Taw qhia
GS 441524 tau txais kev saib xyuas tseem ceeb hauv zej zog kev tshawb fawb thiab kws kho tsiaj vim nws muaj peev xwm kho tau tus kab mob kis, tshwj xeeb yog feline infectious peritonitis (FIP) hauv miv. Kab lus no yuav tshawb txog dab tsiGS 441524 uayog, nws cov khoom siv tshuaj, cov txheej txheem ntawm kev ua, kev siv, thiab kev xav txog kev nyab xeeb. Peb lub hom phiaj yog los muab kev nkag siab zoo rau hauv qhov kev cog lus no, kom koj muaj kev nkag siab zoo ntawm nws qhov tseem ceeb.
Kev nkag siabTIAB SA 441524
Dab tsi yogTIAB SA 441524?
GS 441524 yog ib qho nucleoside analog thiab tshuaj tua kab mob siv hauv cov tshuaj kho tsiaj, tshwj xeeb tshaj yog rau kev kho mob feline infectious peritonitis (FIP). Nws inhibits viral RNA synthesis los ntawm mimicking nucleosides xav tau rau tus kab mob sib kis, yog li cuam tshuam tus kab mob lub peev xwm los tsim dua tshiab. Qhov sib xyaw no tau pom cov lus cog tseg hauv kev kho tus kab mob RNA vim nws cov txiaj ntsig tiv thaiv tus kabmob coronaviruses, suav nrog FIP-ua rau hom kab mob.
Cov roj formula: C12H13N5O4
Molecular Luj: 291.26 g / mol
Cov khoom ntawmTIAB SA 441524
GS 441524 nthuav tawm ntau yam tseem ceeb uas ua rau nws muaj txiaj ntsig zoo tiv thaiv qee yam kab mob:
Antiviral Activity: Inhibits viral replication los ntawm lub hom phiaj RNA-dependent RNA polymerase, ib qho enzyme tseem ceeb rau kev rov ua dua ntawm cov kab mob RNA.
Muaj Peev Xwm Muaj Peev Xwm: Ua kom muaj zog tiv thaiv ntau yam kab mob coronavirus, suav nrog cov uas ua rau FIP.
Kev Nyab Xeeb Profile: Feem ntau ua tau zoo nyob rau hauv cov tsiaj, nrog tsawg dua kev pheej hmoo ntawm kev phiv piv rau lwm yam tshuaj tua kab mob.
Mechanism ntawm Action
Lub luag haujlwm tseem ceeb ntawm kev ua ntawm GS 441524 cuam tshuam nrog inhibition ntawm tus kab mob RNA synthesis. Los ntawm kev sib txuas nws tus kheej rau hauv tus kab mob RNA, GS 441524 cuam tshuam cov txheej txheem rov ua dua, yog li txo cov kab mob hauv cov kab mob.
Inhibition ntawm RNA Polymerase: GS 441524 inhibits RNA-dependent RNA polymerase, tiv thaiv tus kab mob los ntawm kev sib txuas RNA tshiab.
Kev txiav tawm ntawm RNA Chains: Kev koom ua ke ntawm GS 441524 rau hauv cov kab mob RNA ua rau kev txiav tawm ntxov ntawm RNA chains, ntxiv kev cuam tshuam cov kab mob sib kis.
Kev siv GS 44 1524 : :
Kho Feline Infectious Peritonitis (FIP)
FIP yog ib qho mob hnyav thiab feem ntau tuag taus hauv miv, tshwm sim los ntawm qee hom kab mob feline coronavirus.GS 441524 uatau pom qhov ua tau zoo tshaj plaws hauv kev kho tus kab mob no, muab kev cia siab rau cov miv cuam tshuam thiab lawv cov tswv.
Nkag siab FIP
FIP yog tus cwj pwm los ntawm kev mob hnyav hauv ntau lub cev, ua rau cov tsos mob xws li kub taub hau, qaug zog, poob phaus, thiab cov kua dej ntau ntxiv hauv plab lossis hauv siab.
Kev kuaj mob: Kev kuaj mob FIP tuaj yeem nyuaj thiab feem ntau suav nrog kev sib xyaw ua ke ntawm cov tsos mob, kev sim kuaj, thiab kev tshawb fawb pom.
Daim Ntawv FIP: Muaj ob hom ntawv tseem ceeb ntawm FIP: effusive (ntub) thiab non-effusive (qhuav). Daim ntawv effusive yog tus cwj pwm los ntawm cov kua tsub zuj zuj, thaum daim ntawv uas tsis yog-effusive cuam tshuam nrog granulomas thiab qhov txhab ntawm ntau yam kabmob.
