Kev tshawb fawb tshuaj tiv thaiv kab mob ib txwm hloov pauv, tab sis qee yam tshuaj tau dhau los ua qhov tseem ceeb rau kev nkag siab thiab sib ntaus sib tua kab mob.GS-441524 hmoov tau txais kev saib xyuas ntau los ntawm cov kws tshaj lij hauv thaj chaw tshuaj, cov tuam txhab biotechnology, thiab cov kws kho tsiaj tshwj xeeb thoob plaws ntiaj teb. Qhov no nucleoside variant yog ib kauj ruam loj rau hauv kev tawm tsam cov kab mob, tshwj xeeb tshaj yog tawm tsam cov kab mob RNA luam lawv tus kheej. Cov kws tshawb fawb thiab cov tuam txhab tshuaj muaj peev xwm xaiv tau ntse txog qhov twg kom tau txais cov ntsiab lus tseem ceeb no rau lawv cov haujlwm yog tias lawv paub txog nws cov qauv tshuaj lom neeg, kev ua haujlwm lom neeg, thiab kev siv tswv yim.
GS-441524 hmoov yog ib qho tseem ceeb ntawm cov ntaub ntawv tshawb fawb vim qhov kev xav tau ntawm cov tshuaj tua kab mob ntshiab heev. Paub ntau yam txog qhov sib xyaw ua ke no thiab nws ua haujlwm li cas yog qhov muaj txiaj ntsig zoo thaum koj tab tom tsim cov tshuaj tiv thaiv kab mob tshiab, los nrog cov phiaj xwm kho tshiab, lossis ua cov kev tshawb fawb yooj yim. Daim ntawv no hais txog cov yam ntxwv tseem ceeb ntawm no nucleoside analog uas ua rau nws yog ib feem tseem ceeb ntawm kev kawm niaj hnub ntawm cov kab mob.
1. General Specification (hauv Tshuag)
(1) Txhaj tshuaj
20 mg, 6 ml; 30 mg, 8 ml; 40 mg, 10 ml
(2) Tablet
25/45/60/70 mg tab
(3) API (Ntshiab hmoov)
(4) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-1-049
GS-441524 CAS Nr .: 1191237-69-0
Peb muab GS-441524 hmoov, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia thiab cov ntaub ntawv khoom.
Dab tsi yogGS-441524 hmoovthiab Vim Li Cas Nws Thiaj Siv Hauv Kev Tshawb Fawb Antiviral?
Lub GS-441524 hmoov yog ib tug txiv neej ua adenosine nucleoside analog uas tau pom zoo tshuaj tiv thaiv kab mob tiv thaiv kab mob RNA sib txawv. Cov tshuaj no yog niam txiv nucleoside ntawm prodrug remdesivir, uas tau nto moo thoob ntiaj teb thaum muaj tus kab mob sib kis tsis ntev los no. Vim tias nws cov qauv molecules li cas, cov tshuaj no tuaj yeem tiv thaiv tus kab mob RNA los ntawm kev tsim. Qhov no ua rau nws muaj txiaj ntsig zoo rau cov kws tshawb fawb kawm txog yuav ua li cas cov kab mob rov ua dua.
Cov Qauv Zoo rau Kev Tshawb Fawb - Cov Khoom Siv Qib
Thaum nrhiav GS-441524 hmoovrau kev tshawb fawb tshawb fawb, qib purity feem ntau ntsib lossis mus dhau 98%, uas tuaj yeem lees paub los ntawm HPLC tsom xam. Cov kws kho mob ntseeg tau muab cov ntaub ntawv qhia tag nrho ntawm kev tshuaj xyuas uas suav nrog NMR thiab cov txiaj ntsig loj ntawm spectrometry nrog rau lwm cov ntaub ntawv spectroscopic. Cov ntaub ntawv tshawb fawb no ua kom paub tseeb tias cov txiaj ntsig zoo ib yam los ntawm batch mus rau batch, uas tseem ceeb heev kom tau txais cov txiaj ntsig kev tshawb fawb. Txhawm rau khaws cov khoom sib xyaw kom zoo rau lub sijhawm ntev, cov lus qhia khaws cia feem ntau hais kom khaws cia rau hauv qhov chaw txias, qhuav qhov chaw nyob deb ntawm lub teeb thiab noo.
