Bremelanotide(link:https://www.bloomtechz.com/synthetic-chemical/peptide/bremelanotide-powder-cas-189691-06-3.html) yog ib qho tshuaj siv ntau yam, uas muaj kev siv dav dav hauv kev kho mob hauv kev sib deev, insomnia, rog, thiab mob plawv plawv. Los ntawm kev tshawb fawb thiab kev txhim kho tas mus li, Bremelanotide xav tias yuav dhau los ua kev kho mob zoo dua thiab zoo dua, yog li txhim kho tib neeg lub neej zoo. Nws yog ib qho hluavtaws polypeptide hormone uas nws cov qauv zoo ib yam li leptin, tyrosine thiab tawv nqaij melanin uas ib txwm muaj nyob hauv tib neeg lub cev. Nws yog tsuas yog siv nyob rau hauv kev kho mob ntawm kev sib deev dysfunction, insomnia thiab lwm yam kab mob.
1. Kev sib deev tsis zoo:
Kev ua txhaum ntawm kev sib deev yog ib qho teeb meem kev sib deev hauv cov txiv neej thiab poj niam, suav nrog erectile kawg, ejaculation ntxov ntxov, poob libido, thiab ntau dua. Bremelanotide yog ib qho tshuaj zoo rau kev kho mob ntawm kev sib deev dysfunction. Nws tsub kom libido, txhawb erection thiab prolongs kev sib deev kev sib deev los ntawm kev txhawb cov ntshav ntws mus rau hauv lub corpus cavernosum thiab cov ntaub so ntswg qhov chaw mos. Cov kev tshawb fawb tau pom tias Bremelanotide tuaj yeem tsim cov teebmeem no los ntawm kev txhawb nqa Melanocortin -4 receptor (MC4R) hauv nruab nrab paj hlwb.
Bremelanotide tau pib muab rau cov neeg mob los ntawm kev txhaj tshuaj subcutaneous, tab sis qhov ncauj version ntawm Bremelanotide, hu ua Bremelanotide qhov ncauj zaj duab xis, tau tsim tom qab. Qhov no version ntawm Bremelanotide ua rau muaj zog libido nyob rau hauv ua ntej thiab tom qab hloov pauv txiv neej thiab poj niam cov neeg mob. Yog li ntawd, Bremelanotide muaj ib daim ntawv thov kev cia siab rau hauv kev kho mob ntawm kev sib deev dysfunction.
2. Insomnia:
Insomnia yog ib qho kev pw tsaug zog tsis zoo, nrog rau kev nyuaj pw tsaug zog, sawv tau yooj yim, thiab pw tsaug zog tsis zoo. Bremelanotide yog ib qho tshuaj zoo rau kev kho mob ntawm insomnia, uas txhim kho lub excitability ntawm neurons los ntawm stimulating tso tawm ntawm dopamine thiab norepinephrine, yog li pab kom tsaug zog thiab ntev pw tsaug zog.
Cov kev tshawb fawb tau pom tias Bremelanotide tuaj yeem txhim kho cov tsos mob insomnia thaum muab rau cov neeg mob hauv daim ntawv ntawm qhov ncauj lossis qhov ntswg. Hauv kev sim tshuaj, Bremelanotide tshuaj tsuag qhov ntswg tau sim hauv 48 tus neeg laus noj qab haus huv thiab pom tias Bremelanotide txo qis cov tsos mob insomnia thiab txhim kho kev pw tsaug zog zoo thiab ntev.
3. Kev rog:
Bremelanotide yog ib qho kev noj qab haus huv-tswj cov tshuaj hormones uas txo cov qab los noj mov los ntawm stimulating MC4R nyob rau hauv lub hauv paus paj hlwb, yog li pab txo cov tsos mob rog. Cov kev tshawb fawb tau pom tias Bremelanotide tuaj yeem txo cov khoom noj, ua kom cov metabolism hauv basal thiab txo lub cev hnyav.
