) txhawm rau txheeb xyuas thiab lees paub cov qauv thiab kev huv ntawm 18 -Glycyrrhetinic Acid.
18 -Glycyrrhetinic Acid (18 -glycyrrhizic acid) yog ib qho triterpenoid uas muaj qee yam reactive zog. Cov nram qab no yog nws lub ntsiab reactivity zog:
1. Acidity thiab alkalinity: 18 -Glycyrrhetinic Acid muaj carboxyl pawg (-COOH), yog li nws muaj qee yam acidity. Nyob rau hauv cov xwm txheej alkaline, nws tuaj yeem ua rau hydrolyzed los ntawm alkali los tsim cov ntsev sib xws thiab cov khoom siv ntawm 18 -Glycyrrhetinic Acid.
2. Cov tshuaj tiv thaiv oxidation: 18 -Glycyrrhetinic Acid yog oxidized yooj yim. Yog tias raug rau kev ua ntawm oxidizing cov neeg ua haujlwm xws li hydrogen peroxide, ozone, oxygen, thiab lwm yam, nws yuav raug oxidation cov tshuaj tiv thaiv thiab tsim cov khoom sib txawv ntawm oxidation. Tsis tas li ntawd, nws tuaj yeem cuam tshuam nrog qee cov oxidants xws li chromic acid, poov tshuaj persulfate, thiab lwm yam, thiab ua rau cov tshuaj tiv thaiv oxidation los tsim cov khoom siv oxidation.
3. Cov tshuaj tiv thaiv txo qis: 18 -Glycyrrhetinic Acid yog qhov ua rau txo cov tshuaj tiv thaiv, thiab nws tuaj yeem raug txo kom txo qis hauv daim ntawv ntawm 18 -Glycyrrhetinic Acid, xws li 18 -Glycyrrhetinic Acid 3- ketone, los ntawm kev txo cov neeg ua haujlwm xws li sodium sulfite thiab hydrogen gas.
4. Cov tshuaj tiv thaiv Alkylation: 18 -Glycyrrhetinic Acid tuaj yeem raug cov tshuaj tiv thaiv alkylation, xws li methyl iodide, ethyl iodide thiab lwm yam alkylating reagents, los tsim cov khoom sib xws alkylation ntawm 18 -Glycyrrhetinic Acid.
5. Cov tshuaj tiv thaiv Esterification: Cov pab pawg carboxyl hauv 18 -Glycyrrhetinic Acid tuaj yeem hnov mob nrog qee yam cawv los tsim cov ester sib txuas.
6. Cov tshuaj tiv thaiv cleavage txo qis: 18 -Glycyrrhetinic Acid tuaj yeem raug txo qis cov tshuaj tiv thaiv nyob rau hauv qhov kev txiav txim ntawm kev txo tus neeg sawv cev los tsim triterpenoids nrog cov pob txha sib txawv.