Cov ntawv thov hauv Viral Research Programs
Qhov no nucleoside analog yog siv los ntawm kev lag luam kws tshuaj thiab pab pawg tshawb fawb los kawm txog kev tiv thaiv tus kab mob RNA polymerase. Cov tshuaj no yog lub ntsiab lus tseem ceeb rau kev tsim cov tshuaj tiv thaiv kab mob tshiab thiab kawm seb cov tswv cuab ntawm tsev neeg tus mob coronavirus coj li cas. Kev tshawb fawb nrog cov tshuaj no tau pab tshwj xeeb rau kev tshawb fawb kws kho tsiaj vim tias lawv tau pom cov lus cog tseg hauv kev kho qee yam teeb meem kev noj qab haus huv hauv miv. Ntau pawg tshawb fawb uas ua tshuaj tiv thaiv kab mob muaj xws li cov tshuaj no hauv lawv cov khoom siv kuaj vim tias nws ua haujlwm hauv txoj kev nkag siab zoo.
Chemical Structure thiab Molecular Characteristics
Cov molecule muaj cov piam thaj hloov pauv txuas nrog C- adenine puag uas muaj cyano pawg ntxiv rau nws. Qhov kev hloov pauv no rau cov qauv molecule cia nws nyob ib ncig ntawm qee cov phab ntsa hauv cov hlwb thaum tseem tuaj yeem ua phosphorylated los ntawm cellular kinases. Qhov tawm -dawb mus rau dawb crystalline hmoov daim ntawv ua kom cov khoom ruaj khov thaum nws tau khaws cia thiab ua kom cov kev ntsuas tseeb yooj yim dua rau txoj kev sim. Cov kws tshawb fawb nyiam cov tshuaj no vim nws nyob twj ywm tib yam tshuaj nyob rau ntau qhov kev sim khiav, yog li cov txiaj ntsig yeej ib txwm zoo ib yam.
Yuav ua li casGS-441524 hmoovUa haujlwm li Nucleoside Analog hauv Viral Inhibition?
Txhawm rau txheeb xyuas seb qhov nucleoside mimic no txwv cov kab mob los ntawm kev luam lawv tus kheej li cas, peb yuav tsum saib seb nws cuam tshuam li cas nrog cov enzymes hauv cov hlwb thiab cov kab mob. Cov tshuaj ua haujlwm vim nws tuaj yeem zoo li ntuj nucleosides thaum ntxiv cov khoom uas cuam tshuam tus kab mob rov ua dua. Vim tias nws muaj ob qho ntawm cov khoom no, nws ua haujlwm zoo tiv thaiv ntau hom kab mob RNA.
Cellular Uptake thiab Phosphorylation Pathway
Nucleoside transporters hauv cell membranes cia cov cell noj cov tshuaj tom qab muab rau lawv. Raws li cov molecule txav mus rau hauv cov hlwb, kinase enzymes maj mam hloov nws mus rau nws cov active triphosphate daim ntawv. Qhov kev hloov pauv metabolic no yog ib kauj ruam tseem ceeb uas cuam tshuam rau qhov sib xyaw ua ke sib ntaus cov kab mob. Cov khoom lag luam triphosphate sim koom nrog kev loj hlob RNA chains thaum lub sij hawm tus kab mob replication, tab sis ntuj adenosine triphosphate twb muaj lawm.
