N-Boc-Nortropinoneyog ib qho organic compound, uas belongs rau ketone compounds, thiab nws cov tshuaj formula C16H21NO3. Nws yog xim dawb rau daj daj crystalline hmoov, soluble hauv dimethylsulfinamide thiab ethylene glycol, me ntsis soluble hauv chloroform thiab methanol, insoluble hauv dej. Nws qhov hnyav molecular yog 285.3 g / mol. Nws yog ib qho tseem ceeb nruab nrab ntawm cov organic synthesis thiab tuaj yeem siv dav hauv tshuaj, tshuaj tua kab, tshuaj pleev xim thiab lwm yam. Nyob rau hauv lub teb ntawm cov tshuaj, nws yuav siv tau raws li ib tug intermediate nyob rau hauv synthesis ntawm epilepsy tiv thaiv tshuaj, analgesics, antiplatelet tshuaj thiab antithrombotic agents. Hauv thaj chaw ntawm cov tshuaj tua kab, nws tuaj yeem siv los tsim ntau yam tshuaj tua kab thiab tshuaj tua kab, thiab hauv thaj chaw dyes, nws tuaj yeem siv los ua ib qho nruab nrab ntawm cov organic dyes los npaj cov dyes tshiab.
1. Siv nyob rau hauv cov tshuaj:
Raws li lub precursor ntawm nortropinone tebchaw, N-Boc-Nortropinone muaj ntau daim ntawv thov nqi. Nortropinone compounds yog ib chav kawm ntawm cov tshuaj intermediates tseem ceeb uas siv rau hauv kev npaj cov tshuaj, thiab tuaj yeem siv los tsim ntau cov tshuaj tseem ceeb, xws li tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv kab mob vwm.
Cov txheej txheem synthesis ntawm N-Boc-Nortropinone yog qhov yooj yim, thiab nws tuaj yeem npaj tau los ntawm McMurry cov tshuaj tiv thaiv lossis Birch txo cov tshuaj tiv thaiv. Nyob rau tib lub sijhawm, lub nplhaib hauv nruab nrab ntawm qhov sib xyaw tuaj yeem hloov kho rau qee qhov, yog li npaj ntau yam sib txawv.
2. Kev siv tshuaj tua kab:
N-Boc-Nortropinone tuaj yeem siv los ua qhov nruab nrab hauv kev sib txuas ntawm qee cov tshuaj tua kab thiab tshuaj tua kab. Piv txwv li, thaum synthesizing tej yam tshuaj tua kab, N-Boc-Nortropinone tuaj yeem tshwm sim nrog lwm qhov sib xyaw kom tau txais cov tshuaj tua kab. Qhov kom zoo dua ntawm qhov sib xyaw ua cov tshuaj tua kab nruab nrab yog tias nws tuaj yeem dhau los ua ntau cov kauj ruam los npaj ntau yam tshuaj tua kab sib txawv.
3. Daim ntawv thov nyob rau hauv daim teb ntawm dyes:
Raws li qhov nruab nrab ntawm cov organic dyes, N-Boc-Nortropinone tuaj yeem siv los ua ke ntau cov xim tshiab. Piv txwv li, N-Boc-Nortropinone thiab aniline tebchaw tuaj yeem hnov mob kom tau txais cov xim tshiab uas muaj zog dyeing kev ua tau zoo thiab kav ntev.
Chemical Properties:
1. Stability: N-Boc-Nortropinone ruaj khov ntawm chav tsev kub.
2. Solubility: N-Boc-Nortropinone yog soluble hauv organic solvents xws li ethanol, acetone, ether, dimethyl ether, thiab lwm yam, tab sis insoluble hauv dej.
3. Photostability: N-Boc-Nortropinone rhiab heev rau lub teeb thiab yooj yim deteriorated los ntawm lub teeb irradiation.
4. Oxidation: N-Boc-Nortropinone
N-Boc-Nortropinone (N-tert-butoxycarbonyl-nortropinone) yog ib qho tseem ceeb organic compound nrog ntau yam tshuaj muaj nqis. Nws yog ib tug derivative ntawm norrmorphone, uas yuav siv tau nyob rau hauv kev npaj ntawm ntau yam tshuaj, xws li tshuaj pleev ib ce thiab antidepressants. Kev tshawb pom keeb kwm ntawm N-Boc-Nortropinone tuaj yeem taug qab mus rau thaum ntxov 1960s, cov hauv qab no yog cov lus piav qhia ntxaws.
Xyoo 1943, American neurologist Carl F. Cori thiab nws tus poj niam Gerty T. Cori tau ua tiav cov txiaj ntsig glycogenase thaum kawm glycogen metabolism, qhia txog kev decomposition ntawm glycogen txoj hauv kev, uas tau tsim lub hauv paus rau kev kawm txog cov piam thaj metabolism. Txij thaum ntawd los, glycogenase tau dhau los ua cov cuab yeej tseem ceeb rau cov kws tshawb fawb los kawm txog cov piam thaj metabolism.
Thaum xyoo 1960, tus kws tshawb fawb Asmeskas Elliott DuPont tau tshawb pom N-Boc-Nortropinone hauv kev tshawb fawb sib koom nrog National Institutes of Health. DuPont pom tias thaum kawm txog kev sib cuam tshuam ntawm glycogenase thiab norrphanone, kev sib xyaw ntawm N-Boc-Nortropinone thiab glycogenase tuaj yeem txhim kho tau zoo. Qhov kev tshawb pom no tau ua rau muaj kev txaus siab ntawm cov kws tshawb fawb.
Tom qab ntawd, pab pawg DuPont tau ua qhov kev tshawb fawb tob ntxiv ntawm N-Boc-Nortropinone. Lawv pom tias N-Boc-Nortropinone muaj cov yam ntxwv ntawm nororphinone, thiab muaj cov dej solubility zoo thiab tshuaj lom neeg ruaj khov, yog li nws tuaj yeem siv los npaj ntau yam tshuaj. N-Boc-Nortropinone tuaj yeem siv los tsim ntau yam tshuaj, xws li Lidocaine thiab Procaine.
Nrog rau kev siv zog ntawm pab pawg DuPont, N-Boc-Nortropinone tau tshawb fawb ntxiv thiab thov. Cov kev tshawb fawb tau pom tias ntxiv rau kev siv los ua cov tshuaj nruab nrab, nws kuj muaj ntau yam tshuaj muaj txiaj ntsig xws li tshuaj tua kab mob, tiv thaiv kev ntxhov siab, thiab tiv thaiv kev nyuaj siab. Yog li ntawd, N-Boc-Nortropinone tau dhau los ua ib qho tseem ceeb hauv kev siv tshuaj synthesis thiab tau siv dav hauv kev lag luam tshuaj.
Hauv kev xaus, kev tshawb pom keeb kwm ntawm N-Boc-Nortropinone tau dhau los ntawm cov txheej txheem los ntawm kev kawm txog kev sib cuam tshuam ntawm glycogenase kom pom tias muaj ntau yam tshuaj muaj txiaj ntsig. Qhov kev tshawb pom thiab kev siv zog ntawm pab pawg DuPont tau tsim lub hauv paus tseem ceeb rau kev thov thiab kev txhawb nqa ntawm qhov sib xyaw no, thiab tseem ua rau muaj txiaj ntsig tseem ceeb rau kev txhim kho kev lag luam tshuaj.