Kev ua tau zoo ntawmTIAB SA 441524 hauv Kev Kho FIP
Cov kev tshawb fawb soj ntsuam thiab cov ntawv thov hauv ntiaj teb tiag tiag tau pom qhov ua tau zoo ntawm GS 441524 hauv kev kho FIP.
Kev sim tshuaj kho mob: Ntau cov kev tshawb fawb tau pom tias muaj kev txhim kho tseem ceeb hauv cov miv uas kho nrog GS 441524, nrog ntau qhov kev tshem tawm cov tsos mob thiab kev muaj sia nyob ntev.
Kev Noj Qab Haus Huv thiab Kev Tswj Xyuas: Qhov ntau npaum thiab kev tswj hwm ntawm GS 441524 sib txawv raws li qhov hnyav ntawm tus kab mob thiab qhov hnyav ntawm tus miv. Nws feem ntau yog siv los ntawm kev txhaj tshuaj subcutaneous, nrog rau cov tshuaj kho raws li tus miv cov lus teb rau kev kho mob.
Kev tshawb fawb thiab kev loj hlob
Tshaj li nws cov ntaub ntawv kho tsiaj, GS 441524 kuj tseem muaj txiaj ntsig hauv kev tshawb fawb thiab kev txhim kho, tshwj xeeb hauv kev kawm txog tshuaj tiv thaiv kab mob thiab kev txhim kho tshuaj.
Kawm txog Antiviral Mechanisms
Cov kws tshawb fawb siv GS 441524 kom nkag siab yuav ua li cas nucleoside analogs inhibit viral replication, muab kev nkag siab los tsim cov tshuaj tiv thaiv kab mob tshiab.
RNA Viruses: GS 441524 yog siv nyob rau hauv kev tshawb fawb ntawm ntau yam kab mob RNA, pab kom elucidate lub mechanisms ntawm viral replication thiab inhibition.
Kev Tshawb Fawb Sib Piv: Cov kev tshawb fawb sib piv GS 441524 thiab remdesivir pab kom nkag siab txog lawv cov txheeb ze kev ua tau zoo thiab kev nyab xeeb, coj kev txhim kho cov tshuaj tiv thaiv kab mob tshiab.
Muaj peev xwm siv tau hauv tib neeg tshuaj
Thaum GS 441524 feem ntau yog siv hauv cov tshuaj kho tsiaj, nws cov qauv zoo sib xws rau remdesivir ua rau nws muaj kev txaus siab rau tib neeg cov tshuaj.
Kev Tshawb Fawb Kev Siv Tib Neeg: Cov kws tshawb fawb tab tom tshawb nrhiav cov ntawv thov muaj peev xwm ntawm GS 441524 hauv kev kho tib neeg cov kab mob, suav nrog COVID-19.
Kev Txhim Kho Tshuaj Yav Tom Ntej: Kev nkag siab tau txais los ntawm kev tshawb fawb ntawm GS 441524 tuaj yeem qhia txog kev txhim kho cov tshuaj tiv thaiv kab mob tshiab rau tib neeg siv.
Kev nyab xeeb thiab tuav ntawm GS 44 1524 : :
Cia thiab tuav
Kev ruaj ntseg thiab kev tuav pov hwm zooGS 441524 uaNws yog ib qho tseem ceeb kom muaj kev ruaj ntseg thiab kev ua tau zoo.
Cia Lub Sijhawm: Khaws GS 441524 hauv qhov chaw txias, qhuav, deb ntawm tshav ntuj ncaj qha thiab ya raws. Siv cov thawv airtight los tiv thaiv kev sib kis.
Kev Tiv Thaiv Kev Tiv Thaiv: Thaum tuav GS 441524, hnav cov cuab yeej tiv thaiv tus kheej tsim nyog (PPE) xws li hnab looj tes, tsom iav, thiab cov tsho tiv no. Tsis txhob nqus pa thiab tiv thaiv daim tawv nqaij.
Kev Tiv Thaiv Kev Nyab Xeeb
Thaum GS 441524 feem ntau muaj kev nyab xeeb, ua raws li kev tiv thaiv kev nyab xeeb yog qhov tseem ceeb kom txo qis kev pheej hmoo.
Tsis txhob nqus pa: Siv lub fume hood los yog ua haujlwm hauv qhov chaw uas muaj cua zoo kom tsis txhob nqus cov pa GS 441524.