Kev cuam tshuam nrog Viral RNA-Dependent RNA Polymerase
Daim ntawv active triphosphate mus ncaj rau tus kab mob RNA - nyob ntawm RNA polymerase, uas yog cov enzyme uas luam cov khoom siv tshuaj tua kab mob. Qhov hloov pauv nucleotide nres cov txheej txheem txuas txuas ib txwm los ntawm kev ntxiv nws tus kheej rau tus kab mob tshiab RNA strands. Qhov kev cuam tshuam no tshwm sim vim tias cov kev hloov pauv rau cov qauv nres lub hauv paus los ntawm kev koom nrog cov nucleotides tom ntej. Cov kab mob polymerase tsis tuaj yeem nyob ib puag ncig cov tsim no - hauv cov analogs, uas ua rau cov saw hlau xaus thaum ntxov lossis rov ua dua tus nqi poob los ntawm ntau.
Kev xaiv rau Viral Versus Cellular Polymerases
Ib qho txiaj ntsig tseem ceeb ntawm qhov no nucleoside mimic yog tias nws thaiv cov kab mob polymerases zoo dua cellular DNA thiab RNA polymerases. Qhov kev xaiv no txo qis txoj hauv kev muaj kev phom sij thaum khaws cov tshuaj tiv thaiv kab mob. Cov kev tshawb fawb ntawm cov qauv tau pom tias cov kab mob polymerases muaj cov hnab ris uas tuaj yeem haum cov nucleoside hloov pauv yooj yim dua li cov cellular polymerases. Qhov kev nkag siab sib txawv no pab piav qhia tias yog vim li cas cov tshuaj ua haujlwm zoo li cov tshuaj hauv kev sim kuaj.
GS-441524 hmoovMechanism hauv Thaiv RNA Virus Replication
Cov tshuaj tiv thaiv kab mob no txwv tsis pub rov ua dua ntawm RNA cov kab mob los ntawm cov txheej txheem nyuaj uas suav nrog ntau cov kauj ruam biochemical thiab kev sib cuam tshuam ntawm molecular. Ntau txoj haujlwm tau nkag mus rau hauv kev txheeb xyuas cov txheej txheem no kom lawv tuaj yeem siv tau zoo dua hauv kev kho mob thiab ua cov tshuaj tiv thaiv kab mob tshiab.
Kev cuam tshuam rau Viral Proofreading Mechanisms
Ntau tus kab mob RNA muaj cov cheeb tsam exonuclease hauv lawv cov polymerase complexes uas pab kho. Nws yog qhov nthuav tias qhov no nucleoside analog tsis raug txiav tawm los ntawm cov kab mob no kho cov kab ke. Exonuclease domains muaj lub sijhawm nyuaj los lees paub thiab tshem tawm cov molecule ntawm RNA cov hlua vim yog txoj hauv kev uas nws tsim. Qhov kev tawm tsam no ua rau cov tshuaj muaj txiaj ntsig zoo rau cov kab mob vim tias cov analogs uas tau ntxiv nyob rau hauv cov kab mob RNA ntev dua, ua kom lawv cov teebmeem thaiv mus.
Delayed Chain Termination Effect
Hauv kev sib piv rau qee cov nucleoside analogs uas xaus cov saw tam sim ntawd, cov molecule no feem ntau cia ob peb nucleotides ntxiv tom qab nws ntxiv. Lub compound tus qauv ua rau qhov kev ncua ncua sij hawm. Nws tsis tag nrho nres polymerase txoj kev loj hlob, tab sis nws ua rau nws nyuaj heev. Thaum cov polymerase los hla qhov hloov pauv nucleotide, nws qeeb qeeb thiab thaum kawg nres ua haujlwm tag nrho. Kev sim tshuaj biochemical uas ntsuas cov kev ua ntawm polymerase nyob rau hauv lub xub ntiag ntawm cov tshuaj sib txawv tau pab kom elucidate cov txheej txheem no.
Kev koom ua ke rau hauv Viral RNA Strands
Lub polymerase enzyme xaiv nucleotide triphosphates los ntawm lub cell pas dej ua ke ntxiv rau kev loj hlob RNA chains thaum tus kab mob RNA tsim. Lub active daim ntawv ntawm GS-441524 hmoovNws zoo ib yam li ATP ntuj, uas txhais tau hais tias cov kab mob polymerases tuaj yeem khaws nws tawm thiab siv nws. Cov nucleotide hloov pauv dhau los ua ib feem ntawm cov kab mob RNA ib ntus thaum nws ntxiv. Txawm li cas los xij, cov kev hloov pauv uas nws ua rau nws cov qauv ua rau RNA strand tsis ruaj khov, uas txwv tsis pub cov txheej txheem luam tawm mus ntxiv kom zoo.