Hauv Phase II kev soj ntsuam, Bremelanotide tau sim hauv 90 cov neeg mob rog thiab pom tias Bremelanotide tuaj yeem txo lub cev hnyav thiab BMI. Kev sim kuj pom tias Bremelanotide muaj qhov cuam tshuam loj heev rau kev tswj kev qab los noj mov hauv cov neeg mob rog, yog li nws muaj kev thov dav dav hauv kev kho mob rog.
4. Kev ntxhov siab vim mob plawv:
Kev ntxhov siab ntawm cov hlab plawv kab mob yog kab mob plawv thiab vascular cuam tshuam nrog kev ntxhov siab, xws li mob coronary syndrome, myocardial infarction, thiab lwm yam. Bremelanotide txhim kho neuronal excitability thiab cov hlab plawv kev noj qab haus huv nyob rau hauv kev ntxhov siab los ntawm stimulating receptors xws li norepinephrine receptors, dopamine receptors, thiab MC4R.
Hauv kev sim tshuaj me me, Bremelanotide tau sim hauv 10 tus neeg mob uas muaj kev ntxhov siab vim mob plawv, thiab nws tau pom tias Bremelanotide tuaj yeem txhim kho cov neeg mob lub plawv hloov pauv thiab cov ntshav siab, thiab txhim kho lub plawv dhia thiab qoj ib ce.
5. Lwm yam kev siv tshuaj kho mob:
Ntxiv nrog rau cov ntawv thov saum toj no, Bremelanotide kuj tuaj yeem siv los ua cov tawv nqaij softener, tus neeg saib xyuas rau lub cev thiab cov kab mob hauv nruab nrog cev, thiab kev kho tshuaj kho mob. Piv txwv li, Bremelanotide tuaj yeem txhawb kev kho qhov txhab, txhim kho txoj hlab ntsws, thiab lwm yam. Ntxiv mus, cov kev tshawb fawb tshiab qhia tau hais tias Bremelanotide tuaj yeem txo cov rog dawb thiab txhim kho insulin rhiab heev.
Bremelanotide yog polypeptide cov tshuaj hormones feem ntau siv los kho cov teeb meem xws li erectile kawg thiab qis libido.
1. Cov tshuaj tiv thaiv oxidation:
Cov tshuaj tiv thaiv oxidation ntawm Bremelanotide feem ntau yog hais txog nws cov oxidation los ntawm cov pa oxygen, uas yuav ua rau muaj kev hloov hauv cov khoom, xws li xim, duab thiab purity. Cov tshuaj tiv thaiv no tuaj yeem tshwm sim thaum lub sijhawm tsim khoom, khaws cia lossis siv Bremelanotide. Rau cov organic tebchaw, cov tshuaj tiv thaiv oxidation tuaj yeem rhuav tshem ob daim ntawv cog lus, oxidize ib daim ntawv cog lus, lossis ncaj qha hloov cov pab pawg ua haujlwm rau hauv ketones, acids, thiab lwm yam.
2. Txo cov tshuaj tiv thaiv:
Kev txo cov tshuaj tiv thaiv ntawm Bremelanotide feem ntau yog hais txog qhov kev txiav txim ntawm kev txo qee cov tshuaj tiv thaiv kab mob hauv cov tshuaj nyob rau hauv qhov kev txiav txim ntawm tus neeg sawv cev txo. Kev txo cov tshuaj tiv thaiv feem ntau cuam tshuam rau cov tshuaj tiv thaiv oxidation, thiab qhov tshwm sim tuaj yeem yog qhov nce ntawm cov khoom txo qis, txo qhov hnyav molecular, thiab nce hauv purity. Cov tshuaj txo qis xws li sodium borohydride, sulfites, hlau catalysts, thiab lwm yam.