Tiv thaiv tawv nqaij: Hnav cov hnab looj tes tiv thaiv tawv nqaij thiab ntxuav tes kom huv si tom qab tuav.
Pov tseg: Pov tseg GS 441524 pov tseg raws li cov cai hauv zos thiab cov lus qhia. Tsis txhob muab nws tso rau hauv qhov dej los yog muab pov tseg rau hauv cov thoob khib nyiab li niaj zaus.
Yuav Ua Li Cas Tau Txais GS 441524
Tau txais GS 441524 suav nrog kev yuav khoom los ntawm cov chaw muag khoom muaj npe uas tshwj xeeb hauv kev muab cov tshuaj zoo tshaj plaws.
Cov neeg muab kev tshawb fawb: txheeb xyuas cov neeg muag khoom nrog lub koob npe zoo thiab cov ntaub ntawv pov thawj hauv kev muab cov tshuaj-qib sib txuas. Nrhiav cov ntawv pov thawj thiab cov neeg siv khoom tshuaj xyuas.
Verify Purity: Xyuas kom meejGS 441524 uamuaj qib purity siab (feem ntau siab dua 98%) kom ntseeg tau tias kev ua tau zoo thiab kev nyab xeeb.
Tshawb xyuas Cov Cai: Nkag siab txog cov cai lij choj hauv koj lub tebchaws hais txog kev yuav khoom thiab siv GS 441524. Qee thaj tsam yuav muaj kev txwv lossis xav tau kev tso cai tshwj xeeb.
Ntawm Shaanxi BLOOM TECH Co., Ltd, peb tshwj xeeb hauv kev muab GS 441524 zoo.
Cov ntaub ntawv tiv tauj: Rau kev nug thiab kev yuav khoom, hu rau peb. Peb pab neeg yuav pab koj nrog cov ntsiab lus ntawm cov khoom, tus nqi, thiab cov ntaub ntawv xa khoom.
Ua ntej yuav thiab siv GS 441524, nws yog ib qho tseem ceeb uas yuav tau xav txog qhov cuam tshuam txog kev cai lij choj thiab kev coj ncaj ncees.
Raws li txoj cai: Txheeb xyuas cov xwm txheej raug cai ntawm GS 441524 hauv koj cheeb tsam. Qee qhov chaw yuav muaj kev cai nruj rau nws siv, tshwj xeeb tshaj yog rau kev siv tsiaj.
Ethical Use: Xyuas kom meej tias kev siv GS 441524 yog kev coj ncaj ncees, tshwj xeeb tshaj yog nyob rau hauv cov kws kho tsiaj. Tham nrog kws kho tsiaj thiab ua raws li cov lus pom zoo kom tsis txhob siv tsis raug.
Xaus
GS 441524 uasawv cev rau kev nce qib tseem ceeb hauv kev kho tshuaj tiv thaiv kab mob, tshwj xeeb tshaj yog rau feline infectious peritonitis (FIP) hauv miv. Kev nkag siab txog nws cov khoom, cov txheej txheem ntawm kev nqis tes ua, kev siv, thiab kev saib xyuas kev nyab xeeb tuaj yeem pab cov kws tshawb fawb, kws kho tsiaj, thiab cov tswv tsiaj txiav txim siab txog kev siv. Yog xav paub ntxiv, thov hu rau peb ntawmSales@bloomtechz.com.
Cov ntaub ntawv
Pedersen, NC, et al. (2019). "Kev ua tau zoo thiab kev nyab xeeb ntawm Nucleoside Analog GS 441524 rau Kev Kho Mob Miv nrog Kev tshwm sim Feline Infectious Peritonitis." Phau ntawv Journal of Feline Medicine and Surgery, vol. 21, nr. 4, pp. 271-281 ib.
Murphy, BG, et al. (2018). "Lub Nucleoside Analog GS 441524 Strongly Inhibits Feline Infectious Peritonitis (FIP) Virus nyob rau hauv cov ntaub so ntswg kab lis kev cai thiab kev tshawb fawb miv kab mob." Veterinary Microbiology, Vol. 219 Ib., pp.
"GS 441524." PubChem, National Center for Biotechnology Information, https://pubchem.ncbi.nlm.nih.gov/compound/GS 441524.
Brown, AJ, et al. (2019). "Remdesivir: Broad-Spectrum Antiviral Activity thiab muaj peev xwm siv tau los kho ntau yam kab mob kis." Antiviral Research, vol. 169, 104547 ib.
"Nucleoside Analogs hauv Veterinary Medicine." Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, vol. 4 3, nr. Peb Hlis 2, 2020, p. 115-129.