Vim li casGS-441524 hmoovPuas Muaj Kev Kawm rau FIP thiab Coronavirus Qauv?
Qhov sib txawv nucleoside no feem ntau tau kawm hauv thaj chaw ntawm feline infectious peritonitis (FIP) thiab cov qauv sib txawv ntawm tus mob coronavirus. Vim nws txoj kev vam meej tiv thaiv cov kab mob no, qhov sib xyaw ua ke tau ua ntau yam kev tshawb fawb txog nws txoj kev kho mob thiab nws ua haujlwm li cas.
FIP raws li Coronavirus Kev Tshawb Fawb Qauv
Feline coronavirus hloov pauv ua rau FIP, kab mob uas cuam tshuam rau tag nrho lub cev thiab feem ntau xaus rau kev tuag. Tus mob no tsis tau muaj kev kho mob zoo yav dhau los, yog li nws yog ib qho tseem ceeb rau kev kawm kws kho tsiaj. Cov kws tshawb fawb tuaj yeem siv tus kab mob ua piv txwv ntuj los kawm paub ntxiv txog yuav ua li cas tus mob coronaviruses ua rau tus kab mob thiab yuav kho lawv li cas. Kev tshawb fawb siv cov nucleoside analog nyob rau hauv FIP cov neeg mob tau pom cov kev hloov pauv loj hauv cov neeg mob kev noj qab haus huv, uas tau ua rau muaj kev txaus siab rau thaj chaw tshuaj tsiaj thiab tshuaj sib piv.
Pharmacokinetic Properties nyob rau hauv kev sim tej chaw
Cov kws tshawb fawb uas saib cov tshuaj no hauv cov qauv kab mob coronavirus tau pom tias nws nqus tau li cas, faib, tawg, thiab pov tseg. Cov kev sim tshuaj pharmacokinetic no qhia tau tias cov tshuaj muaj peev xwm nkag mus rau cov ntaub so ntswg txaus kom ncav cuag cov hlwb thoob plaws hauv lub cev uas cuam tshuam nrog cov kab mob. Ib nrab-lub neej yog qhov zoo, uas txhais tau hais tias cov sijhawm siv tshuaj tuaj yeem khaws cov nyiaj tsim nyog rau lub sijhawm ntev. Cov kev tshawb fawb bioavailability pab cov kws tshawb fawb txheeb xyuas txoj hauv kev zoo tshaj plaws los muab tshuaj thiab xyuas kom lawv ua haujlwm zoo tshaj plaws.
Sib piv Kev Ua Tau Zoo Tawm tsam Coronavirus Variants
Ntau hom kab mob coronavirus tsawg dua lossis ntau dua rau cov tshuaj tiv thaiv kab mob. Txhawm rau kawm paub ntxiv txog qhov nucleoside analog cov haujlwm no, pawg tshawb fawb tau sim nws cov txheej txheem tiv thaiv ntau hom kab mob coronavirus. Cov kev tshawb fawb sib piv no qhia tau tias cov txheej txheem polymerase tsom feem ntau ua haujlwm tau zoo thoob plaws cov tswv cuab ntawm tsev neeg tus mob coronavirus. Cov txiaj ntsig no ua rau nws tseem ceeb kom saib xyuas seb cov tshuaj no yuav siv li cas los tawm tsam tus kabmob coronavirus tshiab.
Core Biochemical Properties Uas txhaisGS-441524 hmoov
Basic biochemical khoom ntawmGS-441524 hmoovtxiav txim siab seb nws coj li cas hauv kev ua neej nyob thiab ua kom nws haum rau ntau yam kev tshawb fawb siv. Los ntawm kev nkag siab txog cov yam ntxwv no, cov kws tshawb fawb tuaj yeem kwv yees cov txiaj ntsig kev sim tau zoo dua thiab txhim kho lawv cov qauv kev kawm thiab cov txheej txheem.