3. Acylation cov tshuaj tiv thaiv:
Lub xub ntiag ntawm cov amino thiab hydroxyl pab pawg ua haujlwm hauv Bremelanotide tso cai rau acylation cov tshuaj tiv thaiv. Tshwj xeeb, cov pab pawg ua haujlwm hauv Bremelanotide tuaj yeem ua acylated nrog cov tebchaw xws li acid anhydrides los tsim cov esters sib xws. Feem ntau acylation catalysts muaj xws li DCC, EDC, thiab lwm yam.
4. Cov tshuaj tiv thaiv condensation:
Cov tshuaj tiv thaiv condensation yog kev ua ntawm nucleophilic ntxiv ntawm ob lossis ntau lub molecules, uas ua rau tsim cov ntawv cog lus tshiab. Hauv cov txheej txheem ntawm kev npaj Bremelanotide, nws tau txais los ntawm pseudopeptide condensation cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv feem ntau xav tau qhov kev txiav txim ntawm qee cov catalysts, thiab qee cov khoom lag luam raug tsim nyob rau hauv cov txheej txheem. Cov tshuaj tiv thaiv condensation ntawm Bremelanotide feem ntau yog los ntawm anhydride condensation cov tshuaj tiv thaiv.
5. Kev tshem tawm cov tshuaj tiv thaiv:
Kev tshem tawm cov tshuaj tiv thaiv yog hais txog cov tshuaj tiv thaiv uas qee cov pab pawg ua haujlwm (xws li pawg amino, pawg hydroxyl, halogen, thiab lwm yam) hauv cov khoom raug tshem tawm, ua rau kev sib tsoo. Hauv kev npaj ntawm Bremelanotide, kev tshem tawm cov tshuaj tiv thaiv feem ntau yog qhov tsis xav tau cov tshuaj tiv thaiv, vim tias nws tuaj yeem ua rau txo qis hauv kev huv ntawm cov khoom lossis tsim cov khoom tsis zoo.
6. Ntxiv cov tshuaj tiv thaiv:
Cov tshuaj tiv thaiv ntxiv yog cov tshuaj tiv thaiv uas qhov sib ntxiv tshwm sim ntawm ob lossis ntau dua monomers thiab cov ntawv cog lus tshiab tau tsim. Bremelanotide tebchaw muaj ntau pawg ua haujlwm, xws li amino, hydroxyl, acyl, thiab lwm yam, uas tuaj yeem koom nrog cov tshuaj tiv thaiv ntxiv. Thaum lub sij hawm kev npaj ntawm Bremelanotide, ntau yam ntxiv cov tshuaj tiv thaiv yuav tsum tau tsim nws cov qauv molecular.
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7. Amination cov tshuaj tiv thaiv:
Bremelanotide muaj cov amino functional pawg, yog li nws cov derivatives tuaj yeem tau los ntawm cov tshuaj tiv thaiv amination. Piv txwv li, cov ntsev sib xyaw ua ke tuaj yeem tau txais los ntawm reacting Bremelanotide nrog ammonium isopropoxide.
8. Cov tshuaj tiv thaiv Alkylation:
Cov tshuaj tiv thaiv alkylation yog hais txog cov tshuaj tiv thaiv uas hydrogen atoms ntawm lub nplhaib uas muaj ntxhiab lossis lub nplhaib isomeric hauv Bremelanotide tau hloov los ntawm pawg alkyl. Cov tshuaj tiv thaiv no feem ntau yuav tsum tau siv cov alkali hlau lossis organometallic catalysts, thaum tswj cov xwm txheej xws li cov tshuaj tiv thaiv kub thiab sijhawm.
Nyob rau hauv xaus, raws li ib tug polypeptide cov tshuaj hormones compound, Bremelanotide muaj complex qauv thiab tshuaj muaj zog, thiab muaj ntau yam cuam tshuam rau nws synthesis, sib cais thiab purification. Kev nkag siab tob txog cov tshuaj tiv thaiv no yuav pab npaj cov khoom lag luam zoo Bremelanotide thiab muab kev txhawb nqa zoo rau lawv daim ntawv thov kev kho mob.