Solubility thiab Formulation Considerations
Cov compound tsis yaj zoo hauv cov dej ntshiab, tab sis nws yaj yooj yim hauv DMSO thiab lwm cov kuab tshuaj organic uas tau siv dav hauv kev tshawb fawb tshuaj. Hom solubility no cuam tshuam li cas cov formulations tau tsim rau cov kev tshawb fawb uas tshwm sim hauv vitro thiab hauv vivo. Cov kev daws teeb meem feem ntau yog tsim los ntawm cov kws tshawb fawb hauv DMSO. Rau kev sim, cov kev daws teeb meem no tau muab sib xyaw rau hauv dej -raws li buffers. Vim tias qhov sib xyaw ua ke muaj kev nyab xeeb hauv kev daws teeb meem nyob ntawm pH, qhov kub thiab txias, thiab lub teeb, nws tseem ceeb heev uas yuav tsum tau ceev faj txog qhov nws khaws cia.
Stability Profile Raws li ntau yam xwm txheej
Ntev - cov kev tshawb fawb ruaj khov tau pom cov xwm txheej zoo tshaj plaws rau khaws cov khoom sib txuas kom lawv khaws lawv cov purity. Thaum khaws cia ntawm -20℃nyob rau hauv cov ntaub ntawv kaw kom tsis txhob ya raws, GS-441524 hmoov daim ntawv nyob ruaj khov heev. Cov kuab tshuaj sib txawv, qhov siab, thiab qhov kub thiab txias tuaj yeem hloov pauv qhov kev daws teeb meem zoo li cas. Cov ntaub ntawv ruaj khov pab cov kws tshawb fawb uas ua cov kev tshawb fawb ntev los ntawm kev qhia lawv yuav ua li cas npaj thiab khaws cov ntaub ntawv. Cov txheej txheem tshuaj ntsuam xyuas yog siv los ntsuas cov khoom khaws cia tsis tu ncua kom paub tseeb tias nws nyob twj ywm dawb huv thiab ua haujlwm thoob plaws lub sijhawm sim.
Xaus
CovGS-441524 hmoovyog ib kauj ruam loj rau pem hauv ntej hauv kev tshawb fawb antiviral. Nws muab cov kws tshawb fawb muaj zog los kawm txog yuav ua li cas cov kab mob RNA replicate thiab tuaj nrog txoj hauv kev tshiab los kho lawv. Nws yog ib qho tseem ceeb molecule rau cov koom haum tshawb fawb tshuaj thiab kev lag luam biotechnology vim nws muaj qhov zoo -paub nucleoside analog qauv, xaiv inhibits tus kab mob polymerase, thiab tau pom tias ua haujlwm hauv cov qauv kab mob coronavirus. Cov kws tshawb fawb tuaj yeem ua kom cov kev tshawb fawb zoo dua thiab ua kom muaj kev vam meej hauv kev tshawb fawb txog tshuaj tiv thaiv kab mob los ntawm kev nkag siab txog nws cov txiaj ntsig zoo, xws li nws cov yam ntxwv molecular thiab biochemical ua haujlwm. Cov kws tshawb fawb tseem nyiam thiab kawm txog cov khoom siv vim nws tuaj yeem siv rau ntau qhov kev tshawb fawb sib txawv thiab muaj qhov tshwj xeeb zoo. Raws li cov tsev kawm ntawv qib siab thiab cov tuam txhab tshuaj nrhiav txoj hauv kev tshiab los tua cov kab mob, lawv yuav tsum muaj peev xwm nkag mus tau siab - zoo, zoo- cov ntaub ntawv muaj txiaj ntsig txhawm rau ua cov ntaub ntawv uas tuaj yeem siv rov ua dua kom txav mus tom ntej.
FAQ
- Qhov purity theem twg kuv yuav tsum xav kom thaum xajGS-441524 hmoovrau kev tshawb fawb tshuaj?
- Yuav tsum ua li casGS-441524 hmoovmuab khaws cia kom ruaj khov thiab ua haujlwm?
- Cov ntaub ntawv dab tsi yuav tsum nrogGS-441524 hmoovkev xa khoom mus rau kev tshawb fawb?
Koom tes nrog BLOOM TECH rau hwm GS-441524 hmoov Supplier Solutions
Thaum koj kawm xav tau qhov zoo tshaj plawsGS-441524 hmoovkev sib raug zoo ntawm cov neeg muag khoom, BLOOM TECH muaj qhov kev cia siab thiab kev paub uas tsis tuaj yeem raug ntaus. Vim peb cov chaw yog GMP- ntawv pov thawj thiab ua tau raws li US-FDA, EU-GMP, thiab PMDA cov qauv, koj tuaj yeem paub tseeb tias cov khoom peb siv yog tshuaj- qib thiab tuaj nrog cov ntaub ntawv tshawb xyuas tag nrho. Peb tau ua cov organic synthesis rau ntau tshaj 12 xyoo thiab tau tsim kev sib raug zoo nrog 24 ntawm cov tuam txhab tshuaj loj tshaj plaws hauv ntiaj teb. Peb muab cov khoom ruaj khov zoo, tus nqi tsim nyog, thiab cov kws tshaj lij pabcuam thoob plaws tag nrho lub neej ntawm koj qhov project. Peb triple- txoj kev txheeb xyuas qhov zoo kom ntseeg tau tias cov khoom yuav ua tau raws li koj qhov kev xav tau, thiab yog tias tsis yog, peb yuav muab koj cov nyiaj rov qab rau koj. Txawm hais tias koj xav tau me me rau kev kawm lossis ntau ntawm lawv rau kev tsim khoom, peb pawg neeg cog lus muab tus nqi meej, lub sijhawm ua haujlwm raug, thiab kev npaj thauj khoom yooj yim. Hu rau peb pab neeg muaj kev paub hnub no los tham txog koj GS-441524 hmoov yuav tsum:Sales@bloomtechz.com. Cia BLOOM TECH dhau los ua koj tus khub ntseeg siab hauv kev tshawb fawb txog tshuaj tiv thaiv kab mob nrog txhim khu kev qha, siab -cov khoom siv huv huv thiab kev pabcuam tshwj xeeb.
Cov ntaub ntawv
1. Pedersen NC, et al. Kev ua tau zoo ntawm 3C-zoo li protease inhibitor hauv kev kho ntau hom kab mob feline kis kab mob peritonitis. Phau ntawv Journal of Feline Medicine and Surgery. 2018;20(4):378-392.
2. Warren TK, et al. Kev kho tau zoo ntawm lub me me molecule GS-5734 tiv thaiv tus kab mob Ebola hauv rhesus liab. Xwm . 2016;531(7594):381-385.
3. Murphy BG, et al. Cov nucleoside analog GS-441524 muaj zog tiv thaiv kab mob feline infectious peritonitis (FIP) hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb nrhiav kab mob miv. Veterinary Microbiology. 2018; 219:226-233.
4. Siegel D, et al. Kev tshawb nrhiav thiab kev sib txuas ntawm phosphoramidate prodrug ntawm pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) rau kev kho mob Ebola thiab cov kab mob tshwm sim. Phau ntawv Journal of Medicinal Chemistry. 2017;60(5):1648-1661.
5. Gordon CJ, et al. Cov tshuaj tiv thaiv kab mob remdesivir muaj zog inhibits RNA-nyob ntawm RNA polymerase los ntawm Middle East ua pa syndrome coronavirus. Phau ntawv Journal of Biological Chemistry. 2020;295(15):4773-4779.
6. Schooley RT, thiab al. Rov xav txog remdesivir: synthesis, antiviral kev ua, thiab pharmacokinetics ntawm qhov ncauj GS-441524 derivatives. Antimicrobial Agents thiab Chemotherapy. 2021;65(8):e00468-21.